Pyruvate dehydrogenase

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Pyruvate dehydrogenase

Description

Pyruvate dehydrogenase is the first component enzyme of the pyruvate dehydrogenase complex, which catalyzes oxidative decarboxylation of pyruvate in the mt-matrix, and yields acetyl-CoA. PDH is known as the mitochondrial gatekeeper in the core energy pathway of electron flow into the tricarboxylic acid cycle.

Abbreviation: PDH

Reference: Gnaiger 2014 MitoPathways, Hildyard 2003 Biochem J


MitoPedia topics: Enzyme