Description
Proton slip is a property of the proton pumps (Complexes CI, CIII, and CIV) when the proton slips back to the matrix side within the proton pumping process. Slip is different from the proton leak, which depends on Δp and is a property of the inner mt-membrane (including the boundaries between membrane-spanning proteins and the lipid phase). Slip is an uncoupling process that depends mainly on flux and contributes to a reduction in the biochemical coupling efficiency of ATP production and oxygen consumption. Together with proton leak and cation cycling, proton slip is compensated for by LEAK respiration or LEAK oxygen flux, L. Compare: Proton leak.
Reference: BEC 2020.1, Gnaiger 2020 BEC MitoPathways
- Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Specific
- » Artefacts by single dose uncoupling
- » ATP synthase
- » CCCP
- » Coupling-control protocol
- » DNP
- » Dyscoupled respiration
- » FCCP
- » Is respiration uncoupled - noncoupled - dyscoupled?
- » Noncoupled respiration: Discussion
- » Uncoupler
- » Uncoupled respiration - see » Noncoupled respiration
- » Uncoupling proteins
- » Uncoupling protein 1
- » Uncoupler titrations - Optimum uncoupler concentration
- Specific
- Respiratory states and control ratios
- » Biochemical coupling efficiency
- » Coupling-control state
- » Electron-transfer-pathway state
- » Electron-transfer pathway
- ET capacity
- » E-L coupling efficiency
- » Flux control efficiency
- » Flux control ratio
- » LEAK-control ratio
- » LEAK respiration
- » Noncoupled respiration
- » OXPHOS
- » OXPHOS capacity; » State 3
- » OXPHOS-control ratio, P/E ratio
- » Respiratory acceptor control ratio
- » ROUTINE-control ratio
- » ROUTINE respiration
- » ROUTINE state
- » State 3u
- » State 4
- » Uncoupling-control ratio UCR
- Respiratory states and control ratios
- Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
- General (alphabetical order)
- Other keyword lists
- Bioblast links: pH and protons - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- pH and protons
- » pH
- » hydrogen ion H+
- » hydron H+
- » hydronium ion H3O+
- » hydride H-
- » proton p+
- » pH buffering capacity
- » proton flux
- » proton pump versus hydrogen ion pump
- » proton leak
- » proton slip
- » protonmotive force
- pH and protons
- Oroboros pH
- » Oroboros Catalogue: O2k-pH ISE-Module
- » Oroboros Manual pH electrode: MiPNet23.15 O2k-pH ISE-Module
- » MiPNet08.16 pH calibration
- » File:PH-Calibration-List.xls
- » NextGen-O2k, ratiometric: Carboxy SNARF 1
- » NextGen-O2k, ratiometric: HPTS
- » pH calibration buffers
- Oroboros pH
- Oroboros Publications
- HRR - general
- » Oroboros Manual: MiPNet22.11 O2k-FluoRespirometer manual
- » O2k signals and output
- » MiPNet14.06 Instrumental O2 background
- » MiPNet19.18A O2k-Series G: Start
- » ESD
- » O2k configuration
- » O2k control
- » Oroboros FluoRespirometer
- » Oroboros Main Unit#O2k-Series
- » Titration-Injection microPump
- » Compare: O2k-TPP+_ISE-Module
- HRR - general
- DatLab
MitoPedia methods:
Respirometry
MitoPedia topics:
Uncoupler