Samper 2009 Free Radic Biol Med
|Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S (2009) Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med 46:387-96.|
Abstract: Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are currently not well understood. To better define these changes, we examined the gene expression and gene ontology profiles of thymic lymphomas from a commonly used model of carcinogenesis, the p53−/− mouse. These tumors show a highly significant upregulation of mitochondrial biogenesis, mitochondrial protein translation, mtDNA copy number, reactive oxygen species, antioxidant defenses, proton transport, ATP synthesis, hypoxia response, and glycolysis, indicating a fundamental change in the bioenergetic profile of the transformed T cell. Our results suggest that T cell tumorigenesis involves a simultaneous upregulation of mitochondrial biogenesis, mitochondrial respiration, and glycolytic activity. These processes would allow cells to adapt to the stressful tumor environment by facilitating energy production and thereby promote tumor growth. Understanding these adaptations is likely to result in improved therapeutic strategies for this tumor type.
• Keywords: Mitochondria, Reactive oxygen species, Glycolysis, Lymphoma, p53, c-myc, Free radicals
• O2k-Network Lab: ES Madrid Cadenas S
Labels: MiParea: Respiration, mt-Biogenesis;mt-density, Genetic knockout;overexpression Pathology: Cancer Stress:Oxidative stress;RONS
Regulation: Aerobic glycolysis Coupling state: OXPHOS, ET