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Oliveira 2011 Insect Biochem Mol Biol

From Bioblast
Publications in the MiPMap
Oliveira JH, Gonçalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury C (2011) Energy metabolism affects susceptibility of Anopheles gambiae mosquitoes to Plasmodium infection. Insect Biochem Mol Biol 41:349-55.

» PMID: 21320598 Open Access

Oliveira JH, Goncalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury M (2011) Insect Biochem Mol Biol

Abstract: Previous studies showed that Anopheles gambiae L3-5 females, which are refractory (R) to Plasmodium infection, express higher levels of genes involved in redox-metabolism and mitochondrial respiration than susceptible (S) G3 females. Our studies revealed that R females have reduced longevity, faster utilization of lipid reserves, impaired mitochondrial State 3 respiration, increased rate of mitochondrial electron leak and higher expression levels of several glycolytic enzyme genes. Furthermore, when State 3 respiration was reduced in S females by silencing expression of the adenine nucleotide translocator (ANT), hydrogen peroxide generation was higher and the mRNA levels of lactate dehydrogenase increased in the midgut, while the prevalence and intensity of Plasmodiumberghei infection were significantly reduced. We conclude that there are broad metabolic differences between R and S An. gambiae mosquitoes that influence their susceptibility to Plasmodium infection. Keywords: Mosquito; Anopheles gambiae; Metabolism; Mitochondria; Plasmodium infection; Refractoriness; Electron leak; Reactive oxygen species

O2k-Network Lab: BR Rio de Janeiro Oliveira MF


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Stress:Oxidative stress;RONS  Organism: Hexapods 




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