Podrabsky 2010 Apoptosis

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Podrabsky JE, Krumschnabel G (2010) Cell death beyond worms, flies and humans: Unusual model systems for cell death research. Apoptosis 15:243-8.

» PMID: 20140522

Podrabsky JE, Krumschnabel G (2010) Apoptosis

Abstract:

Keywords: Cell death mechanism, Model organism, Evolution


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Review 

Since the discovery of apoptosis as a form of programmed cell death that is pivotal for development, differentiation, the immune response, and tumor suppression—to name just the most important functions—the use of non-mammalian model systems for the study of the molecular pathways important in cell death has been of invaluable benefit. Hence, the study of animals that can be comparatively easily genetically and/or experimentally manipulated, in particular of C. elegans and D. melanogaster, has enabled the detection of novel principles and mechanisms of cell death that are relevant for human physiology and clinical applications within a short and highly productive timeframe.