Schiffer 2013 Abstract MiP2013
|Schiffer TA, Weitzberg E, Lundberg JO, Larsen FJ (2013) Dietary inorganic nitrate reduces basal metabolic rate in man. Mitochondr Physiol Network 18.08.|
According to the rate-of-living and oxidative damage theory of aging, extended lifespan is predicted by low energy metabolism and low reactive oxygen species production rates. Recently, several studies show that dietary inorganic nitrate mainly present in vegetables can reduce oxygen consumption during physical exercise in humans  and contribute to attenuated oxidative stress in animal models of disease . Nitrate accumulates in saliva and is bioactivated through reduction to nitrite by oral bacteria.
We examined the effects of dietary nitrate on basal metabolic rate (BMR) and markers of oxidative stress in man using a double-blind, randomized cross over design. 15 young healthy males volunteered and indirect calorimetry was used to determine basal metabolic rate after three days of dietary intervention with sodium nitrate (NaNO3, 0.1 mmol∙kg-1∙day-1) or placebo (NaCl). The administered amount of nitrate resembles what is found in 100-300 g of nitrate rich vegetables such as beetroot or spinach.
The intervention reduced BMR by 4.3% after nitrate administration compared with placebo (p<0.02). A strong negative correlation was found between the change in salivary nitrate and the change in BMR (r2=0.72; p<0.002). In addition, nitrate supplementation reduced plasma levels of malondialdehyde, indicating lower oxidative stress as a result of the intervention. Thyroid hormone status was unaffected.
The cuisines of cultures known for their longevity are usually rich in vegetables and future studies will reveal whether this life span extension is linked to the high nitrate content in this food group.
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style Pathology: Aging;senescence Stress:Oxidative stress;RONS Organism: Human
Preparation: Intact organism
Dept Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden. - Email: firstname.lastname@example.org
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