Qi 2017 Ann Allergy Asthma Immunol

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Qi S, Cindy Barnig C, Charles AL, Poirot A, Meyer A, Clere-Jehl R, de Blay F, Geny B (2017) Nasal allergen challenge in allergic rhinitis induces mitochondrial dysfunction of peripheral blood mononuclear cells. Ann Allergy Asthma Immunol 118:367-9.

» PMID: 28073613

Qi S, Barnig C, Charles AL, Poirot A, Meyer A, Clere-Jehl R, de Blay F, Geny Bernard (2017) Ann Allergy Asthma Immunol

Abstract: Allergic rhinitis is the most common of the atopic diseases, affecting up to 25% of the population worldwide. Grass pollen sensitization has been recognized as a major cause of allergic rhinitis. On the pathophysiologic level, allergic rhinitis is an IgE-mediated inflammation of the nasal mucosa. Grass pollen allergy, commonly called hay fever, can also cause more general symptoms, such as fatigue and unwellness as seen in flulike syndromes. This might be partly related to the activation of a systemic inflammatory pathway after the local nasal inflammatory response, but data from studies concerning the systemic effects of nasal mucosal allergen exposure are limited.

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Keywords: Mitochondria, VADP, Allergic rhinitis, Nasal allergen challenge, Eosinophils Bioblast editor: Kandolf G O2k-Network Lab: FR Strasbourg Zoll J


Labels: MiParea: Respiration, Patients, Pharmacology;toxicology  Pathology: Other 

Organism: Human  Tissue;cell: Blood cells, Lymphocyte  Preparation: Permeabilized cells 


Coupling state: LEAK, OXPHOS  Pathway: N, S, CIV  HRR: Oxygraph-2k 

PBMC