Quemeneur 2022 Sci Rep

From Bioblast
Publications in the MiPMap
QuΓ©mΓ©neur JB, Danion M, Cabon J, Collet S, Zambonino-Infante JL, Salin K (2022) The relationships between growth rate and mitochondrial metabolism varies over time. https://doi.org/10.1038/s41598-022-20428-9

Β» Sci Rep 12:16066. PMID: 36167968 Open Access

Quemeneur Jean-Baptiste,  Danion Morgane,  Cabon Joelle,  Collet Sophie,  Zambonino-Infante Jose-Luis,  Salin Karine (2022) Sci Rep

Abstract: Mitochondrial metabolism varies significantly between individuals of the same species and can influence animal performance, such as growth. However, growth rate is usually determined before the mitochondrial assay. The hypothesis that natural variation in mitochondrial metabolic traits is linked to differences in both previous and upcoming growth remains untested. Using biopsies to collect tissue in a non-lethal manner, we tested this hypothesis in a fish model (Dicentrarchus labrax) by monitoring individual growth rate, measuring mitochondrial metabolic traits in the red muscle, and monitoring the growth of the same individuals after the mitochondrial assay. Individual variation in growth rate was consistent before and after the mitochondrial assay; however, the mitochondrial traits that explained growth variation differed between the growth rates determined before and after the mitochondrial assay. While past growth was correlated with the activity of the cytochrome c oxidase, a measure of mitochondrial density, future growth was linked to mitochondrial proton leak respiration. This is the first report of temporal shift in the relationship between growth rate and mitochondrial metabolic traits, suggesting an among-individual variation in temporal changes in mitochondrial traits. Our results emphasize the need to evaluate whether mitochondrial metabolic traits of individuals can change over time.

β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: FR Plouzane Salin K

Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Developmental biology 

Organism: Fishes  Tissue;cell: Skeletal muscle  Preparation: Homogenate 

Coupling state: LEAK, OXPHOS  Pathway: N, CIV, NS, ROX  HRR: Oxygraph-2k, O2k-Fluorometer 

2022-11, MgG 

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