Rekuviene 2018 Thesis

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Rekuvienė E (2018) Effect of respiratory complex I inhibitors on mitochondrial permeability transition and cell viability during brain ischemia. Doctoral Dissertation 138.

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Rekuviene E (2018) Doctoral Dissertation

Abstract: Brain ischemia is a condition in which there is insufficient blood flow resulting in deprivation of oxygen and energy supply that quickly affect energy-demanding neuronal cells and cause their death. Mitochondrial damage, particularly opening of mitochondrial permeability transition pore, is thought to be critical in ischemic brain damage. Recent data suggest that pharmacological compounds that affect the electron flow through complex I and reduce its activity may play an important role in regulation of mitochondrial permeability transition pore and can be crucial for cell viability and survival rate. However, little is known about the role of respiratory complex I in regulation of permeability transition and systemic effects of complex I inhibitors, their specificity and molecular mechanisms on brain mitochondrial functions and cell viability during ischemia. The aim of this study is to investigate the effect of respiratory chain complex I inhibitors on regulation of mitochondrial permeability transition pore, mitochondrial functions and cell viability in rat brain cortex and cerebellum during global ischemia. In this study it has been shown that respiratory complex I might be a potential therapeutic target in ischemic brain pathology by regulating mitochondrial permeability transition pore. These novel results can be used in new research of stroke treatment, management and recovery, reducing the risk of complications, extending expectancy and quality of life.

Bioblast editor: Plangger M

Labels: MiParea: Respiration 

Stress:Ischemia-reperfusion, Permeability transition  Organism: Rat  Tissue;cell: Nervous system  Preparation: Isolated mitochondria  Enzyme: Complex I, Complex II;succinate dehydrogenase  Regulation: Inhibitor  Coupling state: LEAK, OXPHOS  Pathway: N, S  HRR: Oxygraph-2k 

Labels, 2019-03