Lourenco 2015 Front Aging Neurosci

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Lourenço CF, Ledo A, Dias C, Barbosa RM, Laranjinha J (2015) Neurovascular and neurometabolic derailment in aging and Alzheimer's disease. Front Aging Neurosci 7:103.

» PMID: 26074816

Lourenco CF, Ledo AM, Dias C, Barbosa RM, Laranjinha J (2015) Front Aging Neurosci

Abstract: The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation. This process-neurovascular coupling-and ensued alterations of glucose and oxygen metabolism-neurometabolic coupling-are accomplished by concerted communication between neural and vascular cells. Evidence suggests that neuronal-derived nitric oxide ((•)NO) is a key player in both phenomena. Alterations in the mechanisms underlying the intimate communication between neural cells and vessels ultimately lead to neuronal dysfunction. Both neurovascular and neurometabolic coupling are perturbed during brain aging and in age-related neuropathologies in close association with cognitive decline. However, despite decades of intense investigation, many aspects remain poorly understood, such as the impact of these alterations. In this review, we address neurovascular and neurometabolic derailment in aging and Alzheimer's disease (AD), discussing its significance in connection with (•)NO-related pathways.

Keywords: Neurovascularcoupling, Neurometabolism, Nitricoxide, Alzheimer’s disease, Aging, Hippocampal slices

O2k-Network Lab: PT Coimbra Laranjinha J

Labels: MiParea: Respiration, Comparative MiP;environmental MiP  Pathology: Aging;senescence, Alzheimer's 

Organism: Mouse  Tissue;cell: Nervous system  Preparation: Intact cells 

Coupling state: ROUTINE, ET  Pathway: ROX  HRR: Oxygraph-2k