O2k-Publications: HEK

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O2k-Publications: HEK

O2k-Publications in the MiPMap

»O2k-Publications: Topics


Human embryonic kidney 293 (HEK 293) cells are derived from human embryonic kidney cells. They are easy to culture in suspension in serum-free media. HEK have many properties of immature neurons, suggesting that the adenovirus was taken up and transformed a neuronal lineage cell in the original kidney culture. HEK 293 cells should not be used as an in vitro model for kidney cell function or studies involving kidney cells. » mRNA detected in 293 cells normally expressed specifically in neuronal cells

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 Was published in yearReferenceOrganismTissue;cell
Cesnekova 2019 Thesis2019Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133.HumanHEK
Callegari 2019 J Mol Biol2019Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M (2019) A MICOS-TIM22 association promotes carrier import into human mitochondria. J Mol Biol [Epub ahead of print].HumanHEK
Castellano-Gonzalez 20192019Castellano-Gonzalez G, Jacobs KR, Don E, Cole NJ, Adams S, Lim CK, Lovejoy DB, Guillemin GJ (2019) Kynurenine 3-monooxygenase activity in human primary neurons and effect on cellular bioenergetics identifies new neurotoxic mechanisms. Neurotox Res 35:530-41.HumanHEK
Castellano-Gonzalez 2019 Neurotox Res2019Castellano-Gonzalez G, Jacobs KR, Don E, Cole NJ, Adams S, Lim CK, Lovejoy DB, Guillemin GJ (2019) Kynurenine 3-monooxygenase activity in human primary neurons and effect on cellular bioenergetics identifies new neurotoxic mechanisms. Neurotox Res 35:530-41.HumanHEK
Komlodi 2018 Methods Mol Biol2018Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55.Human
Mouse
Skeletal muscle
HEK
Marini 2018 Proc Natl Acad Sci U S A2018Marini A, Rotblat B, Sbarrato T, Niklison-Chirou MV, Knight JRP, Dudek K, Jones C, Bushell M, Knight RA, Amelio I, Willis AE, Melino G (2018) TAp73 contributes to the oxidative stress response by regulating protein synthesis. Proc Natl Acad Sci U S A 115:6219-24.HumanKidney
Lung;gill
HEK
Burstein 2018 Hum Mol Genet2018Burstein SR, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, Milner TA, Cloonan SM, Lutz C, Barrientos A, Manfredi G (2018) In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet 27:160-77.Human
Mouse
Heart
Skeletal muscle
Nervous system
HEK
Cunatova 2018 Thesis2018Čunátová K (2018) The role of tissue specific isoforms of subunit 4 in assembly and function of cytochrome c oxidase. PhD Thesis p107.HumanHEK
Doerrier 2018 Methods Mol Biol2018Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70.Human
Mouse
Rat
Saccharomyces cerevisiae
Heart
Skeletal muscle
Endothelial;epithelial;mesothelial cell
Blood cells
HEK
Platelet
Lobo-Jarne 2018 Cell Rep2018Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99.HumanHEK
Efimova 2018 Thesis2018Efimova I (2018) Structural composition and functional properties of mitochondrial FoF1 ATP synthase on models of specific subunits deficiencies. PhD Thesis 94.HumanHEK
Lang 2017 Aging (Albany NY)2017Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP (2017) SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging (Albany NY) 9:2163-89.HumanKidney
HEK
Vigueira 2017 Exp Physiol2017Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN (2017) The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol 102:985-99.HumanKidney
HEK
Schaefer 2017 Neurophotonics2017Schaefer PM, Hilpert D, Niederschweiberer M, Neuhauser L, Kalinina S, Calzia E, Rueck A, von Einem B, von Arnim CAF (2017) Mitochondrial matrix pH as a decisive factor in neurometabolic imaging. Neurophotonics 4:045004.Kidney
HEK
Uppala 2017 Biochem Biophys Res Commun2017Uppala R, Dudiak B, Beck ME, Bharathi SS, Zhang Y, Stolz DB, Goetzman ES (2017) Aspirin increases mitochondrial fatty acid oxidation. Biochem Biophys Res Commun 482:346-51.Human
Mouse
HEK
Fibroblast
Permer 2017 Bachelor Thesis2017Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56.HumanOther cell lines
HEK
Schaefer 2017 Thesis2017Schaefer P (2017) Metabolic imaging in Alzheimer´s disease using NADH autofluorescence. Dissertation p93.HumanHEK
Santos 2017 Sci Rep2017Santos GC, Zeidler JD, Pérez-Valencia JA, Sant'Anna-Silva ACB, Da Poian AT, El-Bacha T, Almeida FCL (2017) Metabolomic analysis reveals vitamin D-induced decrease in polyol pathway and subtle modulation of glycolysis in HEK293T cells. Sci Rep 7:9510.HumanKidney
HEK
Eckert 2017 Aging Dis2017Eckert SH, Gaca J, Kolesova N, Friedland K, Eckert GP, Muller WE (2017) Mitochondrial pharmacology of Dimebon (Latrepirdine) calls for a new look at its possible therapeutic potential in Alzheimer’s Disease. Aging Dis 10.14336/AD.2017.1014.HumanKidney
HEK
Zhang 2017 J Biol Chem2017Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES (2017) Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem 292:10239-49.HumanLiver
HEK
Anand 2016 PLOS ONE2016Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.HEK
Pohland 2016 Neurochem Res2016Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP (2016) MH84: a novel γ-secretase modulator/PPARγ agonist-improves mitochondrial dysfunction in a cellular model of Alzheimer's disease. Neurochem Res 41:231-42.HumanKidney
HEK
Docherty 2016 Stem Cell Res Ther2016Docherty CK, Salt IP, Mercer JR (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Res Ther 7:78.HumanKidney
HEK
MiPNet21.12 Comparison mt respiration media2016
O2k-Protocols
O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.
HumanHEK
Schaefer 2016 PLOS ONE2016Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA (2016) Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLOS ONE 11:e0168157.Human
Mouse
Nervous system
HEK
MiPNet21.14 Reference sample HRR2016
O2k-Protocols
Development of a reference sample for HRR.
HumanHEK
Hawley 2016 Diabetes2016Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG (2016) The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes 65:2784-94.Human
Mouse
Liver
HEK
Schiffer 2016 Am J Physiol Cell Physiol2016Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61.HumanHEK
Skeletal muscle
Makrecka-Kuka 2015 Biomolecules2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
Human
Mouse
Heart
Nervous system
HEK
Grevengoed 2015 J Lipid Res2015Grevengoed TJ, Martin SA, Katunga L, Cooper DE, Anderson EJ, Murphy RC, Coleman RA (2015) Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function. J Lipid Res 56:1572-82.MouseHeart
Other cell lines
HEK
Laursen 2015 Proc Natl Acad Sci USA2015Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO (2015) Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proc Natl Acad Sci USA 112:1607-12.Other mammalsNervous system
HEK
Melo Hanchuk 2015 Cell Signal2015Melo Hanchuk TD, Papa PF, La Guardia PG, Vercesi AE, Kobarg J (2015) Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration. Cell Signal 27:1168-77.HumanHEK
Lim 2015 Am J Cancer Res2015Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701.HumanKidney
Other cell lines
HEK
HeLa
Fibroblast
Chinopoulos 2014 Methods Enzymol2014Chinopoulos C, Kiss G, Kawamata H, Starkov AA (2014) Measurement of ADP-ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption. Methods Enzymol 542:333-48.HumanHEK
Forkink 2014 Biochim Biophys Acta2014Forkink M, Manjeri GR, Liemburg-Apers DC, Nibbeling E, Blanchard M, Wojtala A, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ (2014) Mitochondrial hyperpolarization during chronic Complex I inhibition is sustained by low activity of Complex II, III, IV and V. Biochim Biophys Acta 1837:1247-56.HumanHEK
Echevarría 2014 Biochem J2014Echevarría L, Clemente P, Hernández Sierra R, Gallardo ME, Fernández-Moreno MA, Garesse R (2014) Mammalian GatCAB is essential for mitochondrial translation 1 Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo. Biochem J 460:91-101.Human
Mouse
Other cell lines
HEK
HeLa
Pesta 2012 Methods Mol Biol2012
O2k-Protocols
Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 810:25-58.
HumanFibroblast
HEK
HUVEC
Other cell lines
Skeletal muscle
Stiburek 2012 Mol Biol Cell2012Stiburek L, Cesnekova J, Kostkova O, Fornuskova D, Vinsova K, Wenchich L, Houstek J, Zeman J (2012) YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation. Mol Biol Cell 23: 1010-1023.HumanHEK
Aguirre 2010 Biochim Biophys Acta2010Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65.HEK
Fornunskova 2010 Biochem J2010Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J (2010) Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. Biochem J 428:363-74.HumanHEK
Fornuskova 2010 Thesis2010Fornůsková D (2010) Biochemical and molecular studies of cytochrome c oxidase and ATP synthase deficiencies. PhD Thesis p93.HumanHeart
Skeletal muscle
Nervous system
Liver
HEK
Fibroblast
Cadenas 2006 Biochim Biophys Acta2006Aguirre E, Rodriguez-Juarez F, Gnaiger E, Cadenas S (2006) Measurement of the control of cellular respiration by nitric oxide under normoxia and hypoxia: instrumental comparison including high-resolution respirometry. Biochim Biophys Acta, EBEC Short Reports Suppl 14:136-7.HumanHEK
O2k-Publications in the MiPMap

O2k-Publications: HEK - Abstracts

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 ReferenceOrganismTissue;cell
Gnaiger 2019 NatureConferenceGnaiger E, Passrugger M, Gallee L, Felipe F Garcia-Souza, Zdrazilova L, Doerrier C (2019) High-resolution respirometry and innovations in the Oroboros O2k-technology.HumanBlood cells
HEK
Fibroblast
Platelet
Bastos Sant'Anna Silva 2018 Life Sciences Meeting 2018 Innsbruck ATEffect of cell-permeable succinate and malonate prodrugs on mitochondrial respiration in prostate cancer cells.Kidney
Other cell lines
HEK
Han 2018 MiP2018
MiPsociety
Mitochondrial functional changes elicited by a single near-infrared (670nm) exposure. Han_Presentation
HumanKidney
HEK
Danhelovska 2018 MiP2018
MiPsociety
The relevance of ACBD3 protein in energy metabolism in various cell lines. Danhelovska_Presentation
HumanHEK
HeLa
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna ITCellular succinate transport and mitochondrial respiratory function in prostate cancer.HumanHEK
Genital
Musiol 2018 MiPschool Tromso C4
MiPsociety
Alpha-tomatine as a novel membrane-permeabilizing agent for mitochondrial respiration measurements.
HumanHEK
Chang 2018 Life Sciences Meeting 2018 Innsbruck ATpH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.HumanHEK
Kidney
Doerrier 2018 MiP2018b
Carolina Doerrier
Evaluation of anaplerotic pathways to avoid artefacts in respirometric measurement of fatty acid oxidation.
Human
Mouse
Blood cells
HEK
Heart
Nervous system
Platelet
Doerrier 2018 EBEC2018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Doerrier 2017 Abstract MitoEAGLE Barcelona
COST Action MitoEAGLE
SUIT reference protocol for comparative mitochondrial physiology.
Human
Mouse
Heart
Nervous system
HEK
Doerrier 2017 MiPschool C2
DoerrierC.JPG
Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
Human
Mouse
Heart
Nervous system
HEK
Pajuelo-Reguera 2017 MiP2017
David Pajuelo-Reguera
COX4-1/COX4-2 cell knock-out/knock-in models for the study of cytochrome c oxidase regulation.
HumanHEK
Schaefer 2016 Abstract MitoFit Science Camp 2016Prominent role of amyloid beta and its intracellular localization in Alzheimer´s disease associated mitochondrial dysfunction.HumanNervous system
HEK
Krumschnabel 2016b Abstract MitoFit Science Camp 2016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.HumanKidney
HEK
Lamberti 2016 Abstract MitoFit Science Camp 2016Development of a reference sample for HRR.HumanKidney
HEK
Doerrier 2016 Abstract MitoFit Science Camp 2016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.Human
Mouse
Heart
Blood cells
HEK
Platelet
Krumschnabel 2016 Abstract Mito Xmas Meeting InnsbruckEstablishment of a reference sample for high-resolution respirometry.HumanHEK
Boyle 2015 Abstract MiP2015Kv1.3 channels in mitochondria: Are they important in cellular proliferation?HumanEndothelial;epithelial;mesothelial cell
HEK
Gnaiger 2015 Abstract MiP2015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.HumanHEK
Camacho-Pereira 2013 Abstract IOC75Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.MouseHEK
Liver
Macrophage-derived
Menze 2013 Abstract MiP2013Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08.Drosophila
Artemia
Crustaceans
Hexapods
Other cell lines
CHO
HEK
Macrophage-derived

Comparative: tissues and cells

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