Scott 2013 Abstract MiP2013

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Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08.



MiP2013, Book of Abstracts Open Access

Scott GR, Mahalingam S, McClelland GB (2013)

Event: MiPNet18.08_MiP2013

The hypoxic and cold environment at high altitudes requires endothermic animals to sustain high rates of O2 consumption for both locomotion and thermogenesis while facing a diminished O2 supply. We are examining the mitochondrial mechanisms of genotypic adaptation and phenotypic plasticity that help maintain ATP supply during hypoxia in high-altitude birds and mammals. Respiratory capacity, cytochrome oxidase activity, phosphorylation efficiency, oxygen kinetics, and several other variables were measured in mitochondria isolated from the flight muscle of bar-headed geese and the hindlimb muscle of highland deer mice, and each were compared to closely-related lowland taxa. Our results suggest that several mitochondrial adaptations, coupled with enhanced mitochondrial O2 supply, contribute to performance in hypoxia.

O2k-Network Lab: CA Hamilton Scott GR

Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style 

Organism: Other mammals, Birds  Tissue;cell: Skeletal muscle  Preparation: Isolated mitochondria, Enzyme 

Regulation: Oxygen kinetics  Coupling state: LEAK, OXPHOS 

HRR: Oxygraph-2k 


Affiliations and support

Department of Biology, McMaster University, Hamilton, Ontario, Canada


Supported by NSERC of Canada.