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Posch 2022 BEC

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Bioenergetics Communications        
Gnaiger 2020 BEC MitoPathways
       
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1.
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Bioenergetics Communications
Publications in the MiPMap
Posch W, Dichtl S, Zaderer V, Lass-Flörl C, Wilflingseder D (2022) How to optimize respiratory models for SARS-CoV-2 research. Bioenerg Commun 2022.9. https://doi.org/10.26124/bec:2022-0009

» Bioenerg Commun 2022.9. Open Access pdf
published online 2022-09-08»Watch the presentation«

Posch Wilfried, Dichtl Stefanie, Zaderer Viktoria, Lass-Floerl Cornelia, Wilflingseder Doris (BEC 2022.09) Bioenerg Commun

Abstract: BEC.png https://doi.org/10.26124/bec:2022-0009

Graphical abstract

Sophisticated 3D cell culture tissue models experienced a boom in the last years and in particular human cell culture and 3D respiratory systems greatly supported the development of novel drugs and vaccines during the SARS-CoV-2 pandemic. These models provide multiple benefits in terms of similarities in differentiation, metabolism, receptor expression, polarity, and infectivity compared to human tissues and thus provide excellent models to study the first interactions with the host during pathogen entry. Depending on the experimental approach, the use of 3D models is beneficial – apical-out lung organoids for high content screening (HCS) of treatment options and air-liquid interphase (ALI) models for easy incorporation of immune cells, screening of epithelial integrity or mucociliary clearance. This review gives an overview on the models established in our laboratory and their applications.

Keywords: respiratory models, air-liquid interphase, SARS-CoV-2 Bioblast editor: Tindle-Solomon L

ORCID: ORCID.png Posch Wilfried, ORCID.png Dichtl Stefanie, ORCID.png Zaderer Viktoria, ORCID.png Lass-Flörl Cornelia, ORCID.png Wilflingseder Doris

Preprint

» Posch 2022 MitoFit


Labels: Pathology: Infectious 

Organism: Human  Tissue;cell: Lung;gill, Endothelial;epithelial;mesothelial cell, Lymphocyte 




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