Reference material

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Bioblasts - Richard Altmann and MiPArt by Odra Noel
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Reference material


Reference material (RM) is material or substance one or more of whose property values are sufficiently homogeneous and well established to be used for the calibration of an apparatus, the assessment of a measurement procedure, or for assigning values to materials (adapted from VIM: 1993, 6.13). The adjective 'homogeneous' refers to the physical homogeneity between macroscopic parts of the material, not to any microheterogeneity between molecules of the analyte. Primary reference material is reference material having the highest metrological qualities and whose value is determined by means of a primary reference measurement procedure. The concept "primary calibrator" is subordinate to "calibrator" (see 3.7) and to "primary reference material".

Abbreviation: RM

Reference: ISO 17511:2003 In vitro diagnostic medical devices

MitoPedia concepts: MitoFit Quality Control System 

ISO 13528:2015 Statistical methods for use in proficiency testing by interlaboratory comparison
Certified reference material (CRM): reference material (RM) characterized by a metrologically valid procedure for one or more specified properties, accompanied by an RM certificate that provides the value of the specified property, its associated uncertainty, and a statement of metrological traceability. The concept of value includes a nominal property or a qualitative attributes such as identity or sequence. Uncertainties for such attributes may be expressed as probabilities or levels of confidence.