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Murphy 2018 Cell

From Bioblast
Publications in the MiPMap
Murphy MP, O'Neill LAJ (2018) Krebs cycle reimagined: the emerging roles of succinate and itaconate as signal transducers. Cell 174:780-4. doi: 10.1016/j.cell.2018.07.030

Β» PMID: 30096309 Open Access

Murphy MP, O'Neill LAJ (2018) Cell

Abstract: Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.

β€’ Bioblast editor: Gnaiger E