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NADH electron transfer-pathway state
Description
The NADH electron transfer-pathway state (N) is obtained by addition of NADH-linked substrates (CI-linked), feeding electrons into the N-junction catalyzed by various mt-dehydrogenases. N-supported flux is induced in mt-preparations by the addition of NADH-generating substrate combinations of pyruvate (P), glutamate (G), malate (M), oxaloacetate (Oa), oxoglutarate (Og), citrate, hydroxybutyrate. These N-junction substrates are (indirectly) linked to Complex I by the corresponding dehydrogenase-catalyzed reactions reducing NAD+ to NADH+H+. The most commonly applied N-junction substrate combinations are: PM, GM, PGM. The malate-anaplerotic pathway control state (M alone) is a special case related to malic enzyme (mtME). The glutamate-anaplerotic pathway control state (G alone) supports respiration through glutamate dehydrogenase (mtGDH). Oxidation of tetrahydrofolate is a NAD(P)H linked pathway with formation of formate. In mt-preparations, succinate dehydrogenase (SDH; CII) is largely substrate-limited in N-linked respiration, due to metabolite depletion into the incubation medium. The residual involvement of S-linked respiration in the N-pathway control state can be further suppressed by the CII-inhibitor malonic acid). In the N-pathway control state ET pathway level 4 is active.
Abbreviation: N
Reference: Electron-transfer-pathway state, Gnaiger 2020 BEC MitoPathways
MitoPedia concepts:
MiP concept,
Respiratory state,
SUIT state,
Recommended
MitoPedia methods:
Respirometry
MitoPedia topics:
EAGLE
Communicated by Gnaiger E 2016-03-20, edited 2016-11-29.
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Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
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Komlodi 2021 MitoFit Q | 2021-02-18 | Komlodi T, Cardoso LHD, Doerrier C, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. MitoFit Preprints 2021.2. doi:10.26124/mitofit:2021-0002 | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Heart Nervous system |
Cardoso 2021 MitoFit MgG | 2021-01-29 | Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. MitoFit Preprints 2021.1. doi:10.26124/mitofit:2021-0001 | LEAK OXPHOS ET | N S ROX | Isolated mitochondria | Mouse | Heart |
Cecatto 2021 CaG | 2021-##-## | Cecatto C, Gnaiger E (2021) CaG Manuscript | LEAK | N | Isolated mitochondria | Mouse | Liver |
Knapp-Wilson 2021 bioRxiv | 2021 | Knapp-Wilson A, Pereira GC, Buzzard E, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara P, Collinson I (2021) Maintenance of complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in C. elegans. bioRxiv doi: https://doi.org/10.1101/2021.01.06.425530. | LEAK OXPHOS | N S | Isolated mitochondria | Caenorhabditis elegans | |
Yardeni 2021 Proc Natl Acad Sci U S A | 2021 | Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
Hoppel 2021 Front Physiol | 2021 | Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. Front Physiol 12:632664. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet |
Salin 2021 Mar Environ Res | 2021 | Salin K, Mathieu-Resuge M, Graziano N, Dubillot E, Le Grand F, Soudant P, Vagner M (2021) The relationship between membrane fatty acid content and mitochondrial efficiency differs within- and between- omega-3 dietary treatments. Mar Environ Res [Epub ahead of print]. | LEAK OXPHOS | N NS | Isolated mitochondria | Fishes | Skeletal muscle |
Tonnesen 2021 Mol Cell Biochem | 2021 | Tonnesen PT, Hjortbak MV, Lassen TR, Seefeldt JM, Bøtker HE, Jespersen NR (2021) Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats. Mol Cell Biochem [Epub ahead of print]. | LEAK OXPHOS | F N | Permeabilized tissue | Rat | Heart |
Klepinina 2021 PLoS One | 2021 | Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348. | LEAK ROUTINE OXPHOS ET | N NS ROX | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Christiansen 2021 Sci Rep | 2021 | Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167. | LEAK OXPHOS ET | F N S CIV NS | Permeabilized tissue | Pig | Heart Skeletal muscle Liver |
Giordano 2021 Gene Ther | 2021 | Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther [Epub ahead of print]. | LEAK ROUTINE OXPHOS | N S CIV ROX | Permeabilized cells Intact cells | Mouse | Fibroblast |
Van Polanen 2021 Physiol Rep | 2021 | van Polanen N, Zacharewicz E, de Ligt M, Timmers S, Moonen-Kornips E, Schaart G, Hoeks J, Schrauwen P, Hesselink MKC (2021) Resveratrol-induced remodelling of myocellular lipid stores: A study in metabolically compromised humans. Physiol Rep 9:e14692. | OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
Braga 2021 Sci Rep | 2021 | Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER (2021) Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice. Sci Rep 11:3813. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Nervous system |
Davis, 2021 Journal of Applied Physiology | 2021 | Davis, MS; Barrett, MR (2021) Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. Journal of Applied Physiology Online. | LEAK OXPHOS | N S NS | Permeabilized cells | Dog | Skeletal muscle |
Correia 2021 Hum Mutat | 2021 | Correia SP, Moedas MF, Naess K, Bruhn H, Maffezzini C, Calvo-Garrido J, Lesko N, Wibom R, Schober FA, Jemt A, Stranneheim H, Freyer C, Wedell A, Wredenberg A (2021) Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7. Hum Mutat [Epub ahead of print]. | LEAK OXPHOS | N S NS | Permeabilized cells | Human | Fibroblast |
Holody 2021 Mitochondrion | 2021 | Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H (2021) Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction. Mitochondrion 56:102-10. | LEAK OXPHOS | N S CIV NS ROX | Homogenate | Rat | Nervous system |
Meng 2021 FEBS Open Bio | 2021 | Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio [Epub ahead of print]. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Kidney |
Wigner 2021 Sci Rep | 2021 | Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Other cell lines |
Thoral 2021 Biol Lett | 2021 | Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759. | LEAK OXPHOS | N CIV NS ROX | Homogenate | Fishes | Skeletal muscle |
Pereyra 2021 J Lipid Res | 2021 | Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM (2021) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res [Epub ahead of print]. | LEAK OXPHOS | F N | Homogenate Isolated mitochondria | Mouse | Heart Skeletal muscle Liver |
Baldini 2021 Life Sci | 2021 | Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Fibroblast |
Schmidt 2021 Cancer Metab | 2021 | Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3. | LEAK OXPHOS ET | N S Gp CIV ROX | Isolated mitochondria | Human | Liver |
Moon 2021 J Lipid Res | 2021 | Moon SH, Dilthey BG, Liu X, Guan S, Sims HF, Gross RW (2021) High-Fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress. J Lipid Res [Epub ahead of print]. | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Liver |
Furihata 2021 Commun Biol | 2021 | Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Heart |
MiPNet21.17 BloodCellsIsolation | 2020-10-22 | O2k-Protocols: Isolation of blood cells for HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Intact cells Permeabilized cells | Human | Blood cells Platelet |
Hassan 2020 MitoFit Preprint Arch | 2020-04-30 | Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. MitoFit Preprint Arch 2020.3 doi:10.26124/mitofit:200003. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | |
Souza da Silva 2020 Mol Neurobiol | 2020 | Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
Al-Azab 2020 FEBS J | 2020 | Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104. | LEAK ROUTINE OXPHOS ET | N ROX | Permeabilized cells Intact cells | Human | Other cell lines |
Bloise 2020 Thyroid | 2020 | Bloise FF, Santos AT, Brito JT, Andrade CBV, Oliveira TS, Souza AF, Fontes KN, Silva JD, Blanco NG, Silva PL, Rocco PRM, Fliers E, Boelen A, da-Silva WS, Ortiga-Carvalho TM (2020) Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm. Thyroid 30:1079-90. | LEAK OXPHOS ET | N CIV NS | Permeabilized tissue | Mouse | Skeletal muscle |
Schleier 2020 J Cardiovasc Transl Res | 2020 | Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res [Epub ahead of print]. | LEAK OXPHOS | N NS ROX | Isolated mitochondria | Mouse | Heart |
Silva-Rodrigues 2020 Free Radic Biol Med | 2020 | Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med [Epub ahead of print]. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Rat | Nervous system |
Hartmann 2020 Free Radic Res | 2020 | Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Rat | Skeletal muscle |
Liepinsh 2020 Physiol Rep | 2020 | Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489. | LEAK ROUTINE OXPHOS | F N CIV | Permeabilized cells Intact cells | Human | Blood cells |
Cheng 2020 Am J Physiol Heart Circ Physiol | 2020 | Cheng TC, Philip JL, Tabima DM, Kumari S, Yakubov B, Frump AL, Hacker TA, Bellofiore A, Li R, Sun X, Goss KN, Lahm T, Chesler N (2020) Estrogen receptor alpha prevents right ventricular diastolic dysfunction and fibrosis in female rats . Am J Physiol Heart Circ Physiol [Epub ahead of print]. | LEAK OXPHOS | N S CIV ROX | Permeabilized tissue | Rat | Heart |
Remie 2020 Am J Clin Nutr | 2020 | Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
Allen 2020 Commun Biol | 2020 | Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389. | LEAK OXPHOS ET | N S CIV | Permeabilized tissue | Rat | Heart |
Kupats 2020 Oxid Med Cell Longev | 2020 | Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
Vulczak 2020 Cells | 2020 | Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628. | LEAK OXPHOS ET | N ROX | Permeabilized cells | Mouse | Endothelial;epithelial;mesothelial cell |
Baxter 2020 Elife | 2020 | Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Mouse | Heart |
Khamoui 2020 Physiol Genomics | 2020 | Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16. | LEAK OXPHOS ET | N NS | Intact cells | Mouse | Liver |
Fecker 2020 Biomolecules | 2020 | Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Bundgaard 2020 J Exp Biol | 2020 | Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A (2020) Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. J Exp Biol 222:jeb200410. | LEAK OXPHOS ET | N NS | Permeabilized tissue | Amphibians | Heart |
Woessner 2020 J Appl Physiol (1985) | 2020 | Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Miotto 2020 Am J Physiol Endocrinol Metab | 2020 | Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53. | OXPHOS LEAK | N NS F | Permeabilized tissue | Rat | Skeletal muscle |
Nicolaisen 2020 FASEB J | 2020 | Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C (2020) Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 34:15480-91. | LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Pajuelo-Reguera 2020 Cells | 2020 | Pajuelo Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443. | OXPHOS ET | N S Gp NS Other combinations | Permeabilized cells Oxidase;biochemical oxidation | Human | HEK |
Fuller 2020 J Appl Physiol (1985) | 2020 | Fuller KNZ, McCoin CS, Allen J, Bell-Glenn S, Koestler DC, Dorn Ii GW, Thyfault JP (2020) Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice. J Appl Physiol (1985) 128:1251-61. | LEAK OXPHOS ET | F N NS | Isolated mitochondria | Mouse | Liver |
Macasoi 2020 Oncol Rep | 2020 | Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Fisher 2020 J Physiol | 2020 | Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ, Perkins AV (2020) Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J Physiol [Epub ahead of print]. | OXPHOS ET | N NS ROX | Isolated mitochondria | Human | Genital |
Wang 2020 J Mol Med (Berl) | 2020 | Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61. | LEAK OXPHOS | N ROX | Isolated mitochondria | Mouse | Heart |
Franco 2020 bioRxiv | 2020 | Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 . | LEAK ROUTINE | N S CIV ROX | Intact cells | Human | Macrophage-derived |
Xiong 2020 Biomed Pharmacother | 2020 | Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human Rat | Endothelial;epithelial;mesothelial cell |
Hosmann 2020 Acta Neurochir (Wien) | 2020 | Hosmann A, Milivojev N, Dumitrescu S, Reinprecht A, Weidinger A, Kozlov AV (2020) Cerebral nitric oxide and mitochondrial function in patients suffering aneurysmal subarachnoid hemorrhage-a translational approach. Acta Neurochir (Wien) [Epub ahead of print]. | OXPHOS | N S CIV ROX | Homogenate | Rat | Nervous system |
Maeda 2020 J Cell Mol Med | 2020 | Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20. | LEAK ROUTINE OXPHOS ET | N ROX | Isolated mitochondria Intact cells | Rat | Heart |
Liu 2020 J Clin Invest | 2020 | Liu L, Ding C, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z (2020) Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest 130:4710-25. | LEAK OXPHOS | N | Permeabilized tissue | Mouse | Skeletal muscle |
Soliman 2020 Toxicology | 2020 | Soliman E, Elhassanny AEM, Malur A, McPeek M, Bell A, Leffler N, Van Dross R, Jones JL, Malur AG, Thomassen MJ (2020) Impaired mitochondrial function of alveolar macrophages in carbon nanotube-induced chronic pulmonary granulomatous disease. Toxicology 445:152598. | LEAK | F N | Permeabilized cells | Mouse | Lung;gill |
Almoiliqy 2020 Acta Pharmacol Sin | 2020 | Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Rat | Endothelial;epithelial;mesothelial cell |
Gnad 2020 Cell Metab | 2020 | Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7. | LEAK OXPHOS ET | N S | Permeabilized tissue | Mouse | Skeletal muscle |
Skemiene 2020 Biomolecules | 2020 | Skemiene K, Rekuviene E, Jekabsone A, Cizas P, Morkuniene R, Borutaite V (2020) Comparison of effects of metformin, phenformin, and inhibitors of mitochondrial complex I on mitochondrial permeability transition and ischemic brain injury. Biomolecules 10:E1400. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Nervous system |
McCommis 2020 bioRxiv | 2020 | McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, Todd King M, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Ketogenic diet prevents heart failure from defective mitochondrial pyruvate metabolism. bioRxiv doi: https://doi.org/10.1101/2020.02.21.959635 . | LEAK OXPHOS | F N | Isolated mitochondria | Mouse | Heart |
Lin 2020 Preprints | 2020 | Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567. | LEAK ROUTINE OXPHOS ET | F N S Gp NS ROX | Permeabilized cells Intact cells | Human | Platelet |
Roginski 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682. | LEAK OXPHOS ET | N S NS | Permeabilized cells Isolated mitochondria Homogenate | Rat | Heart Other cell lines |
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Keppner 2020 Thesis | 2020 | Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
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Szibor 2020 J Cell Mol Med | 2020 | Szibor Marten, Schreckenberg Rolf, Gizatullina Zemfira, Dufour Eric, Wiesnet Marion, Dhandapani Praveen Kumar, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Nyman Tuula A, Gaertner Ulrich, Hall Andrew R, Pell Victoria, Viscomi Carlo, Krieg Thomas, Murphy Michael P, Braun Thomas, Gellerich Frank Norbert, Schlueter Klaus-Dieter, Jacobs Howard T(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48. | LEAK OXPHOS | N S CIV | Permeabilized tissue Isolated mitochondria | Mouse | Heart |
Piel 2020 PLoS One | 2020 | Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Liver Platelet |
Dubinin 2020 Biochim Biophys Acta Bioenerg | 2020 | Dubinin MV, Talanov EY, Tenkov KS, Starinets VS, Mikheeva IB, Belosludtsev KN (2020) Transport of Ca2+ and Ca2+-dependent permeability transition in heart mitochondria in the early stages of duchenne muscular dystrophy. Biochim Biophys Acta Bioenerg 1861:148250. | LEAK OXPHOS | N | Isolated mitochondria | Mouse | Heart |
Simard 2020b Metabolites | 2020 | Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411. | LEAK OXPHOS ET | N Gp NS Other combinations ROX | Permeabilized tissue | Drosophila | |
Krabbendam 2020 Cell Death Dis | 2020 | Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263. | LEAK OXPHOS | N S | Isolated mitochondria | Mouse | Nervous system |
Seo 2020 J Clin Med | 2020 | Seo DY, Heo JW, No MH, Yoo SZ, Ko JR, Park DH, Kang JH, Kim CJ, Jung SJ, Han J, Kwak HB (2020) Exercise training protects against atorvastatin-induced skeletal muscle dysfunction and mitochondrial dysfunction in the skeletal muscle of rats. J Clin Med 9:E2292. | LEAK OXPHOS | N | Permeabilized tissue | Rat | Skeletal muscle |
Charles 2020 Nanomedicine (Lond) | 2020 | Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) [Epub ahead of print]. | LEAK OXPHOS | N S CIV ROX | Isolated mitochondria | Human | Endothelial;epithelial;mesothelial cell |
Ferreira 2020 PLoS Genet | 2020 | Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604. | LEAK OXPHOS ET | N ROX | Isolated mitochondria | Mouse | Liver |
Gruenig 2020 Biochem Pharmacol | 2020 | Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860. | LEAK OXPHOS ET | N S DQ CIV ROX | Isolated mitochondria | Mouse | Liver |
Pham 2020 Eur J Appl Physiol | 2020 | Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69. | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Russell 2020 Nutrients | 2020 | Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Vega 2020 Physiol Rep | 2020 | Vega RB, Brouwers B, Parsons SA, Stephens NA, Pino MF, Hodges A, Yi F, Yu G, Pratley RE, Smith SR, Sparks LM (2020) An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. Physiol Rep 8:e14416. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
Wei 2020 Cell Rep | 2020 | Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207. | LEAK OXPHOS ET | F N S NS ROX | Isolated mitochondria | Rat | Kidney |
Frambach 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727. | LEAK OXPHOS | F N S Gp CIV Other combinations ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Andrade 2020 Nutr Metab Cardiovasc Dis | 2020 | Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E (2020) Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis 30:151-61. | LEAK OXPHOS | F N NS | Permeabilized tissue | Mouse | Heart |
Le 2020 J Biol Chem | 2020 | Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria . J Biol Chem 295:12485-97. | LEAK OXPHOS | F N S NS | Intact organism | Human | Heart |
Maddison 2020 PLoS Genet | 2020 | Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F (2020) A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics. PLoS Genet 16:e1009129. | OXPHOS ET | N S NS | Homogenate | Drosophila | |
Monaco 2020 Am J Physiol Endocrinol Metab | 2020 | Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ (2020) Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab 318:E44-E51. | OXPHOS | N S | Permeabilized tissue | Human | Skeletal muscle |
Anderson 2020 Cells | 2020 | Anderson Vulczak, de Oliveira Souza Anderson, Ferrari Gustavo Duarte, Caleiro Seixas Azzolini Ana Elisa, Pereira-da-Silva Gabriela, Alberici Luciane Carla (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:628. | LEAK OXPHOS ET | N ROX | Permeabilized tissue | Mouse | |
Aparicio-Trejo 2020 Free Radic Biol Med | 2020 | Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32. | LEAK OXPHOS | F N S ROX | Isolated mitochondria | Rat | Kidney |
Stepanova 2020 Methods Cell Biol | 2020 | Stepanova A, Galkin A (2020) Measurement of mitochondrial H2O2 production under varying O2 tensions. Methods Cell Biol 155:273-93. | LEAK OXPHOS | S N Gp | Isolated mitochondria | Mouse | Nervous system |
D'Urso 2020 Surg Endosc | 2020 | D'Urso A, Agnus V, Barberio M, Seeliger B, Marchegiani F, Charles AL, Geny B, Marescaux J, Mutter D, Diana M (2020) Computer-assisted quantification and visualization of bowel perfusion using fluorescence-based enhanced reality in left-sided colonic resections. Surg Endosc [Epub ahead of print]. | LEAK OXPHOS | N NS | Human | Endothelial;epithelial;mesothelial cell | |
De-Souza 2020 J Biol Chem | 2020 | De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82. | LEAK OXPHOS | N Gp NS ROX | Isolated mitochondria Intact cells | Caenorhabditis elegans Saccharomyces cerevisiae | |
Cubizolle 2020 J Cell Mol Med | 2020 | Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P (2020) Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. J Cell Mol Med 24:5057-69. | LEAK OXPHOS ET | N S CIV NS | Permeabilized cells | Rat | Endothelial;epithelial;mesothelial cell |
Zhou 2020 Biomed Pharmacother | 2020 | Zhou J, Zhang Y, Li S, Zhou Q, Lu Y, Shi J, Liu J, Wu Q, Zhou S (2020) Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway. Biomed Pharmacother 129:110351. | LEAK OXPHOS | N | Isolated mitochondria | Mouse | Liver |
Song 2020 Obes Facts | 2020 | Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) Increased insulin sensitivity by high-altitude hypoxia in mice with high-fat diet-induced obesity is associated with activated AMPK signaling and subsequently enhanced mitochondrial biogenesis in skeletal muscles. Obes Facts 13:455-72. | LEAK OXPHOS | F N | Permeabilized tissue | Skeletal muscle | |
Grewal 2020 Exp Neurol | 2020 | Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
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Boel 2020 J Exp Biol | 2020 | Boël M, Romestaing C, Duchamp C, Veyrunes F, Renaud S, Roussel D, Voituron Y (2020) Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558. | LEAK ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Macedo 2020 FASEB J | 2020 | Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J [Epub ahead of print]. | LEAK OXPHOS | F N CIV ROX | Intact organism Isolated mitochondria | Caenorhabditis elegans | |
Vanweert 2020 J Clin Endocrinol Metab | 2020 | Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E (2020) Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab [Epub ahead of print]. | LEAK OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
Peruzzotti-Jametti 2020 bioRxiv | 2020 | Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Kittel A, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2020) Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv doi: https://doi.org/10.1101/2020.01.29.923441 . | LEAK | N S Gp CIV ROX | Permeabilized cells | Mouse | Stem cells |
Pajuelo 2020 Cells | 2020 | Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443. | LEAK OXPHOS ET | N S Gp CIV NS ROX | Permeabilized cells | Human | HEK |
Thome 2020 JCI Insight | 2020 | Thome T, Kumar RA, Burke SK, Khattri RB, Salyers ZR, Kelley RC, Coleman MD, Christou DD, Hepple RT, Scali ST, Ferreira LF, Ryan TE (2020) Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease. JCI Insight [Epub ahead of print]. | LEAK OXPHOS | F N S | Isolated mitochondria | Mouse | Skeletal muscle |
Coppin 2020 Cell Death Dis | 2020 | Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360. | LEAK ROUTINE OXPHOS ET | N S Gp CIV NS ROX | Permeabilized cells Intact cells | Human | Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell |
Wu 2020 Chemosphere | 2020 | Wu F, Sokolov EP, Dellwig O, Sokolova IM (2020) Season-dependent effects of ZnO nanoparticles and elevated temperature on bioenergetics of the blue mussel Mytilus edulis. Chemosphere 263:127780. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Molluscs | Other cell lines |
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Isolated mitochondria Intact cells | Rat | Liver Nervous system |
Liu 2020 Am J Physiol Heart Circ Physiol | 2020 | Liu R, Jagannathan R, Sun L, Li F, Yang P, Lee J, Negi V, Perez-Garcia EM, Shiva S, Yechoor VK, Moulik M (2020) Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol 319:H89-99. | LEAK OXPHOS | F N NS | Isolated mitochondria | Mouse | Heart |
Hingst 2020 Mol Metab | 2020 | Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Skeletal muscle |
Ehrlicher 2020 FASEB J | 2020 | Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18. | LEAK OXPHOS ET | F N S NS | Isolated mitochondria | Mouse | Skeletal muscle |
Sharma 2020 Integr Cancer Ther | 2020 | Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437. | LEAK OXPHOS | N S | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
Irion 2020 Stem Cells Int | 2020 | Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 . | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Rat | Heart |
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Szibor 2020 J Biol Chem | 2020 | Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97. | LEAK OXPHOS | N S Gp CIV NS ROX | Isolated mitochondria Intact cells | Mouse | Nervous system |
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Brum 2020 Mol Neurobiol | 2020 | Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system |
Battaglia 2020 Cell Death Dis | 2020 | Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004. | LEAK OXPHOS ET | N S CIV NS ROX | Intact cells | Rat | Nervous system |
Jayakumari 2020 J Diabetes | 2020 | Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55. | LEAK OXPHOS ET | F N S NS ROX | Isolated mitochondria | Human | Heart |
Purhonen 2020 Nat Commun | 2020 | Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Liver Kidney |
Yadav 2020 Cell Death Dis | 2020 | Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186. | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized cells | Human | Heart Stem cells |
Lantier 2020 Diabetes | 2020 | Lantier Louise, Williams Ashley S, Williams Ian M, Guerin Amanda, Bracy Deanna P, Goelzer Mickael, Foretz Marc, Viollet Benoit, Hughey Curtis C, Wasserman David H (2020) Reciprocity between skeletal muscle AMPK deletion and insulin action in diet-induced obese mice. Diabetes 69:1636-49. | OXPHOS | N | Permeabilized tissue | Mouse | Skeletal muscle |
Simard 2020 Metabolites | 2020 | Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363. | LEAK OXPHOS ET | N S Gp NS ROX | Permeabilized tissue | Drosophila | |
Pena 2020 Int J Chronic Dis | 2020 | Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
Severo 2020 Life Sci | 2020 | Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
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Hafstad 2020 Antioxidants (Basel) | 2020 | Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171. | LEAK OXPHOS | F N | Isolated mitochondria | Mouse | Heart |
Briones-Herrera 2020 Free Radic Biol Med | 2020 | Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70. | LEAK OXPHOS | F N S NS ROX | Isolated mitochondria | Rat | Kidney |
Davidson 2020 Circ Res | 2020 | Davidson MT, Grimsrud P, Lai L, Draper J, Fisher-Wellman KH, Narowski TM, Koves TR, Kelly DP, Muoio DM (2020) Extreme acetylation of the cardiac mitochondrial proteome does not promote heart failure. Circ Res 127:1094-108. | LEAK | F N | Isolated mitochondria | Mouse | Heart |
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Boardman 2020 Am J Physiol Heart Circ Physiol | 2020 | Boardman NT, Pedersen TM, Rossvoll L, Hafstad AD, Aasum E (2020) Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance. Am J Physiol Heart Circ Physiol 319:H682-93. | LEAK OXPHOS | F N | Isolated mitochondria | Mouse | Heart |
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Makrecka-Kuka 2020 Cardiovasc Drugs Ther | 2020 | Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther [Epub ahead of print]. | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Heart |
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Li Puma 2020 Am J Physiol Regul Integr Comp Physiol | 2020 | Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:972-80. | LEAK OXPHOS | N NS | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart Skeletal muscle |
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McLaughlin 2020 Sci Rep | 2020 | McLaughlin KL, Kew KA, McClung JM, Fisher-Wellman KH (2020) Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase. Sci Rep 10:3603. | LEAK | F N S | Isolated mitochondria | Mouse | Heart Skeletal muscle |
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Keller 2020 Oxid Med Cell Longev | 2020 | Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629. | LEAK OXPHOS ET | N NS | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
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Alston 2020 Am J Hum Genet | 2020 | Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101. | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized cells Intact cells | Human | Fibroblast |
D'Souza 2020 Nutrients | 2020 | D'Souza K, Mercer A, Mawhinney H, Pulinilkunnil T, Udenigwe CC, Kienesberger PC (2020) Whey peptides stimulate differentiation and lipid metabolism in adipocytes and ameliorate lipotoxicity-induced insulin resistance in muscle cells. Nutrients 12:E425. | LEAK ET | F N | Permeabilized cells | Mouse | Skeletal muscle Fat |
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Belosludtsev 2020 Biochimie | 2020 | Belosludtsev KN, Belosludtseva NV, Kosareva EA, Talanov EY, Gudkov SV, Dubinin MV (2020) Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria. Biochimie 176:150-57. | LEAK OXPHOS | N S CIV | Isolated mitochondria | Rat | Liver |
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Baggio 2020 Neurotoxicology | 2020 | Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Zebrafish | Nervous system |
Barsottini 2020 Commun Biol | 2020 | Barsottini MRO, Copsey A, Young L, Baroni RM, Cordeiro AT, Pereira GAG, Moore AL (2020) Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa. Commun Biol 3:263. | OXPHOS | F N S CIV | Protists | ||
Musi 2020 Aging Cell | 2020 | Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
Hardee 2020 Mol Metab | 2020 | Hardee JP, Martins KJB, Miotto PM, Ryall JG, Gehrig SM, Reljic B, Naim T, Chung JD, Trieu J, Swiderski K, Philp AM, Philp A, Watt MJ, Stroud DA, Koopman R, Steinberg GR, Lynch GS (2020) Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity. Mol Metab [Epub ahead of print]. | OXPHOS LEAK | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
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Bose 2020 Aging Cell | 2020 | Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell [Epub ahead of print]. | LEAK OXPHOS | F N CIV NS ROX | Permeabilized tissue | Mouse | Heart |
Matsuo 2020 Am J Physiol Endocrinol Metab | 2020 | Matsuo FS, Araújo PHC, Mota RF, Carvalho AJR, Queiroz MS, Almeida BB, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK (2020) RANKL induces beige adipocyte differentiation in preadipocytes. Am J Physiol Endocrinol Metab 318:E866-77. | LEAK OXPHOS | N | Permeabilized cells | Mouse | Fat |
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Contreras Mostazo 2020 Cancers (Basel) | 2020 | Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV ROX | Permeabilized cells Intact cells | Human | Blood cells |
Dirks 2020 J Physiol | 2020 | Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37. | LEAK OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
Skemiene 2020 J Bioenerg Biomembr | 2020 | Skemiene K, Pampuscenko K, Rekuviene E, Borutaite V (2020) Protective effects of anthocyanins against brain ischemic damage. J Bioenerg Biomembr 52:71-82. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Nervous system |
Buch 2020 FASEB J | 2020 | Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70. | LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Cassereau 2020 Exp Neurol | 2020 | Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human | Fibroblast |
Larsen 2020 Acta Physiol (Oxf) | 2020 | Larsen FJ, Schiffer TA, Zinner C, Willis SJ, Morales-Alamo D, Calbet J5, Boushel R, Holmberg HC (2020) Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake. Acta Physiol (Oxf) 229:e13463. | OXPHOS | N NS | Isolated mitochondria | Human | Skeletal muscle |
Brunetta 2020 J Physiol | 2020 | Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71. | LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Fat |
Bhaskaran 2020 Aging Cell | 2020 | Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225. | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Kanellopoulos 2020 Cell | 2020 | Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Drosophila | Nervous system Other cell lines |
Dulac 2020 J Physiol | 2020 | Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710. | LEAK OXPHOS | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Avila-Rojas 2020 Food Chem Toxicol | 2020 | Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Rat | Kidney |
Schneider 2020 PLoS One | 2020 | Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710. | LEAK OXPHOS | F N S CIV NS ROX | Permeabilized tissue | Rat | Heart |
Silaidos 2020 Mitochondrion | 2020 | Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
Wefers 2020 Mol Metab | 2020 | Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
Palavicini 2020 JCI Insight | 2020 | Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Nervous system |
Locatelli 2020 FASEB J | 2020 | Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Cruz 2020 Drug Alcohol Depend | 2020 | Cruz JV, Maba IK, Correia D, Kaziuk FD, Cadena SMSC, Zampronio AR (2020) Intermittent binge-like ethanol exposure during adolescence attenuates the febrile response by reducing brown adipose tissue thermogenesis in rats. Drug Alcohol Depend 209:107904. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Fat |
Reutzel 2020 Oxid Med Cell Longev | 2020 | Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769. | LEAK ET OXPHOS | N S CIV ROX | Isolated mitochondria | Mouse | Nervous system |
Larsen 2020 Cardiovasc Drugs Ther | 2020 | Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther [Epub ahead of print]. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Human | Skeletal muscle |
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Hayes 2020 Nutrients | 2020 | Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871. | LEAK ROUTINE OXPHOS ET | N S Gp CIV ROX | Permeabilized cells Intact cells | Human | HeLa |
Rondot 2020 Thesis | 2020 | Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41. | LEAK OXPHOS | N S NS ROX | Permeabilized tissue | Hexapods | Skeletal muscle |
Lensu 2020 Preprints | 2020 | Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Linden J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides targeting Faecalibacterium prausnitzii prevent high fat diet-induced hepatic steatosis in rats. Preprints 2020:2020090241. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Liver |
Janowska 2020 Toxicol In Vitro | 2020 | Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794. | LEAK ROUTINE ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet Blood cells |
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McLaughlin 2020b Sci Rep | 2020 | McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599. | LEAK OXPHOS ET | F N S Gp CIV ROX | Isolated mitochondria | Mouse | Heart Liver Kidney Fat |
Pelster 2020 PLoS One | 2020 | Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Fishes | Kidney Lung;gill |
Makrecka-Kuka 2020 Sci Rep | 2020 | Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. Sci Rep 10:21595. | LEAK OXPHOS | N S NS ROX | Permeabilized cells | Mouse | Endothelial;epithelial;mesothelial cell |
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Gnaiger 2019 MitoFit Preprints | 2019-08-30 | Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6. — Published in BEC: 2020-05-20 Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1 | LEAK OXPHOS ET | F N S Gp DQ CIV NS Other combinations ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | ||
Doerrier 2019 MitoFit Preprint Arch EA | 2019-07-04 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
MiPNet18.05 Amplex-Mouse-heart | 2019-06-24 | O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Schoepf 2019 MitoFit Preprint Arch | 2019-06-11 | Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch doi:10.26124/mitofit:190003. - 2020-03-20 Published in »Nature Communications 11:1487« | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Genital |
Gonzalez-Armenta 2019 J Nutr | 2019 | Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502. | LEAK OXPHOS ET | F N S Gp NS ROX | Permeabilized tissue | Other mammals | Skeletal muscle |
Sambeat 2019 Nat Commun | 2019 | Sambeat A, Ratajczak J, Joffraud M, Sanchez-Garcia JL, Giner MP, Valsesia A, Giroud-Gerbetant J, Valera-Alberni M, Cercillieux A, Boutant M, Kulkarni SS, Moco S, Canto C (2019) Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage. Nat Commun 10:4291. | LEAK OXPHOS ET | N S NS | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Liver |
Ferreira 2019 EMBO J | 2019 | Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O (2019) Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation. EMBO J 38:e102155. | LEAK OXPHOS ET | N S | Isolated mitochondria | Mouse | Heart Liver |
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol | 2019 | Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21. | OXPHOS ET LEAK | N S Gp CIV NS ROX | Permeabilized tissue | Other invertebrates | Skeletal muscle |
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Silva Ramos 2019 PLoS Genet | 2019 | Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085. | LEAK OXPHOS ET | N S Gp | Permeabilized cells Isolated mitochondria | Mouse | Heart Fibroblast |
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Lewis 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes. Am J Physiol Regul Integr Comp Physiol 317:R356-68. | LEAK OXPHOS | F N | Isolated mitochondria | Rat | Skeletal muscle |
Baekkerud 2019 Cardiovasc Toxicol | 2019 | Bækkerud FH, Salerno S, Ceriotti P, Morland C, Storm-Mathisen J, Bergersen LH, Høydal MA, Catalucci D, Stølen TO (2019) High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol 19:422-31. | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue | Mouse | Heart |
Kopinski 2019 Proc Natl Acad Sci U S A | 2019 | Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Other cell lines |
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Rudler 2019 Sci Adv | 2019 | Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5:eaay2118. | LEAK OXPHOS ET | N S | Isolated mitochondria | Mouse | Heart |
Huerta 2019 Aquat Toxicol | 2019 | Huerta B, Chung-Davidson YW, Bussy U, Zhang Y, Bazil JN, Li W (2019) Sea lamprey cardiac mitochondrial bioenergetics after exposure to TFM and its metabolites. Aquat Toxicol 219:105380. | LEAK OXPHOS ET | N S ROX | Isolated mitochondria | Fishes | Heart |
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Christian 2019 Respir Physiol Neurobiol | 2019 | Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62. | LEAK OXPHOS | N | Permeabilized tissue | Mouse | Nervous system |
Oakey 2019 Wellcome Open Res | 2019 | Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion. Wellcome Open Res 3:147. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Skeletal muscle |
Qaed 2019 Oxid Med Cell Longev | 2019 | Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid Med Cell Longev 2019:6521218. | LEAK OXPHOS ET ROUTINE | N S NS ROX | Homogenate Isolated mitochondria Permeabilized cells Intact cells | Rat | Heart |
Thome 2019 Am J Physiol Cell Physiol | 2019 | Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13. | LEAK ROUTINE OXPHOS ET | N NS ROX | Isolated mitochondria Intact cells | Mouse | Skeletal muscle |
McManus 2019 Cell Metab | 2019 | McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90. | LEAK OXPHOS | N ROX | Isolated mitochondria | Mouse | Heart |
Halling 2019 Am J Physiol Endocrinol Metab | 2019 | Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Grandoch 2019 Nat Metab | 2019 | Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M5, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue Isolated mitochondria | Mouse | Fat |
Havird 2019 Philos Trans R Soc Lond B Biol Sci | 2019 | Havird JC, Shah AA, Chicco AJ (2019) Powerhouses in the cold: mitochondrial function during thermal acclimation in montane mayflies. Philos Trans R Soc Lond B Biol Sci 375:20190181. | LEAK OXPHOS | N NS | Isolated mitochondria | Hexapods | |
Ahn 2019 J Cachexia Sarcopenia Muscle | 2019 | Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28. | OXPHOS LEAK | N S CIV NS ROX | Isolated mitochondria | Mouse | Skeletal muscle |
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Scavuzzo 2019 J Neurophysiol | 2019 | Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35. | LEAK OXPHOS | N S CIV NS ROX | Homogenate | Rat | Nervous system |
Cecatto 2019 Mitochondrion | 2019 | Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2019) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13. | LEAK OXPHOS ET | N S | Permeabilized cells Isolated mitochondria | Rat | Liver Other cell lines |
Chiba 2019 J Am Soc Nephrol | 2019 | Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES, Sims-Lucas S (2019) Sirtuin 5 regulates proximal tubule fatty acid oxidation to protect against AKI. J Am Soc Nephrol 30:2384-98. | OXPHOS | N S | Homogenate | Mouse | Kidney |
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Campos 2019 Thesis | 2019 | Campos DF (2019) Os peixes amazônicos vivem perto dos seus limites térmicos? O efeito das mudanças climáticas sobre a ecofisiologia de peixes de Igarapé da Amazônia Central. PhD Thesis 106. | LEAK OXPHOS ET | N S CIV NS ROX | Intact cells | Fishes | Lung;gill |
Garnham 2019 J Cachexia Sarcopenia Muscle | 2019 | Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle 11:79-88. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Rajendran 2019 EMBO Mol Med | 2019 | Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456. | LEAK OXPHOS ET | N S CIV NS | Isolated mitochondria | Mouse | Liver Kidney Heart |
Ahmed 2019 Mol Nutr Food Res | 2019 | Ahmed N, Tcheng M, Roma A, Buraczynski M, Jayanth P, Rea K, Akhtar TA, Spagnuolo PA (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. Mol Nutr Food Res 63:e1900688. | LEAK ROUTINE ET | N ROX | Intact cells | Mouse Rat | Skeletal muscle Islet cell;pancreas;thymus |
Carteri 2019 Toxicol Lett | 2019 | Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Nervous system |
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Boardman 2019 Can J Physiol Pharmacol | 2019 | Boardman NT, Falck AT, Lund T, Chu X, Martin-Armas M, Norvik JV, Jenssen TG, Ytrehus K (2019) Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Can J Physiol Pharmacol 98:139-46. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Heart |
Shao 2019 Cardiovasc Diabetol | 2019 | Shao Q, Meng L, Lee S, Tse G, Gong M, Zhang Z, Zhao J, Zhao Y, Li G, Liu T (2019) Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induce diabetic rats. Cardiovasc Diabetol 18:165. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Heart |
Miranda Mendonca 2019 Neurochem Int | 2019 | Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17. | LEAK OXPHOS ET | N CIV ROX | Permeabilized tissue | Mouse | Nervous system |
Havird 2019 Mitochondrion | 2019 | Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11. | LEAK OXPHOS | N S CIV NS ROX | Isolated mitochondria | Plants | |
Miranda-Silva 2019 Acta Physiologica | 2019 | Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Intact organ Permeabilized tissue Isolated mitochondria | Rat | Heart |
Gratl 2019 Eur J Vasc Endovasc Surg | 2019 | Gratl A, Frese J, Speichinger F, Pesta D, Frech A, Omran S, Greiner A (2019) Regeneration of mitochondrial function in gastrocnemius muscle in peripheral arterial disease after successful revascularisation. Eur J Vasc Endovasc Surg 59:109-15. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
Salin 2019 Proc Biol Sci | 2019 | Salin K, Villasevil EM, Anderson GJ, Lamarre SG, Melanson CA, McCarthy I, Selman C, Metcalfe NB (2019) Differences in mitochondrial efficiency explain individual variation in growth performance. Proc Biol Sci 286:20191466. | OXPHOS | N CIV NS | Homogenate | Fishes | Skeletal muscle Liver |
Monteiro 2019 Thesis | 2019 | Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82. | LEAK OXPHOS ET | N | Permeabilized tissue | Rat | Skeletal muscle |
Andreazza 2019 Nat Commun | 2019 | Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, Whitworth AJ (2019) Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. Nat Commun 10:3280. | OXPHOS | N S | Homogenate | Drosophila | |
Mayeuf-Louchart 2019 Cell Rep | 2019 | Mayeuf-Louchart A, Lancel S, Sebti Y, Pourcet B, Loyens A, Delhaye S, Duhem C, Beauchamp J, Ferri L, Thorel Q, Boulinguiez A, Zecchin M, Dubois-Chevalier J, Eeckhoute J, Vaughn LT, Roach PJ, Dani C, Pederson BA, Vincent SD, Staels B, Duez H (2019) Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation. Cell Rep 29:1410-18. | LEAK OXPHOS | F N S NS | Permeabilized cells | Mouse | Fat |
Datzmann 2019 J Neurosurg | 2019 | Datzmann T, Kapapa T, Scheuerle A, McCook O, Merz T, Unmuth S, Hoffmann A, Mathieu R, Mayer S, Mauer UM, Roehrer S, Yilmazer-Hanke D, Moeller P, Nussbaum BL, Calzia E, Groeger M, Hartmann C, Radermacher P, Wepler M (2019) In-depth characterization of a long-term, resuscitated model of acute subdural hematoma-induced brain injury. J Neurosurg [Epub ahead of print]. | LEAK OXPHOS ET | N NS | Homogenate | Pig | Nervous system |
Douros 2019 JCI Insight | 2019 | Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688. | LEAK OXPHOS ET | N Gp NS | Permeabilized tissue | Mouse | Islet cell;pancreas;thymus |
Calabria 2019 Front Neurosci | 2019 | Calabria Elisa, Scambi Ilaria, Bonafede Roberta, Schiaffino Lorenzo, Peroni Daniele, Potrich Valentina, Capelli Carlo, Schena Federico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Mouse | Nervous system |
Halle 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue Intact cells | Mouse | Skeletal muscle Liver Fat |
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Pharaoh 2019 Mol Neurobiol | 2019 | Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31. | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue Isolated mitochondria Intact cells | Mouse | Skeletal muscle Nervous system Fat |
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Robinson 2019 Am J Physiol Cell Physiol | 2019 | Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347. | LEAK OXPHOS ET | F N S Gp NS Other combinations ROX | Permeabilized cells | Mouse Rat | Skeletal muscle |
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Tyrrell 2019 Circ Res | 2019 | Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314. | OXPHOS ET | N S NS ROX | Mouse | Endothelial;epithelial;mesothelial cell | |
Ferey 2019 Am J Physiol Heart Circ Physiol | 2019 | Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210. | LEAK OXPHOS | N S NS | Permeabilized tissue | Mouse | Heart |
Liu 2019 J Ethnopharmacol | 2019 | Liu M, Yu S, Wang J, Qiao J, Liu Y, Wang S, Zhao Y (2019) Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease. J Ethnopharmacol 247:112213. | OXPHOS | N S | Homogenate | Drosophila | |
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Kwak 2019 Int J Environ Res Public Health | 2019 | Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157. | LEAK OXPHOS ET | F N NS | Permeabilized cells | Human | Skeletal muscle |
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Karusheva 2019 Am J Clin Nutr | 2019 | Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107. | LEAK OXPHOS ET | F N NS ROX | Permeabilized tissue Isolated mitochondria | Human | Skeletal muscle |
Naszai 2019 Sci Rep | 2019 | Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca(2+)N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229. | LEAK OXPHOS | N S NS ROX | Isolated mitochondria | Rat | Liver |
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Pedrotti 2019 Sci Adv | 2019 | Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Intact cells | Mouse | Fat |
Ling 2019 Am J Clin Nutr | 2019 | Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr 110:605-16. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human | Skeletal muscle Fat |
Kumari 2019 Am J Physiol Heart Circ Physiol | 2019 | Kumari S, Braun RK, Tetri L, Barton GP, Hacker TA, Goss KN (2019) Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart. Am J Physiol Heart Circ Physiol 317:H1272-81. | LEAK OXPHOS ET | N S CIV ROX | Permeabilized tissue | Rat | Heart |
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Haberman 2019 Nat Commun | 2019 | Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA (2019) Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun 10:38. | OXPHOS ET | N S NS | Homogenate | Human | Endothelial;epithelial;mesothelial cell |
Jaiswal 2019 Mol Metab | 2019 | Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM (2019) The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Mol Metab 28:1-13. | LEAK OXPHOS | N | Isolated mitochondria | Mouse | Skeletal muscle |
Deutschman 2019 J Cell Sci | 2019 | Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
Inigo 2019 Mol Metab | 2019 | Inigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE (2019) Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab 34:1-15. | LEAK OXPHOS | F N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
McBride 2019 Arch Biochem Biophys | 2019 | McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48. | LEAK OXPHOS | F N CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol | 2019 | Rodríguez-Enríquez S, Pacheco-Velázquez SC, Marín-Hernández Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernández-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernández-Esquivel L, Sánchez-Thomas R, Moreno-Sánchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77. | LEAK OXPHOS | N S | Isolated mitochondria | Rat | Heart Liver |
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Shirakawa 2019 Sci Rep | 2019 | Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T (2019) Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Sci Rep 9:14709. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human | Blood cells |
Rutai 2019 Shock | 2019 | Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95. | LEAK OXPHOS | N S ROX | Homogenate | Rat | Liver |
Ramos 2019 Am J Physiol Cell Physiol | 2019 | Ramos SV, Hughes MC, Perry CGR (2019) Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies. Am J Physiol Cell Physiol 316:C449-C455. | OXPHOS | N | Permeabilized tissue | Rat | Skeletal muscle |
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Dlaskova 2019 Biochim Biophys Acta Bioenerg | 2019 | Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg 1860:659-78. | LEAK ET | N ROX | Intact cells | Human | Liver |
Jiang 2019 EMBO Rep | 2019 | Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG (2019) TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20:e48101. | LEAK OXPHOS ET | N S | Isolated mitochondria | Mouse | Heart |
Heden 2019 Sci Adv | 2019 | Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019) Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv 5:eaax8352. | LEAK OXPHOS | F N S DQ CIV NS ROX | Permeabilized tissue Isolated mitochondria | Mouse | Skeletal muscle |
Magga 2019 Mol Ther | 2019 | Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R (2019) Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury. Mol Ther 27:600-10. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Koop 2019 Int J Cardiol | 2019 | Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B (2019) Right ventricular pressure overload alters cardiac lipid composition. Int J Cardiol 287:96-105. | OXPHOS | F N | Isolated mitochondria | Rat | Heart |
Germain 2019 Int J Med Sci | 2019 | Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38. | LEAK ET | ROX N | Intact cells | Human | Fibroblast |
Diao 2019 Brain Res | 2019 | Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res 1727:146514. | LEAK OXPHOS ET | N | Isolated mitochondria | Mouse | Nervous system |
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Pignanelli 2019 Thesis | 2019 | Pignanelli CJ (2019) Muscular adaptations to low-load resistance training to repetition failure with and without blood flow restriction. Master's Thesis 80. | LEAK OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
Szibor 2019 Biochim Biophys Acta Bioenerg | 2019 | Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Heart |
Oliveira 2019 Mol Nutr Food Res | 2019 | Oliveira TE, Castro É, Belchior T, Andrade ML, Chaves-Filho AB, Peixoto AS, Moreno MF, Ortiz Silva M, Moreira RJ, Inague A, Yoshinaga MY, Miyamoto S, Moustaid-Moussa N, Festuccia WT (2019) Fish oil protects wild type and uncoupling protein 1 deficient mice from obesity and glucose intolerance by increasing energy expenditure. Mol Nutr Food Res 63:e1800813. | ET LEAK | N | Isolated mitochondria | Mouse | Fat |
Wiberg 2019 Eur Heart J Acute Cardiovasc Care | 2019 | Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care [Epub ahead of print]. | OXPHOS ET LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
Cedrone 2019 Thesis | 2019 | Cedrone M (2019) Low birth weight and post-natal diet induced alterations in skeletal muscle oxygen consumption and fiber type composition. Master's Thesis 83. | LEAK OXPHOS | N S | Permeabilized tissue Intact cells | Guinea pig Mouse | Skeletal muscle |
Chroeis 2019 Eur J Sport Sci | 2019 | Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45. | LEAK OXPHOS ET | N NS | Permeabilized tissue | Human | Skeletal muscle |
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Powers 2019 Neurourol Urodyn | 2019 | Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL (2019) Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourol Urodyn 38:1524-32. | LEAK OXPHOS | N S CIV NS | Homogenate | Mouse | Other cell lines |
Martines 2019 Sci Rep | 2019 | Martines AMF, Gerding A, Stolle S, Vieira-Lara MA, Wolters JC, Jurdzinski A, Bongiovanni L, de Bruin A, van der Vlies P, van der Vries G, Bloks VW, Derks TGJ, Reijngoud DJ, Bakker BM (2019) Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Sci Rep 9:14539. | LEAK OXPHOS | F N | Isolated mitochondria | Mouse | Liver |
Pignanelli 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Pignanelli C, Petrick HL, Keyvani F, Heigenhauser GJF, Quadrilatero J, Holloway GP, Burr JF (2019) Low-load resistance training to task-failure with and without blood flow restriction: muscular functional and structural adaptations. Am J Physiol Regul Integr Comp Physiol 318:R284-95. | OXPHOS LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
Power 2019 PLoS One | 2019 | Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740. | LEAK OXPHOS | N NS | Permeabilized tissue | Rat | Heart |
Fink 2019 FASEB J | 2019 | Fink BD, Yu L, Sivitz WI (2019) Modulation of complex II-energized respiration in muscle, heart, and brown adipose mitochondria by oxaloacetate and complex I electron flow. FASEB J 33:11696-705. | OXPHOS | N S | Isolated mitochondria | Mouse | Heart Skeletal muscle Fat |
Aguilar 2019 Cell Rep | 2019 | Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16. | LEAK OXPHOS | N | Homogenate | Mouse | Endothelial;epithelial;mesothelial cell |
Maekawa 2019 Biochem Biophys Rep | 2019 | Maekawa S, Takada S, Furihata T, Fukushima A, Yokota T, Kinugawa S (2019) Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle. Biochem Biophys Rep 21:100717. | OXPHOS | N S NS | Permeabilized tissue Isolated mitochondria | Mouse | Skeletal muscle |
Anton 2019 Front Physiol | 2019 | Anton L, DeVine A, Polyak E, Olarerin-George A, Brown AG, Falk MJ, Elovitz MA (2019) HIF-1α stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol 10:699. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Genital |
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Dannheisig 2019 Cells | 2019 | Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894. | LEAK ROUTINE ET | N S CIV NS ROX | Intact cells Permeabilized cells | Human | HeLa |
Nambu 2019 Eur J Pharmacol | 2019 | Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S (2019) Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. Eur J Pharmacol 866:172810. | LEAK OXPHOS | F N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Thomas 2019 Redox Biol | 2019 | Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155. | LEAK OXPHOS ET | N S NS ROX | Intact cells | Rat | Liver |
Lemieux 2019 bioRxiv | 2019 | Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 . | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Mouse | Blood cells |
Esteves 2019 Oncogene | 2019 | Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36. | LEAK ROUTINE OXPHOS ET | N ROX | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Penniman 2019 Mol Metab | 2019 | Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue Isolated mitochondria | Mouse | Skeletal muscle |
Larsen 2019 Appl Physiol Nutr Metab | 2019 | Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab 44:958-64. | OXPHOS ET LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
Fernando 2019 Exp Gerontol | 2019 | Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Petrick 2019 J Physiol | 2019 | Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol 597:3985-97. | LEAK OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
Ederle 2019 J Clin Med | 2019 | Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Blood cells |
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Gregg 2019 J Biol Chem | 2019 | Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66. | OXPHOS ET LEAK | N S NS ROX | Permeabilized tissue | Mouse | Islet cell;pancreas;thymus |
Azevedo 2019 Food Chem Toxicol | 2019 | Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694. | LEAK OXPHOS ET | N S ROX | Permeabilized tissue | Rat | Liver |
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Bettinazzi 2019 Cryobiology | 2019 | Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109. | LEAK OXPHOS ET | N Gp CIV NS ROX S Other combinations | Permeabilized tissue | Molluscs | Lung;gill |
Dollerup 2019 J Physiol | 2019 | Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Skrivergaard 2019 Viruses | 2019 | Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122. | LEAK ROUTINE OXPHOS ET | N S ROX | Permeabilized cells Intact cells | Human | Other cell lines HeLa |
Papadimitriou 2019 Sci Rep | 2019 | Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
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Malyala 2019 PLoS Comput Biol | 2019 | Malyala S, Zhang Y, Strubbe JO, Bazil JN (2019) Calcium phosphate precipitation inhibits mitochondrial energy metabolism. PLoS Comput Biol 15:e1006719. | OXPHOS LEAK | N S | Isolated mitochondria | Guinea pig | Heart |
Cormier 2019 Sci Rep | 2019 | Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531. | LEAK OXPHOS ET | N Gp NS ROX CIV | Permeabilized tissue | Drosophila | Skeletal muscle |
Paradis 2019 Antioxidants (Basel) | 2019 | Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168. | LEAK OXPHOS | N S CIV | Permeabilized tissue | Mouse | Skeletal muscle |
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Cornacchia 2019 Cell Stem Cell | 2019 | Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L (2019) Lipid deprivation induces a stable, naive-to-primed intermediate state of pluripotency in human PSCs. Cell Stem Cell 25:120-36. | LEAK ET | N CIV | Intact cells | Human | Stem cells |
Hsu 2019 J Clin Med | 2019 | Hsu CC, Tsai HH, Fu TC, Wang JS (2019) Exercise training enhances platelet mitochondrial bioenergetics in stroke patients: a randomized controlled trial. J Clin Med 8:E2186. | LEAK OXPHOS ET | F N S Gp NS ROX | Permeabilized cells | Human | Platelet Blood cells |
Spinazzi 2019 Proc Natl Acad Sci U S A | 2019 | Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86. | LEAK OXPHOS ET | N S CIV NS ROX | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Nervous system |
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Majiene 2019 Nutrients | 2019 | Majiene D, Kuseliauskyte J, Stimbirys A, Jekabsone A (2019) Comparison of the effect of native 1,4-naphthoquinones plumbagin, menadione, and lawsone on viability, redox status, and mitochondrial functions of C6 glioblastoma cells. Nutrients 11:E1294. | LEAK OXPHOS ET | N NS | Permeabilized cells | Rat | Nervous system |
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Chatfield 2019 JACC Basic Transl Sci | 2019 | Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human | Heart |
Dilberger 2019 Nutrients | 2019 | Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886. | LEAK OXPHOS ET | N S CIV NS | Isolated mitochondria | Caenorhabditis elegans | |
Datzmann 2019 Pharmacol Res | 2019 | Datzmann T, Hoffmann A, McCook O, Merz T, Wachter U, Preuss J, Vettorazzi S, Calzia E, Gröger M, Kohn F, Schmid A, Denoix N, Radermacher P, Wepler M (2019) Effects of sodium thiosulfate (Na2S2O3) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis. Pharmacol Res 151:104536. | LEAK OXPHOS | N NS | Homogenate | Pig | Heart Liver Kidney |
Nakajima 2019 Sci Rep | 2019 | Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S (2019) Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Sci Rep 9:3535. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Fat |
Goldberg 2019 Biochem J | 2019 | Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2019) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37. | LEAK ET | F N S NS Other combinations ROX | Isolated mitochondria | Mouse | Heart |
Kumar 2019 Free Radic Biol Med | 2019 | Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99. | LEAK ROUTINE OXPHOS ET | F N S DQ CIV NS ROX | Permeabilized cells Permeabilized tissue Intact cells | Mouse | Skeletal muscle |
Bettink 2019 Mitochondrion | 2019 | Bettink MAW, Harms FA, Dollee N, Specht PAC, Raat NJH, Schoonderwoerd GC, Mik EG (2019) Non-invasive versus ex vivo measurement of mitochondrial function in an endotoxemia model in rat: toward monitoring of mitochondrial therapy. Mitochondrion 50:149-57. | LEAK OXPHOS ET | N S | Homogenate | Rat | Skeletal muscle |
Richter 2019 Life Sci Alliance | 2019 | Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ (2019) Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance 2:e201800219. | OXPHOS ET | N CIV NS | Permeabilized cells | Human | Fibroblast |
Belosludtsev 2019 Biochim Biophys Acta Biomembr | 2019 | Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2019) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr 1861:288-97. | LEAK OXPHOS | N S NS | Isolated mitochondria | Rat | Liver |
McMurray 2019 FASEB J | 2019 | McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26. | LEAK OXPHOS | F N S CIV ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Neyroud 2019 J Muscle Res Cell Motil | 2019 | Neyroud D, Nosacka RL, Judge AR, Hepple RT (2019) Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content. J Muscle Res Cell Motil 40:59-65. | OXPHOS | N NS | Permeabilized cells | Mouse | Skeletal muscle |
Dall 2019 J Biol Chem | 2019 | Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem 294:13304-26. | LEAK OXPHOS ET | F N S | Intact cells | Mouse | Liver |
Mejia 2019 Reprod Biol Endocrinol | 2019 | Mejia JF, Hirschi KM, Tsai KYF, Long MG, Tullis BC, Bitter EEK, Bikman BT, Reynolds PR, Arroyo JA (2019) Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reprod Biol Endocrinol 17:81. | LEAK OXPHOS ET | N NS | Permeabilized cells | Human | Genital |
Harhous 2019 J Mol Cell Cardiol | 2019 | Harhous Z, Badawi S, Bona NG, Pillot B, Augeul L, Paillard M, Booz GW, Canet-Soulas E, Ovize M, Kurdi M, Bidaux G (2019) Critical appraisal of STAT3 pattern in adult cardiomyocytes. J Mol Cell Cardiol 131:91-100. | OXPHOS ET | N CIV ROX | Isolated mitochondria | Mouse | Heart |
Shuvo 2019 J Bioenerg Biomembr | 2019 | Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J Bioenerg Biomembr 51:341-54. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Fungi | |
Wang 2019 Life Sci | 2019 | Wang JW, Xue ZY, Wu AS (2019) Mechanistic insights into δ-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria. Life Sci 247:116942. | LEAK OXPHOS | N S | Isolated mitochondria | Mouse | Heart |
Lefranc 2019 Hypertension | 2019 | Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68. | OXPHOS LEAK | N | Isolated mitochondria | Mouse | Fat |
Cikankova 2019 Naunyn Schmiedebergs Arch Pharmacol | 2019 | Cikánková T, Fišar Z, Bakhouche Y, Ľupták M, Hroudová J (2019) In vitro effects of antipsychotics on mitochondrial respiration. Naunyn Schmiedebergs Arch Pharmacol 392:1209-23. | OXPHOS | N S ROX | Isolated mitochondria | Pig | Nervous system |
Svab 2019 Neurochem Res | 2019 | Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47. | LEAK OXPHOS ET | N S | Isolated mitochondria Intact cells | Guinea pig | Nervous system |
Wang 2019 Metabolism | 2019 | Wang D, Liu CD, Li HF, Tian ML, Pan JQ, Shu G, Jiang QY, Yin YL, Zhang L (2019) LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue. Metabolism 102:154011. | LEAK | F N | Isolated mitochondria | Mouse | Fat |
Paumelle 2019 J Hepatol | 2019 | Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73. | OXPHOS LEAK | F N | Homogenate | Human | Liver |
Cadiz 2019 Comp Biochem Physiol B Biochem Mol Biol | 2019 | Cadiz L, Bundgaard A, Malte H, Fago A (2019) Hypoxia enhances blood O2 affinity and depresses skeletal muscle O2 consumption in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol 234:18-25. | LEAK OXPHOS ET | N NS | Permeabilized tissue | Zebrafish | Skeletal muscle |
Turnbull 2019 Am J Physiol Cell Physiol | 2019 | Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88. | LEAK OXPHOS | N | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
Seo 2019 Exp Neurol | 2019 | Seo JH, Park HS, Park SS, Kim CJ, Kim DH, Kim TW (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043. | LEAK OXPHOS | N NS | Isolated mitochondria | Rat | Nervous system |
Bianco 2019 PLoS One | 2019 | Bianco M, Lopes JA, Beiral HJV, Filho JDD, Frankenfeld SP, Fortunato RS, Gattass CR, Vieyra A, Takiya CM (2019) The contralateral kidney presents with impaired mitochondrial functions and disrupted redox homeostasis after 14 days of unilateral ureteral obstruction in mice. PLoS One 14:e0218986. | LEAK OXPHOS ET | N S | Isolated mitochondria | Mouse | Kidney |
Viana 2019 Sci Rep | 2019 | Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529. | LEAK OXPHOS | N | Permeabilized tissue | Rat | Endothelial;epithelial;mesothelial cell |
Bodis 2019 J Clin Endocrinol Metab | 2019 | Bodis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Muessig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schuermann A, Roden M, Szendroedi J (2019) Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes. J Clin Endocrinol Metab 105:dgz267. | LEAK OXPHOS ET | F N NS | Permeabilized cells | Human | Fat |
Friederich 2019 Mol Genet Metab | 2019 | Friederich MW, Perez FA, Knight KM, Van Hove RA, Yang SP, Saneto RP, Van Hove JLK (2019) Pathogenic variants in NUBPL result in failure to assemble the matrix arm of complex I and cause a complex leukoencephalopathy with thalamic involvement. Mol Genet Metab 129:236-42. | OXPHOS ET | N S CIV NS | Human | Fibroblast | |
Wang 2019 J Biol Chem | 2019 | Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV (2019) Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. J Biol Chem 294:5466-86. | ROUTINE OXPHOS ET | F N S NS | Permeabilized cells Isolated mitochondria Intact cells | Rat | Fibroblast |
Ng 2019 J Biol Chem | 2019 | Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Neuroblastoma |
Pajak 2019 PLoS Genet | 2019 | Pajak A, Laine I, Clemente P, El-Fissi N, Schober FA, Maffezzini C, Calvo-Garrido J, Wibom R, Filograna R, Dhir A, Wedell A, Freyer C, Wredenberg A (2019) Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. PLoS Genet 15:e1008240. | LEAK OXPHOS | N S CIV | Permeabilized tissue | Drosophila | |
Latham 2019 J Anim Sci | 2019 | Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print]. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Horse | Skeletal muscle |
Vaka 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447. | LEAK OXPHOS ET | N CIV ROX | Intact cells Isolated mitochondria | Human Rat | Endothelial;epithelial;mesothelial cell Genital |
Mann 2019 Oncogene | 2019 | Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX F | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
Anderson 2019 Acta Neuropathol | 2019 | Anderson CJ, Bredvik K, Burstein SR, Davis C, Meadows SM, Dash J, Case L, Milner TA, Kawamata H, Zuberi A, Piersigilli A, Lutz C, Manfredi G (2019) ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response. Acta Neuropathol 138:103-21. | LEAK | N S | Isolated mitochondria | Mouse | Heart |
Chao 2019 Am J Physiol Cell Physiol | 2019 | Chao T, Gomez BI, Heard TC, Smith BW, Dubick MA, Burmeister DM (2019) Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine. Am J Physiol Cell Physiol 317:C1229-38. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Pig | Heart |
Nunes 2019 Oxid Med Cell Longev | 2019 | Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Homogenate | Zebrafish | |
Poudel 2019 Can J Physiol Pharmacol | 2019 | Poudel A, Zhou JY, Mekala N, Welchko R, Rosca MG, Li L (2019) Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol 97:699-707. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Skeletal muscle |
Bajzikova 2019 Cell Metab | 2019 | Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. | OXPHOS ET | N S ROX | Permeabilized cells Homogenate | Mouse | Endothelial;epithelial;mesothelial cell Genital Other cell lines |
Cardinale 2019 Front Physiol | 2019 | Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730. | LEAK OXPHOS ET | F N CIV NS ROX | Permeabilized tissue Isolated mitochondria | Human | Skeletal muscle |
Kolleritsch 2019 Cardiovasc Res | 2019 | Kolleritsch S, Kien B, Schoiswohl G, Diwoky C, Schreiber R, Heier C, Maresch LK, Schweiger M, Eichmann TO, Stryeck S, Krenn P, Tomin T, Kolb D, Rülicke T, Hoefler G, Wolinski H, Madl T, Birner-Gruenberger R, Haemmerle G (2019) Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Cardiovasc Res 116:339-52. | LEAK OXPHOS | N | Homogenate | Mouse | Heart |
Shrum 2019 Biomolecules | 2019 | Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules 9:E825. | LEAK OXPHOS | N S CIV ROX | Permeabilized cells | Rat | Kidney |
Bettinazzi 2019 Proc Biol Sci | 2019 | Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708. | LEAK OXPHOS ET | N Gp CIV NS ROX | Permeabilized cells | Molluscs | Lung;gill Genital |
Miotto 2019 FASEB J | 2019 | Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40. | LEAK OXPHOS | N NS F | Permeabilized tissue | Human | Skeletal muscle |
... further results |
- »Abstracts: N-pathway control state
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Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
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Doerrier 2020 PaduaMuscleDays Poster | 2020 | Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
Doerrier 2019 MiP2019 | 2019 | Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. | LEAK ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Santos 2019 MiPschool Coimbra | 2019 | Uncoupling Protein 1 inhibition and mitochondrial respiration in epicardial adipose tissue from hear failure patients. | OXPHOS | F N | Human | Heart Fat | |
Rutai 2019 Crit Care | 2019 | Rutai A, Fejes R, Tallósy SZ, Poles M, Juhász L, Mészáros A, Boros M, Kaszaki J (2019) Potential role of endothelin receptors in the therapy of experimental sepsis. Crit Care. | OXPHOS | N S | Rat | ||
Ravasz 2019 Abstract IOC141 | 2019 | Ravasz D, Bui D, Kitayev A, Greenwood B, Hill C, Komlodi T, Doerrier C, Ozohanics O, Moore AL, Gnaiger E, Kiebish M, Kolev K, Seyfried TN, Willis WT, Narain N, Adam-Vizi V, Chinopoulos C (2019) Endogenous quinones sustain a moderate NADH oxidation by Complex I during anoxia. Mitochondr Physiol Network 24.02. | N S Other combinations | Isolated mitochondria | Mouse | Liver | |
Silva 2019 MiPschool Coimbra | 2019 | Off-target effects of etomoxir on mitochondrial Complex I. | OXPHOS ET | F N Other combinations | Permeabilized cells Isolated mitochondria | Human Mouse | Liver |
Lemieux 2019a MiP2019 | 2019 | Partial prevention of oxidative stress damage to mitochondria with photobiomodulation. | LEAK OXPHOS ET | N S CIV NS | Other invertebrates | ||
Garcia 2019 MiPschool Coimbra | 2019 | Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase. | LEAK OXPHOS | N Gp | Drosophila | ||
Kramer 2019 Abstract IOC141 | 2019 | Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02. | LEAK OXPHOS ET | N CIV NS ROX | Human | Skeletal muscle | |
Silva 2019 ESCI2019 | 2019 | Silva FSG, Komlodi T, Garcia-Souza LF, Bento G, Doerrier C, Oliveira PJ, Gnaiger E (2019) Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir? | OXPHOS ET | F N S | Permeabilized cells Isolated mitochondria | Human Mouse | Liver |
Abdel-Rahman 2019 MiP2019 | 2019 | Mitochondrial respiration in platelets of children with autism spectrum disorder. | ROUTINE OXPHOS | N NS | Intact cells | Human | Platelet |
Beleza 2019 MiPschool Coimbra | 2019 | Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function. | LEAK OXPHOS | N S | Rat | Liver | |
Scandalis 2019 Abstract IOC141 | 2019 | Scandalis LM, Kramer P, Nelson B, Dozier S, Stone J, Kitzman D, Molina AJA (2019) Oxygen consumption of skeletal muscle in heart failure with preserved ejection fraction. Mitochondr Physiol Network 24.02. | ET | N S | Permeabilized tissue | Human | Skeletal muscle |
Pavlovic 2019 MiP2019 | 2019 | Effects of therapeutic metformin concentration on mitochondria in muscle cells. | ROUTINE OXPHOS | N S | Intact cells | Mouse | Skeletal muscle |
Sumbalova 2019a MiP2019 | 2019 | Platelet mitochondrial function, coenzyme Q10, and oxidative stress in patients with chronic kidney diseases. | LEAK OXPHOS | F N S Gp CIV NS ROX | Intact cells | Human | Platelet |
Evinova 2019 MiPschool Coimbra | 2019 | High resolution respirometry of neuroblastoma SK-N-SH and SH-SY 5Y cell lines. | LEAK ROUTINE ET | N | Intact cells | Human | Neuroblastoma |
Holody 2019 MiP2019 | 2019 | Sex-specific changes in neonatal cardiac mitochondrial function in response to perinatal iron deficiency. | N S NS | Permeabilized tissue | Rat | Heart | |
Van der Ende 2019 MiPschool Coimbra | 2019 | Mitochondrial respiration in muscle tissue of colon cancer patients. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Aid-Vanakova 2019 MiP2019 | 2019 | Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model. | LEAK OXPHOS | N S | Mouse | Skeletal muscle Heart | |
Sumbalova 2019b MiP2019 | 2019 | The decline of mitochondrial respiration in isolated platelets after short-term storage. | LEAK OXPHOS | F N S Gp CIV NS ROX | Intact cells | Human | Platelet |
Goncalves Debora 2019 MiPschool Coimbra | 2019 | Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Drosophila | |
Chabi 2019 MiP2019 | 2019 | Generating reference values on mitochondrial respiration in permeabilized muscle fibers. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Minuzzi 2019 MiPschool Coimbra | 2019 | A pilot study on mitochondrial function of mouse skin using high-resolution respirometry. | LEAK OXPHOS ET | F N S | Permeabilized tissue | Mouse | Endothelial;epithelial;mesothelial cell |
Kandel 2019 Biophys J | 2019 | Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J. | LEAK OXPHOS | F N S | Isolated mitochondria | Rat | Heart Kidney |
Lelcu 2019 MiP2019 | 2019 | Assessment of platelet respiration in blood malignancies: a pilot study in children and adults. | LEAK OXPHOS ET | N NS ROX | Permeabilized cells | Human | Platelet |
Garcia-Roves 2019 MiPschool Coimbra | 2019 | Generating reference values on mitochondrial respiration in permeabilized muscle fibers. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Nemec 2018 MiP2018 | 2018 | Aerobic/strength exercise intervention modulates skeletal muscle mitochondrial function in seniors. | LEAK | F N NS Other combinations | Permeabilized tissue | Human | Skeletal muscle |
Dubouchaud 2018 MiPschool Tromso | 2018 | AMPK deficiency elicits changes in OXPHOS in heart mitochondria. | N CIV NS | Isolated mitochondria | Mouse | Heart | |
Stankova 2018 MiP2018 | 2018 | Impact of western diet on energy metabolism in mouse liver. | OXPHOS ET | S F N | Homogenate | Mouse | Liver |
Doerrier 2018 MiP2018a | 2018 | Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Pchelin 2018 IOC130 | 2018 | Activation of heterodimeric receptor to erythropoietin with its agonist CdEPO regulates brain mitochondrial bioenergetics after local acute ischemia/reperfusion in C57BL/6 mice. | LEAK | N | Isolated mitochondria | Mouse | Nervous system |
Wilson 2018 Virginia Tech | 2018 | Wilson ZT, Perry JB, Brow DA (2018) High-resolution respirometry of heart mitochondria in healthy and stressed states. Virginia Tech. | OXPHOS | N | Isolated mitochondria | Heart | |
Kidere 2018 MiPschool Tromso E2 | 2018 | Cytoplasmic hybrid cells as a model to characterize the OXPHOS system: control sample with glutamate metabolism defect. | N NS S | Isolated mitochondria | Human | Platelet | |
Chang 2018 Biophys J | 2018 | Mitochondrial dysfunction in malignant hyperthermia susceptible skeletal muscle. | OXPHOS | N S | Permeabilized tissue | Human Mouse | Skeletal muscle |
Lemieux 2018 MiP2018 | 2018 | Plasticity of a critical regulator of energy production under hypothermia, the phosphorylation system. | OXPHOS | N S | Intact organism | Other invertebrates | |
Krajcova 2018 ICO134 | 2018 | Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Human | Skeletal muscle |
Meszaros 2018 EBEC2018 | 2018 | Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration. | LEAK OXPHOS ET | N | Isolated mitochondria | Mouse | Heart Nervous system Liver |
Doerrier 2018 MiP2018c | 2018 | Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Liu 2018 Atherosclerosis Suppl | 2018 | Liu D (2018) Enhanced Trpc3-mediated mitochondrial respiratory dysfunction by inhibition of mitochondria-hexokinase in monocytes from hypertension rats. Atherosclerosis Suppl. | ROUTINE OXPHOS ET | N NS | Intact cells | Rat | Blood cells |
Isola 2018 MiPschool Tromso C3 | 2018 | AMPK deficiency elicits changes in OXPHOS in heart mitochondria. | N CIV NS | Isolated mitochondria | Mouse | Heart | |
Schoepf 2018 33rd Annual EAU Congress Copenhagen | 2018 | Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue. | LEAK OXPHOS ET | F N NS Other combinations ROX | Permeabilized cells Permeabilized tissue | Human | Genital |
Votion 2018 MiP2018 | 2018 | Functional diagnosis of mitochondrial defects in equine atypical myopathy and targeted mitochondrial therapy: a preliminary study. | OXPHOS | F N S NS | Intact cells | Horse | Skeletal muscle |
Ravasz 2018 Abstract The evolving concept of mitochondria | 2018 | Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria. | LEAK OXPHOS | N | Isolated mitochondria | Mouse | Liver |
Pereira da Silva Grilo da Silva 2018 MiP2018 | 2018 | The unspecific effect of etomoxir on mitochondrial respiration. | OXPHOS ET | F N S NS Other combinations | Permeabilized cells Isolated mitochondria | Human Mouse | Nervous system Liver Other cell lines |
Chicco 2018 MiP2018b | 2018 | Defective cardiolipin remodeling and cardiac mitochondrial dysfunction: supercomplexes or just complex? | OXPHOS | F N NS | Permeabilized tissue | Mouse | Heart |
Meszaros 2018 Mt Med Hinxton | 2018 | High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments. | LEAK OXPHOS ET | N CIV NS | Isolated mitochondria | Mouse | Heart Nervous system Liver |
Gnaiger 2018 MiP2018 | 2018 | Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks of mitochondrial physiology Part 2. | OXPHOS | N F S Gp DQ CIV NS Other combinations | |||
Krajcova 2018 MiPschool Tromso E2 | 2018 | High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. | LEAK OXPHOS ET | N NS ROX | Homogenate | Human | Heart |
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells | Human | HEK Kidney |
Keller 2018 MiP2018 | 2018 | The structural molecular diversity of mitochondrial cardiolipins. | F N | Intact cells | Mouse | Heart Nervous system | |
Doerrier 2018 MiP2018b | 2018 | Evaluation of anaplerotic pathways to avoid artefacts in respirometric measurement of fatty acid oxidation. | OXPHOS | F N | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system Blood cells HEK Platelet |
McMaster 2018 Am J Obstet Gynecol | 2018 | Preeclampsia is associated with placental mitochondrial dysfunction. | LEAK ROUTINE OXPHOS ET | N | Isolated mitochondria | Human | |
Acuna-Castroviejo 2018 MiP2018 | 2018 | Mitochondria, melatonin, and neuroinflammation in Parkinson's disease. Acuna-Castroviejo_Presentation | LEAK OXPHOS | N | Mouse | Nervous system | |
Garcia-Roves 2018 MiP2018b | 2018 | Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation | OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
White 2018 J Anim Sci | 2018 | Differing mitochondrial capacity in two separate skeletal muscles from calm and temperamental Brahman heifers. | OXPHOS | N | Bovines | Skeletal muscle | |
Konopka 2018 FASEB J | 2018 | Konopka AR, Castor WM, Reid J, Schoenberg H, Laurin J, Wolff C, Hamilton K, Miller B (2018) Metformin blunts exercise-induced improvements in skeletal muscle mitochondrial respiration independent of changes in mitochondrial biogenesis. FASEB J. | OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
Doerrier 2018 ESCI2018 | 2018 | High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease | LEAK ROUTINE OXPHOS ET | F N S Gp ROX CIV | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | Human Mouse | Heart Skeletal muscle Nervous system Blood cells HEK |
Komlodi 2018b EBEC2018 | 2018 | Endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria. | N | Isolated mitochondria | Mouse | Liver | |
Gnaiger 2018 MiPschool Tromso A1 | 2018 | Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control. | LEAK ET OXPHOS | F N S Gp DQ CIV NS Other combinations | |||
Belosludtsev 2018 MiP2018 | 2018 | Effect of bedaquiline and delamanid on the functions of rat liver mitochondria. | N S | Isolated mitochondria | Rat | Liver | |
Wuest 2018 MiP2018b | 2018 | The antibiotic doxycycline impairs cardiac mitochondrial and contractile function. | OXPHOS ET | N S | Rat | Heart Other cell lines | |
Doerrier 2018 EBEC2018 | 2018 | Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system Blood cells HEK Platelet |
Hunt 2018 J Urol | 2018 | Marked increase in mitochondrial respiration, hydrogen peroxide emitting potential and ATP production in the urothelium versus detrusor smooth muscle. | N S CIV NS | Intact cells | Mouse | Endothelial;epithelial;mesothelial cell | |
Greyslak 2018 FASEB J | 2018 | Greyslak KT, Hetrick B, Takahashi DL, Dean T, Kievit P, Sullivan EL, McCurdy CE (2018) Exposure to a western-style diet during early development reduces skeletal muscle lipid metabolism and CI-dependent oxidative capacity in juvenile non-human primate offspring. FASEB J. | N | Other mammals | Skeletal muscle | ||
Wuest 2018 MiPschool Tromso D3 | 2018 | Metabolic flexibility and mitochondrial function in the diabetic heart. | OXPHOS | N S | Pig Mouse Rat | Heart | |
Truu 2017 Abstract IOC122 | 2017 | Bioenergetics of colorectal cancer. | OXPHOS | N S | Endothelial;epithelial;mesothelial cell | ||
Gnaiger 2017 MiPschool A4 | 2017 | Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology. | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Permeabilized tissue Isolated mitochondria | |||
Urban 2017 MiP2017 | 2017 | Kinetics of inhibition of energy metabolism pathways by propofol in human skeletal muscle homogenates. | F N NS | Homogenate | Human | Skeletal muscle | |
Sobotka 2017 Abstract MITOEAGLE Barcelona | 2017 | The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation | OXPHOS ET | F N S Gp ROX | Isolated mitochondria | Rat | Liver |
Krylova 2017 MiPschool Obergurgl | 2017 | High-resolution respirometry in diagnostic of mitochondrial complex I deficiency. | LEAK ROUTINE ET | N S | Intact cells Permeabilized cells | Endothelial;epithelial;mesothelial cell Fibroblast | |
Siewiera 2017 MiP2017 | 2017 | Changes in blood platelet and brain mitochondrial respiration during short and long-lasting STZ-induced diabetes. | LEAK ET | N | Homogenate Intact cells | Rat | Nervous system Blood cells Platelet |
Wu 2017 FASEB J | 2017 | Effects of eccentric and concentric cycling exercise regimens on hypoxia-mediated mitochondrial bioenergetics of platelets in sedentary males. | F N S Gp | Human | Blood cells Platelet | ||
Hellgren 2017 MiPschool Obergurgl | 2017 | Effect of prenatal hypoxia on adult mitochondrial respiration and ROS production. | LEAK ROUTINE ET | N | Homogenate | Mouse | Heart |
Scheiber 2017 Europ Heart J | 2017 | High-resolution respirometry in human endomyocardial biopsies to assess myocardial mitochondrial function. | OXPHOS | F N NS | Permeabilized tissue | Human | Heart |
Komlodi 2017 MiP2017 | 2017 | H2O2 production under hypoxia in brain and heart mitochondria: does O2 concentration matter? | LEAK OXPHOS | N NS | Isolated mitochondria | Mouse | Heart Nervous system |
Amick 2017 MiPschool Obergurgl | 2017 | Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates. | LEAK OXPHOS | F N | Isolated mitochondria | Other mammals | Nervous system |
Gnaiger 2017 MiPschool C1 | 2017 | Apparent Complex IV excess capacity and biochemical thresholds. | N S CIV NS ROX | Permeabilized cells Permeabilized tissue Isolated mitochondria | |||
Boyle 2017 MiP2017 | 2017 | Type 2 diabetes causes systemic skeletal muscle complex I mitochondrial dysfunction in chronic heart failure patients. | N S | Permeabilized tissue | Human | Skeletal muscle | |
Siewiera 2017 Abstract MITOEAGLE Barcelona | 2017 | The effect of metformin on blood platelet bioenergetics and platelet function. | ROUTINE ET | N | Intact cells | Human | Blood cells Platelet |
Ukropec 2017 MITOEAGLE Obergurgl | 2017 | Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment? | LEAK OXPHOS ET | F N S Gp NS | Permeabilized cells | Skeletal muscle | |
Brazdova 2017 MiP2017 | 2017 | Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production. | F N NS | Isolated mitochondria | Fat | ||
Chang 2017 FASEB J | 2017 | Effects of cycling exercise on mitochondrial function and efficacy of peripheral blood mononuclear cells under hypoxic condition in sedentary men. | ROUTINE | N | Permeabilized cells Intact cells | Blood cells | |
White 2017 J Anim Sci | 2017 | Influence of temperament on skeletal muscle mitochondrial capacity of Brahman cows. | OXPHOS ET | N S NS | Bovines | Skeletal muscle | |
Isola 2017 MiPschool Obergurgl | 2017 | Do mitochondria counteract diabetes impairment by means of morphological and physiological strategies? | OXPHOS | F N | Isolated mitochondria | Rat | |
Nakajima 2017 Europ Heart J | 2017 | Mitochondrial dysfunction in epicardial adipose tissue; possible role in progression of coronary artery disease. | OXPHOS | F N NS | Permeabilized tissue | Human | Fat |
Meszaros 2017 MiP2017 | 2017 | Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Nervous system Liver Kidney |
Collins 2017 MiPschool Obergurgl | 2017 | The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics. | OXPHOS | F N S Gp CIV NS ROX | Intact cells | ||
Doerrier 2017 MiPschool C2 | 2017 | Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system HEK |
Doerrier 2017 MiP2017 WG2 | 2017 | Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z. | LEAK OXPHOS ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
Dubouchaud 2017 Abstract MITOEAGLE Barcelona | 2017 | Impact of high-fat diet or PUFAs consumption on the mitochondrial function. | OXPHOS | F N | Permeabilized tissue Isolated mitochondria | Rat | Skeletal muscle Liver |
Krajcova 2017 MITOEAGLE Obergurgl | 2017 | Developing a method of assessing mitochondrial functions in homogenates of human heart muscle. | LEAK OXPHOS ET | N NS | Homogenate | Human | |
Kolonics 2017 MiP2017 | 2017 | Different molecular composition of Lysimachia species result in distinct metabolism. | OXPHOS | N NS | Mouse Plants | Heart Liver | |
Lin 2017 FASEB J | 2017 | Mitochondrial respiration is fiber-type specific in skeletal muscles. | LEAK ROUTINE | N NS | Permeabilized tissue | Rat | Skeletal muscle |
Keppner 2017 MiPschool Obergurgl | 2017 | Different respiratory states to determine LEAK and uncoupled respiration in the SUIT protocol: effect and consequences. | LEAK OXPHOS ET | N NS | Permeabilized cells | Blood cells | |
Labieniec-Watala 2017 MiP2017 | 2017 | Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation | OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Genital |
Sobotka 2017 MiP2017 | 2017 | Metabolic changes in rat liver mitochondria during the development of liver steatosis. | OXPHOS ET | N NS | Isolated mitochondria | Rat | Liver |
Markova 2017 MiPschool Obergurgl | 2017 | Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase. | LEAK OXPHOS | N S CIV NS ROX | Homogenate | Rat | Heart |
Panajatovic 2017 IOC124 | 2017 | Role of PGC-1α associated mitochondrial biogenesis in statin-induced myotoxicity. | N S NS | Permeabilized tissue | Mouse | Skeletal muscle | |
Doerrier 2017 MiP2017 C1 | 2017 | Effects of warm ischemia on cardiac mitochondria to detect specific targets by high-resolution respirometry (HRR) | LEAK ET | F N S CIV NS | Isolated mitochondria | Mouse | Heart |
Gnaiger 2017 Abstract EUROMIT2017 Cologne | 2017 | Again not a Warburg effect - mitochondrial function in primary prostate cancer. | OXPHOS ET | N NS S | Human | Endothelial;epithelial;mesothelial cell Genital Fibroblast | |
Waldauf 2017 MITOEAGLE Obergurgl | 2017 | Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates. | LEAK OXPHOS ET | F N S CIV NS | Homogenate | Human | Skeletal muscle |
Markova 2017 MiP2017 | 2017 | Porcine sepsis and associated myocardial depression. | LEAK OXPHOS | N S CIV NS ROX | Pig | Heart | |
Komlodi 2017 Abstract MITOEAGLE Barcelona | 2017 | Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria. | OXPHOS LEAK ET | N S | Isolated mitochondria Homogenate | Guinea pig Mouse | Nervous system Kidney Heart Liver |
Komlodi 2017 MiPschool Obergurgl | 2017 | Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production. | LEAK OXPHOS | N S Gp Other combinations ROX | Isolated mitochondria | Mouse | Nervous system |
Gnaiger 2017 Abstract MitoEAGLE Barcelona | 2017 | Quality first: a paradigm shift in mt-respiratory control towards global connection. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human Mouse | Heart Genital |
Muntean 2017 MiP2017 | 2017 | Impairment of platelet mitochondrial respiration in metabolic syndrome: A pilot study. | N S | Human | Blood cells Platelet | ||
Aasander Frostner 2017 MiP2017 | 2017 | Cell-permeable succinate and malonate as research tools. Aasander Frostner_Poster | N | Intact cells | Human | Heart Liver Blood cells Fibroblast | |
Meszaros 2017 MiPschool Obergurgl | 2017 | (Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration. | LEAK OXPHOS | N S | Isolated mitochondria | Mouse | Liver Nervous system Kidney |
Vaka 2017 Hypertension | 2017 | Abstract P265: Placental ischemia causes renal mitochondrial impairment in reduced uterine perfusion pressure rats. | OXPHOS | N S | Isolated mitochondria | Rat | Kidney Genital |
Hoppel 2017 MiP2017 | 2017 | Pathways of mitochondrial fatty acid oxidation. Hoppel_Presentation | OXPHOS | F N S | Rat | Liver | |
Schilling 2017 J Mol Cell Cardiol | 2017 | Loss of caveolin-1 alters cardiac mitochondrial function and increases susceptibility to stress. | OXPHOS | N CIV NS | Isolated mitochondria | Mouse | Heart |
Gainutdinov 2017 MITOEAGLE Obergurgl | 2017 | Different ways of reactive oxygen species (ROS) formation by brain mitochondria. | N S Gp | Isolated mitochondria | Mouse Rat | Nervous system | |
Truu 2017 MiP2017 | 2017 | Bioenergetic comparison of human colorectal and breast cancer clinical patients. | N NS | Permeabilized tissue | Human | ||
Wuest 2017 Abstract MITOEAGLE Barcelona | 2017 | Mitochondrial Complex I function in heart failure: different angles to analyze mitochondrial function. | N S | Rat | Heart | ||
Holzknecht 2017 MiPschool Obergurgl | 2017 | Metabolic characterization of Fahd1 knock-out cardiomyocytes in a mammalian model organism - an outlook. | F N | Mouse | Heart | ||
Doerrier 2017 Abstract MitoEAGLE Barcelona | 2017 | SUIT reference protocol for comparative mitochondrial physiology. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system HEK |
Garcia-Roves 2017 MiP2017 | 2017 | Mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. MitoEAGLE WG2 pilot study. Garcia-Roves_Presentation | OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Larsen 2017 MiP2017 WG2 | 2017 | The effect on respiratory capacity using different respiration buffers. | OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
Juhasz 2017 MiPschool Obergurgl | 2017 | Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats. | LEAK OXPHOS | N S | Homogenate | Rat | Liver |
Nemec 2017 MiP2017 | 2017 | Three-month exercise modulates skeletal muscle mitochondria function in patients with mild cognitive impairment. | LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
Irving 2017 MiP2017 | 2017 | Impact of acute exercise on PBMC respiratory function and methodological considerations. | LEAK ROUTINE OXPHOS ET | N NS ROX | Blood cells | ||
Madlala 2016 Abstract MitoFit Science Camp 2016 | 2016 | Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates. | LEAK OXPHOS ET | N | Permeabilized cells | Human | Liver |
Laner 2016 Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
Pileggi 2016 Abstract MitoFit Science Camp 2016 | 2016 | Voluntary exercise prevents high fat diet-induced cardiac mitochondrial dysfunction in male rats. | F N NS | Permeabilized tissue | Rat | Heart | |
Lamberti 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a reference sample for HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Human | Kidney HEK | |
Laner 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
Hoppel 2016b Abstract MitoFit Science Camp 2016 | 2016 | Comparison of permeabilized skeletal muscle fibers or isolated mitochondria for the detection of oxidative phosphorylation defects. | N S CIV | Permeabilized cells Homogenate Isolated mitochondria | Human | Skeletal muscle | |
Sobotka 2016 Abstract IOC116 | 2016 | Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11 | LEAK OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Isolated mitochondria | Rat | Liver |
Maarman 2016 Abstract MitoFit Science Camp 2016 | 2016 | Melatonin rescues uric acid-induced impairment of respiration in myotubes. | OXPHOS | N | Mouse | Skeletal muscle Other cell lines | |
Louw 2016 Abstract FASEB J | 2016 | Exercise limits loss of respiratory function seen with doxorubicin treatment without affecting muscle function. | ET | N S | Permeabilized tissue | Mouse | Skeletal muscle |
Chicco 2016b Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m. | LEAK OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
Krumschnabel 2016a Abstract MitoFit Science Camp 2016 | 2016 | O2k-Protocols: Mitochondrial preparations for HRR. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart |
Garcia-Souza 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Assessment of fatty acid oxidation in mouse brain and liver mitochondria. | OXPHOS | F N | Homogenate Isolated mitochondria | Nervous system Liver | |
Hoppel 2016c Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial respiration in permeabilized skin fibroblasts. | OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Cecatto 2016 Abstract IOC116 | 2016 | Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11 | LEAK OXPHOS ET | F N CIV Other combinations | Permeabilized tissue Isolated mitochondria | Rat | Nervous system Liver |
Chicco 2016c Abstract MitoFit Science Camp 2016 | 2016 | Investigating the mechanism of cardiac mitochondrial respiratory impairment in Barth Syndrome. | OXPHOS | F N S CIV Other combinations | Mouse | Heart | |
Murphy 2016 Abstract FASEB J | 2016 | Metformin limits loss of mitochondrial respiration seen with doxorubicin treatment without affecting muscle function. | ET | N S | Permeabilized tissue | Mouse | Skeletal muscle |
Pelnena 2016 Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS enzyme activity measurements in mitochondria isolated from peripheral blood leukocytes in control group and patients with suspected mitochondrial disease. | N | Isolated mitochondria | Human | Blood cells Macrophage-derived | |
Doerrier 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | Human Mouse | Heart Blood cells HEK Platelet |
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck | 2016 | Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry. | LEAK OXPHOS ET | F N S Gp CIV ROX | Isolated mitochondria | Mouse | Heart |
Davies 2016 Abstract Proceedings of The Physiological Society | 2016 | Development of mitochondrial function in the cortex and cerebellum of the ovine fetus. | LEAK OXPHOS | N S NS | Homogenate | Bovines | Nervous system |
Sparagna 2016 Abstract IOC109 | 2016 | Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01. | LEAK OXPHOS | N S NS | Human | Heart | |
Volani 2016 Abstract MitoFit Science Camp 2016 | 2016 | Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs. | LEAK OXPHOS ET | N S | Homogenate | Mouse Rat | Liver Blood cells Lymphocyte |
Schoepf 2016 Abstract Androgens 2016 | 2016 | Mitochondrial function and mitochondrial heteroplasmy levels differ between benign and malignant prostate tissue. | N S | Genital | |||
Markova 2016 Abstract MitoFit Science Camp 2016 | 2016 | Porcine hearts samples preparation: PBI-Shredder or saponin? | N S NS | Permeabilized tissue Homogenate | Pig | Heart | |
Sumbalova 2016b Abstract MitoFit Science Camp 2016 | 2016 | Human blood cells: isolation and HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Intact cells | Human | Blood cells Lymphocyte Platelet |
Osiki 2016 Abstract MitoFit Science Camp 2016 | 2016 | Suitability of octanoylcarnitine & malate for assessment of beta oxidation capacity by respirometry in aconitase-inhibited samples. | OXPHOS ET | F N Other combinations | Rat | Skeletal muscle | |
Kane 2016 Abstract MitoFit Science Camp 2016 | 2016 | Effects of inhibiting myosin-ATPase on mitochondrial respiratory capacity in permeabilized skeletal muscle. | OXPHOS | F N | Permeabilized tissue | Rat | Skeletal muscle |
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Mitochondrial function in primary prostate cancer. | LEAK OXPHOS ET | N S Other combinations | Permeabilized tissue | Human | |
Soendergaard 2016 Abstract IOC109 | 2016 | Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01. | OXPHOS ET | N NS | Permeabilized tissue | Human | Skeletal muscle |
Krumschnabel 2016b Abstract MitoFit Science Camp 2016 | 2016 | O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry. | LEAK OXPHOS ET | N S NS ROX | Human | Kidney HEK | |
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry. | LEAK OXPHOS ET | F N S NS ROX | Mouse | Nervous system | |
Burtscher J 2016 Abstract MitoFit Science Camp 2016 | 2016 | Oxidative phosphorylation in the healthy and epileptic mouse brain. | OXPHOS ET | N S | Homogenate | Mouse | Nervous system |
Herminghaus 2016 Abstract MitoFit Science Camp 2016 | 2016 | Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis. | LEAK OXPHOS | N NS | Rat | Liver Endothelial;epithelial;mesothelial cell | |
Sumbalova 2016a Abstract MitoFit Science Camp 2016 | 2016 | Optimizing strategies on the malate concentration in SUIT protocols. | OXPHOS ET | N S NS | Rat | Nervous system | |
Volani 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo. | LEAK ROUTINE OXPHOS ET | N S | Homogenate | Mouse | Liver |
Gnaiger 2016 Abstract UMDF2016 | 2016 | Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. | LEAK OXPHOS ET | F N NS | Permeabilized cells Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast |
Bezuidenhout 2016b Abstract MitoFit Science Camp 2016 | 2016 | Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers. | LEAK OXPHOS ET | N S ROX | Permeabilized tissue | Mouse | Skeletal muscle |
Weber 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Loss of PTEN in prostate cancer cells leads to a switch to succinate-mediated mitochondrial respiration associated with increased expression of NaDC3 and HIF-1alpha. | ROUTINE | N NS | Permeabilized cells Intact cells | Human Mouse | Genital |
Hoppel 2016a Abstract MitoFit Science Camp 2016 | 2016 | Skeletal muscle mitochondria in diagnostic studies. | F N Other combinations | Isolated mitochondria | Human | Skeletal muscle Liver | |
Krizova 2016 Abstract IOC116 | 2016 | Krizova J, Macakova M, Bohuslavova B, Klima J, Ellederova Z, Zeman J, Motlik J, Hansikova H (2016) Complex I-dependent respiration decline is a marker of Huntington`s disease in spermatozoa of transgenic minipig model. Mitochondr Physiol Network 21.11 | N | Permeabilized cells | Pig | Genital | |
Kokassaar 2015 Eesti Arst | 2015 | Erinevused wolframiinidefitsiidiga ja normaalsete hiirte lihaste hingamisahelate komplekside aktiivsuses. | N NS | Permeabilized tissue | Skeletal muscle | ||
George 2015 Abstract MiPschool Greenville 2015 | 2015 | Mitochondria do not directly oxidize lactate within the cerebral cortex or hippocampus. | OXPHOS | N | Permeabilized tissue | Human Mouse Rat | Skeletal muscle Nervous system |
Smenes 2015 Abstract IOC100 | 2015 | Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01. | LEAK ROUTINE ET | N S | Human | Skeletal muscle | |
Ehinger 2015 Abstract MiPschool London 2015 | 2015 | Cell-permeable mitochondrial complex II substrates – a new compound class for treatment of complex I-linked mitochondrial disease. | N S | Intact cells Permeabilized tissue | Human | Heart Blood cells Fibroblast | |
Sumbalova 2015 Abstract MiP2015 | 2015 | High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods. | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Nervous system |
Maarman 2015 Abstract MiPschool Cape Town 2015 | 2015 | Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure. | LEAK OXPHOS | N S NS | Isolated mitochondria | Rat | Heart |
Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N NS | Permeabilized tissue | Human | Heart |
Shevchuk 2015 Abstract MiP2015 | 2015 | Analysis of energy fluxes in colorectal cancer saponin skinned tissues and Caco-2 cells. | OXPHOS | N S | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
Morris 2015 Abstract MiPschool Greenville 2015 | 2015 | Intrinsic high aerobic capacity is associated with protection of mitochondrial respiratory capacity and decreased inflammation following chronic high-fat/high-cholesterol diet challenge. | OXPHOS ET | N | Rat | Liver | |
Gnaiger 2015 Abstract MiPschool Cape Town 2015 | 2015 | The functional design of the electron transfer system (ETS) and mitochondrial respiratory control. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | ||
Dyrstad 2015 Abstract MiPschool London 2015 | 2015 | Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells. | LEAK ROUTINE ET | N ROX | Human | Endothelial;epithelial;mesothelial cell Other cell lines | |
Laner 2015 Abstract MiP2015 | 2015 | Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
Madlala 2015 Abstract MiPschool Cape Town 2015 | 2015 | Fructose-induced ROS production: The role of uric acid and transforming growth factor (TGF)-β1. | N | Permeabilized cells | Human | Liver Other cell lines | |
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N S NS ROX | Permeabilized cells Permeabilized tissue | Blood cells Lymphocyte Platelet | |
Sleiman 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs. | LEAK OXPHOS ET | N S | Homogenate | Pig | Skeletal muscle |
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Rat | Heart |
Calzia 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise. | LEAK OXPHOS ET | N S ROX | Human | Skeletal muscle | |
Laner 2015 Abstract MiPschool Cape Town 2015 | 2015 | The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. | LEAK ROUTINE OXPHOS ET | N S NS | Isolated mitochondria Intact cells | Mouse Saccharomyces cerevisiae | Heart |
Sundier 2015 Abstract MiPschool London 2015 | 2015 | Mitochondrial ROS generation in cardiomyocyte reperfusion injury is modulated by succinate accumulation during ischaemia. | N S | Intact cells | Mouse Rat | Heart | |
Kovalcikova 2015 Abstract MiP2015 | 2015 | Derangements of myocardial mitochondrial function in patients with end-stage heart failure is associated with reduced endonuclease G. | N | Human | Heart | ||
Mussulini 2015 Abstract MiPschool London | 2015 | Changes of brain substrates preference and metabolism during seizure induced by pentylenetetrazole in adult zebrafish. | ROUTINE ET | N S | Intact organ | Zebrafish | Nervous system |
Weidgang 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39. | LEAK OXPHOS ET | N S | Homogenate | Mouse | Heart Skeletal muscle Liver Kidney |
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II | 2015 | On coupling control of mitochondrial respiration. What is wrong with the RCR? | LEAK ROUTINE OXPHOS ET | N S ROX | |||
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS | F N | Permeabilized tissue | Mouse | Skeletal muscle |
Hoppel 2015 Abstract MiP2015 | 2015 | Effects of ultramarathon performance on mitochondrial respiration in human platelets. | ROUTINE OXPHOS ET | N S NS | Permeabilized cells | Human | Blood cells Platelet |
Sheldon 2015 Abstract MiPschool Greenville 2015 | 2015 | eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease. | LEAK OXPHOS ET | N NS | Mouse | Liver | |
Galina 2015 Abstract MiP2015 | 2015 | High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. | LEAK | N S ROX | Permeabilized tissue | Rat | Skeletal muscle |
Van Dyk 2015 Abstract MiPschool Cape Town 2015 | 2015 | Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer. | LEAK ROUTINE ET | N ROX | Isolated mitochondria | Human | Other cell lines Fibroblast |
Rousarova 2015 Abstract MiPschool London 2015 | 2015 | Estimation of ROS production in isolated mitochondria after treatment with an acetaminophen metabolite. | N S | Isolated mitochondria | Rat | Liver Kidney | |
Devaux 2015 Abstract MiP2015 | 2015 | Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression. | LEAK OXPHOS ET | N S | Homogenate | Fishes | Nervous system |
Bezuidenhout 2015 Abstract MiPschool Cape Town 2015 | 2015 | A study of the effects of fructose feeding & exercise on SIRT 3 regulation in skeletal muscle. | N | Rat | |||
Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS | F N NS | Permeabilized tissue | ||
Gnaiger 2015 Abstract MiP2015 | 2015 | Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Intact cells | Human | HEK |
Chang 2015 Abstract EB2015 | 2015 | Different effects of interval and continuous exercise regimens on capacity of mitochondria oxidative phosphorylation in lymphocyte. | F N NS | Permeabilized cells Intact cells | Human | Macrophage-derived | |
Laner 2015 Abstract MiPschool Greenville 2015 | 2015 | Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | OXPHOS ET | F N S NS | Permeabilized tissue | Dog | Skeletal muscle |
Volani 2015 Abstract IOC106 | 2015 | Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10. | ROUTINE OXPHOS ET | N S | Homogenate Intact cells | Human Mouse | Heart Liver Blood cells Lymphocyte |
Brown 2015 Abstract MiPschool Cape Town 2015 | 2015 | Protection of post-ischemic mitochondrial bioenergetics by targeting cardiolipin-dependent membrane fluidity. | OXPHOS | N S NS | Intact organism Permeabilized tissue Isolated mitochondria | Rat | Heart |
Pettersen 2015 Abstract MiPschool London 2015 | 2015 | Metabolic adjustments after reversible induction of mitochondrial biogenesis via AMPK/NRF1 in HeLa cells. | N | ||||
Renshaw 2015 Abstract MiP2015 | 2015 | Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress? | LEAK OXPHOS ET | N S | Homogenate | Fishes | Nervous system |
George 2015 Abstract MiPschool Cape Town 2015 | 2015 | Regulation of LCAD and SIRT3 activities by NAD+ in skeletal muscle of fructose-fed rats. | N | Permeabilized tissue | Rat | Skeletal muscle | |
McCurdy 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS | F N | Permeabilized tissue | Other mammals | Skeletal muscle |
Kaambre 2015 Abstract MiP2015 | 2015 | Quantitative characterization of respiratory parameters of human colorectal and breast cancer clinical material. | N | Isolated mitochondria | Human | Endothelial;epithelial;mesothelial cell | |
Doerrier 2014 Abstract SECF | 2014 | Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Isolated mitochondria | Mouse | Heart |
Burtscher 2014 Abstract MiP2014 | 2014 | Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain. | OXPHOS ET | N S CIV NS | Permeabilized tissue | Mouse | Nervous system |
Herminghaus 2014 Abstract MiP2014 | 2014 | Severity of polymicrobial sepsis modulates mitochondrial function in rat liver. | LEAK OXPHOS | N S | Isolated mitochondria | Rat | Liver |
Wohlwend 2014 Abstract MiP2014 | 2014 | Exercise modality specific mitochondrial adaptations in skeletal muscle of elderly people. | OXPHOS | N NS | Permeabilized cells | Human | Skeletal muscle |
Lai 2014 Abstract2 MiP2014 | 2014 | Bioenergetic differences between permeabilized red and white fibers of a non-obese model of type II diabetes. | N S CIV | Permeabilized cells | Rat | Skeletal muscle | |
Schoepf 2014 Abstract MiP2014 | 2014 | OXPHOS analysis in small prostate biopsies. | LEAK OXPHOS ET | N S CIV NS | Permeabilized tissue | Human | Genital |
Hickey 2014 Abstract MiP2014 | 2014 | Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart. | OXPHOS | N S | Permeabilized tissue | Rat | Heart |
Volt 2014 Abstract The 2014 Ageing Summit | 2014 | Effects of melatonin on the age-dependent dysregulation of the Nf-Kb/Nlrp3 activation during sepsis. | N S NS | Permeabilized tissue | Mouse | Heart | |
Coen 2014 Abstract MiP2014 | 2014 | Exercise improves insulin sensitivity and muscle mitochondrial respiration following Roux-en-Y gastric bypass surgery. | N NS | Permeabilized tissue | Human | Skeletal muscle | |
Laner 2014 Abstract MiP2014 | 2014 | Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers. | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized tissue | Dog | Skeletal muscle |
Larsen 2014 Abstract MiP2014 | 2014 | The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. | OXPHOS | F N S NS | Permeabilized tissue | Human | Skeletal muscle Fat |
Sparks 2014 Abstract MiP2014 | 2014 | NAMPT remodels substrate metabolism in skeletal muscle. | LEAK OXPHOS | N S | Permeabilized tissue | Mouse | Skeletal muscle |
Horscroft 2014 Abstract MiP2014 | 2014 | Substrate utilisation in the hypoxic heart: a glycolysis/glucose oxidation mismatch? | OXPHOS | F N | Rat | Heart | |
MacDonald 2014 Abstract MiP2014 | 2014 | The mitochondrial enzyme 4-hydroxy-2-oxoglutarate aldolase (HOGA) – involvement in the TCA cycle. | N | Isolated mitochondria | Rat | Heart Nervous system Liver Kidney | |
Shaikh 2014 Circulation | 2014 | Shaikh SR, Moukdar F, Alleman RJ, Lark DS, Neufer PD, Brown D (2014) The cardiolipin-targeting peptide Bendavia improves post-ischemic mitochondrial energetics by sustaining native respiratory protein complexes. Am Heart Assoc 130:A17592. | N S | Permeabilized tissue | Rat | Heart | |
Sumbalova 2014 Abstract MiP2014 | 2014 | Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain. | OXPHOS ET | F N S NS | Isolated mitochondria | Rat | Nervous system Liver |
Komlodi 2014 Abstract MiP2014 | 2014 | Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation. | OXPHOS ET | N S | Isolated mitochondria | Guinea pig | Nervous system |
Paju 2014 Abstract MiP2014 | 2014 | Characterization of the effects of pro-inflammatory cytokines on energy metabolism in human myoblasts. | OXPHOS | N S | Permeabilized cells | Human | Skeletal muscle |
Tretter 2014 Abstract MiP2014 | 2014 | Cool or heat? Bioenergetic and ROS homeostatic approach to therapeutic hypothermia. | N S | Isolated mitochondria | Guinea pig | Nervous system | |
Krumschnabel 2014 Abstract MiP2014 | 2014 | Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
Pecina 2014 Abstract MiP2014 | 2014 | Manifestation of mitochondrial disorders of nuclear origin in lymphocytes. | OXPHOS | N S Gp CIV | Permeabilized cells | Human | Blood cells Lymphocyte |
Brown DA 2014 Abstract MiP2014 | 2014 | The cardiolipin-targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes. | OXPHOS | N S | Permeabilized tissue | Rat | Heart |
Volodina 2014 Abstract MiP2014 | 2014 | Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Rat | Liver |
Lai 2014 Abstract1 MiP2014 | 2014 | Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle. | LEAK OXPHOS | N | Isolated mitochondria | Rat Dog | Heart Skeletal muscle Fibroblast |
Rodrigues 2014 Abstract MiP2014 | 2014 | Bioenergetics’ traits of tongue cancer metastatic cells. | F N S | Permeabilized cells | Mouse | Lymphocyte | |
Boushel 2013 Abstract MiP2013 | 2013 | Boushel RC (2013) Convective O2 delivery, diffusion and mitochondrial OXPHOS components of VO2 during exercise in health and disease. Mitochondr Physiol Network 18.08. | OXPHOS | N S NS | Intact organism Permeabilized cells Permeabilized tissue | Human | Skeletal muscle |
Pichaud 2013 Abstract MiP2013 | 2013 | Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp CIV NS ROX | Permeabilized tissue | Drosophila Hexapods | Skeletal muscle |
Christen 2013 Abstract MiP2013 | 2013 | Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08. | OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Other mammals Fishes | Heart |
Krumschnabel 2013 Abstract MiP2013 | 2013 | Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse Fishes | Heart Nervous system Liver |
Prouteau-Angebault 2013 Abstract IOC75 | 2013 | Prouteau-Angebault C (2013) Are cardiolipins involved in the mitochondrial respiratory chain defect in OPA1 mouse model? Mitochondr Physiol Network 18.03. | OXPHOS | N S CIV | Permeabilized cells Homogenate Isolated mitochondria | Mouse | Skeletal muscle Nervous system |
Irving 2013 Abstract MiP2013 | 2013 | Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N NS | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Liver Fat |
Gellerich 2013 Abstract MiP2013 | 2013 | Gellerich FN, Korzeniewski B, Gizatullina Z, Debska-Vielhaber G, Gainutdinov T, König R, Reymann K, Vielhaber S(2013) The mitochondrial gas pedal, a unique property of neurons exists also in heart and skeletal muscle but not in astrocytes. New evidences by in silico investigations and (patho-)physiological consequences. Mitochondr Physiol Network 18.08. | OXPHOS | N | Isolated mitochondria | Nervous system | |
Chicco 2013 Abstract MiP2013 | 2013 | Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N Other combinations | Permeabilized tissue | Human Other mammals | Skeletal muscle |
Slinde 2013 Abstract MiP2013 | 2013 | Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N ROX | Permeabilized tissue Isolated mitochondria | Other mammals Fishes | Heart Liver Blood cells |
Shabalina 2013 Abstract IOC79 | 2013 | Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07 | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Heart Skeletal muscle Liver |
Kotwica 2013 Abstract MiP2013 | 2013 | Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | F N S | Permeabilized tissue | Mouse | Heart Skeletal muscle |
Pecina 2013 Abstract MiP2013 | 2013 | Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp NS Other combinations ROX | Permeabilized cells Homogenate | Human | Blood cells Lymphocyte |
Camacho-Pereira 2013 Abstract IOC75 | 2013 | Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Liver HEK Macrophage-derived |
Garcia-Roves 2013 Abstract MiP2013 | 2013 | Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S CIV NS | Permeabilized cells Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system Liver Islet cell;pancreas;thymus Fat |
Cavalcanti de Albuquerque 2013 Abstract MiP2013 | 2013 | Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S Gp NS ROX | Intact organism Permeabilized tissue | Rat | Skeletal muscle |
Darveau 2013 Abstract MiP2013 | 2013 | Darveau CA, Teulier L, Crevier J, Weber JM (2013) Diversity and evolution of mitochondrial metabolism: Proline as a metabolic reward for pollinators. Mitochondr Physiol Network 18.08. | OXPHOS | N S Gp NS Other combinations | Permeabilized tissue | Hexapods | Skeletal muscle |
Tepp 2013 Abstract MiP2013 | 2013 | Tepp K, Anmann T, Varikmaa M, Timohhina N, Shevchuk I, Chekulayev V, Saks V, Kaambre T (2013) Bioenergetic aspects of postnatal development of cardiac cells: Formation of structure-function relationship. Mitochondr Physiol Network 18.08. | OXPHOS | N S CIV | Intact cells Permeabilized cells Permeabilized tissue | Rat | Heart |
Tretter 2013 Abstract MiP2013 | 2013 | Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08. | N | Isolated mitochondria | Guinea pig | Heart Nervous system Liver | |
Lemieux 2013 Abstract MiP2013 | 2013 | Lemieux H, Warren BE, Lucchinetti E, Lou PH, Zhang L, Gandhi M, Clanachan AS, Zaugg M(2013) Early mitochondrial dysfunction associated with type 2 diabetes mellitus in the heart and skeletal muscle. Mitochondr Physiol Network 18.08. | OXPHOS | F N S CIV NS Other combinations | Permeabilized tissue | Rat | Heart Skeletal muscle |
Laner 2013 ASMRM | 2013 | Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Menze 2013 Abstract MiP2013 | 2013 | Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS | N | Intact organism Intact cells Permeabilized cells Isolated mitochondria Enzyme | Drosophila Artemia Crustaceans Hexapods | Other cell lines CHO HEK Macrophage-derived |
Jezek 2013 Abstract MiP2013 | 2013 | Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S ROX | Isolated mitochondria Intact cells | Mouse | Lung;gill Islet cell;pancreas;thymus |
Galina 2013 Abstract MiP2013 | 2013 | Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S | Permeabilized cells Isolated mitochondria Enzyme Intact cells | Rat | Skeletal muscle Nervous system Liver Other cell lines |
Dungel 2013 Abstract MiP2013 | 2013 | Dungel P, Perlinger M, Faulhammer B, Weidinger A, Redl H, Kozlov AV (2013) Iron-mediated injury of mitochondria is attenuated by nitrite. Mitochondr Physiol Network 18.08. | OXPHOS | N S | Isolated mitochondria | Rat | Liver |
Vercesi 2013 Abstract MiP2013 | 2013 | Vercesi AE (2013) Mitochondrial respiration, Ca2+ transport and oxidative stress: Fungi, trypanosomes, plants and mammals. Mitochondr Physiol Network 18.08. | OXPHOS | N | Permeabilized cells Isolated mitochondria | Rat Other invertebrates Fungi Plants Protists | Heart |
Amoedo 2013 Abstract MiP2013 | 2013 | Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S ROX | Permeabilized cells Enzyme Intact cells | Mouse | Endothelial;epithelial;mesothelial cell Other cell lines |
Oliveira HC 2013 Abstract MiP2013 | 2013 | Oliveira HC, Dorighello GG, Rovani JC, Raposo HF, Paim BA, Vercesi AE (2013) Intermittent fasting improves oxidative stress but not metabolic disturbances and atherosclerosis in hypercholesterolemic mice. Mitochondr Physiol Network 18.08. | ROUTINE | N | Intact organism Homogenate Isolated mitochondria | Mouse | Liver |
Gnaiger 2013 Abstract Mito2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
Gnaiger 2013 Abstract MiP2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
Hand 2013 Abstract MiP2013 | 2013 | Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S | Intact organism Homogenate Isolated mitochondria Enzyme | Artemia Crustaceans | |
Chicco 2013 Abstract IOC79 | 2013 | Chicco AJ (2013) Substrate-specific impairment of oxidative phosphorylation in Tafazzin-deficient cardiac mitochondria: potential role of CoA deficiency. Mitochondr Physiol Network 18.07 | OXPHOS | F N S | Permeabilized cells Isolated mitochondria | Mouse | Heart |
Dzialowski 2013 Abstract MiP2013 | 2013 | Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Intact organism Permeabilized tissue | Birds | Skeletal muscle |
Volska 2013 Abstract MiP2013 | 2013 | Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reoxygenation injury. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | N | Isolated mitochondria | Rat | Nervous system |
Borutaite 2013 Abstract MiP2013 | 2013 | Borutaite V, Jablonskiene G, Arandarcikaite O (2013) Mitochondrial response to heart and brain ischemia. Mitochondr Physiol Network 18.08. | LEAK OXPHOS | N S | Isolated mitochondria | Pig Rat | Heart Nervous system |
Oliveira MF 2013 Abstract MiP2013 | 2013 | Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV ROX | Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Intact cells | Human Drosophila Hexapods Other invertebrates | Skeletal muscle Neuroblastoma |
Hendricks 2013 Abstract MiP2013 | 2013 | Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Nervous system |
Chicco 2013 Abstract MiP2013 Poster | 2013 | Chicco AJ, Claiborne MS, Le CH, Mulligan CM (2013) Remodeling of skeletal muscle mitochondria in response to exercise training in taz shRNA mouse model of human Barth Syndrome. Mitochondr Physiol Network 18.08. | OXPHOS | N | Isolated mitochondria | Mouse | Skeletal muscle |
Dela 2013 Abstract MiP2013 | 2013 | Dela F (2013) Glucose tolerance and skeletal muscle coenzyme Q(10). Mitochondr Physiol Network 18.08. | OXPHOS | N S NS | Permeabilized tissue | Human | Skeletal muscle |
Hickey 2013 Abstract MiP2013 | 2013 | Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S CIV NS | Permeabilized tissue | Other mammals Fishes | Heart |
Votion 2013 Abstract MiP2013 | 2013 | Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08. | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Horse | Skeletal muscle |
Horscroft 2012 Abstract IOC72 | 2012 | Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13. | LEAK OXPHOS ET | N NS | Human | Skeletal muscle | |
Dzialowski 2012 Abstract IOC72 | 2012 | Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13. | LEAK OXPHOS | N S NS | Isolated mitochondria | Reptiles | Heart Skeletal muscle |
Sumbalova 2012 Abstract Bioblast | 2012 | Sumbalova Z, Fasching M, Gnaiger E (2012) Evaluation of mitochondrial respiration and membrane potential in mouse brain homogenate. Mitochondr Physiol Network 17.12:61. | N | Homogenate Isolated mitochondria | Mouse | Nervous system | |
Doerrier 2012 Abstract Bioblast | 2012 | Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Heart |
Jacobs 2012 Abstract Bioblast | 2012 | Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | F N S NS | Permeabilized cells | Human | Skeletal muscle |
Votion 2012 Abstract Bioblast | 2012 | Votion DM (2012) The cause of atypical myopathy in grazing European horses revealed. Mitochondr Physiol Network 17.12. | OXPHOS | N S NS | Permeabilized cells | Horse | Skeletal muscle |
Galina 2012 Abstract Bioblast | 2012 | Simonin V, Galina A (2012) Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner. Mitochondr Physiol Network 17.12. | OXPHOS | N S NS | |||
Gnaiger 2012 Abstract-FEPS-Santiago de Compostela | 2012 | Gnaiger E (2012) Aging and mitochondrial physiology. The effect of exercise and caloric balance on oxidative phosphorylation (OXPHOS). Abstract FEPS, Santiago de Compostela, Spain. Symposium: Advances in Aging and Mitochondria Research. September 08-12. | F N S NS | Human Horse | |||
Chicco 2012 Abstract Bioblast | 2012 | Chicco AJ (2012) Substrate-specific impairment of cardiac mitochondrial respiration in Taz-deficient mice: Insight into the pathogenesis of Barth Syndrome. Mitochondr Physiol Network 17.12. | N S | Mouse | Heart | ||
Wojtczak 2012 Abstract Bioblast | 2012 | Wojtczak L, Suski JM, Wieckowski MR, Schoenfeld P (2012) A novel putative function of uncoupling proteins. Mitochondr Physiol Network 17.12. | N | Rat | Heart Skeletal muscle | ||
Hand 2012 Abstract Bioblast | 2012 | Patil Y, Gnaiger E, Hand SC (2012) Respiration in embryo lysates reveals diminished Complex I activity and inhibition of the phosphorylation system during diapause in Artemia franciscana. Mitochondr Physiol Network 17.12. | OXPHOS ET | N S NS | Homogenate | Artemia Crustaceans | |
Acuna-Castroviejo 2012 Abstract Bioblast | 2012 | Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12. | ROUTINE OXPHOS | N S NS | Intact organism Isolated mitochondria Intact cells | Mouse Rat | Heart Skeletal muscle Nervous system Liver |
Mark 2012 Abstract Bioblast | 2012 | Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12. | LEAK ROUTINE OXPHOS | N S CIV NS | Permeabilized tissue Isolated mitochondria | Fishes | Heart Liver |
Irving 2012 Abstract IOC72 | 2012 | Irving BA (2012) AgRP deficient female mice have elevated body weight and hypothalamic mitochondrial oxidative capacity. Mitochondr Physiol Network 17.13. | OXPHOS | N S NS | Permeabilized tissue | Mouse Rat | Skeletal muscle Nervous system Liver Fat |
Labieniec-Watala 2012 Abstract Bioblast | 2012 | Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse Rat | Heart Liver Fibroblast |
Bouillaud 2012 Abstract Bioblast | 2012 | Bouillaud F (2012) Sulfide - a remarkable mitochondrial substrate. Mitochondr Physiol Network 17.12. | N CIV Other combinations | Human | CHO | ||
Burtscher J 2012 Abstract Bioblast | 2012 | Burtscher J, Eigentler A, Gnaiger E, Schwarzer C (2012) Mitochondrial function in the mouse hippocampus. Mitochondr Physiol Network 17.12. | N S CIV | Homogenate | Mouse | Nervous system | |
Towheed 2012 Abstract IOC72 | 2012 | Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13. | LEAK ROUTINE OXPHOS ET | N S NS | Intact organism Permeabilized tissue | Drosophila Hexapods | |
Le 2012 Abstract Bioblast | 2012 | Le CH, Hocker AD, Dreyer HC, Roach RC, Gnaiger E, Chicco AJ (2012) Two-week acclimatization to 5200m markedly alters substrate utilization and increases OXPHOS efficiency, with no effect on respiratory capacity in skeletal muscle mitochondria. Mitochondr Physiol Network 17.12. | OXPHOS ET | N S | Permeabilized tissue | Human | Skeletal muscle |
Cervinkova 2012 Abstract Bioblast | 2012 | Cervinkova Z, Stankova P, Cervinka M, Kucera O, Drahota Z (2012) Evaluation of mitochondrial functions – an important tool for experimental hepatology. Mitochondr Physiol Network 17.12. | OXPHOS | N S | Permeabilized cells Homogenate Isolated mitochondria Intact cells | Rat | Liver |
Horvath 2012 Abstract Bioblast | 2012 | Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
Pesta 2011Abstract Mitochondrial Medicine-Training | 2011 | Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
Sumbalova 2011 Abstract Mitochondrial Medicine | 2011 | Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
Gnaiger 2011 Abstract-MonteVerita | 2011 | Gnaiger E (2011) Mitochondrial respiratory capacity at maximum aerobic exercise levels: Are intracellular oxygen levels limiting? Abstract Monte Verita. | OXPHOS | N S NS | Human | ||
Gnaiger 2011 Abstract-Berlin | 2011 | Gnaiger E (2011) Fewer mitochondria - mitochondrial 'fever': Mitochondrial physiology and capacity of oxidative phosphorylation in active and sedentary life styles. Abstract Targeting Mitochondria Berlin. | F N S NS | Human | |||
Pesta 2010 MiP Abstract | 2010 | Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010. | LEAK OXPHOS ET | F N S NS | Human | ||
Matallo MiP2010 | 2010 | Matallo J, Reich V, Calzia E, Radermacher P, Groeger M (2010) Interactions between sulfide and mitochondrial respiration in cultured murine alveolar macrophage. Abstract. MiP2010. | OXPHOS ET | N S | Permeabilized cells | Lung;gill Macrophage-derived | |
Garedew 2006 Biochim Biophys Acta | 2006 | Garedew A, Lemieux H, Schachner T, Blier PU, Tardif J-C, Gnaiger E (2006) High excess capacity of cytochrome c oxidase in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):167-8. | OXPHOS | N S NS | Permeabilized tissue Enzyme Oxidase;biochemical oxidation | Mouse | Heart |
Gnaiger 2005 Abstract MiP2005 | 2005 | Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R (2005) High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age. MiP2005. | OXPHOS ET | F N CIV NS | Permeabilized tissue | Human | Skeletal muscle |