Neuzil Jiri

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


Neuzil Jiri


MitoPedia topics: EAGLE 

COST: Member


COST WG3: WG3 COST WG4: WG4


Name Neuzil Jiri, Prof. Dr.
Institution
Jiri Neuzil

Molecular Therapy Group, Institute of Biotechnology,

Czech Academy of Sciences, CZ

____

Apoptosis Research Group,

School of Medical Science,

Griffith Health Institute,

Griffith University, AU

Address Videnska 1083

Prague 4, 142 20

City Prague and Southport
State/Province
Country Czech Republic and Australia
Email Jiri.Neuzil@img.cas.cz
Weblink
O2k-Network Lab AU Queensland Neuzil J, CZ Prague Neuzil J


Labels: Field of research: Basic 



Publications

 PublishedReference
Miklovicova 2024 Biochim Biophys Acta Mol Basis Dis2024Miklovicova S, Volpini L, Sanovec O, Monaco F, Vanova KH, Novak J, Boukalova S, Zobalova R, Klezl P, Tomasetti M, Bobek V, Fiala V, Vcelak J, Santarelli L, Bielcikova Z, Komrskova K, Kolostova K, Pacak K, Dvorakova S, Neuzil J (2024) Mitochondrial respiratory complex II is altered in renal carcinoma. Biochim Biophys Acta Mol Basis Dis 1871:167556. https://doi.org/10.1016/j.bbadis.2024.167556
Vacurova 2022 Nat Commun2022Vacurova E, Trnovska J, Svoboda P, Skop V, Novosadova V, Reguera DP, Petrezselyová S, Piavaux B, Endaya B, Spoutil F, Zudova D, Stursa J, Melcova M, Bielcikova Z, Werner L, Prochazka J, Sedlacek R, Huttl M, Hubackova SS, Haluzik M, Neuzil J (2022) Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice. https://doi.org/10.1038/s41467-022-29486-z
Fialova 2022 Biomed Pharmacother2022Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Šmigová J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, Brábek J, Jakubek M, Neuzil J, Masarik M (2022) Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. https://doi.org/10.1016/j.biopha.2022.113582
Arbon 2022 Antimicrob Agents Chemother2022Arbon D, Ženíšková K, Šubrtová K, Mach J, Štursa J, Machado M, Zahedifard F, Leštinová T, Hierro-Yap C, Neuzil J, Volf P, Ganter M, Zoltner M, Zíková A, Werner L, Sutak R (2022) Repurposing of MitoTam: Novel anti-cancer drug candidate exhibits potent activity against major protozoan and fungal pathogens. https://doi.org/10.1128/aac.00727-22
Vidimce 2021 Front Pharmacol2021Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715.
Sandoval-Acuna 2021 Cancer Res2021Sandoval-Acuña C, Torrealba N, Tomkova V, Jadhav SB, Blazkova K, Merta L, Lettlova S, Adamcová MK, Rosel D, Brábek J, Neuzil J, Stursa J, Werner L, Truksa J (2021) Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy. Cancer Res 81:2289-303.
Boukalova 2020 Biochim Biophys Acta Mol Basis Dis2020Boukalova S, Hubackova S, Milosevic M, Ezrova Z, Neuzil J, Rohlena J (2020) Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer. Biochim Biophys Acta Mol Basis Dis 1866:165759. https://doi.org/10.1016/j.bbadis.2020.165759
BEC 2020.1 doi10.26124bec2020-0001.v12020Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
6th Biannual Meeting on Mitochondria Apoptosis & Cancer 2019 Prague CZ2019-09-17Prague, CZ, 2019 September 17-20. 6th Biannual Meeting on Mitochondria Apoptosis & Cancer
Bajzikova 2019 Cell Metab2019Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. 10.1016/j.cmet.2018.10.014
Blecha 2017 Free Radic Biol Med2017Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66.
Rohlenova 2016 Antioxid Redox Signal2016Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103.
Khera 2015 Placenta2015Khera A, Dong LF, Holland OJ, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9.
Yan 2015 BMC Cancer2015Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.
Kluckova 2015 Cell Death Dis2015Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.
Pasdar 2015 PLoS One2015Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549.
Kluckova 2015 Methods Mol Biol2015Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94.
Truksa 2015 Antioxid Redox Signal2015Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900.
Tan 2015 Cell Metab2015Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94.
Moreno-Sanchez 2013 FEBS J2013Moreno-Sánchez R, Hernández-Esquivel L, Rivero-Segura NA, Marín-Hernández A, Neuzil J, Ralph SJ, Rodríguez-Enríquez S (2013) Reactive oxygen species are generated by the respiratory Complex II - evidence for lack of contribution of the reverse electron flow in Complex I. FEBS J 280:927-38.

Abstracts

 PublishedReference
Neuzil 2022 Abstract Bioblast20226.4. «10+5»
Neuzil Jiri
Endaya BB, Le TDD, Kucera L, Lopes Oliveira G, Neuzil Jiri (2022) Metabolic switch supports proliferation in regenerating liver. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
Rohlena 2017 MiP20172017
MiPsociety
Reactivation of dihydroorotate dehydrogenase by respiration restores tumor growth of mitochondrial DNA-depleted cancer cells.
Blecha 2015 Abstract MiP20152015Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.
Lettlova 2015 Abstract MiP20152015Role of the microRNA-301a in the regulation of mitochondrial function in cancer cells.
Rohlena 2015 Abstract MiP20152015Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.
Rohlenova 2015 Abstract MiP20152015Mitochondrial targeting of tamoxifen enhances its activity against Her2high breast cancer.
Kluckova 2014 Abstract MiP20142014Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.
Bajzikova 2013 Abstract IOC792013Bajzikova M (2013) Mitochondrially targeted vitamin E succinate and its effects on mitochondrial oxidative phosphorylation system. Mitochondr Physiol Network 18.07.

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