OXPHOS-capacity

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OXPHOS-capacity

Description

P.jpg OXPHOS-capacity (P) is the respiratory capacity of mitochondria in the ADP-activated state of oxidative phosphorylation, at saturating concentrations of ADP (possibly in contrast to State 3), inorganic phosphate, oxygen, and defined reduced substrates. » MiPNet article

Abbreviation: P

Reference: Gnaiger 2019 MitoFit Preprint Arch, Gnaiger 2014 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
Questions.jpg




Coupled energy cycles of oxidative phosphorylation stimulated by saturating concentrations of ADP and inorganic phosphate. 2[H] indicates the reduced hydrogen equivalents of CHO substrates (NS) and electron transfer to oxygen. H+out are protons pumped out of the matrix phase to the positive P-phase. Proton flow to the negative matrix phase (H+in) drives the phosphorylation of ADP to ATP. The capacity of the phosphorylation system may contribute to the limitation of flux. Proton leaks dissipate energy of translocated protons from the positive P-phase to the negative N-phase. Measurement of OXPHOS-capacity is possible in mt-preparations supported by an ET-pathway competent substrate state, exemplifed as the NS-pathway (CI&II-linked substrate supply) (Gnaiger 2014 MitoPathways).

OXPHOS (P) and State 3

Publications in the MiPMap
Gnaiger E (2014) OXPHOS (P) and State 3. Mitochondr Physiol Network 2016-07-15.

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Oroboros (2016) MiPNet

Abstract: P.jpg OXPHOS-capacity (P) is the respiratory capacity of mitochondria in the ADP-activated state of oxidative phosphorylation, at saturating concentrations of ADP (possibly in contrast to State 3), inorganic phosphate, oxygen, and defined reduced substrates. Since OXPHOS is partially coupled, intrinsic uncoupling and dyscoupling contribute to the control of flux in the OXPHOS state (State P). Oxygen consumption in the OXPHOS state, P, therefore, is partitioned into the free OXPHOS-capacity, ≈P, strictly coupled to phosphorylation, ~P, and nonphosphorylating LEAK respiration, LP, compensating for proton leaks, slip and cation cycling: P = ≈P+LP. It is frequently assumed that LEAK respiration, L, as measured in the LEAK state, overestimates the LEAK component of respiration, LP, as measured in the OXPHOS state, particularly if the protonmotive force is not adjusted to equivalent levels in L and LP. However, if the LEAK component increases with enzyme turnover during P, the low enzyme turnover during L may counteract the effect of the higher Δpmt. OXPHOS-capacity is expressed (i) per mt-marker (O2 flux per mt-protein, CS, etc); if ET-capacity, E, is used as a functional mitochondrial marker, then OXPHOS-capacity is expressed as the P/E ratio (flux control ratio). (ii) OXPHOS-capacity is expressed per tissue or cell mass, integrating mt-quantity (density) and mt-quality (O2 flux). (iii) OXPHOS-capacity is expressed per cell (O2 flow), which then is a function of mt-density, mt-quality, and cell size. If conditions for measurement and expression of respiration vary, explicit symbols are used, expressing OXPHOS-capacity as oxygen flux in state P, JO2P or as oxygen flow in state P, IO2P. If these conditions are defined and remain consistent within a given context, then the simple symbol P for respiratory state can be used to substitute the more explicit expression for respiratory activity.


O2k-Network Lab: AT Innsbruck Gnaiger E


Related terms in Bioblast

P.jpg OXPHOS-capacity, P
R.jpg ROUTINE, R
E.jpg ET-capacity, E
L.jpg LEAK, L
ROX.jpg ROX, Rox


Publications in the MiPMap


» List of publications: OXPHOS
Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order. 
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
MiPNet18.05 Amplex-Mouse-heart2019-06-24
O2k-Protocols
O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate.
LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
MiPNet20.14 AmplexRed H2O2-production2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of H2O2 production with Amplex UltraRed.
LEAK
OXPHOS
ET
SIsolated mitochondriaMouseHeart
MiPNet12.23 FiberRespiration2019-01-10
O2k-Protocols contents
Mitochondrial respiration in permeabilized fibers: Needle biopsies from horse skeletal muscle.
LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHorseSkeletal muscle
Wolf 2019 Cells2019Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289.LEAK
ROUTINE
ET
OXPHOS
ROX
N
NS
Intact cells
Permeabilized cells
MouseFibroblast
Gaviraghi 2019 Anal Biochem2019Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueHexapodsSkeletal muscle
Andreazza 2019 Nat Commun2019Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, Whitworth AJ (2019) Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. Nat Commun 10:3280.OXPHOSN
S
HomogenateDrosophila
Malyala 2019 PLoS Comput Biol2019Malyala S, Zhang Y, Strubbe JO, Bazil JN (2019) Calcium phosphate precipitation inhibits mitochondrial energy metabolism. PLoS Comput Biol 15:e1006719.OXPHOS
LEAK
N
S
Isolated mitochondriaGuinea pigHeart
Oses 2019 Epilepsy Res2019Oses JP, Müller AP, Strogulski NR, Moreira JD, Böhmer AE, Hansel G, Carteri RB, Busnello JV, Kopczynski A, Rodolphi MS, Souza DO, Portela LV (2019) Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production. Epilepsy Res 152:35-41.LEAK
OXPHOS
ROUTINE
N
CIV
NS
HomogenateRatNervous system
McCoin 2019 Am J Physiol Endocrinol Metab2019McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab 317:E298-E311.LEAK
OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Zhang 2019 Biochem Biophys Res Commun2019Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Chao 2019 J Appl Physiol (1985)2019Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 126:1541-49.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissuePigSkeletal muscle
Chroeis 2019 Eur J Sport Sci2019Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Chabi 2019 MitoFit Preprint Arch EA2019Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MitoEAGLE.0001.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kharechkina 2019 Biochim Biophys Acta Gen Subj2019Kharechkina ES, Nikiforova AB, Teplova VV, Odinokova IV, Krestinina OV, Baburina YL, Kruglova SA, Kruglov AG (2019) Regulation of permeability transition pore opening in mitochondria by external NAD(H). Biochim Biophys Acta Gen Subj 1863:771-83.LEAK
OXPHOS
ET
SIsolated mitochondriaRatLiver
Kim 2019 Biochim Biophys Acta Mol Basis Dis2019Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I, Minamino T, Cho KI, Park YS, Kim S, Han J (2019) Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis 1865:165524.LEAK
OXPHOS
NIsolated mitochondria
Permeabilized tissue
MouseHeart
Havird 2019 Mitochondrion2019Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.LEAK
OXPHOS
N
S
CIV
NS
ROX
Isolated mitochondriaPlants
Flis 2019 Int J Mol Sci2019Flis DJ, Dzik K, Kaczor JJ, Cieminski K, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2019) Swim training modulates mouse skeletal muscle energy metabolism and ameliorates reduction in grip strength in a mouse model of amyotrophic lateral sclerosis. Int J Mol Sci 20:E233.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Brunetta 2019 J Funct Foods2019Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Bundgaard 2019 Sci Rep2019Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A (2019) Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury. Sci Rep 9:2850.LEAK
OXPHOS
SIsolated mitochondriaMouse
Reptiles
Heart
Neyroud 2019 J Muscle Res Cell Motil2019Neyroud D, Nosacka RL, Judge AR, Hepple RT (2019) Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content. J Muscle Res Cell Motil 40:59-65.OXPHOSN
NS
Permeabilized cellsMouseSkeletal muscle
Rose 2019 Am J Physiol Endocrinol Metab2019Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A Comparative Study of Mitochondrial Respiration in Circulating Blood Cells and Skeletal Muscle Fibers in Women. Am J Physiol Endocrinol Metab 317:E503-E512.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Intact cells
Permeabilized cells
Permeabilized tissue
HumanBlood cells
Platelet
Skeletal muscle
Nakajima 2019 Sci Rep2019Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S (2019) Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Sci Rep 9:3535.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanFat
Harhous 2019 J Mol Cell Cardiol2019Harhous Z, Badawi S, Bona NG, Pillot B, Augeul L, Paillard M, Booz GW, Canet-Soulas E, Ovize M, Kurdi M, Bidaux G (2019) Critical appraisal of STAT3 pattern in adult cardiomyocytes. J Mol Cell Cardiol 131:91-100.OXPHOS
ET
N
CIV
ROX
Isolated mitochondriaMouseHeart
Ling 2019 Am J Clin Nutr2019Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr 110:605-16.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Fat
Gonzalez-Armenta 2019 J Nutr2019Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized tissueOther mammalsSkeletal muscle
Esteves 2019 Oncogene2019Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene [Epub ahead of print].ET
LEAK
OXPHOS
ROUTINE
N
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Cecatto 2019 Toxicol In Vitro2019Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2019) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665.LEAK
OXPHOS
ET
N
S
Permeabilized tissueRatSkeletal muscle
Pino 2019 Physiol Genomics2019Pino MF, Stephens NA, Eroshkin AM, Yi F, Hodges A, Cornnell HH, Pratley RE, Smith SR, Wang M, Han X, Coen PM, Goodpaster BH, Sparks LM (2019) Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with type 2 diabetes. Physiol Genomics [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
Permeabilized cells
Permeabilized tissue
HumanSkeletal muscle
Douros 2019 JCI Insight2019Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.ET
LEAK
OXPHOS
Gp
N
NS
Permeabilized tissueMouseIslet cell;pancreas;thymus
Mazzoli 2019 Nutrients2019Mazzoli A, Crescenzo R, Cigliano L, Spagnuolo MS, Cancelliere R, Gatto C, Iossa S (2019) Early hepatic oxidative stress and mitochondrial changes following western diet in middle aged rats. Nutrients 11:E2670.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Rajendran 2019 EMBO Mol Med2019Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaMouseLiver
Kidney
Heart
Ng 2019 J Biol Chem2019Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18.ET
LEAK
OXPHOS
CIV
N
NS
ROX
S
Permeabilized cellsHumanNeuroblastoma
Majiene 2019 Nutrients2019Majiene D, Kuseliauskyte J, Stimbirys A, Jekabsone A (2019) Comparison of the effect of native 1,4-naphthoquinones plumbagin, menadione, and lawsone on viability, redox status, and mitochondrial functions of C6 glioblastoma cells. Nutrients 11:E1294.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsRatNervous system
Richter 2019 Life Sci Alliance2019Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ (2019) Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance 2:e201800219.OXPHOS
ET
N
CIV
NS
Permeabilized cellsHumanFibroblast
Chiurillo 2019 Mol Biol Cell2019Chiurillo MA, Lander N, Bertolini MS, Vercesi AE, Docampo R (2019) Functional analysis and importance for host cell infection of the Ca2+-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi. Mol Biol Cell 30:1676-90.LEAK
OXPHOS
ET
SPermeabilized cellsProtists
Papadimitriou 2019 Sci Rep2019Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Baekkerud 2019 Cardiovasc Toxicol2019Bækkerud FH, Salerno S, Ceriotti P, Morland C, Storm-Mathisen J, Bergersen LH, Høydal MA, Catalucci D, Stølen TO (2019) High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol 19:422-31.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
Paradis 2019 Antioxidants (Basel)2019Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168.LEAK
OXPHOS
N
S
CIV
Permeabilized tissueMouseSkeletal muscle
Oakey 2019 Wellcome Open Res2019Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion. Wellcome Open Res 3:147.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Scheiber 2019 Exp Mol Med2019Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissue
Isolated mitochondria
HumanHeart
Cassereau 2019 Exp Neurol2019Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2019) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHumanFibroblast
Blais-Lecours 2019 Am J Respir Cell Mol Biol2019Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D (2019) Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. Am J Respir Cell Mol Biol [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanOther cell lines
Latham 2019 J Anim Sci2019Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Miotto 2019 FASEB J2019Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40.LEAK
OXPHOS
N
NS
F
Permeabilized tissueHumanSkeletal muscle
Fink 2019 FASEB J2019Fink BD, Yu L, Sivitz WI (2019) Modulation of complex II-energized respiration in muscle, heart, and brown adipose mitochondria by oxaloacetate and complex I electron flow. FASEB J [Epub ahead of print].OXPHOSN
S
Isolated mitochondriaMouseHeart
Skeletal muscle
Fat
Rawat 2019 J Mol Biol2019Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.LEAK
OXPHOS
CIV
N
ROX
S
Permeabilized cellsMouseNervous system
Other cell lines
Chatfield 2019 JACC Basic Transl Sci2019Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57.ET
LEAK
OXPHOS
N
NS
S
Permeabilized tissueHumanHeart
Grauso 2019 Sci Rep2019Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro. Sci Rep 9:11360.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Zhou 2019 Int J Mol Sci2019Zhou X, Luethi D, Sanvee GM, Bouitbir J, Liechti ME, Krähenbühl S (2019) Molecular toxicological mechanisms of synthetic cathinones on C2C12 myoblasts. Int J Mol Sci 20:E1561.OXPHOSNPermeabilized cellsMouseSkeletal muscle
Braganza 2019 JCI Insight2019Braganza AC, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Cooper 2019 Exp Physiol2019Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2019) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.LEAK
OXPHOS
ET
F
N
Permeabilized tissueMouseNervous system
Spinazzi 2019 Proc Natl Acad Sci U S A2019Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.ET
LEAK
OXPHOS
CIV
N
NS
ROX
S
Intact cells
Isolated mitochondria
Permeabilized cells
MouseNervous system
Viana 2019 Sci Rep2019Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529.LEAK
OXPHOS
NPermeabilized tissueRatEndothelial;epithelial;mesothelial cell
Powers 2019 Neurourol Urodyn2019Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL (2019) Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourol Urodyn 38:1524-32.LEAK
OXPHOS
N
S
CIV
NS
HomogenateMouseOther cell lines
Haberman 2019 Nat Commun2019Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA (2019) Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun 10:38.OXPHOS
ET
N
S
NS
HomogenateHumanEndothelial;epithelial;mesothelial cell
Miranda-Silva 2019 Acta Physiologica2019Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact organ
Permeabilized tissue
Isolated mitochondria
RatHeart
Pichaud 2019 Front Genet2019Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Aubin 2019 Thesis2019Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99.ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanLymphocyte
Azevedo 2019 Food Chem Toxicol2019Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueRatLiver
McBride 2019 Arch Biochem Biophys2019McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.LEAK
OXPHOS
CIV
F
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Doig 2019 bioRxiv2019Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Nold 2019 Psychoneuroendocrinology2019Nold V, Sweatman C, Karabatsiakis A, Böck C, Bretschneider T, Lawless N, Fundel-Clemens K, Kolassa IT, Allers KA (2019) Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress. Psychoneuroendocrinology 107:148-59.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Garrido-Maraver 2019 Cell Death Dis2019Garrido-Maraver J, Celardo I, Costa AC, Lehmann S, Loh SHY, Martins LM (2019) Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin. Cell Death Dis 10:288.OXPHOS
ET
N
S
Permeabilized tissueDrosophila
Robinson 2019 Am J Physiol Cell Physiol2019Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.LEAK
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cellsMouse
Rat
Skeletal muscle
Axton 2019 J Nutr2019Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.ET
LEAK
OXPHOS
N
NS
ROX
S
Isolated mitochondriaZebrafishSkeletal muscle
Gonzalez-Mariscal 2019 FASEB J2019González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Kolleritsch 2019 Cardiovasc Res2019Kolleritsch S, Kien B, Schoiswohl G, Diwoky C, Schreiber R, Heier C, Maresch LK, Schweiger M, Eichmann TO, Stryeck S, Krenn P, Tomin T, Kolb D, Rülicke T, Hoefler G, Wolinski H, Madl T, Birner-Gruenberger R, Haemmerle G (2019) Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Cardiovasc Res [Epub ahead of print].LEAK
OXPHOS
NHomogenateMouseHeart
Petrick 2019 J Physiol2019Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol 597:3985-97.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Liu 2019 J Ethnopharmacol2019Liu M, Yu S, Wang J, Qiao J, Liu Y, Wang S, Zhao Y (2019) Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease. J Ethnopharmacol [Epub ahead of print].OXPHOSN
S
HomogenateDrosophila
Moretti-Almeida 2019 Fungal Genet Biol2019Moretti-Almeida G, Thomazella DPT, Pereira GAG, Monteiro G (2019) Heterologous expression of an alternative oxidase from Moniliophthora perniciosa in Saccharomyces cerevisiae: antioxidant function and in vivo platform for the study of new drugs against witches' broom disease. Fungal Genet Biol 126:50-55.OXPHOSROXIsolated mitochondriaSaccharomyces cerevisiae
Mueller 2019 Neurochem Int2019Mueller TE, Nunes MEM, Rodrigues NR, Fontana BD, Hartmann DD, Franco JL, Rosemberg DB (2019) Neurochemical mechanisms underlying acute and chronic ethanol-mediated responses in zebrafish: The role of mitochondrial bioenergetics. Neurochem Int 131:104584.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafishNervous system
Teulier 2019 Comp Biochem Physiol A Mol Integr Physiol2019Teulier L, Thoral E, Queiros Q, McKenzie DJ, Roussel D, Dutto G, Gasset E, Bourjea J, Saraux C (2019) Muscle bioenergetics of two emblematic Mediterranean fish species: Sardina pilchardus and Sparus aurata. Comp Biochem Physiol A Mol Integr Physiol 235:174-79.LEAK
OXPHOS
ET
F
N
NS
ROX
Intact cellsFishesSkeletal muscle
Laouafa 2019 Acta Physiol (Oxf)2019Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.LEAK
OXPHOS
ET
N
S
NS
ROX
CIV
Permeabilized tissueRatNervous system
Vaka 2019 Am J Physiol Regul Integr Comp Physiol2019Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.LEAK
OXPHOS
ET
N
CIV
ROX
Intact cells
Isolated mitochondria
Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
De-Souza-Ferreira 2019 J Neurochem2019de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40.LEAK
OXPHOS
ET
N
Gp
CIV
NS
Isolated mitochondriaRatNervous system
Okoye 2019 Aquat Toxicol2019Okoye CN, MacDonald-Jay N, Kamunde C (2019) Effects of bioenergetics, temperature and cadmium on liver mitochondria reactive oxygen species production and consumption. Aquat Toxicol 214:105264.LEAK
OXPHOS
NIsolated mitochondriaFishesLiver
Hughes 2019 J Physiol2019Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR (2019) Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol [Epub ahead of print].OXPHOS
LEAK
N
NS
Permeabilized tissueMouseHeart
Driescher 2019 Heliyon2019Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.LEAK
OXPHOS
ET
F
N
CIV
ROX
Permeabilized tissueRatHeart
Reda 2019 Sci Rep2019Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fisher-Wellman 2019 Cell Rep2019Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.LEAK
OXPHOS
ET
F
N
S
Gp
Isolated mitochondriaMouseHeart
Skeletal muscle
Kwak 2019 Int J Environ Res Public Health2019Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cellsHumanSkeletal muscle
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis2019Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Shirakawa 2019 Sci Rep2019Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T (2019) Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Sci Rep 9:14709.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHumanBlood cells
Devaux 2019 Front Physiol2019Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis Maintains the Function of Brain Mitochondria in Hypoxia-Tolerant Triplefin Fish: A Strategy to Survive Acute Hypoxic Exposure? Front Physiol 9:1941.LEAK
OXPHOS
ET
Other combinations
N
NS
Permeabilized tissue
Isolated mitochondria
FishesNervous system
Mejia 2019 Reprod Biol Endocrinol2019Mejia JF, Hirschi KM, Tsai KYF, Long MG, Tullis BC, Bitter EEK, Bikman BT, Reynolds PR, Arroyo JA (2019) Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reprod Biol Endocrinol 17:81.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsHumanGenital
Koop 2019 Int J Cardiol2019Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B (2019) Right ventricular pressure overload alters cardiac lipid composition. Int J Cardiol 287:96-105.OXPHOSF
N
Isolated mitochondriaRatHeart
Paumelle 2019 J Hepatol2019Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.OXPHOS
LEAK
F
N
HomogenateHumanLiver
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol2019Rodríguez-Enríquez S, Pacheco-Velázquez SC, Marín-Hernández Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernández-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernández-Esquivel L, Sánchez-Thomas R, Moreno-Sánchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77.LEAK
OXPHOS
N
S
Isolated mitochondriaRatHeart
Liver
Jaskiewicz 2019 J Clin Med2019Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.ROUTINE
OXPHOS
ET
LEAK
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Other cell lines
Dilberger 2019 Nutrients2019Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Courtes 2019 Biomed Pharmacother2019Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111: 1438-46.OXPHOS
LEAK
N
S
NS
ROX
Isolated mitochondriaRatLiver
Schoepf 2019 MitoFit Preprint Arch2019Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch doi:10.26124/mitofit:190003.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueHumanGenital
Gancheva 2019 Nat Commun2019Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, Jähnert M, Weiss J, Strassburger K, Schlensak M, Schürmann A, Roden M (2019) Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat Commun 10:4179.LEAK
OXPHOS
ET
Permeabilized tissueHumanSkeletal muscle
Sabogal-Guaqueta 2019 Biomed Pharmacother2019Sabogal-Guáqueta AM, Hobbie F, Keerthi A, Oun A, Kortholt A, Boddeke E, Dolga A (2019) Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomed Pharmacother 118:109295.ET
LEAK
OXPHOS
NIsolated mitochondriaMouseNervous system
Doerrier 2019 MitoFit Preprint Arch EA2019Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Monteiro 2019 Thesis2019Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82.LEAK
OXPHOS
ET
NPermeabilized tissueRatSkeletal muscle
Sukovas 2019 J Bioenerg Biomembr2019Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr 51:301-10.LEAK
OXPHOS
NPermeabilized cellsHumanGenital
Ferreira 2019 Nat Commun2019Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun 10:329.LEAK
OXPHOS
ET
NSIsolated mitochondriaRatHeart
Carteri 2019 Toxicol Lett2019Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseNervous system
Halle 2019 Am J Physiol Regul Integr Comp Physiol2019Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Liver
Fat
Miranda Mendonca 2019 Neurochem Int2019Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized tissueMouseNervous system
Jansen 2019 Am J Physiol Heart Circ Physiol2019Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseHeart
Kumar 2019 Free Radic Biol Med2019Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Bettinazzi 2019 Proc Biol Sci2019Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
Permeabilized cellsMolluscsLung;gill
Genital
Grandoch 2019 Nat Metab2019Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M5, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseFat
Kappler 2019 Am J Physiol Endocrinol Metab2019Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R (2019) Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints. Am J Physiol Endocrinol Metab 317:E374-E387.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Skeletal muscle
Liver
Ederle 2019 J Clin Med2019Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanBlood cells
Cecatto 2019 Mitochondrion2019Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2019) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13.LEAK
OXPHOS
ET
N
S
Permeabilized cells
Isolated mitochondria
RatLiver
Kunz 2019 Am J Physiol Endocrinol Metab2019Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab 317:E460-E472.LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
D'Amico 2019 Mol Cell2019D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J (2019) The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell 73:775-87.OXPHOSS
NS
ROX
HomogenateMouseSkeletal muscle
Krischek 2019 Meat Sci2019Krischek C, Popp J, Sharifi AR (2019) Biochemical alterations in the Musculus triceps brachii and Musculus longissimus thoracis during early postmortem period in pigs. Meat Sci 152:121-26.OXPHOSNPermeabilized tissuePigSkeletal muscle
Pedrotti 2019 Sci Adv2019Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cellsMouseFat
Zeng 2019 Toxicol Rep2019Zeng R, Zhou Q, Zhang W, Fu X, Wu Q, Lu Y, Shi J, Zhou S (2019) Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro. Toxicol Rep 6:637-44.OXPHOSSIntact cells
Isolated mitochondria
RatNervous system
Ferey 2019 Am J Physiol Heart Circ Physiol2019Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210.LEAK
OXPHOS
N
S
NS
Permeabilized tissueMouseHeart
Lerchner 2019 Anal Bioanal Chem2019Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. Anal Bioanal Chem 411:3763-68.LEAK
OXPHOS
ET
ROXIntact cellsProtists
Svab 2019 Neurochem Res2019Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47.LEAK
OXPHOS
ET
N
S
Isolated mitochondria
Intact cells
Guinea pigNervous system
Kakimoto 2019 PLoS One2019Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733.LEAK
OXPHOS
F
NS
Isolated mitochondriaMouseLiver
Cadiz 2019 Comp Biochem Physiol B Biochem Mol Biol2019Cadiz L, Bundgaard A, Malte H, Fago A (2019) Hypoxia enhances blood O2 affinity and depresses skeletal muscle O2 consumption in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol 234:18-25.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueZebrafishSkeletal muscle
Hunter 2019 J Appl Physiol (1985)2019Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between VO2max, cycle economy & mitochondrial respiration in untrained/trained. J Appl Physiol (1985) [Epub ahead of print].LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Kirby 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Kirby AR, Cox GK, Nelson D, Heuer RM, Stieglitz JD, Benetti DD, Grosell M, Crossley DA 2nd (2019) Acute crude oil exposure alters mitochondrial function and ADP affinity in cardiac muscle fibers of young adult Mahi-mahi (Coryphaena hippurus). Comp Biochem Physiol C Toxicol Pharmacol 218:88-95.ET
LEAK
OXPHOS
CIV
N
NS
ROX
S
Permeabilized tissueFishesHeart
Cesnekova 2019 Thesis2019Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133.OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanHEK
Fowler 2019 Int J Mol Sci2019Fowler ED, Hauton D, Boyle J, Egginton S, Steele DS, White E (2019) Energy metabolism in the failing right ventricle: limitations of oxygen delivery and the creatine kinase system . Int J Mol Sci 20:1805.OXPHOSPermeabilized cellsRatHeart
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol2019Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.OXPHOS
ET
LEAK
N
S
Gp
CIV
NS
ROX
Permeabilized tissueOther invertebratesSkeletal muscle
Cormier 2019 Sci Rep2019Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.LEAK
OXPHOS
ET
N
Gp
NS
ROX
CIV
Permeabilized tissueDrosophilaSkeletal muscle
Detaille 2019 PLoS One2019Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatHeart
Bouitbir 2019 Toxicology2019Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Rat
Mouse
Heart
Woodman 2019 Cardiovasc Res2019Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2019) Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress. Cardiovasc Res [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
HomogenateRatKidney
Christian 2019 Respir Physiol Neurobiol2019Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62.LEAK
OXPHOS
NPermeabilized tissueMouseNervous system
Bahhir 2019 PLoS Genet2019Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet [Epub ahead of print].LEAK
OXPHOS
CIV
Gp
N
ROX
HomogenateDrosophila
Wang 2019 J Biol Chem2019Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV (2019) Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. J Biol Chem 294:5466-86.ROUTINE
OXPHOS
ET
F
N
S
NS
Permeabilized cells
Isolated mitochondria
Intact cells
RatFibroblast
Karusheva 2019 Am J Clin Nutr2019Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Zhang 2019 Redox Biol2019Zhang Y, Bharathi SS, Beck ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol 26:101253.LEAK
OXPHOS
N
NS
F
Isolated mitochondriaMouseLiver
Petrick 2019 Biochem J2019Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.OXPHOS
LEAK
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Power 2019 PLoS One2019Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740.LEAK
OXPHOS
N
NS
Permeabilized tissueRatHeart
Dall 2019 J Biol Chem2019Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem 294:13304-26.LEAK
OXPHOS
ET
F
N
S
Intact cellsMouseLiver
Mousovich-Neto 2019 Exp Physiol2019Mousovich-Neto F, Matos MS, Costa ACR, de Melo Reis RA, Atella GC, Miranda-Alves L, Carvalho DP, Ketzer LA, Corrêa da Costa VM (2019) Brown adipose tissue remodeling induced by corticosterone in Wistar male rats. Exp Physiol 104:514-28.OXPHOSNSIsolated mitochondriaRatFat
Wiberg 2019 Eur Heart J Acute Cardiovasc Care2019Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care [Epub ahead of print].OXPHOS
ET
LEAK
N
NS
Permeabilized tissueHumanSkeletal muscle
Bertolini 2019 MBio2019Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca2+ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. MBio 10:e00348-19.LEAK
OXPHOS
ET
Permeabilized cellsProtists
Shuvo 2019 J Bioenerg Biomembr2019Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J Bioenerg Biomembr [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaFungi
Ramos 2019 Am J Physiol Cell Physiol2019Ramos SV, Hughes MC, Perry CGR (2019) Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies. Am J Physiol Cell Physiol 316:C449-C455.OXPHOSNPermeabilized tissueRatSkeletal muscle
Chang 2019 Br J Anaesth2019Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HumanSkeletal muscle
Halbach 2019 Am J Physiol Regul Integr Comp Physiol2019Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A (2019) Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol 317:R160-R168.LEAK
OXPHOS
N
NS
Intact cellsMouseLiver
De Moura Escobar 2019 Toxicol In Vitro2019de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro [Epub ahead of print].LEAK
OXPHOS
N
S
ROX
Permeabilized cellsHumanNeuroblastoma
Ahn 2019 J Cachexia Sarcopenia Muscle2019Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28.OXPHOS
LEAK
N
S
CIV
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Jiang 2019 EMBO Rep2019Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG (2019) TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20:e48101.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Belosludtsev 2019 Biochim Biophys Acta Biomembr2019Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2019) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr 1861:288-97.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaRatLiver
Gvozdjakova 2019 Bratisl Lek Listy2019Gvozdjakova A, Sumbalova Z, Kucharska J, Chladekova A, Rausova Z, Vancova O, Komlosi M, Ulicna O, Mojto V (2019) Platelet mitochondrial bioenergetic analysis in patients with nephropathies and non-communicable diseases: a new method. Bratisl Lek Listy 120:630-35.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Diao 2019 Brain Res2019Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res [Epub ahead of print].LEAK
OXPHOS
ET
NIsolated mitochondriaMouseNervous system
Bianco 2019 PLoS One2019Bianco M, Lopes JA, Beiral HJV, Filho JDD, Frankenfeld SP, Fortunato RS, Gattass CR, Vieyra A, Takiya CM (2019) The contralateral kidney presents with impaired mitochondrial functions and disrupted redox homeostasis after 14 days of unilateral ureteral obstruction in mice. PLoS One 14:e0218986.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseKidney
Zhu 2019 Aging Cell2019Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.LEAK
OXPHOS
ET
N
NS
S
ROX
Isolated mitochondriaMouseLiver
Thomas 2019 Redox Biol2019Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsRatLiver
Bettinazzi 2019 Cryobiology2019Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
S
Other combinations
Permeabilized tissueMolluscsLung;gill
Pajak 2019 PLoS Genet2019Pajak A, Laine I, Clemente P, El-Fissi N, Schober FA, Maffezzini C, Calvo-Garrido J, Wibom R, Filograna R, Dhir A, Wedell A, Freyer C, Wredenberg A (2019) Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. PLoS Genet 15:e1008240.LEAK
OXPHOS
CIV
N
S
Permeabilized tissueDrosophila
Fernando 2019 Exp Gerontol2019Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Sambeat 2019 Nat Commun2019Sambeat A, Ratajczak J, Joffraud M, Sanchez-Garcia JL, Giner MP, Valsesia A, Giroud-Gerbetant J, Valera-Alberni M, Cercillieux A, Boutant M, Kulkarni SS, Moco S, Canto C (2019) Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage. Nat Commun 10:4291.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fisar 2019 Clin Biochem2019Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Martines 2019 Sci Rep2019Martines AMF, Gerding A, Stolle S, Vieira-Lara MA, Wolters JC, Jurdzinski A, Bongiovanni L, de Bruin A, van der Vlies P, van der Vries G, Bloks VW, Derks TGJ, Reijngoud DJ, Bakker BM (2019) Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Sci Rep 9:14539.LEAK
OXPHOS
F
N
Isolated mitochondriaMouseLiver
Silva Ramos 2019 PLoS Genet2019Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085.LEAK
OXPHOS
ET
N
S
Gp
Permeabilized cells
Isolated mitochondria
MouseHeart
Fibroblast
Lemieux 2019 bioRxiv2019Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
MouseBlood cells
Perry 2019 J Mol Cell Cardiol2019Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.LEAK
OXPHOS
N
S
ROX
Isolated mitochondria
Permeabilized cells
RatHeart
Munro 2019 Aging Cell2019Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.LEAK
OXPHOS
N
NS
S
Isolated mitochondriaMouse
Other mammals
Heart
Skeletal muscle
Mayeuf-Louchart 2019 Cell Rep2019Mayeuf-Louchart A, Lancel S, Sebti Y, Pourcet B, Loyens A, Delhaye S, Duhem C, Beauchamp J, Ferri L, Thorel Q, Boulinguiez A, Zecchin M, Dubois-Chevalier J, Eeckhoute J, Vaughn LT, Roach PJ, Dani C, Pederson BA, Vincent SD, Staels B, Duez H (2019) Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation. Cell Rep 29:1410-18.LEAK
OXPHOS
F
N
S
NS
Permeabilized cellsMouseFat
McManus 2019 Cell Metab2019McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90.LEAK
OXPHOS
N
ROX
Isolated mitochondriaMouseHeart
Mazaki 2019 Biochem Biophys Res Commun2019Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H (2019) Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells. Biochem Biophys Res Commun 513:708-13.OXPHOSN
S
Permeabilized cellsHumanBlood cells
Larsen 2019 Appl Physiol Nutr Metab2019Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab 44:958-64.OXPHOS
ET
LEAK
N
NS
Permeabilized tissueHumanSkeletal muscle
Electron transfer-pathway state2019Gnaiger E (2019) ET-pathway states. Mitochondr Physiol Network 2019-06-11 (last edit since 2016-11-08).LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
SMP
Garcia-Roche 2019 PLoS One2019García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsBovinesLiver
Stepanova 2019 Antioxid Redox Signal2019Stepanova A, Sosunov S, Niatsetskaya Z, Konrad C, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseNervous system
Garnham 2019 J Cachexia Sarcopenia Muscle2019Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Gregg 2019 J Biol Chem2019Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66.ET
LEAK
OXPHOS
N
NS
ROX
S
Permeabilized tissueMouseIslet cell;pancreas;thymus
Long 2019 Methods Mol Biol2019Long Q, Huang L, Huang K, Yang Q (2019) Assessing mitochondrial bioenergetics in isolated mitochondria from mouse heart tissues using Oroboros Oxygraph-2k. Methods Mol Biol 1966:237-46.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseHeart
Chao 2019 Am J Physiol Cell Physiol2019Chao T, Gomez BI, Heard TC, Smith BW, Dubick MA, Burmeister DM (2019) Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine. Am J Physiol Cell Physiol [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissuePigHeart
Gaglianone 2019 Sci Rep2019Gaglianone RB, Santos AT, Bloise FF, Ortiga-Carvalho TM, Costa ML, Quirico-Santos T, da Silva WS, Mermelstein C (2019) Reduced mitochondrial respiration and increased calcium deposits in the EDL muscle, but not in soleus, from 12-week-old dystrophic mdx mice. Sci Rep 9:1986.LEAK
OXPHOS
ET
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Berru 2019 Sci Rep2019Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Cardinale 2019 Front Physiol2019Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Lefranc 2019 Hypertension2019Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68.OXPHOS
LEAK
NIsolated mitochondriaMouseFat
Macedo 2019 Biochim Biophys Acta Mol Cell Biol Lipids2019Macedo F, Martins GL, Luévano-Martínez LA, Viana GM, Riske KA, Inague A, Yoshinaga MY, Aguilaniu H, Miyamoto S, Glezer I, da Cunha FM (2019) Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans. Biochim Biophys Acta Mol Cell Biol Lipids [Epub ahead of print].LEAK
OXPHOS
N
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Tetsi 2019 Antioxidants (Basel)2019Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B (2019) Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 8:E93.LEAK
OXPHOS
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Hirschi 2019 Biol Reprod2019Hirschi KM, Tsai KYF, Davis T, Clark JC, Knowlton MN, Bikman BT, Reynolds PR, Arroyo JA (2019) Growth arrest specific protein (Gas)-6/AXL signaling induces preeclampsia (PE) in rats. Biol Reprod [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
RatGenital
Wang 2019 Free Radic Biol Med2019Wang SQ, Yang XY, Cui SX, Gao ZH, Qu XJ (2019) Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer. Free Radic Biol Med 134:87-98.OXPHOS
LEAK
Isolated mitochondriaMouseHeart
Liver
Endothelial;epithelial;mesothelial cell
Sonjak 2019 J Gerontol A Biol Sci Med Sci2019Sonjak V, Jacob KJ, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT (2019) Reduced mitochondrial content, elevated ROS, and modulation by denervation in skeletal muscle of pre-frail/frail elderly women. J Gerontol A Biol Sci Med Sci [Epub ahead of print].LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Hafen 2019 J Appl Physiol (1985)2019Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57.ET
LEAK
OXPHOS
N
NS
ROX
S
Permeabilized tissueHumanSkeletal muscle
Gururaja Rao 2019 Cells2019Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaDrosophila
Wessels 2019 Obesity (Silver Spring)2019Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanFat
Fiorenza 2019 FASEB J2019Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J 33:8976-89.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Boardman 2019 Can J Physiol Pharmacol2019Boardman NT, Falck AT, Lund T, Chu X, Martin-Armas M, Norvik JV, Jenssen TG, Ytrehus K (2019) Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Can J Physiol Pharmacol [Epub ahead of print].LEAK
OXPHOS
NIsolated mitochondriaRatHeart
Magga 2019 Mol Ther2019Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R (2019) Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury. Mol Ther 27:600-10.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Lewis 2019 Int J Mol Sci2019Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Quantification of mitochondrial oxidative phosphorylation in metabolic disease: application to Type 2 diabetes. Int J Mol Sci 20:5271.OXPHOSHuman
Rat
Skeletal muscle
Park 2019 Behav Brain Res2019Park SS, Park HS, Kim CJ, Baek SS, Kim TW (2019) Exercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe. Behav Brain Res 372:112049.LEAK
OXPHOS
N
NS
RatNervous system
McMurray 2019 FASEB J2019McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J [Epub ahead of print].LEAK
OXPHOS
F
N
S
CIV
ROX
Permeabilized tissueMouseSkeletal muscle
Rojas-Morales 2019 Free Radic Biol Med2019Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.LEAK
OXPHOS
NIsolated mitochondriaRatKidney
Kopinski 2019 Proc Natl Acad Sci U S A2019Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Mann 2019 Oncogene2019Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
F
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Devaux 2019 J Exp Biol2019Devaux JBL, Hickey AJR, Renshaw GMC (2019) Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/reoxygenation. J Exp Biol 222:jeb191353.ET
LEAK
OXPHOS
ROUTINE
N
NS
S
HomogenateFishesNervous system
Li 2019 Int Urol Nephrol2019Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70.ROUTINE
OXPHOS
ET
LEAK
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Rodinova 2019 Dis Model Mech2019Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaPigSkeletal muscle
Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (Sciaenops ocellatus). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueFishesHeart
Skeletal muscle
Cikankova 2019 Naunyn Schmiedebergs Arch Pharmacol2019Cikánková T, Fišar Z, Bakhouche Y, Ľupták M, Hroudová J (2019) In vitro effects of antipsychotics on mitochondrial respiration. Naunyn Schmiedebergs Arch Pharmacol 392:1209-23.OXPHOSN
S
ROX
Isolated mitochondriaPigNervous system
Dent 2019 J Appl Physiol (1985)2019Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Maresch 2019 Hepatol Commun2019Maresch LK, Benedikt P, Feiler U, Eder S, Zierler KA, Taschler U, Kolleritsch S, Eichmann TO, Schoiswohl G, Leopold C, Wieser B, Lackner C, Rülicke T, van Klinken J, Kratky D, Moustafa T, Hoefler G, Haemmerle G (2019) Intestine‐specific overexpression of carboxylesterase 2c protects mice from diet‐induced liver steatosis and obesity. Hepatol Commun 3:227-45.LEAK
OXPHOS
FHomogenateMouseEndothelial;epithelial;mesothelial cell
Trevino 2019 Am J Physiol Endocrinol Metab2019Trevino MB, Zhang X, Standley RA, Wang M, Han X, Reis FCG, Periasamy M1, Yu G, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2019) Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Metab [Epub ahead of print].LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Gnaiger 2019 MitoPathways2019
O2k-Protocols
Gnaiger E (2019) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Mitochondr Physiol Network 24.05. Oroboros MiPNet Publications, Innsbruck:112 pp.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Turnbull 2019 Am J Physiol Cell Physiol2019Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol [Epub ahead of print].LEAK
OXPHOS
NPermeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6.LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Aguilar 2019 Cell Rep2019Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16.LEAK
OXPHOS
NHomogenateMouseEndothelial;epithelial;mesothelial cell
Teh 2019 Mol Cancer Ther2019Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.LEAK
ROUTINE
OXPHOS
ET
N
S
DQ
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Human
Mouse
Other cell lines
Bajzikova 2019 Cell Metab2019Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416.OXPHOS
ET
N
S
ROX
Permeabilized cells
Homogenate
MouseEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Itkis 2019 Mitochondrion2019Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Scavuzzo 2019 J Neurophysiol2019Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.LEAK
OXPHOS
CIV
N
NS
ROX
S
HomogenateRatNervous system
Ruegsegger 2019 FASEB J2019Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseNervous system
Yan 2019 Int Immunopharmacol2019Yan M, Yu Y, Mao X, Feng J, Wang Y, Chen H, Xie K, Yu Y (2019) Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. Int Immunopharmacol 71:61-7.LEAK
OXPHOS
SIsolated mitochondriaMouseLiver
Crescenzo 2019 Mol Neurobiol2019Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Jaiswal 2019 Mol Metab2019Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM (2019) The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Mol Metab 28:1-13.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Desmoulins 2019 Mol Metab2019Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77.OXPHOS
ET
LEAK
N
NS
HomogenateRatNervous system
Ruegsegger 2019 JCI Insight2019Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681.LEAK
OXPHOS
ET
ROXIsolated mitochondriaMouseNervous system
Zhao 2019 Basic Res Cardiol2019Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
RatHeart
Fibroblast
Cannon 2019 J Appl Physiol (1985)2019Cannon DT, Rodewohl L, Adams V, Breen EC, Bowen TS (2019) Skeletal myofiber VEGF deficiency leads to mitochondrial, structural and contractile alterations in mouse diaphragm. J Appl Physiol (1985) [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Halling 2019 Am J Physiol Endocrinol Metab2019Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.ET
LEAK
OXPHOS
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
MiPNet21.06 SUIT RP2018-06-25
O2k-Protocols
SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
MiPNet21.17 BloodCellsIsolation2018-04-09
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Rossignoli 2018 J Nutr Biochem2018Rossignoli CP, Dechandt CRP, Souza AO, Sampaio IH, Vicentini TM, Teodoro BG, Neto MPC, Ferrari GD, Couto-Lima CA, Alberici LC (2018) Effects of intermittent dietary supplementation with conjugated linoleic acid and fish oil (EPA/DHA) on body metabolism and mitochondrial energetics in mice. J Nutr Biochem 60:16-23.ET
LEAK
OXPHOS
N
S
Isolated mitochondria
Permeabilized cells
MouseFat
Liver
Nervous system
Skeletal muscle
Corrochano 2018 Hum Mol Genet2018Corrochano S, Blanco G, Williams D, Wettstein J, Simon M, Kumar S, Moir L, Agnew T, Stewart M, Landman A, Kotiadis VN, Duchen MR, Wackerhage H, Rubinsztein DC, Brown SDM, Acevedo-Arozena A (2018) A genetic modifier suggests that endurance exercise exacerbates Huntington's disease. Hum Mol Genet 27:1723-31.OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Schiffer 2018 PLoS One2018Schiffer TA, Christensen M, Gustafsson H, Palm F (2018) The effect of inactin on kidney mitochondrial function and production of reactive oxygen species. PLoS One 13:e0207728.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatKidney
Chen 2018 Endocrinology2018Chen Y, McCommis KS, Ferguson D, Hall AM, Harris CA, Finck BN (2018) Inhibition of the mitochondrial pyruvate carrier by tolylfluanid. Endocrinology 159:609-21.OXPHOSN
NS
Isolated mitochondriaMouseFat
Fox 2018 Thesis2018Fox JC (2018) FROST450, a novel microtubule targeting agent: resistance and cross-resistance in an ovarian cancer cell line. Bachelor's Thesis 27.LEAK
OXPHOS
ET
N
NS
ROX
Intact cellsHumanGenital
Logan 2018 Mol Metab2018Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE (2018) Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Mol Metab 9:141-55.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaMouseNervous system
Chabi 2018 J Bioenerg Biomembr2018Chabi B, Fouret G, Lecomte J, Cortade F, Pessemesse L, Baati N, Coudray C, Lin L, Tong Q, Wrutniak-Cabello C, Casas F, Feillet-Coudray C (2018) Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition. J Bioenerg Biomembr 50:131-42.LEAK
OXPHOS
N
S
CIV
NS
Homogenate
Isolated mitochondria
MouseSkeletal muscle
Jelenik 2018 Diabetes2018Jelenik T, Flögel U, Álvarez-Hernández E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Müller-Wieland D, Moellendorf S, Gödecke A, Kelm M, Westenfeld R, Roden M, Szendroedi J (2018) Insulin resistance and vulnerability to cardiac ischemia. Diabetes 67:2695-702.LEAK
OXPHOS
F
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Heart
Barca 2018 Hum Mol Genet2018Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12.LEAK
ROUTINE
OXPHOS
ET
F
N
S
DQ
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Menezes-Filho 2018 Biochim Biophys Acta Bioenerg2018Menezes-Filho SL, Amigo I, Luévano-Martínez LA, Kowaltowski AJ (2018) Fasting promotes functional changes in liver mitochondria. Biochim Biophys Acta Bioenerg 1860:129-35.OXPHOS
ET
N
S
Isolated mitochondriaMouseLiver
Chung 2018 J Exp Biol2018Chung DJ, Sparagna GC, Chicco AJ, Schulte PM (2018) Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol 221. pii: jeb174458.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Isolated mitochondriaFishesLiver
Christensen 2018 Diabetes Metab Res Rev2018Christensen M, Schiffer TA, Gustafsson H, Krag SP, Nørregaard R, Palm F (2018) Metformin attenuates renal medullary hypoxia in diabetic nephropathy through uncoupling protein-2 inhibition. Diabetes Metab Res Rev 21:e3091.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatKidney
Scalzo 2018 Physiol Rep2018Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB (2018) Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep 6:e13754.LEAK
OXPHOS
ET
F
NS
Other combinations
Permeabilized tissueRatHeart
Mayer 2018 Endocrinology2018Mayer AL, Zhang Y, Feng EH, Higgins CB, Adenekan O, Pietka TA, Beatty WL, DeBosch BJ (2018) Enhanced hepatic PPARα activity links GLUT8 deficiency to augmented peripheral fasting responses in male mice. Endocrinology 159:2110-26.OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Ravasz 2018 Biochim Biophys Acta2018Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2018) Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD+ supports substrate-level phosphorylation during respiratory inhibition. Biochim Biophys Acta 1859:909-24.LEAK
OXPHOS
F
N
DQ
Isolated mitochondriaMouseLiver
Giordano 2018 Am J Respir Cell Mol Biol2018Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M (2018) Alternative oxidase attenuates cigarette smoke-induced lung dysfunction and tissue damage. Am J Respir Cell Mol Biol 60:515-22.OXPHOSN
S
CIV
ROX
Permeabilized cellsMouseFibroblast
Setz 2018 Hear Res2018Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D (2018) Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti. Hear Res 361:52-65.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cellsMouseOther cell lines
Cardinale 2018 Acta Physiol (Oxf)2018Cardinale DA, Larsen FJ, Jensen-Urstad M, Rullman E, Søndergaard H, Morales-Alamo D, Ekblom B, Calbet JAL, Boushel R (2018) Muscle mass and inspired oxygen influence oxygen extraction at maximal exercise: Role of mitochondrial oxygen affinity. Acta Physiol (Oxf) 225:e13110.OXPHOSF
N
NS
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Apostolopoulou 2018 Thesis2018Apostolopoulou M (2018) Determinants of insulin sensitivity in obesity and recent-onset type 2 diabetes mellitus. PhD Thesis 77.OXPHOS
ET
F
N
NS
Homogenate
Isolated mitochondria
HumanLiver
Augustynek 2018 Int J Mol Sci2018Augustynek B, Koprowski P, Rotko D, Kunz WS, Szewczyk A, Kulawiak B (2018) Mitochondrial BK channel openers CGS7181 and CGS7184 exhibit cytotoxic properties. Int J Mol Sci 19. pii: E353.OXPHOSNIsolated mitochondriaRatNervous system
Bouwkamp 2018 Neurol Genet2018Bouwkamp CG, Afawi Z, Fattal-Valevski A, Krabbendam IE, Rivetti S, Masalha R, Quadri M, Breedveld GJ, Mandel H, Tailakh MA, Beverloo HB, Stevanin G, Brice A, van IJcken WFJ, Vernooij MW, Dolga AM, de Vrij FMS, Bonifati V, Kushner SA (2018) ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia. Neurol Genet 4:e223.OXPHOS
ET
NIsolated mitochondriaHuman
Manoharan 2018 Thesis2018Manoharan N (2018) Characterization of mitochondrial respiration in atlantic salmon (Salmo salar) fed with glutamate and succinate enhanced diet. Master's Thesis 52.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateFishesHeart
Liver
Belosludtsev 2018 Biochemistry (Mosc)2018Belosludtsev KN, Belosludtseva NV, Tenkov KS, Sharapov VA, Kosareva EA, Dubinin MV (2018) Effect of dequalinium on respiration and the inner membrane permeability of rat liver mitochondria. Biochemistry (Mosc) 12:121–27.OXPHOSROXIsolated mitochondriaRatLiver
Vinel 2018 Nat Med2018Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradere JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C (2018) The exerkine apelin reverses age-associated sarcopenia. Nat Med 24:1360-71.OXPHOSN
S
Permeabilized tissueMouseSkeletal muscle
Wang 2018 J Nutr Biochem2018Wang Y, Fouret G, Bonafos B, Blachnio-Zabielska A, Leroy T, Crouzier D, Barea B, Gaillet S, Moro C, Lecomte J, Coudray C, Feillet-Coudray C (2018) Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats. J Nutr Biochem 64:182-97.OXPHOS
LEAK
N
NS
Isolated mitochondriaRatSkeletal muscle
Cejvanovic 2018 Free Radic Biol Med2018Cejvanovic V, Kjær LK, Bergholdt HKM, Torp-Pedersen A, Henriksen T, Weimann A, Ellervik C, Poulsen HE (2018) Iron induced RNA-oxidation in the general population and in mouse tissue. Free Radic Biol Med 115:127-35.OXPHOSN
NS
Permeabilized tissueMouseSkeletal muscle
Dechandt 2018 Am J Physiol Regul Integr Comp Physiol2018Dechandt CR, Vicentini TM, Lanfredi GP, da Silva RMP Jr, Espreafico EM, de Oliveira JAC, Faça VM, Garcia-Cairasco N, Alberici LC (2018) The highly efficient power house in the Wistar Audiogenic Rat (WAR), an epileptic rat strain. Am J Physiol Regul Integr Comp Physiol 316:R243-R254.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissue
Isolated mitochondria
RatHeart
Skeletal muscle
Liver
Flis 2018 Oxid Med Cell Longev2018Flis DJ, Dzik K, Kaczor JJ, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2018) Swim training modulates skeletal muscle energy metabolism, oxidative stress, and mitochondrial cholesterol content in amyotrophic lateral sclerosis mice. Oxid Med Cell Longev 5940748.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Lu 2018 Cell Rep2018Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H*, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Davis 2018 FASEB J2018Davis RAH, Deemer SE, Bergeron JM, Little JT, Warren JL, Fisher G, Smith DL Jr, Fontaine KR, Dickinson SL, Allison DB, Plaisance EP (2018) Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet. FASEB J 33:2409-21.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Monaco 2018 Am J Physiol Regul Integr Comp Physiol2018Monaco CMF, Miotto PM, Huber JS, van Loon LJC, Simpson JA, Holloway GP (2018) Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats. Am J Physiol Regul Integr Comp Physiol 315:R191-R204.LEAK
OXPHOS
N
NS
Permeabilized tissue
Isolated mitochondria
RatHeart
Andriamihaja 2018 Mol Metab2018Andriamihaja M, Lan A, Beaumont M, Grauso M, Gotteland M, Pastene E, Cires MJ, Carrasco‑Pozo C, Tomé D, Blachier F (2018) Proanthocyanidin‑containing polyphenol extracts from fruits prevent the inhibitory effect of hydrogen sulfide on human colonocyte oxygen consumption. Mol Metab 12:39-47.OXPHOSIntact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Sprenger 2018 EMBO Mol Med2018Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2018) Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med 11:e9288.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseNervous system
Trumbeckaite 2018 J Bioenerg Biomembr2018Trumbeckaite S, Cesna V, Jasukaitiene A, Baniene R, Gulbinas A (2018) Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines. J Bioenerg Biomembr 50:329-38.OXPHOSN
S
Permeabilized cellsHumanOther cell lines
Sumbalova 2018 Recent Advances Mitochondr Med Coenzyme Q102018Sumbalová Z, Garcia-Souza LF, Cizmarova B, Volani C, Gnaiger E (2018) Analysis of mitochondrial function in human blood cells. In: Recent advances in mitochondrial medicine and Coenzyme Q10. Gvozdjáková A, Cornelissen G, Singh RB eds, Nova Sciences:255-68.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Kahl 2018 Stroke2018Kahl A, Stepanova A, Konrad C, Anderson C, Manfredi G, Zhou P, Iadecola C, Galkin A (2018) Critical role of flavin and glutathione in complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury. Stroke 49:1223-31.LEAK
OXPHOS
CIVHomogenateMouseNervous system
Aparicio-Trejo 2018 Free Radic Biol Med2018Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96.LEAK
OXPHOS
N
S
NS
ROX
Intact cells
Isolated mitochondria
RatKidney
Isohanni 2018 Neurogenetics2018Isohanni P, Carroll CJ, Jackson CB, Pohjanpelto M, Lönnqvist T, Suomalainen A (2018) Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth. Neurogenetics 19:49-53.OXPHOS
ET
N
S
CIV
NS
Permeabilized cellsHumanSkeletal muscle
Blood cells
Fibroblast
Van Erp 2018 Sci Rep2018Van Erp AC, Rebolledo RA, Hoeksma D, Jespersen NR, Ottens PJ, Nørregaard R, Pedersen M, Laustsen C, Burgerhof JGM, Wolters JC, Ciapaite J, Bøtker HE, Leuvenink HGD, Jespersen B (2018) Organ-specific responses during brain death: increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys. Sci Rep 8:4405.OXPHOS
ET
F
N
S
NS
Isolated mitochondriaRatLiver
Kidney
Goswami 2018 Biophys J2018Goswami I, Perry JB, Allen ME, Brown DA, von Spakovsky MR, Verbridge SS (2018) Influence of pulsed electric fields and mitochondria-cytoskeleton interactions on cell respiration. Biophys J 114:2951-64.OXPHOS
ET
NIntact cellsMouseOther cell lines
Real-Hohn 2018 bioRxiv2018Real-Hohn A, Navegantes C, Ramos K, Ramos-Filho D, Cahuê F, Galina A, Salerno V (2018) Hexokinase: a central player in the synergism of high-intensity intermittent exercise and every-other-day intermittent fasting regimen on energy metabolism adaptations. bioRxiv doi: https://doi.org/10.1101/389668.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueRatSkeletal muscle
MitoEAGLE blood cells 12018MitoEAGLE blood cells group (2018) An interlaboratory guide through procedures for mitochondrial respiratory studies with intact and permeabilized peripheral blood mononuclear cells and platelets. - Updated: 2018-02-23LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Urazov 2018 Sovrem Tekhnologii Med2018Urazov MD, Astrakhanova TA, Usenko AV, Mishchenko TA, Schelchkova NA, Kravchenko GA, Vedunova MV, Mitroshina EV (2018) New aspects of central nervous system adaptation to prenatal hypoxia. Sovrem Tekhnologii Med 10:60-68.OXPHOS
LEAK
N
S
NS
Isolated mitochondriaMouseNervous system
Scaini 2018 Eur Neuropsychopharmacol2018Scaini G, Quevedo J, Velligan D, Roberts DL, Raventos H, Walss-Bass C (2018) Second generation antipsychotic-induced mitochondrial alterations: Implications for increased risk of metabolic syndrome in patients with schizophrenia. Eur Neuropsychopharmacol 28:369-80.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Lymphocyte
Perks 2018 Cell Rep2018Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42.LEAK
OXPHOS
ET
N
Gp
S
Isolated mitochondriaMouseHeart
Civiletto 2018 EMBO Mol Med2018Civiletto G, Dogan SA, Cerutti R, Fagiolari G, Moggio M, Lamperti C, Benincá C, Viscomi C, Zeviani M (2018) Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis. EMBO Mol Med 10:e8799.OXPHOSCIV
S
Isolated mitochondriaMouseSkeletal muscle
Paech 2018a Toxicology2018Paech F, Mingard C, Grünig D, Abegg VF, Bouitbir J, Krähenbühl S (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology 395:34-44.ET
LEAK
OXPHOS
CIV
DQ
N
ROX
S
Isolated mitochondria
Permeabilized cells
Human
Mouse
Liver
Other cell lines
Hancock 2018 Elife2018Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M (2018) Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. Elife 7:e41044.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Goncalves 2018 Neurotoxicology2018Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatNervous system
Burtscher 2018 Front Mol Neurosci2018Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C (2018) Proenkephalin derived peptides are involved in the modulation of mitochondrial respiratory control during epileptogenesis. Front Mol Neurosci doi:10.3389/fnmol.2018.00351.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Kappler 2018 Thesis2018Kappler L (2018) Method development for valid high‐resolution profiling of mitochondria and Omics investigation of mitochondrial adaptions to excess energy intake and physical exercise. Dissertation p181.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Skeletal muscle
Liver
Other cell lines
Angebault 2018 Sci Signal2018Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380.LEAK
OXPHOS
N
S
NS
Permeabilized cellsHumanFibroblast
Belosludtsev 2018 Biochim Biophys Acta2018Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2018) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta 1861:288-97.OXPHOSN
S
NS
Isolated mitochondriaRatLiver
Mkrtchyan 2018 Biochim Biophys Acta2018Mkrtchyan GV, Üçal M, Müllebner A, Dumitrescu S, Kames M, Moldzio R, Molcanyi M, Schaefer S, Weidinger A, Schaefer U, Hescheler J, Duvigneau JC, Redl H, Bunik VI, Kozlov AV (2018) Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex. Biochim Biophys Acta 1859:925-31.OXPHOSN
S
HomogenateRatNervous system
Takahashi 2018 Sci Rep2018Takahashi K, Miura Y, Ohsawa I, Shirasawa T, Takahashi M (2018) In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization. Sci Rep 8:15585.OXPHOSNIsolated mitochondriaMouseNervous system
Audia 2018 Basic Res Cardiol2018Audia JP, Yang XM, Crockett ES, Housley N, Haq EU, O'Donnell K, Cohen MV, Downey JM, Alvarez DF (2018) Caspase‑1 inhibition by VX‑765 administered at reperfusion in P2Y12 receptor antagonist‑treated rats provides long‑term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol 113:32.OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueRatHeart
Allard 2018 J Clin Endocrinol Metab2018Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84.OXPHOSF
N
S
Gp
CIV
NS
Permeabilized tissueHumanSkeletal muscle
Hsiao 2018 Anal Biochem2018Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20.OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Intact cellsHumanBlood cells
Burstein 2018 Hum Mol Genet2018Burstein SR, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, Milner TA, Cloonan SM, Lutz C, Barrientos A, Manfredi G (2018) In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet 27:160-77.LEAK
OXPHOS
ET
N
CIV
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Skeletal muscle
Nervous system
HEK
Maurya 2018 Cell Rep2018Maurya SK, Herrera JL, Sahoo SK, Reis FCG, Vega RB, Kelly DP, Periasamy M (2018) Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle. Cell Rep 24:2919-31.OXPHOSN
NS
Permeabilized tissueMouseSkeletal muscle
Rivas 2018 Am J Physiol Endocrinol Metab2018Rivas E, Herndon DN, Porter C, Meyer W, Suman OE. (2018) Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury.. Am J Physiol Endocrinol Metab. 314(3):E232-E240.LEAK
OXPHOS
Permeabilized tissueHumanSkeletal muscle
Wilmanns 2018 Mol Metab2018Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueMouseHeart
Gonzalez-Freire 2018 Aging Cell2018Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L (2018) Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: the Baltimore longitudinal study of aging. Aging Cell 17.LEAK
OXPHOS
NSPermeabilized tissueHumanSkeletal muscle
Papadimitriou 2018 Thesis2018Papadimitriou ID (2018) The influence of ACTN3 R577X genotype on performance and muscle adaptations to a single bout of exercise . PhD Thesis 125.OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Bhaskaran 2018 EMBO Rep2018Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep 19. pii: e45009.LEAK
OXPHOS
N
S
NS
MouseFat
Becker 2018 EMBO Rep2018Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A (2018) CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep 19. pii: e45126.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseLiver
Fat
Pardo 2018 FASEB J2018Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseFat
Nan 2018 Circ Res2018Nan J, Hu H, Sun Y, Zhu L, Wang Y, Zhong Z, Zhao J, Zhang N, Wang Y, Wang Y, Ye J, Zhang L, Hu X, Zhu W, Wang J (2018) TNFR2 stimulation promotes mitochondrial fusion via Stat3- and NF-kB-dependent activation of OPA1 expression. Circ Res 121:392-410.ROUTINE
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaMouseHeart
Niu 2018 Cancer Metab2018Niu X, Chen YJ, Crawford PA, Patti GJ (2018) Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells. Cancer Metab 6:19.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaHumanHeLa
Vatner 2018 Aging Cell2018Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF (2018) Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell 17:e12751.LEAK
OXPHOS
N
S
NS
Intact cellsMouseFat
Lo 2018 Am J Physiol Renal Physiol2018Lo S, MacMillan-Crow LA, Parajuli N (2018) Renal cold storage followed by transplantation impairs proteasome function and subsequently mitochondrial protein homeostasis. Am J Physiol Renal Physiol 316:F42-F53.OXPHOS
LEAK
N
S
ROX
Permeabilized cellsRatKidney
Other cell lines
Khamoui 2018 J Dev Orig Health Dis2018Khamoui AV, Desai M, Ross MG, Rossiter HB (2018) Sex-specific effects of maternal and postweaning high-fat diet on skeletal muscle mitochondrial respiration. J Dev Orig Health Dis 16:1-8.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Ignatenko 2018 Nat Commun2018Ignatenko O, Chilov D, Paetau I, de Miguel E, Jackson CB, Capin G, Paetau A, Terzioglu M, Euro L, Suomalainen A (2018) Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy. Nat Commun 9:70.OXPHOS
ET
N
CIV
NS
HomogenateMouseNervous system
Jang 2018 J Med Toxicol2018Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM (2018) Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol 14:144-51.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Briones-Herrera 2018 Food Chem Toxicol2018Briones-Herrera A, Avila-Rojas SH, Aparicio-Trejo OE, Cristóbal M, León-Contreras JC, Hernández-Pando R, Pinzón E, Pedraza-Chaverri J, Sánchez-Lozada LG, Tapia E (2018) Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Food Chem Toxicol 115:185-97.LEAK
OXPHOS
N
NS
S
Isolated mitochondriaRatKidney
Sirsat 2018 Comp Biochem Physiol A Mol Integr Physiol2018Sirsat SKG, Dzialowski EM (2018) Ontogeny of skeletal and cardiac muscle mitochondria oxygen fluxes in two breeds of chicken. Comp Biochem Physiol A Mol Integr Physiol 215:20-7.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueBirdsHeart
Skeletal muscle
Lund 2018 Acta Physiol (Oxf)2018Lund MT, Larsen S, Hansen M, Courraud J, Floyd AK, Støckel M, Helge JW, Dela F (2018) Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery. Acta Physiol (Oxf) 223:e13032.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Marie 2018 Cell Death Dis2018Marie M, Bigot K, Angebault C, Barrau C, Gondouin P, Pagan D, Fouquet S, Villette T, Sahel JA, Lenaers G, Picaud S (2018) Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells. Cell Death Dis 9:287.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsEndothelial;epithelial;mesothelial cell
Scott 2018 Integr Comp Biol2018Scott GR, Guo KH, Dawson NJ (2018) The mitochondrial basis for adaptive variation in aerobic performance in high-altitude deer mice. Integr Comp Biol 58:506-18.OXPHOS
ET
N
S
CIV
NS
Permeabilized tissue
Isolated mitochondria
MouseHeart
Skeletal muscle
Falcao-Tebas 2018 J Physiol2018Falcão-Tebas F, Kuang J, Arceri C, Kerris JP, Andrikopoulos S, Marin EC, McConell GK (2018) Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by paternal high fat diet. J Physiol 597:121-36.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatSkeletal muscle
Reguis Yadao 2018 Thesis2018Reguis Yadao DR (2018) Smooth muscle cell mitochondrial respiration – effects of aerobic training and type I diabetes. Master's Thesis 71.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueMouseOther cell lines
Song 2018 Proc Natl Acad Sci U S A2018Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, Sweeney G (2018) Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes. Proc Natl Acad Sci U S A 115:1576-81.LEAK
OXPHOS
ET
N
S
NS
Intact cellsRatHeart
Mikulas 2018 Dent Mater2018Mikulás K, Hermann P, Gera I, Komlódi T, Horváth G, Ambrus A, Tretter L (2018) Triethylene glycol dimethacrylate impairs bioenergetic functions and induces oxidative stress in mitochondria via inhibiting respiratory Complex I. Dent Mater 34:e166-e181.OXPHOS
ET
N
S
Isolated mitochondriaGuinea pigNervous system
Tsuda 2018 J Cachexia Sarcopenia Muscle2018Tsuda M, Fukushima A, Matsumoto J, Takada S, Kakutani N, Nambu H, Yamanashi K, Furihata T, Yokota T, Okita K, Kinugawa S, Anzai T (2018) Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure. J Cachexia Sarcopenia Muscle 9:844-59.OXPHOS
LEAK
F
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Cecatto 2018 J Cell Biochem2018Cecatto C, Wajner A, Vargas CR, Wajner SM, Amaral AU, Wajner M (2018) High vulnerability of the heart and liver to 3-hydroxypalmitic acid-induced disruption of mitochondrial functions in intact cell systems. J Cell Biochem 119:7678-86.LEAK
OXPHOS
ET
NIntact cells
Permeabilized cells
RatHeart
Nervous system
Liver
Valentine 2018 J Gerontol A Biol Sci Med Sci2018Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N (2018) NFκB regulates muscle development and mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Thrush 2018 Int J Obes (Lond)2018Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack R, Al-Dirbashi OY, Dent R, McPherson R, Harper ME (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond) 42:353-62.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Cree-Green 2018 Diabetes2018Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, Mcclatchey PM, Bauer TA, Regensteiner JG, Reusch JEB (2018) Supplemental oxygen improves in-vivo mitochondrial oxidative phosphorylation flux in sedentary obese adults with type 2 diabetes. Diabetes 67:1369-79.ET
LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Ounpuu 2018 Biochem Cell Biol2018Ounpuu L, Truu L, Shevchuk I, Chekulayev V, Klepinin A, Koit A, Tepp K, Puurand M, Rebane-Klemm E, Käämbre T (2018) Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochem Cell Biol [Epub ahead of print].LEAK
OXPHOS
CIV
N
ROX
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Brunetta 2018 Exp Physiol2018Brunetta HS, de Paula GC, de Oliveira J, Martins EL, Dos Santos GJ, Filho AG, Rafacho A, de Bem AF, Nunes EA (2018) Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice. Exp Physiol 104:306-21.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Carter 2018 J Appl Physiol (1985)2018Carter HN, Pauly M, Tryon LD, Hood DA (2018) Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle. J Appl Physiol (1985) 124:1605-15.OXPHOSNIntact cellsRatSkeletal muscle
Marinho 2018 Evid Based Complement Alternat Med2018Marinho PC, Vieira AB, Pereira PG, Rabelo K, Ciambarella BT, Nascimento ALR, Cortez E, Moura AS, Guimarães FV, Martins MA, Barquero G, Ferreira RN, de Carvalho JJ (2018) Capybara oil improves hepatic mitochondrial dysfunction, steatosis, and inflammation in a murine model of nonalcoholic fatty liver disease. Evid Based Complement Alternat Med 2018:4956079.LEAK
OXPHOS
Intact cellsMouseLiver
Laouafa 2018 Adv Exp Med Biol2018Laouafa S, Roussel D, Marcouiller F, Soliz J, Bairam A, Joseph V (2018) Role of estradiol receptor beta (ERβ) on arterial pressure, respiratory chemoreflex and mitochondrial function in young and aged female mice. Adv Exp Med Biol 1071:115-27.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueMouseNervous system
Bricambert 2018 Nat Commun2018Bricambert J, Alves-Guerra MC, Esteves P, Prip-Buus C, Bertrand-Michel J, Guillou H, Chang CJ, Vander Wal MN, Canonne-Hergaux F, Mathurin P, Raverdy V, Pattou F, Girard J, Postic C, Dentin R (2018) The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun 9:2092.ET
LEAK
OXPHOS
N
S
HomogenateMouseLiver
Fisher-Wellman 2018 Cell Rep2018Fisher-Wellman KH, Davidson MT, Narowski TM, Lin CT, Koves TR, Muoio DM (2018) Mitochondrial diagnostics: A multiplexed assay platform for comprehensive assessment of mitochondrial energy fluxes. Cell Rep 24:3593-606.LEAK
OXPHOS
F
N
S
Isolated mitochondriaMouseHeart
Skeletal muscle
Woodman 2018 FASEB J2018Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2018) Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver. FASEB J 32:3254-63.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateRatLiver
Kidney
Zimin 2018 Br J Anaesth2018Zimin PI, Woods CB, Kayser EB, Ramirez JM, Morgan PG, Sedensky MM (2018) Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I. Br J Anaesth 120:1019-32.OXPHOS
LEAK
N
S
ROX
Isolated mitochondriaMouseNervous system
Okerblom 2018 Proc Biol Sci2018Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC (2018) Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proc Biol Sci 285:20181656.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Stein 2018 Cell Rep2018Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL (2018) Mitoregulin: A lncRNA-encoded microprotein that supports mitochondrial supercomplexes and respiratory efficiency. Cell Rep 23:3710-20.LEAK
OXPHOS
F
N
Permeabilized tissueHumanHeart
Skeletal muscle
Havird 2018 bioRxiv2018Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2018) Assessing mitochondrial function in angiosperms with highly divergent mitochondrial genomes. bioRxiv doi: https://doi.org/10.1101/448902.LEAK
OXPHOS
N
S
CIV
NS
Isolated mitochondriaPlants
Distefano 2018 J Cachexia Sarcopenia Muscle2018Distefano G, Standley RA, Zhang X, Carnero EA, Yi F, Cornnell HH, Coen PM (2018) Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle 9:279-94.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Arena 2018 Mol Cell2018Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609.OXPHOSN
S
NS
Permeabilized cellsHumanLung;gill
Other cell lines
Ahn 2018 Redox Biol2018Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47-58.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Francisco 2018 J Neurochem2018Francisco A, Ronchi JA, Navarro CDC, Figueira TR, Castilho RF (2018) Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. J Neurochem 147:663-77.LEAK
OXPHOS
NIsolated mitochondriaMouseNervous system
Paech 2018b Toxicology2018Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23.LEAK
OXPHOS
ET
N
S
DQ
CIV
ROX
NS
Isolated mitochondriaMouseLiver
Campbell 2018 Free Radic Biol Med2018Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, Qian WJ, Marcinek DJ (2018) Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med 134:268-81.LEAK
OXPHOS
CIV
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Hedges 2018 FASEB J2018Hedges CP, Bishop DJ, Hickey AJR (2018) Voluntary wheel running prevents the acidosis-induced decrease in skeletal muscle mitochondrial reactive oxygen species emission. FASEB J 33:4996-5004.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Martins 2018 Comp Biochem Physiol B Biochem Mol Biol2018Martins EL, Ricardo JC, de-Souza-Ferreira E, Camacho-Pereira J, Ramos-Filho D, Galina A (2018) Rapid regulation of substrate use for oxidative phosphorylation during a single session of high intensity interval or aerobic exercises in different rat skeletal muscles. Comp Biochem Physiol B Biochem Mol Biol 217:40-50.ET
LEAK
OXPHOS
F
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Kim 2018 Free Radic Biol Med2018Kim M, Stepanova A, Niatsetskaya Z, Sosunov S, Arndt S, Murphy MP, Galkin A, Ten VS (2018) Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury. Free Radic Biol Med 124:517-24.OXPHOSN
S
Isolated mitochondriaMouseNervous system
Kong 2018 Proteomics2018Kong D, Tian X, Li Y*, Zhang S, Cheng Y, Huo L, Ma H, Yang Z, Ren L, Zhang M, Zhang W (2018) Revealing the inhibitory effect of ginseng on mitochondrial respiration through synaptosomal proteomics. Proteomics 18:e1700354.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Rocha 2018 J Physiol Biochem2018Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A (2018) Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice. J Physiol Biochem 75:65-72.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissueMouseHeart
Manakov 2018 J Physiol Biochem2018Manakov D, Kolar D, Zurmanova J, Pravenec M, Novotny J (2018) Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36. J Physiol Biochem 74:479-89.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Isolated mitochondriaRatHeart
Larsen 2018 Physiol Rep2018Larsen S, Lundby AM, Dandanell S, Oberholzer L, Keiser S, Andersen AB, Haider T, Lundby C (2018) Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males. Physiol Rep 6:e13793.OXPHOS
ET
LEAK
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Temelie 2018 Oxid Med Cell Longev2018Temelie M, Savu DI, Moisoi N (2018) Intracellular and intercellular signalling mechanisms following DNA damage are modulated by PINK1. Oxid Med Cell Longev 1391387.OXPHOS
ET
N
NS
Permeabilized cellsHuman
Mouse
Nervous system
Other cell lines
Fibroblast
Kovalcikova 2018 Thesis2018Kovalčíková J (2018) Functional characterisation of new components of mitochondrial proteome. PhD Thesis p104.LEAK
OXPHOS
ET
N
NS
HomogenateMouse
Rat
Heart
Liver
Hoffmann 2018 Sci Rep2018Hoffmann C, Höckele S, Kappler L, Hrabĕ de Angelis M, Häring HU, Weigert C (2018) The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells. Sci Rep 8:737.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cellsHumanSkeletal muscle
Fouret 2018 Br J Nutr2018Fouret G, Gaillet S, Lecomte J, Bonafos B, Djohan F, Barea B, Badia E, Coudray C, Feillet-Coudray C (2018) 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet. Br J Nutr 119:368-80.OXPHOSN
NS
RatLiver
Zdralevic 2018 J Biol Chem2018Ždralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouysségur J, Kreutz M (2018) Double genetic disruption of lactate dehydrogenase A and B is required to ablate the 'Warburg effect' restricting tumor growth to oxidative metabolism. J Biol Chem 293:15947-61.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Logan 2018 Thesis2018Logan C (2018) Nitrate and nitrite differentially affect respiration in zebrafish during exercise. Honors Baccalaureate of Science in Nutrition p44.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaZebrafishSkeletal muscle
Friederich 2018 Nat Commun2018Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B Jr, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK (2018) Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nat Commun 9:4065.ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
Human
Fungi
Fibroblast
Chicco 2018 J Biol Chem2018Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC (2018) Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem 293:6659-71.LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueHumanSkeletal muscle
Wuest 2018 Cell Metab2018Wüst S, Dröse S, Heidler J, Wittig I, Klockner I, Franko A, Bonke E, Günther S, Gärtner U, Boettger T, Braun T (2018) Metabolic maturation during muscle stem cell differentiation is achieved by miR-1/133a-mediated inhibition of the Dlk1-Dio3 mega gene cluster. Cell Metab 27:1026-39.OXPHOSN
S
CIV
Intact cellsMouseSkeletal muscle
Santos Bertolini 2018 Thesis2018Santos Bertolini M (2018) Functional study of MICU1 and MICU2 proteins in calcium signaling of Trypanosoma cruzi. Master's Thesis 108.LEAK
OXPHOS
ET
SPermeabilized cellsProtists
Keller 2018 Oxid Med Cell Longev2018Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB (2018) Sepiapterin improves vascular reactivity and insulin-stimulated glucose in wistar rats. Oxid Med Cell Longev 2018:7363485.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueRatEndothelial;epithelial;mesothelial cell
Gam 2018 Acta Diabetol2018Gam CMBF, Mortensen OH, Larsen LH, Poulsen SS, Qvortrup K, Mathiesen ER, Damm P, Quistorff B (2018) Diabetes, myometrium, and mitochondria in pregnant women at term. Acta Diabetol 55:999-1010.LEAK
OXPHOS
F
N
NS
S
Isolated mitochondriaHumanGenital
Thompson 2018 EMBO Mol Med2018Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW (2018) OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med 10:e9060.LEAK
OXPHOS
N
CIV
ROX
Gp
Other combinations
HomogenateDrosophila
Siira 2018 EMBO Rep2018Siira SJ, Rossetti G, Richman TR, Perks K, Ermer JA, Kuznetsova I, Hughes L, Shearwood AJ, Viola HM, Hool LC, Rackham O, Filipovska A (2018) Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z. EMBO Rep 19:e46198.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Monaco 2018b Diabetologia2018Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ, Perry CGR (2018) Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia 61:1411-23.OXPHOSN
S
Gp
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Merz 2018 Intensive Care Med Exp2018Merz T, Wepler M, Nußbaum B, Vogt J, Calzia E, Wang R, Szabo C, Radermacher P, McCook O (2018) Cystathionine-γ-lyase expression is associated with mitochondrial respiration during sepsis-induced acute kidney injury in swine with atherosclerosis. Intensive Care Med Exp 6:43.ET
LEAK
OXPHOS
F
N
NS
ROX
S
HomogenatePigKidney
Nacarelli 2018 Geroscience2018Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience [Epub ahead of print].OXPHOSF
N
S
NS
Isolated mitochondriaHumanHeart
Fibroblast
Dela 2018 Acta Physiol (Oxf)2018Dela F, Ingersen A, Andersen NB, Nielsen MB, Petersen HHH, Hansen CN, Larsen S, Wojtaszewski J, Helge JW (2018) Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes. Acta Physiol (Oxf) 226:e13245.OXPHOS
LEAK
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Dawson 2018 Acta Physiol (Oxf)2018Dawson NJ, Lyons SA, Henry DA, Scott GR (2018) Effects of chronic hypoxia on diaphragm function in deer mice native to high altitude. Acta Physiol (Oxf) 223:e13030.LEAK
OXPHOS
N
CIV
NS
Permeabilized tissueOther mammalsSkeletal muscle
Sims 2018 JCI Insight2018Sims CA, Guan Y, Mukherjee S, Singh K, Botolin P, Davila A Jr, Baur JA (2018) Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock. JCI Insight 3:120182.OXPHOSN
S
CIV
ROX
Permeabilized cells
Isolated mitochondria
RatLiver
Kidney
Baaten 2018 Haematologica2018Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ (2018) Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica 103:1557-67.OXPHOSN
NS
Intact cellsHumanBlood cells
Platelet
Champigny 2018 Mar Drugs2018Champigny CM, Cormier RPJ, Simard CJ, St-Coeur PD, Fortin S, Pichaud N (2018) Omega-3 monoacylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: insights from Drosophila melanogaster. Mar Drugs 16:E453.LEAK
OXPHOS
ET
N
S
NS
ROX
Gp
Permeabilized tissueDrosophila
Bjoerndal 2018 Nutr Metab (Lond)2018Bjørndal B, Alterås EK, Lindquist C, Svardal A, Skorve J, Berge RK (2018) Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice. Nutr Metab (Lond) 15:10.OXPHOS
ET
F
N
ROX
HomogenateMouseLiver
Garcia-Roche 2018 Redox Biol2018García-Roche M, Casal A, Carriquiry M, Radi R, Celia Quijano C, Cassina A (2018) Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies. Redox Biol 17:207-12.LEAK
OXPHOS
ET
N
NS
ROX
S
Permeabilized tissueRat
Bovines
Liver
Trewin 2018 Am J Physiol Regul Integr Comp Physiol2018Trewin AJ, Parker L, Shaw CS, Hiam D, Garnham AP, Levinger I, McConell GK, Stepto NK (2018) Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration and cell signaling as endurance exercise even with less work. Am J Physiol Regul Integr Comp Physiol 315:R1003-R1016.ET
LEAK
OXPHOS
N
NS
ROX
S
Permeabilized tissueHumanSkeletal muscle
Salin 2018 Integr Comp Biol2018Salin K, Villasevil EM, Anderson GJ, Selman C, Chinopoulos C, Metcalfe NB (2018) The RCR and ATP/O indices can give contradictory messages about mitochondrial efficiency. Integr Comp Biol 58:486-94.LEAK
OXPHOS
N
S
NS
ROX
HomogenateFishesLiver
Souza 2018 Sci Rep2018Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep 8:17772.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueRatHeart
Skeletal muscle
Rundle 2018 Environ Sci Technol2018Rundle K, Sharaf M, Stevens D, Kamunde C, Van Den Heuvel MR (2018) Oil sands-derived naphthenic acids are oxidative uncouplers and impair electron transport in isolated mitochondria. Environ Sci Technol 52:10803-11.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaFishesLiver
Eimre 2018 Oxid Med Cell Longev2018Eimre M, Paju K, Peet N, Kadaja L, Tarrend M, Kasvandik S, Seppet J, Ivask M, Orlova E, Kõks S (2018) Increased mitochondrial protein levels and bioenergetics in the musculus rectus femoris of Wfs1-deficient mice. Oxid Med Cell Longev 2018:3175313.OXPHOS
LEAK
N
S
CIV
ROX
Permeabilized tissueMouseSkeletal muscle
Treberg 2018 Comp Biochem Physiol B Biochem Mol Biol2018Treberg JR, Braun K, Zacharias P, Kroeker K (2018) Multidimensional mitochondrial energetics: Application to the study of electron leak and hydrogen peroxide metabolism. Comp Biochem Physiol B Biochem Mol Biol 224:121-28.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouse
Rat
Skeletal muscle
Schiffer 2018 Am J Physiol Renal Physiol2018Schiffer TA, Gustafsson H, Palm F (2018) Kidney outer medulla mitochondria are more efficient compared with cortex mitochondria as a strategy to sustain ATP production in a suboptimal environment. Am J Physiol Renal Physiol 315:F677-F681.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatKidney
Chung 2018 Integr Comp Biol2018Chung DJ, Healy TM, McKenzie JL, Chicco AJ, Sparagna GC, Schulte PM (2018) Mitochondria, temperature, and the pace of life. Integr Comp Biol 58:578-90.OXPHOSNPermeabilized tissue
Isolated mitochondria
FishesHeart
Nervous system
Liver
Fischer 2018 BMC Musculoskelet Disord2018Fischer MJ, Horvath G, Krismer M, Gnaiger E, Goebel G, Pesta DH (2018) Evaluation of mitochondrial function in chronic myofascial trigger points - a prospective cohort pilot study using high-resolution respirometry. BMC Musculoskelet Disord 19:388.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Musi 2018 Aging Cell2018Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2018) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.LEAK
OXPHOS
ET
F
N
S
NS
HomogenateMouseNervous system
Stepanova 2018 J Cereb Blood Flow Metab2018Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A (2018) Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. J Cereb Blood Flow Metab 39:1790-802.OXPHOS
ET
LEAK
N
S
ROX
Isolated mitochondriaRatNervous system
Wen 2018 PLOS Pathog2018Wen JJ, Yin YW, Garg NJ (2018) PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance. PLOS Pathog 14:e1007065.OXPHOSN
S
NS
Permeabilized tissueMouseHeart
Other cell lines
Tripodi 2018 Biochim Biophys Acta Mol Cell Res2018Tripodi F, Castoldi A, Nicastro R, Reghellin V, Lombardi L, Airoldi C, Falletta E, Maffioli E, Scarcia P, Palmieri L, Alberghina L, Agrimi G, Tedeschi G, Coccetti P (2018) Methionine supplementation stimulates mitochondrial respiration. Biochim Biophys Acta Mol Cell Res 1865:1901-13.OXPHOS
LEAK
N
S
Isolated mitochondriaSaccharomyces cerevisiae
Zhang 2018 Cardiovasc Diabetol2018Zhang X, Zhang Z, Yang Y, Suo Y, Liu R, Qiu J, Zhao Y, Jiang N, Liu C, Tse G, Li G, Liu T (2018) Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits. Cardiovasc Diabetol 17:160.OXPHOS
LEAK
NIsolated mitochondriaRabbitHeart
Smenes 2018 Interact Cardiovasc Thorac Surg2018Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanHeart
Silaidos 2018 Biol Sex Differ2018Silaidos C, Pilatus U, Grewal R, Matura S, Lienerth B, Pantel J, Eckert GP (2018) Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain. Biol Sex Differ 9:34.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanNervous system
Blood cells
Tyagi 2018 Sci Rep2018Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S (2018) SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep 8:17547.ET
LEAK
OXPHOS
N
NS
HomogenateMouseNervous system
Bryant 2018 Thesis2018Bryant HJ (2018) The role of mitochondrial uncoupling in temperature responses in Atlantic killifish, Fundulus heteroclitus. Master's Thesis p126.LEAK
OXPHOS
ET
F
S
Isolated mitochondriaFishesNervous system
Liver
Fat
Bradley 2018 Biochim Biophys Acta2018Bradley RM, Bloemberg D, Aristizabal Henao JJ, Hashemi A, Mitchell AS, Fajardo VA, Bellissimo C, Mardian EB, Bombardier E, Paré MF, Moes KA, Stark KD, Tupling AR, Quadrilatero J, Duncan RE (2018) Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fiber type in extensor digitorum longus muscle. Biochim Biophys Acta 1863:700-11.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Wang 2018 Cell Physiol Biochem2018Wang P, Hu Y, Yao D, Li Y (2018) Omi/HtrA2 regulates a aitochondria-dependent apoptotic pathway in a murine model of septic encephalopathy. Cell Physiol Biochem 49:2163-73.LEAK
OXPHOS
N
S
CIV
RatNervous system
Casal 2018 J Anim Sci2018Casal A, Garcia-Roche M, Navajas EA, Cassina A, Carriquiry M (2018) Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes. J Anim Sci 96:4431-43.LEAK
OXPHOS
ET
N
S
ROX
Intact cellsBovinesLiver
Reutzel 2018 Oxid Med Cell Longev2018Reutzel M, Grewal R, Silaidos C, Zotzel J, Marx S, Tretzel J, Eckert GP (2018) Effects of long-term treatment with a blend of highly purified olive secoiridoids on cognition and brain ATP levels in aged NMRI mice. Oxid Med Cell Longev 2018:4070935.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Ko 2018 Pflugers Arch2018Ko TH, Marquez JC, Kim HK, Jeong SH, Lee S, Youm JB, Song IS, Seo DY, Kim HJ, Won DN, Cho KI, Choi MG, Rhee BD, Ko KS, Kim N, Won JC, Han J (2018) Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts. Pflugers Arch 470:263-75.LEAK
OXPHOS
N
ROX
Isolated mitochondriaRatHeart
Hedges 2018 J Appl Physiol (1985)2018Hedges CP, Woodhead JST, Wang HW, Mitchell CJ, Cameron-Smith D, Hickey AJR, Merry TL (2018) Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. J Appl Physiol (1985) 126:454-61.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Blood cells
Lymphocyte
Meinild Lundby 2018 Acta Physiol (Oxf)2018Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C (2018) Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis. Acta Physiol (Oxf) 222, e12905.OXPHOS
LEAK
ET
NS
F
N
CIV
Permeabilized tissueHumanSkeletal muscle
Stepanova 2018 J Neurochem2018Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2018) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem 148:731-45.LEAK
OXPHOS
N
S
Gp
NS
ROX
Isolated mitochondriaMouseNervous system
Kang 2018 Exp Mol Med2018Kang YC, Son M, Kang S, Im S, Piao Y, Lim KS, Song MY, Park KS, Kim YH, Pak YK (2018) Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson's disease models. Exp Mol Med 50:105.OXPHOSNIsolated mitochondriaHumanNervous system
Toledo 2018 Obesity (Silver Spring)2018Toledo FGS, Dubé JJ, Goodpaster BH, Stefanovic-Racic M, Coen PM, DeLany JP (2018) Mitochondrial respiration is associated with lower energy expenditure and lower aerobic capacity in African American women. Obesity (Silver Spring) 26:903-9.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Arnoux 2018 Elife2018Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A (2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife 7:e38744.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Ale-Agha 2018 PLOS Biol2018Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Köhrer K, Deenen R, Unfried K, Altschmied J, Haendeler J (2018) CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system - New mode of action for caffeine. PLOS Biol 6:e2004408.OXPHOSN
S
CIV
Isolated mitochondriaMouseHeart
De Medeiros 2018 Biochim Biophys Acta2018de Medeiros WA, da Silva LA, Dall'Igna DM, Michels M, Manfredini A, Dos Santos Cardoso J, Constantino L, Scaini G, Vuolo F, Streck EL, Ritter C, Dal-Pizzol F (2018) N-acetylcysteine effects on a murine model of chronic critical limb ischemia. Biochim Biophys Acta 1864:454-63.OXPHOSF
N
NS
Rat
Dohlmann 2018 Physiol Rep2018Dohlmann TL, Hindsø M, Dela F, Helge JW, Larsen S (2018) High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle. Physiol Rep 6:e13857.OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Fat
Carter 2018 J Physiol2018Carter HN, Kim Y, Erlich AT, Zarrin-Khat D, Hood DA (2018) Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. J Physiol 596:3567-84.LEAK
OXPHOS
N
NS
Permeabilized tissueRatSkeletal muscle
Ryan 2018 JCI Insight2018Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM (2018) Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants. JCI Insight 3:123235.OXPHOS
LEAK
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Mavroudis 2018 Eur J Cardiothorac Surg2018Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ (2018) Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. Eur J Cardiothorac Surg 54:162-68.LEAK
ET
OXPHOS
N
S
CIV
NS
ROX
HomogenatePigNervous system
Zhuang 2018 Thesis2018Zhuang Y (2018) Potential application of alternative oxidase (AOX) in neurodegenerative diseases. Master's Thesis p71.OXPHOSN
S
CIV
ROX
Isolated mitochondriaMouseNervous system
Budai 2018 Br J Surg2018Budai A, Horváth G, Tretter L, Radák Z, Koltai E, Bori Z, Torma F, Lukáts Á, Röhlich P, Szijártó A, Fülöp A (2018) Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model. Br J Surg 106:120-31.OXPHOSN
S
Isolated mitochondriaRatLiver
Durand 2018 Blood Purif2018Durand PY, Nicco C, Serteyn D, Attaf D, Edeas M (2018) Microbiota quality and mitochondrial activity link with occurrence of muscle cramps in hemodialysis patients using citrate dialysate: a pilot study. Blood Purif 46:301-8.LEAK
ROUTINE
OXPHOS
ET
S
ROX
Intact cellsHumanPlatelet
Docherty 2018 Atherosclerosis2018Docherty CK, Carswell A, Friel E, Mercer JR (2018) Impaired mitochondrial respiration in human carotid plaque atherosclerosis: A potential role for Pink1 in vascular smooth muscle cell energetics. Atherosclerosis 268:1-11.OXPHOSN
CIV
NS
ROX
Permeabilized tissueHumanEndothelial;epithelial;mesothelial cell
Coleman 2018 Sci Rep2018Coleman V, Sa-Nguanmoo P, Koenig J, Schulz TJ, Grune T, Klaus S, Kipp AP, Ost M (2018) Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci Rep 8:2446.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Teulier 2018 J Fish Biol2018Teulier L, Guillard L, Leon C, Romestaing C, Voituron Y (2018) Consequences of electroshock-induced narcosis in fish muscle: from mitochondria to swim performance. J Fish Biol 92:1805-18.OXPHOS
ET
N
NS
ROX
Intact cellsFishes
Zebrafish
Skeletal muscle
Cardinale 2018 Thesis2018Cardinale DA (2018) The significance of mitochondrial respiratory function in regulating oxygen uptake and performance in humans. PhD Thesis 99.LEAK
OXPHOS
F
N
NS
Isolated mitochondria
Permeabilized tissue
HumanSkeletal muscle
Dandanell 2018 Scand J Med Sci Sports2018Dandanell S, Meinild-Lundby AK, Andersen AB, Lang PF, Oberholzer L, Keiser S, Robach P, Larsen S, Rønnestad BR, Lundby C (2018) Determinants of maximal whole-body fat oxidation in elite cross-country skiers: role of skeletal muscle mitochondria. Scand J Med Sci Sports 28:2494-504.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Hafen 2018 J Appl Physiol (1985)2018Hafen PS, Preece CN, Sorensen JR, Hancock CR, Hyldahl RD (2018) Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle. J Appl Physiol (1985) 125:1447-55.OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Gorgey 2018 Eur J Appl Physiol2018Gorgey AS, Witt O, O'Brien L, Cardozo C, Chen Q, Lesnefsky EJ, Graham ZA (2018) Mitochondrial health and muscle plasticity after spinal cord injury. Eur J Appl Physiol 119:315-31.OXPHOS
LEAK
N
S
CIV
NS
Permeabilized tissueHumanSkeletal muscle
Kauppila 2018 Thesis2018Kauppila JHK (2018) Generating mammalian mitochondrial disease models with mitochondrial DNA mutations. PhD Thesis p120.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Liver
Von Schulze 2018 J Physiol2018Von Schulze A, McCoin CS, Onyekere C, Allen J, Geiger P, Dorn GW, Morris EM, Thyfault JP (2018) Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α, and BNIP3 mediated mitophagy. J Physiol 596:6157-71.OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Komlodi 2018 Methods Mol Biol2018Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Human
Mouse
Skeletal muscle
HEK
Lee 2018 Neurol Genet2018Lee RG, Sedghi M, Salari M, Shearwood AJ, Stentenbach M, Kariminejad A, Goullee H, Rackham O, Laing NG, Tajsharghi H, Filipovska A (2018) Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction. Neurol Genet 4:e276.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized cellsHumanFibroblast
Britto 2018 BMC Biol2018Britto FA, Cortade F, Belloum Y, Blaquière M, Gallot YS, Docquier A, Pagano AF, Jublanc E, Bendridi N, Koechlin-Ramonatxo C, Chabi B, Francaux M, Casas F, Freyssenet D, Rieusset J, Giorgetti-Peraldi S, Carnac G, Ollendorff V, Favier FB (2018) Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. BMC Biol 16:65.LEAK
OXPHOS
F
N
NS
Other combinations
Isolated mitochondria
Permeabilized cells
MouseSkeletal muscle
Goncalves 2018 Life Sci2018Gonçalves DF, de Carvalho NR, Leite MB, Courtes AA, Hartmann DD, Stefanello ST, da Silva IK, Franco JL, Soares FAA, Dalla Corte CL (2018) Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics. Life Sci 193:234-41.LEAK
OXPHOS
N
S
NS
ROX
HomogenateMouseLiver
Oemer 2018 Proc Nat Acad Sci U S A2018Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Tetri 2018 Front Physiol2018Tetri LH, Diffee GM, Barton GP, Braun RK, Yoder HE, Haraldsdottir K, Eldridge MW, Goss KN (2018) Sex-specific skeletal muscle fatigability and decreased mitochondrial oxidative capacity in adult rats exposed to postnatal hyperoxia. Front Physiol 9:326.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueRatSkeletal muscle
Lobo-Jarne 2018 Cell Rep2018Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99.LEAK
OXPHOS
ET
N
S
NS
ROX
Gp
Permeabilized cellsHumanHEK
Other cell lines
Rampello 2018 Microb Cell2018Rampello NG, Stenger M, Westermann B, Osiewacz HD (2018) Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging. Microb Cell 5:198–207.OXPHOSN
CIV
Isolated mitochondriaFungi
Nielsen 2018 Neurosci Lett2018Nielsen B, Cejvanovic V, Wörtwein G, Hansen AR, Marstal KK, Weimann A, Bjerring PN, Dela F, Poulsen HE, Jørgensen MB (2018) Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neurosci Lett 690:1-5.LEAK
OXPHOS
ET
N
NS
ROX
S
HomogenateRatNervous system
Cruz 2018 Chem Biol Interact2018Cruz LC, Ecker A, Rodrigues NR, Martins IK, Posser T, Maciel FE, Vargas MA, Barbosa NV, Franco JL (2018) Honey protects against wings posture error and molecular changes related to mitochondrial pathways induced by hypoxia/reoxygenation in adult Drosophila melanogaster. Chem Biol Interact 291:245-52.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaDrosophila
Lu 2018 Cell Discov2018Lu Z, Wei X, Sun F, Zhang H, Gao P, Pu Y, Wang A, Chen J, Tong W, Li Q, Zhou X, Yan Z, Zheng H, Yang G, Huang Y, Liu D, Zhu Z (2018) Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery. Cell Discov 4:58.OXPHOS
ET
F
N
ROX
Isolated mitochondriaRatSkeletal muscle
Liver
Dejos 2018 Sci Rep2018Dejos C, Kuny S, Han WH, Capel H, Lemieux H, Sauvé Y (2018) Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3). Sci Rep 8:5944.OXPHOSN
S
CIV
NS
ROX
HomogenateMouseEndothelial;epithelial;mesothelial cell
Jelenik 2018 Mol Metab2018Jelenik T, Dille M, Müller-Lühlhoff S, Kabra DG, Zhou Z, Binsch C, Hartwig S, Lehr S, Chadt A, Peters EMJ, Kruse J, Roden M, Al-Hasani H, Castañeda TR (2018) FGF21 regulates insulin sensitivity following long-term chronic stress. Mol Metab 16:126-38.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Groennebaek 2018 Front Physiol2018Groennebaek T, Jespersen NR, Jakobsgaard JE, Sieljacks P, Wang J, Rindom E, Musci RV, Bøtker HE, Hamilton KL, Miller BF, de Paoli FV, Vissing K (2018) Skeletal muscle mitochondrial protein synthesis and respiration increase with low-load blood flow restricted as well as high-load resistance training. Front Physiol 9:1796.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Brouwers 2018 Front Physiol2018Brouwers B, Stephens NA, Costford SR, Hopf ME, Ayala JE, Yi F, Xie H, Li JL, Gardell SJ, Sparks LM, Smith SR (2018) Elevated nicotinamide phosphoribosyl transferase in skeletal muscle augments exercise performance and mitochondrial respiratory capacity following exercise training. Front Physiol 9:704.OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Stanford 2018 Cell Metab2018Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ (2018) 12,13-diHOME: an exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab 27:1111-20.LEAK
OXPHOS
ET
F
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Tosi 2018 J Bioenerg Biomembr2018Tosi I, Art T, Cassart D, Farnir F, Ceusters J, Serteyn D, Lemieux H, Votion DM (2018) Altered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy. J Bioenerg Biomembr 50:379-90.ET
OXPHOS
N
NS
ROX
S
Permeabilized tissueHorseSkeletal muscle
Burney 2018 Thesis2018Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Intact cells
RatOther cell lines
Cardinale 2018 Physiol Rep2018Cardinale DA, Gejl KD, Ørtenblad N, Ekblom B, Blomstrand E, Larsen FJ (2018) Reliability of maximal mitochondrial oxidative phosphorylation in permeabilized fibers from the vastus lateralis employing high-resolution respirometry. Physiol Rep 6. doi: 10.14814/phy2.13611.LEAK
OXPHOS
F
N
Permeabilized tissueHumanSkeletal muscle
Cardinale 2018 Front Physiol2018Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133.OXPHOSF
N
NS
Isolated mitochondriaHumanSkeletal muscle
Ferri 2018 Eur J Appl Physiol2018Ferri A, Panariti A, Miserocchi G, Rocchetti M, Buoli Comani G, Rivolta I, Bishop DJ (2018) Tissue specificity of mitochondrial adaptations in rats after 4 weeks of normobaric hypoxia. Eur J Appl Physiol 118:1641-52.LEAK
OXPHOS
NPermeabilized tissueRatHeart
Skeletal muscle
Holland 2018 Cell Death Dis2018Holland OJ, Cuffe JSM, Dekker Nitert M, Callaway L, Kwan Cheung KA, Radenkovic F, Perkins AV (2018) Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death Dis 9:1150.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanGenital
Gratl 2018 Thesis2018Gratl A (2018) High-resolution respirometry for measurement of mitochondrial function in PAD patients before and after revascularisation. PhD Thesis 69.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Boutoual 2018 Sci Rep2018Boutoual R, Meseguer S, Villarroya M, Martín-Hernández E, Errami M, Martín MA, Casado M, Armengod ME (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. Sci Rep 8:1163.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Chen 2018 Hum Mol Genet2018Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.OXPHOS
ET
F
N
S
DQ
CIV
NS
Isolated mitochondriaHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Weber 2018 Int J Mol Sci2018Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129.ET
OXPHOS
ROUTINE
F
N
NS
Other combinations
ROX
S
Intact cells
Permeabilized cells
HumanGenital
Park 2018 J Clin Invest2018Park H, He A, Tan M, Johnson JM, Dean JM, Pietka TA, Chen Y, Zhang X, Hsu FF, Razani B, Funai K, Lodhi IJ (2018) Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. J Clin Invest 129:694-711.OXPHOS
ET
LEAK
F
N
S
Permeabilized tissueMouseFat
Astrakhanova 2018 Sovrem Tekhnologii Med2018Astrakhanova ТА, Urazov МD, Usenko АV, Mitroshina ЕV, Mishchenko ТА, Schelchkova NА, Vedunova МV (2018) BDNF-mediated regulation of the brain mitochondria functional state in hypoxia. Sovrem Tekhnologii Med 10:88-94.OXPHOS
LEAK
N
S
Isolated mitochondriaMouseNervous system
Sokolov 2018 Mitochondrion2018Sokolov EP, Sokolova IM (2018) Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45:29-37.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMolluscsLung;gill
Rodriguez-Nuevo 2018 EMBO J2018Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A (2018) Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J 37.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Wefers 2018 Proc Natl Acad Sci U S A2018Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P (2018) Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A 115:7789-94.OXPHOS
ET
F
N
Intact cellsHumanSkeletal muscle
Pape 2018 Nutrients2018Pape JA, Newey CR, Burrell HR, Workman A, Perry K, Bikman BT, Bridgewater LC, Grose JH (2018) Per-Arnt-Sim kinase (PASK) deficiency increases cellular respiration on a standard diet and decreases liver triglyceride accumulation on a western high-fat high-sugar diet. Nutrients 10:1990.OXPHOS
LEAK
NSPermeabilized tissueMouseSkeletal muscle
Liver
Ederer 2018 Int J Mol Sci2018Ederer KA, Jin K, Bouslog S, Wang L, Gorman GS, Rowe GC, Abadir P, Raftery D, Moellering D, Promislow D, Jumbo-Lucioni P, De Luca M (2018) Age- and genotype-specific effects of the angiotensin-converting enzyme inhibitor lisinopril on mitochondrial and metabolic parameters in Drosophila melanogaster. Int J Mol Sci 19:3351.LEAK
OXPHOS
NIsolated mitochondriaDrosophila
Shen 2018 Biosci Rep2018Shen NY, Ng SY, Toepp SL, Ljubicic V (2018) Protein arginine methyltransferase expression and activity during myogenesis. Biosci Rep 38. pii: BSR20171533.OXPHOSN
NS
Permeabilized cellsMouseSkeletal muscle
Barbeau 2018 Biochem J2018Barbeau PA, Miotto PM, Holloway GP (2018) Mitochondrial derived reactive oxygen species influence ADP sensitivity, but not CPT-I substrate sensitivity. Biochem J 475:2997-3008.OXPHOSF
N
NS
Permeabilized tissueMouseSkeletal muscle
Kolb 2018 J Am Soc Nephrol2018Kolb AL, Corridon PR, Zhang S, Xu W, Witzmann FA, Collett JA, Rhodes GJ, Winfree S, Bready D, Pfeffenberger ZJ, Pomerantz JM, Hato T, Nagami GT, Molitoris BA, Basile DP, Atkinson SJ, Bacallao RL (2018) Exogenous gene transmission of isocitrate dehydrogenase 2 mimics ischemic preconditioning protection. J Am Soc Nephrol 29:1154-64.OXPHOSN
NS
Isolated mitochondriaKidney
Cronin 2018 Nature2018Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563:564-68.ROUTINE
OXPHOS
ET
LEAK
N
S
Permeabilized cells
Intact cells
MouseLymphocyte
Karlsson 2018 J Neurotrauma2018Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmér E, Hansson MJ, Margulies S, Kilbaugh T (2018) Neuroprotective effects of cyclosporine in a porcine pre-clinical trial of focal traumatic brain injury. J Neurotrauma [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenatePigNervous system
Rekuviene 2018 Thesis2018Rekuvienė E (2018) Effect of respiratory complex I inhibitors on mitochondrial permeability transition and cell viability during brain ischemia. Doctoral Dissertation 138.LEAK
OXPHOS
N
S
Isolated mitochondriaRatNervous system
Roy Chowdhury 2018 Mol Cell Neurosci2018Roy Chowdhury S, Djordjevic J, Thomson E, Smith DR, Albensi BC, Fernyhough P (2018) Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents. Mol Cell Neurosci 90:49-59.OXPHOS
ET
SMouse
Rat
Nervous system
McWilliams 2018 Open Biol2018McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK (2018) Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol 8:180108.LEAK
OXPHOS
ET
NHomogenateMouseNervous system
Silva 2018 Nat Cell Biol2018Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH (2018) EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nat Cell Biol 20:162-74.OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueIslet cell;pancreas;thymus
Monzio Compagnoni 2018 Biochim Biophys Acta Mol Basis Dis2018Monzio Compagnoni G, Kleiner G, Bordoni A, Fortunato F, Ronchi D, Salani S, Guida M, Corti C, Pichler I, Bergamini C, Fato R, Pellecchia MT, Vallelunga A, Del Sorbo F, Elia A, Reale C, Garavaglia B, Mora G, Albanese A, Cogiamanian F, Ardolino G, Bresolin N, Corti S, Comi GP, Quinzii CM, Di Fonzo A (2018) Mitochondrial dysfunction in fibroblasts of multiple system atrophy. Biochim Biophys Acta Mol Basis Dis 1864:3588-97.OXPHOS
ET
ROUTINE
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Remor 2018 Mol Neurobiol2018Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, da Luz Scheffer D, Andia DC, Portinho D, de Souza AP, de Oliveira PA, Prediger RD, Torres AI, Linhares RMM, Walz R, Ronsoni MF, Hohl A, Rafacho A, Aguiar AS Jr, De Paul AL, Latini A (2018) Chronic metabolic derangement-induced cognitive deficits and neurotoxicity are associated with REST inactivation. Mol Neurobiol 56:1539-57.LEAK
OXPHOS
NIntact cellsRatNervous system
Warnsmann 2018 Mech Ageing Dev2018Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD (2018) A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction. Mech Ageing Dev 170:45-58.LEAK
OXPHOS
ET
NIsolated mitochondriaFungi
Harmuth 2018 Front Mol Neurosci2018Harmuth T, Prell-Schicker C, Weber JJ, Gellerich F, Funke C, Drießen S, Magg JCD, Krebiehl G, Wolburg H, Hayer SN, Hauser S, Krüger R, Schöls L, Riess O, Hübener-Schmid J (2018) Mitochondrial morphology, function and homeostasis are impaired by expression of an N-terminal calpain cleavage fragment of Ataxin-3. Front Mol Neurosci 11:368.LEAK
ET
ROUTINE
OXPHOS
N
S
Homogenate
Intact cells
MouseFibroblast
Magnifico 2018 Oxid Med Cell Longev2018Magnifico MC, Xhani M, Popov M, Saso L, Sarti P, Arese M (2018) Nonylphenol and octylphenol differently affect cell redox balance by modulating the nitric oxide signaling. Oxid Med Cell Longev 2018:1684827.ROUTINE
OXPHOS
N
S
CIV
ROX
Permeabilized cells
Intact cells
HumanLiver
Other cell lines
Zhang 2018 J Mol Cell Cardiol2018Zhang G, Sheng M, Wang J, Teng T, Sun Y, Yang Q, Xu Z (2018) Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser727. J Mol Cell Cardiol 118:169-82.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Isolated mitochondria
MouseHeart
Krug 2018 Thesis2018Krug KP (2018) Adaptation of metabolism and respiratory chain functions in pulmonary arterial vascular muscle cells under chronic hypoxia: especially considering the cytochrome c oxidase subunit 4 isoform 2. Doctoral Dissertation 136.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
ROX
Intact cells
Permeabilized cells
RatOther cell lines
Chou 2018 Int J Cardiol2018Chou CH, Fu TC, Tsai HH, Hsu CC, Wang CH, Wang JS (2018) High-intensity interval training enhances mitochondrial bioenergetics of platelets in patients with heart failure. Int J Cardiol 274:214-20.LEAK
ROUTINE
OXPHOS
ET
F
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanPlatelet
Rudnicki 2018 Elife2018Rudnicki M, Abdifarkosh G, Nwadozi E, Ramos SV, Makki A, Sepa-Kishi DM, Ceddia RB, Perry CG, Roudier E, Haas TL (2018) Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth. Elife 7:e39780.OXPHOSN
NS
HomogenateMouseFat
Martins 2018 Oxid Med Cell Longev2018Martins IK, de Carvalho NR, Macedo GE, Rodrigues NR, Ziech CC, Vinadé L, Filho VMB, Menezes IA, Franco J, Posser T (2018) Anacardium microcarpum promotes neuroprotection dependently of AKT and ERK phosphorylation but does not prevent mitochondrial damage by 6-OHDA. Oxid Med Cell Longev 2018:2131895.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateChickenNervous system
Miotto 2018 Thesis2018Miotto PM (2018) The influence of exercise and high fat feeding on the regulation of mitochondrial substrate sensitivity in skeletal muscle. PhD Thesis p185.OXPHOSF
N
NS
Permeabilized cellsMouseSkeletal muscle
Tarpey 2018 Skelet Muscle2018Tarpey MD, Amorese AJ, Balestrieri NP, Ryan TE, Schmidt CA, McClung JM, Spangenburg EE (2018) Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function. Skelet Muscle 8:14.OXPHOSN
S
CIV
NS
ROX
MouseSkeletal muscle
Fets 2018 Nat Chem Biol2018Fets L, Driscoll PC, Grimm F, Jain A, Nunes PM, Gounis M, Doglioni G, Papageorgiou G, Ragan TJ, Campos S, Silva Dos Santos M, MacRae JI, O'Reilly N, Wright AJ, Benes CH, Courtney KD, House D, Anastasiou D (2018) MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG. Nat Chem Biol 14:1032-42.OXPHOSNPermeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Davila 2018 Elife2018Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA (2018) Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife 7:e33246.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseSkeletal muscle
Liver
Jang 2018 Intensive Care Med Exp2018Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanBlood cells
Wu 2018 Adv Sci2018Wu S, Zhang A, Li S, Chatterjee S, Qi R, Segura-Ibarra V, Ferrari M, Gupte A, Blanco E, Hamilton DJ (2018) Polymer functionalization of isolated mitochondria for cellular transplantation and metabolic phenotype alteration. Adv Sci 1700530.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseLiver
Kim 2018 Pflugers Arch2018Kim Y, Triolo M, Erlich AT, Hood DA (2018) Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pflugers Arch 471:431-40.OXPHOSN
NS
Permeabilized tissueRatSkeletal muscle
Johnson 2018 J Mol Cell Cardiol2018Johnson JM, Ferrara PJ, Verkerke ARP, Coleman CB, Wentzler EJ, Neufer PD, Kew KA, de Castro Brás LE, Funai K (2018) Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome. J Mol Cell Cardiol 121:94-102.OXPHOS
ET
F
N
S
NS
Isolated mitochondriaMouseHeart
Skeletal muscle
Friederich-Persson 2018 Acta Physiol (Oxf)2018Friederich-Persson M, Persson P, Hansell P, Palm F (2018) Deletion of Uncoupling Protein-2 reduces renal mitochondrial leak respiration, intrarenal hypoxia and proteinuria in a mouse model of type 1 diabetes. Acta Physiol (Oxf) 223:e13058.LEAK
OXPHOS
NIsolated mitochondriaMouseKidney
Lander 2018 J Biol Chem2018Lander N, Chiurillo MA, Bertolini MS, Storey M, Vercesi AE, Docampo R (2018) Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi. J Biol Chem 293:17402-17.LEAK
OXPHOS
ET
N
S
Permeabilized cellsProtists
Kleszczynski 2018 Int J Mol Sci2018Kleszczyński K, Bilska B, Stegemann A, Flis DJ, Ziolkowski W, Pyza E, Luger TA, Reiter RJ, Böhm M, Slominski AT (2018) Melatonin and its metabolites ameliorate UVR-induced mitochondrial oxidative stress in human MNT-1 melanoma cells. Int J Mol Sci 19:E3786.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseLiver
Petiz 2018 Chem Biol Interact2018Petiz LL, Pires ADRA, Echevarria A, Rodrigues-Santos CE, Eliane Merlin Rocha M, Acco A, Cadena SMSC (2018) Effects of a new antiprotozoal drug, N,N'-diphenyl-4-methoxy-benzamidine, on energy-linked functions of rat liver mitochondria. Chem Biol Interact 279:34-42.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaRatLiver
Hayward 2018 Thesis2018Hayward L (2018) The effect of anoxia on mitochondrial function in a hibernator (Ictidomys tridecemlineatus). Master's Thesis 57.OXPHOS
LEAK
N
NS
Isolated mitochondriaOther mammalsLiver
Holloway 2018 Cell Rep2018Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48.OXPHOS
ET
LEAK
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Scheiber 2018 J Cardiovasc Transl Res2018Scheiber D, Zweck E, Jelenik T, Horn P, Albermann S, Masyuk M, Boeken U, Saeed D, Kelm M Roden M, Szendroedi J, Westenfeld R (2018) Reduced myocardial mitochondrial ROS production in mechanically unloaded hearts. J Cardiovasc Transl Res 12:107-15.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueHumanHeart
Puurand 2018 Int J Mol Sci2018Puurand M, Tepp K, Klepinin A, Klepinina L, Shevchuk I, Kaambre T (2018) Intracellular energy-transfer networks and high-resolution respirometry: a convenient approach for studying their function. Int J Mol Sci 19:e2933.OXPHOSNPermeabilized cells
Rodrigues 2018 Sci Rep2018Rodrigues APC, Camargo AF, Andjelkovic A, Jacobs HT, Oliveira MT (2018) Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase. Sci Rep 8:10882.OXPHOSN
CIV
ROX
Homogenate
Oxidase;biochemical oxidation
Drosophila
Pamenter 2018 PLoS One2018Pamenter ME, Lau GY, Richards JG (2018) Effects of cold on murine brain mitochondrial function. PLoS One 13:e0208453.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueMouseNervous system
Koit 2018 US Patent2018Koit A, Kaambre T (2018) Method for selecting patients responsive for cancer treatments. US Patent US20180017547A1.OXPHOSF
N
NS
Permeabilized cellsHuman
Rodrigues 2018 Free Radic Biol Med2018Rodrigues NR, Macedo GE, Martins IK, Gomes KK, de Carvalho NR, Posser T, Franco JL (2018) Short-term sleep deprivation with exposure to nocturnal light alters mitochondrial bioenergetics in Drosophila. Free Radic Biol Med 120:395-406.ET
LEAK
OXPHOS
ROUTINE
CIV
N
NS
ROX
S
Isolated mitochondriaDrosophila
Van Den Brink 2018 PLoS Genet2018Van Den Brink DM, Cubizolle A, Chatelain G, Davoust N, Girard V, Johansen S, Napoletano F, Dourlen P, Guillou L, Angebault-Prouteau C, Bernoud-Hubac N, Guichardant M, Brabet P, Mollereau B (2018) Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. PLoS Genet 14:e1007627.LEAK
OXPHOS
F
N
S
NS
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Sahl 2018 Anal Biochem2018Sahl RE, Morville T, Kraunsøe R, Dela F, Helge JW, Larsen S (2018) Variation in mitochondrial respiratory capacity and myosin heavy chain composition in repeated muscle biopsies. Anal Biochem 556:119-24.OXPHOS
ET
N
NS
Permeabilized cells
Isolated mitochondria
Intact cells
Human
Mouse
Saccharomyces cerevisiae
Skeletal muscle
Weisz 2018 Hum Mol Genet2018Weisz ED, Towheed A, Monyak RE, Toth MS, Wallace DC, Jongens TA (2018) Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function. Hum Mol Genet 27:95-106.OXPHOS
ET
LEAK
N
S
NS
ROX
Isolated mitochondriaDrosophilaSkeletal muscle
MacMillan-Crow 2018 Intern Med Rev (Wash D C)2018MacMillan-Crow LA, Mayeux PR (2018) Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis. Intern Med Rev (Wash D C) 4.OXPHOS
LEAK
N
S
ROX
Permeabilized tissueMouseKidney
Rajasekaran 2018 FASEB J2018Rajasekaran R, Felser A, Nuoffer JM, Dufour JF, St-Pierre MV (2018) The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism. FASEB J 32:5143-61.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaMouseLiver
Salin 2018 Funct Ecol2018Salin K, Villasevil EM, Anderson GJ, Auer SK, Selman C, Hartley RC, Mullen W, Chinopoulos C, Metcalfe NB (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Funct Ecol DOI: 10.1111/1365-2435.13125.LEAK
OXPHOS
CIV
NS
ROX
HomogenateFishesLiver
Robach 2018 Scand J Med Sci Sports2018Robach P, Hansen J, Pichon A, Meinild Lundby AK, Dandanell S, Slettaløkken Falch G, Hammarström D, Pesta DH, Siebenmann C, Keiser S, Kérivel P, Whist JE, Rønnestad BR, Lundby C (2018) Hypobaric live high-train low does not improve aerobic performance more than live low-train low in cross-country skiers. Scand J Med Sci Sports 28:1636-52.OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Nelson 2018 Amino Acids2018Nelson MM, Builta ZJ, Monroe TB, Doorn JA, Anderson EJ (2018) Biochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. Amino Acids 51:97-102.OXPHOSPermeabilized tissueHumanHeart
Kauppila 2018 Nucleic Acids Res2018Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouse
Fink 2018 J Biol Chem2018Fink BD, Bai F, Yu L, Sheldon RD, Sharma A, Taylor EB, Sivitz WI (2018) Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. J Biol Chem 293:19932-41.OXPHOSN
NS
S
Isolated mitochondriaMouseSkeletal muscle
Efimova 2018 Thesis2018Efimova I (2018) Structural composition and functional properties of mitochondrial FoF1 ATP synthase on models of specific subunits deficiencies. PhD Thesis 94.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanHEK
Leckey 2018 FASEB J2018Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J 32:2979-91.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Zhang 2018 J Gerontol A Biol Sci Med Sci2018Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2018) Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J Gerontol A Biol Sci Med Sci 73:1313-22.LEAK
OXPHOS
F
N
NS
MouseSkeletal muscle
Pileggi 2018 Free Radic Biol Med2018Pileggi CA, Hedges CP, D'Souza RF, Durainayagam BR, Markworth JF, Hickey AJR, Mitchell CJ, Cameron-Smith D (2018) Exercise recovery increases skeletal muscle H2O2 emission and mitochondrial respiratory capacity following two-weeks of limb immobilization. Free Radic Biol Med 124:241-8.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Konopka 2018 Aging Cell2018Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF (2018) Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell 18:e12880.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueHumanSkeletal muscle
Fuhrmann 2018 Cell Mol Life Sci2018Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci 75:3051-67.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Isolated mitochondria
Intact cells
Human
Klepinin 2018 J Bioenerg Biomembr2018Klepinin A, Ounpuu L, Mado K, Truu L, Chekulayev V, Puurand M, Shevchuk I, Tepp K, Planken A, Kaambre T (2018) The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. J Bioenerg Biomembr 50:339-54.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseHeart
Neuroblastoma
Singh 2018 Arch Toxicol2018Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, Krähenbühl S, Bouitbir J (2018) PGC-1β modulates statin-associated myotoxicity in mice. Arch Toxicol 93:487-504.OXPHOS
LEAK
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Dogan 2018 Cell Metab2018Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C (2018) Perturbed redox signaling exacerbates a mitochondrial myopathy. Cell Metab 28:764-77.LEAK
OXPHOS
N
S
CIV
ROX
Isolated mitochondriaMouseSkeletal muscle
Martinez 2018 Arch Biochem Biophys2018Martínez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A, Coluccio Leskow F, Velazquez F (2018) Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment. Arch Biochem Biophys 651:1-12.ET
LEAK
OXPHOS
N
ROX
S
Isolated mitochondriaRatNervous system
De Moura Alvorcem 2018 Mitochondrion2018De Moura Alvorcem L, Britto R, Parmeggiani B, Glanzel NM, Da Rosa-Junior NT, Cecatto C, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2018) Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum. Mitochondrion 47:141-50.LEAK
OXPHOS
ET
N
S
NS
HomogenateRatNervous system
Ramil 2018 Thesis2018Ramil LR, Gulbinas A, Cesna V (2018) “HIPEC” hyperthermic intraperitoneal chemotherapy. Evaluation of intraperitoneal free cancer cells. Master's Thesis.OXPHOS
LEAK
N
S
Isolated mitochondriaHumanEndothelial;epithelial;mesothelial cell
Marini 2018 Proc Natl Acad Sci U S A2018Marini A, Rotblat B, Sbarrato T, Niklison-Chirou MV, Knight JRP, Dudek K, Jones C, Bushell M, Knight RA, Amelio I, Willis AE, Melino G (2018) TAp73 contributes to the oxidative stress response by regulating protein synthesis. Proc Natl Acad Sci U S A 115:6219-24.OXPHOSNHomogenateHumanKidney
Lung;gill
HEK
Braz-Mota 2018 Sci Total Environ2018Braz-Mota S, Campos DF, MacCormack TJ, Duarte RM, Val AL, Almeida-Val VMF (2018) Mechanisms of toxic action of copper and copper nanoparticles in two Amazon fish species: Dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi). Sci Total Environ 630:1168-80.LEAK
OXPHOS
ET
N
NS
ROX
FishesLung;gill
... further results
Publications in the MiPMap

Abstracts: OXPHOS

Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Silva 2019 ESCI20192019Silva FSG, Komlodi T, Garcia-Souza LF, Bento G, Doerrier C, Oliveira PJ, Gnaiger E (2019) Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir?OXPHOS
ET
F
N
S
Permeabilized cells
Isolated mitochondria
Human
Mouse
Liver
Axelrod 2019 Abstract IOC1412019Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02.OXPHOS
ET
FMouseSkeletal muscle
Gnaiger 2019 MiP20192019
Erich Gnaiger
OXPHOS capacity in human muscle tissue and body mass excess – the MitoEAGLE mission towards an integrative database (Version 4; 2019-10-23).
OXPHOSNSIntact organism
Isolated mitochondria
Permeabilized tissue
HumanSkeletal muscle
Beleza 2019 MiPschool Coimbra2019
Jorge Beleza
Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function.
LEAK
OXPHOS
N
S
RatLiver
Goikoetxea-Usandizaga 2019 MiPschool Coimbra2019
Naroa Goikoetxea Usandizaga
Methylation Controlled J protein (MCJ): A therapeutic target in hepatic ischemia and reperfusion injury.
OXPHOSHomogenate
Isolated mitochondria
Intact cells
MouseLiver
Dominguez-Amorocho 2019 MiP20192019
MiPsociety
Role of Sirtuin 1/3 in CD4+ T cells activation and differentiation in obese and transplanted animals.
LEAK
ET
OXPHOS
ROXMouseLymphocyte
Pavlovic 2019 MiP20192019
Barbara Cannon
Effects of therapeutic metformin concentration on mitochondria in muscle cells.
ROUTINE
OXPHOS
N
S
Intact cellsMouseSkeletal muscle
Goncalves Debora 2019 MiPschool Coimbra2019
MiPsociety
Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.
LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateDrosophila
Van der Ende 2019 MiPschool Coimbra2019
Miranda van der Ende
Mitochondrial respiration in muscle tissue of colon cancer patients.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kramer 2019 Abstract IOC1412019Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.LEAK
OXPHOS
ET
N
CIV
NS
ROX
HumanSkeletal muscle
Timohhina 2019 MiP20192019
Natalja Timohhina
Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.
LEAK
OXPHOS
ET
ROXHumanEndothelial;epithelial;mesothelial cell
Garcia-Roves 2019 MiPschool Coimbra2019
Pablo Garcia-Roves
Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Minuzzi 2019 MiPschool Coimbra2019
MiPsociety
A pilot study on mitochondrial function of mouse skin using high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Chabi 2019 MiP20192019
Béatrice Chabi
Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Kandel 2019 Biophys J2019Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J.LEAK
OXPHOS
F
N
S
Isolated mitochondriaRatHeart
Kidney
Aid-Vanakova 2019 MiP20192019
MiPsociety
Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model.
LEAK
OXPHOS
N
S
MouseSkeletal muscle
Heart
Silva 2019 MiPschool Coimbra2019
Filomena Pereira da Silva Grilo da Silva
Off-target effects of etomoxir on mitochondrial complex I.
OXPHOS
ET
F
N
Other combinations
Permeabilized cells
Isolated mitochondria
Human
Mouse
Liver
Santos 2019 MiPschool Coimbra2019
MiPsociety
Uncoupling Protein 1 inhibition and mitochondrial respiration in epicardial adipose tissue from hear failure patients.
OXPHOSF
N
HumanHeart
Fat
Lemieux 2019a MiP20192019
Hélène Lemieux
Partial prevention of oxidative stress damage to mitochondria with photobiomodulation.
LEAK
OXPHOS
ET
N
S
CIV
NS
Other invertebrates
Rutai 2019 Crit Care2019Rutai A, Fejes R, Tallósy SZ, Poles M, Juhász L, Mészáros A, Boros M, Kaszaki J (2019) Potential role of endothelin receptors in the therapy of experimental sepsis. Crit Care.OXPHOSN
S
Rat
Lelcu 2019 MiP20192019
Theia Lelcu
Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.
LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanPlatelet
Abdel-Rahman 2019 MiP20192019
MiPsociety
Mitochondrial respiration in platelets of children with autism spectrum disorder.
ROUTINE
OXPHOS
N
NS
Intact cellsHumanPlatelet
Garcia 2019 MiPschool Coimbra2019
Geovana Garcia
Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase.
LEAK
OXPHOS
N
Gp
Drosophila
Chang 2018 Biophys J2018Mitochondrial dysfunction in malignant hyperthermia susceptible skeletal muscle.OXPHOSN
S
Permeabilized tissueHuman
Mouse
Skeletal muscle
Porter 2018 MiP2018b2018
MiPsociety
Skeletal muscle mitochondrial thermogenesis in hypermetabolic humans.
LEAK
OXPHOS
Krajcova 2018 MiPschool Tromso E22018
Adela Krajcova
High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.
LEAK
OXPHOS
ET
N
NS
ROX
HomogenateHumanHeart
Konopka 2018 FASEB J2018Konopka AR, Castor WM, Reid J, Schoenberg H, Laurin J, Wolff C, Hamilton K, Miller B (2018) Metformin blunts exercise-induced improvements in skeletal muscle mitochondrial respiration independent of changes in mitochondrial biogenesis. FASEB J.OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Meszaros 2018 EBEC20182018Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration.ET
LEAK
OXPHOS
NIsolated mitochondriaMouseHeart
Liver
Nervous system
Sobotka 2018 MiP20182018
Ondrej Sobotka
Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay.
LEAK
OXPHOS
Isolated mitochondriaMouse
Saccharomyces cerevisiae
Heart
Nervous system
Komlodi 2018 EBEC20182018Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Wilson 2018 Virginia Tech2018Wilson ZT, Perry JB, Brow DA (2018) High-resolution respirometry of heart mitochondria in healthy and stressed states. Virginia Tech.OXPHOSNIsolated mitochondriaHeart
Ravasz 2018 Abstract The evolving concept of mitochondria2018Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondriaLEAK
OXPHOS
NIsolated mitochondriaMouseLiver
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT2018pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cellsHumanHEK
Kidney
Chicco 2018 MiP2018a2018
Adam J Chicco
Maternal aging increases granulosa cell mitochondrial ROS release and reduces oocyte OXPHOS-linked respiration: implications for embryo development.
OXPHOS
ET
HorseGenital
Gnaiger 2018 MiP20182018
Erich Gnaiger
Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks of mitochondrial physiology Part 2.
OXPHOSN
F
S
Gp
DQ
CIV
NS
Other combinations
Kovalev 2018 EMBS2018Kovalev A, Sokolova I, Sukhotin A (2018) Allometry of mitochondrial respiration in mussels. EMBS.LEAK
OXPHOS
ET
CIVIsolated mitochondriaMolluscsLiver
Islet cell;pancreas;thymus
Danhelovska 2018 MiP20182018
MiPsociety
The relevance of ACBD3 protein in energy metabolism in various cell lines. Danhelovska_Presentation
OXPHOSHumanHEK
HeLa
Doerrier 2018 MiP2018a2018
Carolina Anneliese Doerrier
Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Doerrier 2018 EBEC20182018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Liu 2018 Atherosclerosis Suppl2018Liu D (2018) Enhanced Trpc3-mediated mitochondrial respiratory dysfunction by inhibition of mitochondria-hexokinase in monocytes from hypertension rats. Atherosclerosis Suppl.ROUTINE
OXPHOS
ET
N
NS
Intact cellsRatBlood cells
Gnaiger 2018 AussieMit2018Komlodi T, Sobotka O, Doerrier C, Gnaiger E (2018) Mitochondrial H2O2 production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU.LEAK
ROUTINE
OXPHOS
NSIsolated mitochondria
Intact cells
Mouse
Saccharomyces cerevisiae
Heart
Nervous system
Schoepf 2018 33rd Annual EAU Congress Copenhagen2018Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.LEAK
OXPHOS
ET
F
N
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Chicco 2018 MiP2018b2018
Adam J Chicco
Defective cardiolipin remodeling and cardiac mitochondrial dysfunction: supercomplexes or just complex?
OXPHOSF
N
NS
Permeabilized tissueMouseHeart
Gnaiger 2018 MiPschool Tromso A12018
Erich Gnaiger
Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.
LEAK
ET
OXPHOS
F
N
S
Gp
DQ
CIV
NS
Other combinations
Li 2018 IBEC2018Li C, Li N, Zhang Y (2018) UPRmt and mitophagy are selectively activated depending on muscle fiber types in insulin resistant rats. IBEC.LEAK
OXPHOS
RatSkeletal muscle
Liu Atherosclerosis2018Liu D (2018) Enhanced Trpc3-mediated mitochondrial respiratory dysfunction by inhibition of mitochondria-hexokinase in monocytes from hypertension rats. Atherosclerosis.ROUTINE
OXPHOS
ET
N
CIV
NS
Intact cellsRat
Doerrier 2018 MiP2018c2018
Carolina Doerrier
Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Wuest 2018 MiP2018b2018
Wuest Rob
The antibiotic doxycycline impairs cardiac mitochondrial and contractile function.
OXPHOS
ET
N
S
RatHeart
Other cell lines
Stelfa 2018 MiP20182018
MiPsociety
Neuroprotective compound R-phenibut protects brain mitochondria against anoxia-reoxygenation damage in vitro.
OXPHOSSHomogenateRatNervous system
Komlodi 2018 AussieMit2018Komlodi T, Hunger M, Moore AL, Gnaiger E (2018) Electron transfer at the Q-junction: new perspectives from combined measurement of mitochondrial O2 flux, H2O2 flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Doerrier 2018 ESCI20182018
Carolina Anneliese Doerrier
High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
ROX
CIV
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Nervous system
Blood cells
HEK
Lemieux 2018 MiP20182018
Helene Lemieux
Plasticity of a critical regulator of energy production under hypothermia, the phosphorylation system.
OXPHOSN
S
Intact organismOther invertebrates
Garipi 2018 MiPschool Tromso E22018Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS productionLEAK
ROUTINE
OXPHOS
ET
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Pereira da Silva Grilo da Silva 2018 MiP20182018
Filomena Pereira da Silva Grilo da Silva
The unspecific effect of etomoxir on mitochondrial respiration.
OXPHOS
ET
F
N
S
NS
Other combinations
Permeabilized cells
Isolated mitochondria
Human
Mouse
Nervous system
Liver
Other cell lines
Garcia-Roves 2018 MiP2018b2018
Pablo Garcia-Roves
Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Hoppel 2018 MiPschool Tromso D12018
Charles Hoppel
Two populations of muscle mitochondria: heart and skeletal muscle.
OXPHOSIsolated mitochondriaRat
Dog
Other mammals
Heart
Skeletal muscle
Stankova 2018 MiP20182018
Pavla Krivakova-Stankova
Impact of western diet on energy metabolism in mouse liver.
OXPHOS
ET
S
F
N
HomogenateMouseLiver
Makrecka-Kuka 2018 MiP20182018
Marina Makrecka-Kuka
Fatty acid oxidation in brain: from aging to ischemia and sepsis.
OXPHOSFHomogenateMouse
Rat
Nervous system
Meszaros 2018 Mt Med Hinxton2018High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments.LEAK
OXPHOS
ET
N
CIV
NS
Isolated mitochondriaMouseHeart
Nervous system
Liver
Votion 2018 MiP20182018
Dominique-Marie Votion
Functional diagnosis of mitochondrial defects in equine atypical myopathy and targeted mitochondrial therapy: a preliminary study.
OXPHOSF
N
S
NS
Intact cellsHorseSkeletal muscle
Wuest 2018 MiPschool Tromso D32018
Wuest Rob
Metabolic flexibility and mitochondrial function in the diabetic heart.
OXPHOSN
S
Pig
Mouse
Rat
Heart
McMaster 2018 Am J Obstet Gynecol2018Preeclampsia is associated with placental mitochondrial dysfunction.LEAK
ROUTINE
OXPHOS
ET
NIsolated mitochondriaHuman
Acuna-Castroviejo 2018 MiP20182018
Dario Acuna-Castroviejo
Mitochondria, melatonin, and neuroinflammation in Parkinson's disease. Acuna-Castroviejo_Presentation
LEAK
OXPHOS
NMouseNervous system
Bastos Sant'Anna Silva 2018 MiPschool Tromso C42018
Ana Bastos Sant'Anna
Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.
LEAK
ROUTINE
OXPHOS
ET
S
ROX
Intact cellsHumanGenital
Doerrier 2018 MiP2018b2018
Carolina Doerrier
Evaluation of anaplerotic pathways to avoid artefacts in respirometric measurement of fatty acid oxidation.
OXPHOSF
N
Homogenate
Isolated mitochondria
Permeabilized cells
Human
Mouse
Blood cells
HEK
Heart
Nervous system
Platelet
De Goede 2018 MiP20182018
MiPsociety
Timing of feeding behavior affects daily rhythms in body temperature and muscle mitochondrial metabolism.
OXPHOS
ET
Permeabilized tissueRatSkeletal muscle
Kuka 2018 MiP20182018
MiPsociety
The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases.
LEAK
OXPHOS
RatHeart
White 2018 J Anim Sci2018Differing mitochondrial capacity in two separate skeletal muscles from calm and temperamental Brahman heifers.OXPHOSNBovinesSkeletal muscle
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT2018Cellular succinate transport and mitochondrial respiratory function in prostate cancer.ROUTINE
LEAK
OXPHOS
ET
S
ROX
Permeabilized cells
Intact cells
HumanHEK
Genital
Krajcova 2018 ICO1342018Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateHumanSkeletal muscle
Garcia-Roves 2017 MiP20172017
Pablo Garcia-Roves
Mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. MitoEAGLE WG2 pilot study. Garcia-Roves_Presentation
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Juhasz 2017 MiPschool Obergurgl2017
Juhasz L.jpg
Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.
LEAK
OXPHOS
N
S
HomogenateRatLiver
Sobotka 2017 MiP20172017
Ondrej Sobotka
Metabolic changes in rat liver mitochondria during the development of liver steatosis.
OXPHOS
ET
N
NS
Isolated mitochondriaRatLiver
Truu 2017 Abstract IOC1222017Bioenergetics of colorectal cancer.OXPHOSN
S
Endothelial;epithelial;mesothelial cell
Vaka 2017 Hypertension2017Abstract P265: Placental ischemia causes renal mitochondrial impairment in reduced uterine perfusion pressure rats.OXPHOSN
S
Isolated mitochondriaRatKidney
Genital
Doerrier 2017 MiP2017 WG22017
Carolina Anneliese Doerrier
Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z.
LEAK
OXPHOS
ET
N
NS
Permeabilized tissueMouseSkeletal muscle
Dubouchaud 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Impact of high-fat diet or PUFAs consumption on the mitochondrial function.
OXPHOSF
N
Permeabilized tissue
Isolated mitochondria
RatSkeletal muscle
Liver
Krajcova 2017 MITOEAGLE Obergurgl2017
Krajcova A
Developing a method of assessing mitochondrial functions in homogenates of human heart muscle.
LEAK
OXPHOS
ET
N
NS
HomogenateHuman
Kolonics 2017 MiP20172017
Attila Kolonics
Different molecular composition of Lysimachia species result in distinct metabolism.
OXPHOSN
NS
Mouse
Plants
Heart
Liver
Gnaiger 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
Quality first: a paradigm shift in mt-respiratory control towards global connection.
LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHuman
Mouse
Heart
Genital
Isola 2017 MiPschool Obergurgl2017
Isola Raffa recente piccola.jpg
Do mitochondria counteract diabetes impairment by means of morphological and physiological strategies?
OXPHOSF
N
Isolated mitochondriaRat
Makrecka-Kuka 2017 MiP20172017
Marina Makrecka-Kruka
Heart, brain and kidneys: who will survive? Tissue-specific changes in mitochondrial function in the experimental model of endotoxemia.
OXPHOSPermeabilized tissue
Homogenate
MouseHeart
Nervous system
Kidney
Larsen 2017 MiP2017 WG22017
Steen Larsen
The effect on respiratory capacity using different respiration buffers.
OXPHOSN
NS
Permeabilized tissueHumanSkeletal muscle
Amick 2017 MiPschool Obergurgl2017
Amick picture.jpg
Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.
LEAK
OXPHOS
F
N
Isolated mitochondriaOther mammalsNervous system
Hoppel 2017 MiP20172017
Charles Hoppel
Pathways of mitochondrial fatty acid oxidation. Hoppel_Presentation
OXPHOSF
N
S
RatLiver
Nemec 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Functional state of mitochondria in patients with preclinical cognitive deficit.
OXPHOS
ET
FPermeabilized tissueHumanSkeletal muscle
Waldauf 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates.
LEAK
OXPHOS
ET
F
N
S
CIV
NS
HomogenateHumanSkeletal muscle
Kovalcikova 2017 MiP20172017
Kovalcikova Jana
Mitochondrial protein TMEM70: key role in the biogenesis of ATP synthase verified in a mouse knockout model.
LEAK
OXPHOS
MouseHeart
Liver
Komlodi 2017 Abstract MITOEAGLE Barcelona2017
COST Action MitoEAGLE
Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria.
OXPHOS
LEAK
ET
N
S
Isolated mitochondria
Homogenate
Guinea pig
Mouse
Nervous system
Kidney
Heart
Liver
Distefano 2017 MiPschool Obergurgl2017
Giovanna Distefano
Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.
LEAK
OXPHOS
ET
F
NS
Permeabilized tissueHumanSkeletal muscle
Scheiber 2017 Europ Heart J2017High-resolution respirometry in human endomyocardial biopsies to assess myocardial mitochondrial function.OXPHOSF
N
NS
Permeabilized tissueHumanHeart
Schilling 2017 J Mol Cell Cardiol2017Loss of caveolin-1 alters cardiac mitochondrial function and increases susceptibility to stress.OXPHOSN
CIV
NS
Isolated mitochondriaMouseHeart
Collins 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.
OXPHOSF
N
S
Gp
CIV
NS
ROX
Intact cells
Irving 2017 MiP20172017
Brian Irving
Impact of acute exercise on PBMC respiratory function and methodological considerations.
LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Blood cells
Doerrier 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
SUIT reference protocol for comparative mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Ukropec 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?
LEAK
OXPHOS
ET
F
N
S
Gp
NS
Permeabilized cellsSkeletal muscle
Lemieux 2017 MiP20172017
Helene Lemieux
Compounding effects of age and sexual dimorphism on cardiac mitochondrial function in type 2 diabetes.
OXPHOSF
CIV
Permeabilized tissueRatHeart
Sobotka 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation
OXPHOS
ET
F
N
S
Gp
ROX
Isolated mitochondriaRatLiver
O'Brien 2017 Abstract IOC1222017PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia.LEAK
OXPHOS
FMouseSkeletal muscle
Nakajima 2017 Europ Heart J2017Mitochondrial dysfunction in epicardial adipose tissue; possible role in progression of coronary artery disease.OXPHOSF
N
NS
Permeabilized tissueHumanFat
White 2017 J Anim Sci2017Influence of temperament on skeletal muscle mitochondrial capacity of Brahman cows.OXPHOS
ET
N
S
NS
BovinesSkeletal muscle
Markova 2017 MiPschool Obergurgl2017
Michaela Markova
Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.
LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatHeart
Komlodi 2017 MiP20172017
Timea Komlodi
H2O2 production under hypoxia in brain and heart mitochondria: does O2 concentration matter?
LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseHeart
Nervous system
Gnaiger 2017 Abstract EUROMIT2017 Cologne2017
EUROMIT2017
Again not a Warburg effect - mitochondrial function in primary prostate cancer.
OXPHOS
ET
N
NS
S
HumanEndothelial;epithelial;mesothelial cell
Genital
Fibroblast
Gnaiger 2017 MiPschool A12017
Gnaiger Erich.jpg
Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cells
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Markova 2017 MiP20172017
Michaela Markova
Porcine sepsis and associated myocardial depression.
LEAK
OXPHOS
N
S
CIV
NS
ROX
PigHeart
Michalak 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanBlood cells
Keppner 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Different respiratory states to determine LEAK and uncoupled respiration in the SUIT protocol: effect and consequences.
LEAK
OXPHOS
ET
N
NS
Permeabilized cellsBlood cells
Labieniec-Watala 2017 MiP20172017
Magda Labieniec-Watala
Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanGenital
Meszaros 2017 MiPschool Obergurgl2017
Andras Meszaros
(Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration.
LEAK
OXPHOS
N
S
Isolated mitochondriaMouseLiver
Nervous system
Kidney
Meszaros 2017 MiP20172017
Andras Meszaros
Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity.
LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseNervous system
Liver
Kidney
Han 2017 Abstract IOC1222017Retinal mitochondria respiration defects precede hyperglycemia onset in type 2 diabetes.OXPHOSNSHomogenateRatNervous system
Doerrier 2017 MiPschool C22017
DoerrierC.JPG
Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Han 2017 MiP20172017
MiPsociety
Metabolic syndrome differentially impacts the retina and underlying retinal pigment epithelium cells.
LEAK
OXPHOS
S
CIV
NS
RatNervous system
Aasum 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochondrial function in the diabetic heart – effect of an acute fat-load.
OXPHOSIsolated mitochondriaMouseHeart
Komlodi 2017 MiPschool Obergurgl2017
Timea Komlodi
Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production.
LEAK
OXPHOS
N
S
Gp
Other combinations
ROX
Isolated mitochondriaMouseNervous system
Volani 2016 Abstract MitoFit Science Camp 20162016Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs.LEAK
OXPHOS
ET
N
S
HomogenateMouse
Rat
Liver
Blood cells
Lymphocyte
Laner 2016 Abstract Mito Xmas Meeting Innsbruck2016OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Davies 2016 Abstract Proceedings of The Physiological Society2016Development of mitochondrial function in the cortex and cerebellum of the ovine fetus.LEAK
OXPHOS
N
S
NS
HomogenateBovinesNervous system
Maarman 2016 Abstract MitoFit Science Camp 20162016Melatonin rescues uric acid-induced impairment of respiration in myotubes.OXPHOSNMouseSkeletal muscle
Other cell lines
Laner 2016 Abstract MitoFit Science Camp 20162016OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Chicco 2016a Abstract MitoFit Science Camp 20162016Oxygen dependence of H2O2 release from skeletal muscle and cardiac mitochondria: influence of sample preparation.OXPHOSNSPermeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Skeletal muscle
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Krumschnabel 2016b Abstract MitoFit Science Camp 20162016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.LEAK
OXPHOS
ET
N
S
NS
ROX
HumanKidney
HEK
Gnaiger 2016 Abstract Mito Xmas Meeting Innsbruck2016The world as a laboratory: exploring mitochondrial fitness.OXPHOSHumanSkeletal muscle
Chicco 2016c Abstract MitoFit Science Camp 20162016Investigating the mechanism of cardiac mitochondrial respiratory impairment in Barth Syndrome.OXPHOSF
N
S
CIV
Other combinations
MouseHeart
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Chicco 2016b Abstract MitoFit Science Camp 20162016OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.LEAK
OXPHOS
ET
F
N
Permeabilized tissueHumanSkeletal muscle
Krumschnabel 2016a Abstract MitoFit Science Camp 20162016O2k-Protocols: Mitochondrial preparations for HRR.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Marcinek 2016 Abstract MitoFit Science Camp 20162016Targeting mitochondrial redox stress reveals two phases for reversal of mitochondrial dysfunction in aged mouse skeletal muscle.OXPHOSPermeabilized tissueMouseSkeletal muscle
Garcia-Souza 2016 Abstract Mito Xmas Meeting Innsbruck2016Assessment of fatty acid oxidation in mouse brain and liver mitochondria.OXPHOSF
N
Homogenate
Isolated mitochondria
Nervous system
Liver
Calzia 2016 Abstract MitoFit Science Camp 20162016Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains.LEAK
OXPHOS
ET
NSFishesHeart
Skeletal muscle
Nervous system
Liver
Sobotka 2016 Abstract IOC1162016Sobotka O, Kucera O, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11ET
LEAK
OXPHOS
CIV
F
Gp
N
NS
Other combinations
ROX
S
Isolated mitochondriaRatLiver
Osiki 2016 Abstract MitoFit Science Camp 20162016Suitability of octanoylcarnitine & malate for assessment of beta oxidation capacity by respirometry in aconitase-inhibited samples.OXPHOS
ET
F
N
Other combinations
RatSkeletal muscle
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Sparagna 2016 Abstract IOC1092016Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01.LEAK
OXPHOS
N
S
NS
HumanHeart
Neufer 2016 Abstract MitoFit Science Camp 20162016Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers.OXPHOSPermeabilized tissue
Isolated mitochondria
Skeletal muscle
Blood cells
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck2016Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Burtscher J 2016 Abstract MitoFit Science Camp 20162016Oxidative phosphorylation in the healthy and epileptic mouse brain.OXPHOS
ET
N
S
HomogenateMouseNervous system
Cecatto 2016 Abstract IOC1162016Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ET
F
N
CIV
Other combinations
Permeabilized tissue
Isolated mitochondria
RatNervous system
Liver
Volani 2016 Abstract Mito Xmas Meeting Innsbruck2016Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo.LEAK
ROUTINE
OXPHOS
ET
N
S
HomogenateMouseLiver
Herminghaus 2016 Abstract MitoFit Science Camp 20162016Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis.LEAK
OXPHOS
N
NS
RatLiver
Endothelial;epithelial;mesothelial cell
Kane 2016 Abstract MitoFit Science Camp 20162016Effects of inhibiting myosin-ATPase on mitochondrial respiratory capacity in permeabilized skeletal muscle.OXPHOSF
N
Permeabilized tissueRatSkeletal muscle
Soendergaard 2016 Abstract IOC1092016Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01.OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Makrecka-Kuka 2016 Abstract MitoFit Science Camp 20162016Long-chain acylCoAs vs acylcarnitines in mitochondrial bioenergetics: from in vitro to in vivo.OXPHOSFIsolated mitochondriaRatHeart
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck2016Mitochondrial function in primary prostate cancer.ET
LEAK
OXPHOS
N
Other combinations
S
Permeabilized tissueHuman
Hoppel 2016c Abstract MitoFit Science Camp 20162016Mitochondrial respiration in permeabilized skin fibroblasts.ET
OXPHOS
CIV
N
NS
ROX
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.LEAK
OXPHOS
ET
F
N
S
NS
ROX
MouseNervous system
Hellgren 2016 Abstract Proceedings of The Physiological Society2016Sexual dimorphism in cardiac mitochondria following intrauterine hypoxia.OXPHOSNervous system
Heart
Madlala 2016 Abstract MitoFit Science Camp 20162016Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates.LEAK
OXPHOS
ET
NPermeabilized cellsHumanLiver
Sumbalova 2016a Abstract MitoFit Science Camp 20162016Optimizing strategies on the malate concentration in SUIT protocols.OXPHOS
ET
N
S
NS
RatNervous system
Gnaiger 2016 Abstract UMDF20162016Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Bezuidenhout 2016b Abstract MitoFit Science Camp 20162016Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueMouseSkeletal muscle
Brown 2015 Abstract MiPschool Cape Town 20152015Protection of post-ischemic mitochondrial bioenergetics by targeting cardiolipin-dependent membrane fluidity.OXPHOSN
S
NS
Intact organism
Permeabilized tissue
Isolated mitochondria
RatHeart
Gnaiger 2015 Abstract DrugDiscovery conference 20152015A lifestyle drug for mitochondrial fitness – from respiratory mitochondrial diagnosis to therapy.OXPHOSHuman
Devaux 2015 Abstract MiP20152015Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.ET
LEAK
OXPHOS
N
S
HomogenateFishesNervous system
Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
FPermeabilized tissue
Valenti 2015 Abstract MiPschool London 20152015Different modulation of mitochondrial function by epigallocatechin-3 gallate in human disease: a matter of life and death.OXPHOSEndothelial;epithelial;mesothelial cell
Rohlena 2015 Abstract MiP20152015Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.ROUTINE
OXPHOS
ET
S
ROX
Permeabilized cells
Isolated mitochondria
HumanOther cell lines
McCurdy 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOSF
N
Permeabilized tissueOther mammalsSkeletal muscle
Maarman 2015 Abstract MiPschool Cape Town 20152015Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaRatHeart
Calzia 2015 Abstract MiP20152015Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.LEAK
OXPHOS
ET
N
S
ROX
HumanSkeletal muscle
Lindquist 2015 Abstract IOC1062015Alteraas EK, Lindquist C, Berge RK, Bjorndal B (2015) OXPHOS capacity in mouse liver altered by modified fatty acids that inhibit or stimulate beta-oxidation. Mitochondr Physiol Network 20.10.OXPHOS
ET
HomogenateMouseLiver
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
FPermeabilized tissueHuman
Rat
Skeletal muscle
Oliveira 2015 Abstract IOC1002015Oliveira MT, Saari S, Andjelkovic A, Jacobs HT (2015) Investigating the metabolic alterations caused by the transgenic expression of the mitochondrial alternative oxidase of Ciona intestinalis in Drosophila melanogaster. Mitochondr Physiol Network 20.01.OXPHOSHexapods
Other invertebrates
Doerrier 2015 Abstract MiPschool Greenville 20152015"Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.LEAK
OXPHOS
SIsolated mitochondriaMouseHeart
Doerrier 2015 Abstract MiP20152015Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.LEAK
OXPHOS
SIsolated mitochondriaMouseHeart
Hill 2015 Abstract MiPschool London 20152015A novel inhibitor of the mitochondrial permeability transition pore is beneficial in an experimental model of multiple sclerosis.OXPHOS
ET
Isolated mitochondriaMouseLiver
Shevchuk 2015 Abstract MiP20152015Analysis of energy fluxes in colorectal cancer saponin skinned tissues and Caco-2 cells.OXPHOSN
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Madlala 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Madlala 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOSFPermeabilized tissueRatSkeletal muscle
Ojuka 2015 Abstract MiPschool Cape Town 20152015Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation.LEAK
OXPHOS
ET
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Hoppel 2015 Abstract MiP20152015Effects of ultramarathon performance on mitochondrial respiration in human platelets.ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cellsHumanBlood cells
Platelet
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chou 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Blood cells
Lymphocyte
Platelet
Gnaiger 2015 Abstract MiPschool Cape Town 20152015The functional design of the electron transfer system (ETS) and mitochondrial respiratory control.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Funk 2015 Abstract MiPschool Greenville 20152015Isolated mitochondria from liver and brain of long-lived growth hormone receptor gene disrupted mice demonstrate reduced respiration rates.LEAK
OXPHOS
Isolated mitochondriaMouseNervous system
Liver
Renshaw 2015 Abstract MiP20152015Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress?LEAK
OXPHOS
ET
N
S
HomogenateFishesNervous system
Bhattarai 2015 Abstract MiPschool Greenville 20152015Exercise improves whole-body and skeletal muscle oxidative capacity in burned children.OXPHOSPermeabilized tissueHumanSkeletal muscle
Sleiman 2015 Abstract MiP20152015Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs.LEAK
OXPHOS
ET
N
S
HomogenatePigSkeletal muscle
Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
NS
Permeabilized tissueHumanHeart
Ali 2015 Abstract MiPschool Cape Town 20152015Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics.LEAK
OXPHOS
ET
MouseHeart
Nervous system
Gnaiger 2015 Abstract MiP20152015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Intact cells
HumanHEK
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueRatHeart
Laner 2015 Abstract MiPschool Cape Town 20152015The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Isolated mitochondria
Intact cells
Mouse
Saccharomyces cerevisiae
Heart
Matarne 2015 Abstract MiPschool Greenville 20152015Chronic activation of AMP-activated protein kinase increases oxidative capacity and monocarboxylate transporter expression in skeletal muscle of pigs.OXPHOSPigSkeletal muscle
Sumbalova 2015 Abstract MiP20152015High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseNervous system
Sheldon 2015 Abstract MiPschool Greenville 20152015eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease.LEAK
OXPHOS
ET
N
NS
MouseLiver
Weidgang 2015 Abstract MiP20152015Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39.LEAK
OXPHOS
ET
N
S
HomogenateMouseHeart
Skeletal muscle
Liver
Kidney
Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
FPermeabilized tissue
Nuskova 2015 Abstract MiPschool London 20152015Insufficient energy provision or increased oxidative stress – what matters more in ATP synthase deficiencies?ROUTINE
OXPHOS
HumanHEK
Karabatsiakis 2015 Abstract MiP20152015Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.LEAK
ROUTINE
OXPHOS
ET
ROXHumanBlood cells
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
F
N
Permeabilized tissueMouseSkeletal muscle
Ost 2015 Abstract IOC1002015Ost M (2015) “Mitokines” and the organismal role of mitochondrial function in energy homeostasis & metabolism. Mitochondr Physiol Network 20.01.LEAK
OXPHOS
Permeabilized tissueMouseSkeletal muscle
Fibroblast
George 2015 Abstract MiPschool Greenville 20152015Mitochondria do not directly oxidize lactate within the cerebral cortex or hippocampus.OXPHOSNPermeabilized tissueHuman
Mouse
Rat
Skeletal muscle
Nervous system
Laner 2015 Abstract MiP20152015Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Pretorius 2015 Abstract MiPschool Cape Town 20152015Metallothioneins are involved in mitochondrial function and disease.OXPHOSMouse
Laner 2015 Abstract MiPschool Greenville 20152015Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.OXPHOS
ET
F
N
S
NS
Permeabilized tissueDogSkeletal muscle
Boyle 2015 Abstract MiP20152015Kv1.3 channels in mitochondria: Are they important in cellular proliferation?OXPHOSHumanEndothelial;epithelial;mesothelial cell
HEK
Smith 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Smith 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
FPermeabilized tissue
De Bari 2015 Abstract MiPschool London 20152015The mitochondrial metabolism of lactate isomers in human prostate cancer cells.OXPHOSHomogenate
Isolated mitochondria
HumanGenital
Ali 2015 Abstract MiP20152015Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!LEAK
OXPHOS
ET
HomogenateMouseHeart
Nervous system
Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Coen 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOSF
N
NS
Permeabilized tissue
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II2015On coupling control of mitochondrial respiration. What is wrong with the RCR?LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Morris 2015 Abstract MiPschool Greenville 20152015Intrinsic high aerobic capacity is associated with protection of mitochondrial respiratory capacity and decreased inflammation following chronic high-fat/high-cholesterol diet challenge.OXPHOS
ET
NRatLiver
Volani 2015 Abstract IOC1062015Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10.ROUTINE
OXPHOS
ET
N
S
Homogenate
Intact cells
Human
Mouse
Heart
Liver
Blood cells
Lymphocyte
Amoedo 2014 Abstract MiP20142014The metabolic panorama during tumor progression towards malignancy.OXPHOSF
S
Permeabilized cellsOther cell lines
Power 2014 Abstract MiP20142014The hot heart: cardiac mitochondrial energetics during hyperthermia.LEAK
OXPHOS
Isolated mitochondriaRatHeart
Hahn 2014 Abstract MiP20142014Validation of oxygen consumption measurements in muscle and fibroblasts from patients with mitochondrial diseases.OXPHOSPermeabilized cellsHumanSkeletal muscle
Fibroblast
Komlodi 2014 Abstract MiP20142014Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation.OXPHOS
ET
N
S
Isolated mitochondriaGuinea pigNervous system
Laner 2014 Abstract MiP20142014Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized tissueDogSkeletal muscle
Horscroft 2014 Abstract MiP20142014Substrate utilisation in the hypoxic heart: a glycolysis/glucose oxidation mismatch?OXPHOSF
N
RatHeart
Mracek 2014 Abstract MiP20142014Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.OXPHOSSPermeabilized tissueHumanHeart
Zapisek 2014 Abstract MiP20142014YER077C encodes a novel PPR protein essential for mitochondrial genome expression in Saccharomyces cerevisiae.OXPHOSSaccharomyces cerevisiae
Bristot 2014 Abstract MiP20142014High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.LEAK
OXPHOS
Intact cellsHumanFibroblast
Schoepf 2014 Abstract MiP20142014OXPHOS analysis in small prostate biopsies.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueHumanGenital
Harrison 2014 Abstract MiP20142014The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia.OXPHOSIsolated mitochondriaRat
Bovines
Heart
Krumschnabel 2014 Abstract MiP20142014Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Dennerlein 2014 Abstract IOC962014Dennerlein S (2014) Insights into COX-assembly: An important but not the only OXPHOS complex. Mitochondr Physiol Network 19.11.OXPHOSHuman
Jana Prado 2014 Abstract MiP20142014Defining the role of mitochondrial electron transfer Complex I on the modulation of Ca2+ homeostasis: effects of metformin on cancer cell metabolism. Mitochondr Physiol Network 19.13.OXPHOS
Neufer 2014 Abstract MiP20142014Assessing ATP production and oxygen consumption simultaneously in permeabilized fibers: ATP/O.OXPHOSPermeabilized tissueMouseSkeletal muscle
Zorzano 2014 Abstract MiP20142014Metabolic implications of mitofusin 2 dysfunction.LEAK
OXPHOS
MouseSkeletal muscle
Brown DA 2014 Abstract MiP20142014The cardiolipin-targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes.OXPHOSN
S
Permeabilized tissueRatHeart
Sparks 2014 Abstract MiP20142014NAMPT remodels substrate metabolism in skeletal muscle.LEAK
OXPHOS
N
S
Permeabilized tissueMouseSkeletal muscle
Hepple 2014 Abstract MiP20142014Denervation modulates mitochondrial function when aging muscle atrophy becomes severe: implications for therapeutic intervention.OXPHOSPermeabilized tissueHumanSkeletal muscle
Paes 2014 Abstract IOC 2014-04 Schroecken2014Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ET
S
Other combinations
Permeabilized cells
Oxidase;biochemical oxidation
Protists
Lai 2014 Abstract1 MiP20142014Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.LEAK
OXPHOS
NIsolated mitochondriaRat
Dog
Heart
Skeletal muscle
Fibroblast
Doerrier 2014 Abstract SECF2014Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseHeart
Jezek 2014 Abstract MiP20142014Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.LEAK
OXPHOS
Isolated mitochondriaOther cell lines
Paju 2014 Abstract MiP20142014Characterization of the effects of pro-inflammatory cytokines on energy metabolism in human myoblasts.OXPHOSN
S
Permeabilized cellsHumanSkeletal muscle
Sobotka 2014 Abstract IOC952014Sobotka O (2014) Effect of α-Tocopheryl succinate on Complex II. Mitochondr Physiol Network 19.10OXPHOSSHomogenate
Isolated mitochondria
RatHeart
Liver
Burtscher 2014 Abstract MiP20142014Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain.OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueMouseNervous system
Sumbalova 2014 Abstract MiP20142014Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.OXPHOS
ET
F
N
S
NS
Isolated mitochondriaRatNervous system
Liver
Herbst 2014 Abstract MiP20142014Analysis of mitochondrial function in multiple brain regions through in situ permeabilization.OXPHOSPermeabilized tissue
Isolated mitochondria
MouseNervous system
Mendonca 2014 Abstract IOC 2014-04 Schroecken2014Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ET
Nervous system
Other cell lines
Neuroblastoma
Larsen 2014 Abstract MiP20142014The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue.OXPHOSF
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Fat
Pecina 2014 Abstract MiP20142014Manifestation of mitochondrial disorders of nuclear origin in lymphocytes.OXPHOSN
S
Gp
CIV
Permeabilized cellsHumanBlood cells
Lymphocyte
Dohlmann 2014 Abstract MiP20142014Mitochondrial adaptations to high-intensity training in young and elderly men and women.OXPHOS
ET
Permeabilized cellsHumanSkeletal muscle
HeLa
Fibroblast
Kandashvili 2014 Abstract MiP20142014Regulation of energy metabolism in human colorectal cancer cells in situ.OXPHOSPermeabilized tissueHumanEndothelial;epithelial;mesothelial cell
Porter 2014 Abstract IOC952014Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10LEAK
OXPHOS
ET
Permeabilized tissueHumanSkeletal muscle
Herminghaus 2014 Abstract MiP20142014Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.LEAK
OXPHOS
N
S
Isolated mitochondriaRatLiver
Busch 2014 Abstract MiP20142014Mitochondrial fusion and fission dynamics are indispensable for homogenization of inner mitochondrial membrane proteins: insights from superresolution studies.OXPHOSHuman
Volodina 2014 Abstract MiP20142014Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaRatLiver
Maedo 2014 Abstract IOC 2014-04 Schroecken2014Maedo K, Kaldma A, Planken A, Klepinin A, Chekulayev V, Varikmaa M, Tepp K, Chevchuk I, Kaambre T (2014) Regulation of mitochondrial respiration in human colorectal cancer cells in situ: the possible role of beta-tubulins. Mitochondr Physiol Network 19.02.OXPHOSPermeabilized tissueHumanEndothelial;epithelial;mesothelial cell
Perry 2014 Abstract MiP20142014Evaluation of critical experimental parameters for assessing mitochondrial bioenergetics in permeabilized myofibers.OXPHOSPermeabilized tissueHumanSkeletal muscle
Grefte 2014 Abstract MiP20142014Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II.OXPHOSMouseSkeletal muscle
Kluckova 2014 Abstract MiP20142014Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.OXPHOS
ET
SOther cell lines
Gnaiger 2014 Abstract MiP20142014Cell ergometry: OXPHOS and ET-pathway coupling efficiency.OXPHOS
Hickey 2014 Abstract MiP20142014Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart.OXPHOSN
S
Permeabilized tissueRatHeart
Maddalena 2014 Abstract MiP20142014Experimental considerations for evaluating bioenergetic effects of a mitochondria-targeted compound, TPP-IOA.OXPHOSIsolated mitochondria
Wohlwend 2014 Abstract MiP20142014Exercise modality specific mitochondrial adaptations in skeletal muscle of elderly people.OXPHOSN
NS
Permeabilized cellsHumanSkeletal muscle
Prouteau-Angebault 2013 Abstract IOC752013Prouteau-Angebault C (2013) Are cardiolipins involved in the mitochondrial respiratory chain defect in OPA1 mouse model? Mitochondr Physiol Network 18.03.OXPHOSN
S
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
MouseSkeletal muscle
Nervous system
Dungel 2013 Abstract MiP20132013Dungel P, Perlinger M, Faulhammer B, Weidinger A, Redl H, Kozlov AV (2013) Iron-mediated injury of mitochondria is attenuated by nitrite. Mitochondr Physiol Network 18.08.OXPHOSN
S
Isolated mitochondriaRatLiver
Lemieux 2013 Abstract MiP20132013Lemieux H, Warren BE, Lucchinetti E, Lou PH, Zhang L, Gandhi M, Clanachan AS, Zaugg M(2013) Early mitochondrial dysfunction associated with type 2 diabetes mellitus in the heart and skeletal muscle. Mitochondr Physiol Network 18.08.OXPHOSF
N
S
CIV
NS
Other combinations
Permeabilized tissueRatHeart
Skeletal muscle
Gellerich 2013 Abstract MiP20132013Gellerich FN, Korzeniewski B, Gizatullina Z, Debska-Vielhaber G, Gainutdinov T, König R, Reymann K, Vielhaber S(2013) The mitochondrial gas pedal, a unique property of neurons exists also in heart and skeletal muscle but not in astrocytes. New evidences by in silico investigations and (patho-)physiological consequences. Mitochondr Physiol Network 18.08.OXPHOSNIsolated mitochondriaNervous system
Gnaiger 2013 Abstract Mito20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Boushel 2013 Abstract MiP20132013Boushel RC (2013) Convective O2 delivery, diffusion and mitochondrial OXPHOS components of VO2 during exercise in health and disease. Mitochondr Physiol Network 18.08.OXPHOSN
S
NS
Intact organism
Permeabilized cells
Permeabilized tissue
HumanSkeletal muscle
Jacobs 2013 Abstract MiP20132013Jacobs R, Flück D, Bonne TC, Bürgi S, Christensen PM, Toigo M, Lundby C (2013) Improvements in exercise performance with high-intensity interval training are facilitated by an increase in skeletal muscle mitochondria content. Mitochondr Physiol Network 18.08.OXPHOSIntact organism
Permeabilized tissue
HumanSkeletal muscle
Szibor 2013 Abstract MiP20132013Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ROXIsolated mitochondria
Oxidase;biochemical oxidation
MouseHeart
Skeletal muscle
Nervous system
Liver
Lung;gill
Gnaiger 2013 Abstract Neurocon Kolkata2013Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Kolkata, India. Symposium: Neurocon 2013. January 17-20.OXPHOSPermeabilized tissueHumanSkeletal muscle
Hand 2013 Abstract MiP20132013Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Intact organism
Homogenate
Isolated mitochondria
Enzyme
Artemia
Crustaceans
Quistorff 2013 Abstract MiP20132013Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
S
Other combinations
RatSkeletal muscle
Liver
Dela 2013 Abstract MiP20132013Dela F (2013) Glucose tolerance and skeletal muscle coenzyme Q(10). Mitochondr Physiol Network 18.08.OXPHOSN
S
NS
Permeabilized tissueHumanSkeletal muscle
Camacho-Pereira 2013 Abstract IOC752013Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.ET
LEAK
OXPHOS
ROUTINE
N
NS
S
Intact cells
Isolated mitochondria
Permeabilized cells
MouseHEK
Liver
Macrophage-derived
Dzialowski 2013 Abstract MiP20132013Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Intact organism
Permeabilized tissue
BirdsSkeletal muscle
Lindenberg 2013 Abstract MiP20132013Lindenberg K, Matallo J, Fleischer C, Lenk T, Lehnert S, Jahn O, Otto M, Calzia E, Landwehrmeyer GB (2013) Similar alterations in mitochondrial proteome of brain and skeletal muscle in two transgenic mouse models for Huntington´s disease. Mitochondr Physiol Network 18.08.OXPHOSIsolated mitochondriaMouseSkeletal muscle
Nervous system
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact organism
Permeabilized tissue
RatSkeletal muscle
DeLany 2013 TOS2013Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness.LEAK
OXPHOS
Permeabilized tissueHumanSkeletal muscle
Brandt 2013 Abstract MiP20132013Brandt T, Mourier A, Stewart JB, Larsson NG, Kühlbrandt W (2013) Structure and function of aged mouse mitochondria. Mitochondr Physiol Network 18.08.OXPHOSIsolated mitochondriaMouseHeart
Liver
Kidney
Korzeniewski 2013 Abstract MiP20132013Korzeniewski B (2013) Regulation of oxidative phosphorylation during work transitions in different tissues results from its kinetic properties. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Heart
Skeletal muscle
Tepp 2013 Abstract MiP20132013Tepp K, Anmann T, Varikmaa M, Timohhina N, Shevchuk I, Chekulayev V, Saks V, Kaambre T (2013) Bioenergetic aspects of postnatal development of cardiac cells: Formation of structure-function relationship. Mitochondr Physiol Network 18.08.OXPHOSN
S
CIV
Intact cells
Permeabilized cells
Permeabilized tissue
RatHeart
Krumschnabel 2013 Abstract MiP20132013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouse
Fishes
Heart
Nervous system
Liver
Shabalina 2013 Abstract IOC792013Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseHeart
Skeletal muscle
Liver
Schulte 2013 Abstract MiP20132013Chung DJ, Schulte PM, Richards JG (2013) The effect of low-temperature acclimation on mitochondrial function in the common killifish (Fundulus heteroclitus), a top-down elasticity analysis. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Isolated mitochondriaFishesLiver
Salin 2013 Abstract MiP20132013Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
S
CIV
Isolated mitochondria
Enzyme
Oxidase;biochemical oxidation
Other mammals
Amphibians
Liver
Menze 2013 Abstract MiP20132013Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
NIntact organism
Intact cells
Permeabilized cells
Isolated mitochondria
Enzyme
Drosophila
Artemia
Crustaceans
Hexapods
Other cell lines
CHO
HEK
Macrophage-derived
Hickey 2013 Abstract MiP20132013Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueOther mammals
Fishes
Heart
Lundby 2013 Abstract MiP20132013Lundby C, Bonne T, Flück D, Jacobs R, Meinild AK, Lundby S, Robach P (2013) The effects of hypoxic training on aerobic performance in normoxia and moderate hypoxia: a randomized, double blind, placebo controlled study. Mitochondr Physiol Network 18.08.OXPHOSPermeabilized tissueHumanSkeletal muscle
Galina 2013 Abstract MiP20132013Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
Permeabilized cells
Isolated mitochondria
Enzyme
Intact cells
RatSkeletal muscle
Nervous system
Liver
Other cell lines
Calzia 2013 Abstract MiP20132013Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
Pig
Mouse
Liver
Kotwica 2013 Abstract MiP20132013Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
N
S
Permeabilized tissueMouseHeart
Skeletal muscle
Vercesi 2013 Abstract MiP20132013Vercesi AE (2013) Mitochondrial respiration, Ca2+ transport and oxidative stress: Fungi, trypanosomes, plants and mammals. Mitochondr Physiol Network 18.08.OXPHOSNPermeabilized cells
Isolated mitochondria
Rat
Other invertebrates
Fungi
Plants
Protists
Heart
Pecina 2013 Abstract MiP20132013Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Homogenate
HumanBlood cells
Lymphocyte
Amoedo 2013 Abstract MiP20132013Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.ET
LEAK
OXPHOS
ROUTINE
N
ROX
S
Enzyme
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Bir 2013 Abstract MiP20132013Bir A, Sen O, Anand S, Banerjee P, Sahoo A, Khemka V, Cappai R, Chakrabarti S (2013) α-Synuclein mediated alterations in mitochondrial oxidative phosphorylation system: Implications in the pathogenesis of Parkinson’s disease. Mitochondr Physiol Network 18.08.OXPHOSIsolated mitochondria
Intact cells
RatNervous system
Other cell lines
Shabalina 2013 Abstract MiP20132013Shabalina IG, Petrovic N, Kalinovich AV, Cannon B, Nedergaard J (2013) Comparative study of brown and white adipose tissue mitochondria in mice upon cold acclimation. Mitochondr Physiol Network 18.08.OXPHOS
ET
GpIsolated mitochondriaFat
Gnaiger 2013 Abstract MiP20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Irving 2013 Abstract MiP20132013Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
NS
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fat
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Permeabilized cells
Permeabilized tissue
Homogenate
Intact cells
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Holloway 2013 Abstract MiP20132013Holloway GP (2013) Tissue specific changes in respiratory substrate kinetics in the ZDF rat and in response to resveratrol supplementation. Mitochondr Physiol Network 18.08.OXPHOSPermeabilized tissueRatHeart
Skeletal muscle
Chicco 2013 Abstract MiP20132013Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
Other combinations
Permeabilized tissueHuman
Other mammals
Skeletal muscle
Larsen FJ 2013 Abstract MiP20132013Larsen FJ, Schiffer TA, Lundberg JO, Weitzberg E (2013) Human mitochondria has a unique response to ischemia-reperfusion injury compared to mitochondria from rat, mouse and pig . Mitochondr Physiol Network 18.08.OXPHOSROXIsolated mitochondriaHuman
Pig
Mouse
Rat
Volska 2013 Abstract MiP20132013Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reoxygenation injury. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
NIsolated mitochondriaRatNervous system
Laner 2013 ASMRM2013Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Blier 2013 Abstract MiP20132013Blier PU, Lemieux H, Pichaud N (2013) Holding our breath in our modern world: are mitochondria keeping the pace with global changes? Mitochondr Physiol Network 18.08.OXPHOSOther invertebrates
Chicco 2013 Abstract MiP2013 Poster2013Chicco AJ, Claiborne MS, Le CH, Mulligan CM (2013) Remodeling of skeletal muscle mitochondria in response to exercise training in taz shRNA mouse model of human Barth Syndrome. Mitochondr Physiol Network 18.08.OXPHOSNIsolated mitochondriaMouseSkeletal muscle
Slinde 2013 Abstract MiP20132013Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissue
Isolated mitochondria
Other mammals
Fishes
Heart
Liver
Blood cells
Hendricks 2013 Abstract MiP20132013Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Garcia-Roves 2013 Abstract MiP20132013Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08.ET
LEAK
OXPHOS
CIV
N
NS
S
Homogenate
Permeabilized cells
Permeabilized tissue
MouseFat
Islet cell;pancreas;thymus
Liver
Nervous system
Skeletal muscle
Palm 2013 Abstract MiP20132013Palm F, Hansell P, Friederich-Persson M (2013) Role of mitochondrial function for the onset and progression of kidney disease. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Intact organ
Intact cells
Isolated mitochondria
Mouse
Rat
Kidney
Chicco 2013 Abstract IOC792013Chicco AJ (2013) Substrate-specific impairment of oxidative phosphorylation in Tafazzin-deficient cardiac mitochondria: potential role of CoA deficiency. Mitochondr Physiol Network 18.07OXPHOSF
N
S
Isolated mitochondria
Permeabilized cells
MouseHeart
Darveau 2013 Abstract MiP20132013Darveau CA, Teulier L, Crevier J, Weber JM (2013) Diversity and evolution of mitochondrial metabolism: Proline as a metabolic reward for pollinators. Mitochondr Physiol Network 18.08.OXPHOSN
S
Gp
NS
Other combinations
Permeabilized tissueHexapodsSkeletal muscle
Larsen S 2013 Abstract MiP20132013Larsen S, Dohlmann TL, Hindsø M, Dela F, Helge JW (2013) High intensity training decreases mitochondrial ADP sensitivity in human adipose and skeletal muscle tissue. Mitochondr Physiol Network 18.08.OXPHOSIntact organism
Permeabilized tissue
HumanSkeletal muscle
Fat
Votion 2013 Abstract MiP20132013Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08.ET
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueHorseSkeletal muscle
Gnaiger 2013 Abstract ASMRM2013Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul.LEAK
OXPHOS
Human
Borutaite 2013 Abstract MiP20132013Borutaite V, Jablonskiene G, Arandarcikaite O (2013) Mitochondrial response to heart and brain ischemia. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
N
S
Isolated mitochondriaPig
Rat
Heart
Nervous system
Christen 2013 Abstract MiP20132013Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08.ET
OXPHOS
CIV
N
NS
ROX
S
Isolated mitochondriaFishes
Other mammals
Heart
Staples 2013 Abstract MiP20132013Staples JF(2013) Mechanisms of mitochondrial metabolic suppression in hibernation. Mitochondr Physiol Network 18.08.OXPHOSSIsolated mitochondriaOther mammalsLiver
Oliveira Pinto 2013 Abstract IOC752013Oliveira Pinto M (2013) Studies on the energy and redox metabolism of the blood fluke Schistosoma mansoni. Mitochondr Physiol Network 18.03.OXPHOSOther combinationsIntact organismOther invertebrates
Jezek 2013 Abstract MiP20132013Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Isolated mitochondria
Intact cells
MouseLung;gill
Islet cell;pancreas;thymus
Pichaud 2013 Abstract MiP20132013Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophila
Hexapods
Skeletal muscle
Scott 2013 Abstract MiP20132013Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Isolated mitochondria
Enzyme
Other mammals
Birds
Skeletal muscle
Hoppel 2012 Abstract Bioblast2012Hoppel CL (2012) Mitochondrial functional testing – muscle biopsy, isolated mitochondria and others. Mitochondr Physiol Network 17.12.OXPHOSPermeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Liver
Hepple 2012 Abstract Bioblast2012Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.LEAK
OXPHOS
Permeabilized tissue
Isolated mitochondria
Skeletal muscle
Acuna-Castroviejo 2012 Abstract Bioblast2012Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12.ROUTINE
OXPHOS
N
S
NS
Intact organism
Isolated mitochondria
Intact cells
Mouse
Rat
Heart
Skeletal muscle
Nervous system
Liver
Horscroft 2012 Abstract IOC722012Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ET
N
NS
HumanSkeletal muscle
Labieniec-Watala 2012 Abstract Bioblast2012Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
Mouse
Rat
Heart
Liver
Fibroblast
Horvath 2012 Abstract Bioblast2012Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.ET
LEAK
OXPHOS
N
NS
S
HomogenateMouseHeart
Cervinkova 2012 Abstract Bioblast2012Cervinkova Z, Stankova P, Cervinka M, Kucera O, Drahota Z (2012) Evaluation of mitochondrial functions – an important tool for experimental hepatology. Mitochondr Physiol Network 17.12.OXPHOSN
S
Permeabilized cells
Homogenate
Isolated mitochondria
Intact cells
RatLiver
Kamath 2012 Abstract IOC722012Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ET
Isolated mitochondriaRat
Le 2012 Abstract Bioblast2012Le CH, Hocker AD, Dreyer HC, Roach RC, Gnaiger E, Chicco AJ (2012) Two-week acclimatization to 5200m markedly alters substrate utilization and increases OXPHOS efficiency, with no effect on respiratory capacity in skeletal muscle mitochondria. Mitochondr Physiol Network 17.12.OXPHOS
ET
N
S
Permeabilized tissueHumanSkeletal muscle
Dzialowski 2012 Abstract IOC722012Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaReptilesHeart
Skeletal muscle
Doerrier 2012 Abstract Bioblast2012Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseHeart
Amoedo 2012 Abstract Bioblast2012Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
ET
SIntact cellsMouseOther cell lines
Votion 2012 Abstract Bioblast2012Votion DM (2012) The cause of atypical myopathy in grazing European horses revealed. Mitochondr Physiol Network 17.12.OXPHOSN
S
NS
Permeabilized cellsHorseSkeletal muscle
Plenge 2012 Endocrine Abstracts2012Plenge U, Guadeloupe-Grau A, Andersen P, Lundby C, Dela F, Pott F, Helge J, Belhage B, Boushel RC (2012) Recombinant erythropoietin treatment enhances mitochondrial function in human skeletal muscle. Endocrine Abstracts 29 P302 .OXPHOSPermeabilized tissueHumanSkeletal muscle
Galina 2012 Abstract Bioblast2012Simonin V, Galina A (2012) Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner. Mitochondr Physiol Network 17.12.OXPHOSN
S
NS
Tronstad 2012 Abstract Bioblast2012Nikolaisen J, Nilsson LIH, Hagland HR, Koopman WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12.OXPHOSHuman
Rat
Liver
Endothelial;epithelial;mesothelial cell
Blood cells
Irving 2012 Abstract IOC722012Irving BA (2012) AgRP deficient female mice have elevated body weight and hypothalamic mitochondrial oxidative capacity. Mitochondr Physiol Network 17.13.OXPHOSN
S
NS
Permeabilized tissueMouse
Rat
Skeletal muscle
Nervous system
Liver
Fat
Jacobs 2012 Abstract Bioblast2012Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized cellsHumanSkeletal muscle
Hand 2012 Abstract Bioblast2012Patil Y, Gnaiger E, Hand SC (2012) Respiration in embryo lysates reveals diminished Complex I activity and inhibition of the phosphorylation system during diapause in Artemia franciscana. Mitochondr Physiol Network 17.12.OXPHOS
ET
N
S
NS
HomogenateArtemia
Crustaceans
Mark 2012 Abstract Bioblast2012Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
N
S
CIV
NS
Permeabilized tissue
Isolated mitochondria
FishesHeart
Liver
Hedges IBEC20122012Hedges CP, Hickey AJ, McMahon CD, Smith HK (2012) A fiber-type-specific role for myostatin in regulating mitochondrial function. IBEC2012.OXPHOSPermeabilized tissueMouseSkeletal muscle
Towheed 2012 Abstract IOC722012Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Intact organism
Permeabilized tissue
Drosophila
Hexapods
Nuskova 2011 Abstract IOC612011Nuskova H, Pecina P, Kovarova N, Dell’Agnello C, Zeviani M, Houstek J (2011) Cytochrome c oxidase with decreased H+/e− ratio in SURF1 knockout mice. MiPNet16.01.OXPHOSIsolated mitochondria
Intact cells
MouseEndothelial;epithelial;mesothelial cell
Fibroblast
Pesta 2011Abstract Mitochondrial Medicine-Training2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Magnifico 2011 Abstract IOC612011Magnifico MC, Arese M, Mastronicola D, Forte E, Giuffre A, Testa F, Sarti P (2011) NO-signalling and cell bioenergetics. MiPNet16.01.OXPHOSIntact cellsHumanEndothelial;epithelial;mesothelial cell
Gnaiger 2011 Abstract SMRM-Hyderabad2011Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad.LEAK
OXPHOS
Human
Pinho 2011 Abstract IOC652011Pinho JPC, Goncalves RL, Oliveira MF (2011) Studies on the dynamic changes of mitochondrial function following a blood meal in the kissing bug Rhodnius prolixus. MiPNet16.03.OXPHOSIsolated mitochondria
Enzyme
Hexapods
Sumbalova 2011 Abstract Mitochondrial Medicine2011Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Lemieux 2011 Abstract Bordeaux2011Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. MiP2011OXPHOSHumanHeart
Pesta 2011Abstract ACSM2011Pesta D, Jacobs R, Macek C, Hoppel F, Faulhaber M, Lundby C, Burtscher M, Gnaiger E, Schocke M (2011) Investigation of muscle metabolism of the quadriceps via high-resolution respirometry and 31P MRS in connection with a 10 week endurance training. Medicine & Science in Sports & Exercise 43: 71OXPHOSPermeabilized cellsHumanSkeletal muscle
Gnaiger 2011 Abstract-MonteVerita2011Gnaiger E (2011) Mitochondrial respiratory capacity at maximum aerobic exercise levels: Are intracellular oxygen levels limiting? Abstract Monte Verita.OXPHOSN
S
NS
Human
Pesta 2011Abstract Mitochondrial Medicine-Diagnosis2011Pesta D, Wiethuechter A, Karall D, Schocke M, Gnaiger E (2011) Functional mitochondrial diagnosis in a patient suffering from sudden exercise intolerance. Abstract Mitochondrial Medicine Chicago.OXPHOSPermeabilized tissue
Homogenate
Human
Lane MiP20102010Lane N (2010) Mitochondria and the origin of complex life. Abstract MiP2010.OXPHOSEubacteria
Archea
Gnaiger Abstract MiP2010 2-012010Gnaiger E (2010) Measuring the upper limit of mitochondrial performance - how and why?OXPHOSIsolated mitochondria
Intact cells
HumanFibroblast
Matallo MiP20102010Matallo J, Reich V, Calzia E, Radermacher P, Groeger M (2010) Interactions between sulfide and mitochondrial respiration in cultured murine alveolar macrophage. Abstract. MiP2010.OXPHOS
ET
N
S
Permeabilized cellsLung;gill
Macrophage-derived
Kim MiP20102010Kim HK, Park WS, Choi SW, Ha SH, Kim N, Han J (2010) BH4 deficiency involved in cardiac mitochondria metabolic pathway remodelling. MiP2010.OXPHOSMouseHeart
Pesta 2010 Abstract IOC602010Pesta D, Macek C, Hoppel F, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) The impact of endurance training on muscle oxidative capacity. MiPNet15.10.OXPHOSEnzymeHuman
El-Bacha MiP20102010Amoedo ND, Rodrigues MF, Pezutto P, Lourenco MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: studies on mitochondrial physiology and bioenergetics.OXPHOSIntact cellsOther cell lines
ElBacha 2010 Abstract IOC602010El-Bacha T, Abud M, Galina A, Da Poian AT (2010) Bioenergetics of liver mitochondria from mice infected with Dengue virus. MiPNet15.10.OXPHOSIsolated mitochondriaMouseLiver
Pesta 2010 MiP Abstract2010Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.LEAK
OXPHOS
ET
F
N
S
NS
Human
Amoedo 2010 Abstract MiP20102010Amoêdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06.OXPHOS
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Dela MiP20102010Kraunsoee R, Boushel RC, Hansen CN, Schjerling P, Qvortrup K, Stoecke M, Mikines KJ, Dela F (2010) Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. Mitochondr Physiol Network 15.6:50-1.OXPHOSPermeabilized tissueHuman
Vaupel MiP20102010Vaupel P, Mayer A (2010) Evidence against a mitochondrial dysfunction in cancer cells as a hallmark of malignant growth. Abstract MiP2010.OXPHOSIntact cells
Garedew 2006 Biochim Biophys Acta2006Garedew A, Lemieux H, Schachner T, Blier PU, Tardif J-C, Gnaiger E (2006) High excess capacity of cytochrome c oxidase in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):167-8.OXPHOSN
S
NS
Permeabilized tissue
Enzyme
Oxidase;biochemical oxidation
MouseHeart
Lemieux 2006 Biochim Biophys Acta2006Lemieux H, Garedew A, Blier PU, Tardif J-C, Gnaiger E (2006) Temperature effects on the control and capacity of mitochondrial respiration in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):201-2.OXPHOSPermeabilized tissue
Enzyme
Oxidase;biochemical oxidation
MouseHeart
Gnaiger 2005 Abstract MiP20052005High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age.OXPHOS
ET
F
N
CIV
NS
Permeabilized tissueHumanSkeletal muscle



Labels:




Coupling state: OXPHOS 

HRR: Theory 



MitoPedia concepts: Respiratory state, SUIT concept, SUIT state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE