Morato 2016 Abstract IOC116

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Morato L, Guillot de Suduiraut MI, Grosse J, Zanoletti O, Riccio O, Fournier C, Sandi C (2016) Impaired mitochondrial function mediates early life stress-induced depression. Mitochondr Physiol Network 21.11

Link: Mitochondr Physiol Network 21.11

Morato L, Guillot de Suduiraut MI, Grosse J, Zanoletti O, Riccio O, Fournier C, Sandi C (2016)

Event: IOC116

Early-life exposure to stressful experiences has been described as a predisposing factor to develop psychopathologies including anxiety and depression. In our lab, we outlined a paradigm of unpredictable stress in C57BL/6 mice that aims to model exposure to fearful experiences during childhood and puberty. We observed that stressed animals present increased anxiety, depression-like behaviors and decreased sociability. Aiming at understanding the neuronal mechanisms whereby early life stress can induce these behavioral alterations, we performed a gene expression analysis in the nucleus accumbens, a critical brain region for the stress response. Remarkably, we observed that the nucleus accumbens of stressed animals exhibits a reduced expression of master-regulators of mitochondrial function such as SIRT1 and PGC-1a, concomitant with a reduction in mitochondrial respiration measured by high-resolution respirometry. These findings might pave the way for the use of mitochondrial boosters to treat stress-related disorders such as depression.


O2k-Network Lab: CH Lausanne Sandi C


Labels: MiParea: Respiration, nDNA;cell genetics, Exercise physiology;nutrition;life style, mt-Medicine, mt-Awareness  Pathology: Other  Stress:Mitochondrial disease  Organism: Mouse 




HRR: Oxygraph-2k 


Affiliations

1-Lab Behavioral Genetics, Brain Mind Inst, École Polytechnique Fédérale de Lausanne, Switzerland. - laia.moratofornaguera@epfl.ch