MitoKIN - Systematic barcoding of kinase-controlled mitochondrial function
MitoKIN: FFG BRIDGE 1
- FFG BRIDGE 1 30. Call - Project No. 877163, University of Innsbruck, Institute of Biochemistry
- Duration: 36 months
- Start: 2020-02-03
- Led by the Institute of Biochemistry at the University of Innsbruck, the MitoKIN project aims to connect specific/broad kinase activities to precise metabolic functions (mitochondria) relevant for cell proliferation or survival. Applied inhibitors could then be used to barcode involved kinase pathways that change the metabolome by boosting or preventing mitochondrial functions.
- The MitoKIN project has three major aims:
- 1. Impact of specific/general kinase inhibition on metabolism & mitochondrial function.
- 2. Perturbation of PKA signaling in cancer cells (high cAMP levels).
- 3. Perturbation of PKA signaling in neurodegenerative disease models (low cAMP levels).
- Eduard Stefan, Ph.D. - Institute of Biochemistry, University of Innsbruck - https://www.uibk.ac.at/biochemistry/people/stefan/
Oroboros project involvement
- Oroboros Instruments will provide both infrastructure and the expertise required to conduct the respirometric measurements of the project.
- The Institute of Biochemistry has been equipped with 3 O2ks for the duration of the project.
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News and articles
- Krebs, Kinasen und Zellkraftwerke www.uibk.ac.at, 2020-02-04
This project has received funding from the Austrian Reserach Promotion Funding Agency (FFG).