Pedersen 2022 Nat Commun

Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. Nat Commun 13:2931. https://doi.org/10.1038/s41467-022-30629-5

» PMID: 35614135 Open Access

Pedersen Julie S,  Rygg Marte O,  Chroeis Karoline,  Sustarsic Elahu G,  Gerhart-Hines Zach,  Wever Albrechtsen Nicolai J,  Serizawa Reza R,  Kristiansen Viggo B,  Basse Astrid L,  Boilesen Astrid EB,  Olsen Beth H,  Hansen Torben,  Gluud Lise Lotte,  Madsbad Sten,  Larsen Steen,  Bendtsen Flemming,  Dela Flemming (2022) Nat Commun

Abstract: Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been hypothesised to contribute to the development of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). It is unknown whether OXPHOS capacities in human visceral (VAT) and subcutaneous adipose tissue (SAT) associate with NAFLD severity and how hepatic OXPHOS responds to improvement in NAFLD. In biopsies sampled from 62 patients with obesity undergoing bariatric surgery and nine control subjects without obesity we demonstrate that OXPHOS is reduced in VAT and SAT while increased in the liver in patients with obesity when compared with control subjects without obesity, but this was independent of NAFLD severity. In repeat liver biopsy sampling in 21 patients with obesity 12 months after bariatric surgery we found increased hepatic OXPHOS capacity and mitochondrial DNA/nuclear DNA content compared with baseline. In this work we show that obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD severity, however, bariatric surgery increases hepatic OXPHOS and mitochondrial biogenesis.

• Bioblast editor: Plangger M • O2k-Network Lab: DK Copenhagen Gerhart-Hines Z, DK Copenhagen Larsen S, DK Copenhagen Dela F

Correction: FADH₂ and Complex II

FADH₂ is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).

Gnaiger E (2024) Complex II ambiguities ― FADH₂ in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - »Bioblast link«

Labels: MiParea: Respiration, Patients  Pathology: Obesity 

Organism: Human  Tissue;cell: Fat, Liver  Preparation: Permeabilized tissue 

Coupling state: ET, LEAK, OXPHOS  Pathway: F, N, S, CIV, NS  HRR: Oxygraph-2k 

2022-11