Nunnari 2012 Cell
|Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health. Cell 148:1145-59. https://doi.org/10.1016/j.cell.2012.02.035|
Abstract: Mitochondria perform diverse yet interconnected functions, producing ATP and many biosynthetic intermediates while also contributing to cellular stress responses such as autophagy and apoptosis. Mitochondria form a dynamic, interconnected network that is intimately integrated with other cellular compartments. In addition, mitochondrial functions extend beyond the boundaries of the cell and influence an organism's physiology by regulating communication between cells and tissues. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease.
• Bioblast editor: Gnaiger E
- Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.8. https://doi.org/10.26124/mitofit:2021-0008
Labels: MiParea: mt-Medicine Pathology: Neurodegenerative
MitoFit 2021 BCA