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OctPGM pathway control state

From Bioblast


high-resolution terminology - matching measurements at high-resolution


OctPGM pathway control state

Description

OctPGM: Octanoylcarnitine & Pyruvate & Glutamate & Malate.

MitoPathway control state: FN

SUIT protocols: SUIT-002

This substrate combination supports N-linked flux which is typically higher than FAO capacity (F/FN<1 in the OXPHOS state). In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare malate-anaplerotic pathway control state, M alone), and pyruvate and glutamate is added to compare FAO as the background state with FN as the reference state.

Abbreviation: OctPGM

Reference: MiPNet21.06 SUIT RP

More details
ยป FN
ยป Additive effect of convergent electron flow
ยป Respiratory complexes - more than five
ยป OctGM
ยป Convergent electron flow

OctPGML

FN pathway in the LEAK state can be evaluated in the following SUIT protocols:

OctPGMP

FN pathway in the OXPHOS state can be evaluated in the following SUIT protocols:


OctPGME

FN pathway in the ET state can be evaluated in the following SUIT protocols:


1PM;2D;3U;4G;5S;6Oct;7Rot;8Gp-



SUIT RP2



MitoPedia concepts: SUIT state