Meszaros A

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MiPsociety
COST Action CA15203 MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


 

Meszaros A


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1


COST WG4: WG4

COST ECI: ECI


Name Mészáros András, MD, PhD
Institution
MeszarosA.JPG


Medical University of Innsbruck

Departement of Visceral-Transplant and Thoracic Surgery

  • Research on: Biologically active gases, nitric oxide, mitochondrial membrane potential, oxygen kinetics

Andras is collaborating with Oroboros Instruments since April 2017.

Address Schoepfstrasse 18, A-6020
City Innsbruck
State/Province
Country Austria
Email andras.meszaros@oroboros.at
Weblink https://www.researchgate.net/profile/Andras_Meszaros2

https://www.chirurgie-innsbruck.at/en/team/d/87/dr-andras-meszaros

O2k-Network Lab AT Innsbruck Oroboros, HU Szeged Boros M


Labels: Field of research: Basic  Topics: hypoxia, reoxygenation, electrophyl methyl groups (EMGs), methane, long-chain fatty acids 


Publications

 PublishedReference
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6.
Di Marcello 2019 MitoFit Preprint Arch EA2019Di Marcello M, Iglesias-Gonzalez J, Meszaros A, Haider M, Gnaiger E, Huete-Ortega M (2019) Partitioning between cytochrome c oxidase and alternative oxidase studied by oxygen kinetics of dark respiration in Chlamydomonas reinhardtii: a microalgae model organism. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0005.v3.
Doerrier 2018 Methods Mol Biol2018Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70.
Rademann 2017 Oxid Med Cell Longev2017Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Röstel F, Kaszaki J, Szabo A, Skulachev VP, Bauer M, Bahrami S, Weis S, Kozlov AV, Osuchowski MF (2017) Mitochondria-targeted antioxidants SKQ1 and MitoTEMPO failed to exert a long-term beneficial effect in murine polymicrobial sepsis. Oxid Med Cell Longev 6412682.
Tuboly 2017 Sci Rep2017Tuboly E, Molnár R, Tőkés T, Turányi RN, Hartmann P, Mészáros AT, Strifler G, Földesi I, Siska A, Szabó A, Mohácsi Á, Szabó G, Boros M (2017) Excessive alcohol consumption induces methane production in humans and rats. Sci Rep 7:7329.
Strifler 2016 PLOS ONE2016Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLOS ONE 11:e0146363.
Strifler 2016 Magyar Sebeszet2016Strifler G, Meszaros A, Pecz D, Ficzere A, Barath B, Mihaly B, Hartmann P (2016) A májfunkció vizsgálata respirometriával - Examination of liver mitochondria with respirometry. Magyar Sebészet 69:194–8.

Abstracts

 PublishedReference
Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT2019Cellular succinate transport and mitochondrial respiratory function in prostate cancer.
Rutai 2019 Crit Care2019Rutai A, Fejes R, Tallósy SZ, Poles M, Juhász L, Mészáros A, Boros M, Kaszaki J (2019) Potential role of endothelin receptors in the therapy of experimental sepsis. Crit Care.
Bastos Sant'Anna Silva 2018 Life Sciences Meeting 2018 Innsbruck AT2018Effect of cell-permeable succinate and malonate prodrugs on mitochondrial respiration in prostate cancer cells.
Meszaros 2018 Mt Med Hinxton2018High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments.
Meszaros 2018 EBEC20182018Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration.
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT2018Cellular succinate transport and mitochondrial respiratory function in prostate cancer.
Bastos Sant'Anna Silva 2018 MiPschool Tromso C42018
Ana Bastos Sant'Anna
Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.
Meszaros 2017 MiPschool Obergurgl2017
Andras Meszaros
(Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration.
Meszaros 2017 MiP20172017
Andras Meszaros
Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity.
Meszaros 2014 Abstract MiP20142014Methodological aspects of assessing mitochondrial function in small intestinal mucosal samples of rats and guinea pigs.

MitoEAGLE Short-Term Scientific Mission

Motivation letter
My name is András Mészáros and I am working as associate professor in the Institute of Surgical Research at the University of Szeged, Hungary. I got my M.D. degree in 2012 and I was working as PhD fellow in the same institute for three years subsequently before taking the current position. My main research interest is to understand mitochondrial dysfunction during oxido-reductive stress conditions (hypoxia, ischemia-reperfusion) in animal models and cultured cells. My further aim is to characterize acting mechanism of novel biologically active gaseous compounds in mitochondria. I have been working with High Resolution Respirometry and basic fluorometry for three years, gaining experience maínly with tissue homogenate and isolated mitochondría. An essential step now is to extend my expertise toward assessment of other functions than oxygen consumption.
The main objective of the planned STSM training is to get acquainted with and to standardize fluorometric measurements of isolated mitochondria and cultured cells. During the 8 days of short-term visit at the MitoFit Laboratory three new techniques could be learned:(l) measurement of reactive oxygen species production of permeabilized cells using H2O2-sensitive fluorescent probes; (2) determination of mitochondrial membrane potential and (3) assessment of mitochondrial phosphate/oxygen ratio by measuring ATP levels fluorometrically. Preparation and execution of each method will be learned with emphasis on internal quality control and possible adaptation of measurement protocols to samples from various tissues. Furthermore, we are going to use tools of complex data analysis and calibration.
Fulfillment of the proposed research plan during the STSM training would contribute significantly to the objectives of the MitoEAGLE Working Group 1 (standardization of protocols in respirometry).I wish to actively participate in the MitoEAGLE project, in, among others, establishing and testing reference protocols to provide basis for comparison of results obtained in various laboratories. To this end, a short stay at the MitoFit Laboratory of Oroboros Instruments could provide a perfect platform having up-to-date instrumental background, well established measurement protocols and top level proficiency.
STSM request: download pdf


MitoEAGLE

        • Benefits for COST and for the COST Action MitoEAGLE
I am working mainly with immune cells from blood and liver mitochondria, while enterocytes and epithelial cells are the major targets of my plans for the next few months.

Participated at


Visiting scientist in the Oroboros MitoFit Laboratory

O2k-Network

András Mészáros : Visiting scientist at the Oroboros MitoFit Laboratory

  • November 21 to 28 2016