Sobotka 2022 Abstract Bioblast

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Sobotka Lubos
Sobotka Lubos, Sobotka O (2022) The Crabtree effect and clinical nutrition.
Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 Β»Watch the presentationΒ«

Link: Bioblast 2022: BEC Inaugural Conference

Sobotka Lubos, Sobotka Ondrej (2022)

Event: Bioblast 2022

Glucose (Glc) and its polymers are the most abundant organic molecules in nature. It is produced by green plants out of CO2, water and energy from the sun. Glc is the foundation to many other molecules (e.g., nucleic acids, amino acids, lipids, mucopolysaccharides) and plays a crucial role in the formation of reducing equivalents necessary for anabolic, antioxidative, immune, and other processes. Our cells can also oxidize Glc to gain energy in the form of ATP but due to limited supplies in the human body it is used preferably for non-oxidative metabolism.

Anabolic pathways such as the pentose phosphate pathway require fuel in the form of Glc. During anabolism, an incomplete oxidation and continuous turnover of Glc/lactate occurs on the level of the whole organism. This turnover is higher during growth, pregnancy and regeneration but also during inflammation, oxidative stress and other stressful situations [1].

Almost one hundred years ago, Crabtree showed that various dividing cells metabolise Glc to lactate despite functional mitochondria and sufficient oxygen. This pathway is preferred over complete Glc oxidation despite full enzymatic equipment for oxidative phosphorylation. This phenomenon was called the Crabtree effect.

In our organism, part of Glc is completely oxidized if the dietary intake is higher than the requirements for non-oxidative anabolic pathways. Low Glu oxidation and insulin resistance indicate that intake is lower than requirements for non-oxidative pathways. This assumption was apparent in our recent observation that increased Glc intake improved insulin sensitivity in diabetic and nondiabetic ICU patients [2]. Therefore, aerobic glycolysis due to Crabtree effect may indicate higher needs of carbohydrates during nutritional support [3].

  1. Soeters PB, Shenkin A, Sobotka L, Soeters MR, de Leeuw PW, Wolfe RR (2021) The anabolic role of the Warburg, Cori-cycle and Crabtree effects in health and disease. https://doi.org/10.1016/j.clnu.2021.02.012
  2. Skorepa P, Sobotka O, Vanek J, Ticha A, Fortunato J, Manak J, Blaha V, Horacek JM, Sobotka L (2020) The impact of glucose-based or lipid-based total parenteral nutrition on the free fatty acids profile in critically ill patients. https://doi.org/10.3390/nu12051373
  3. Sobotka L, Sobotka O (2021) The predominant role of glucose as a building block and precursor of reducing equivalents. https://doi.org/10.1097/MCO.0000000000000786

β€’ Keywords: Glucose, Insulin resistance, Metabolism, Nutrition, Crabtree effect

β€’ O2k-Network Lab: CZ Hradec Kralove Cervinkova Z


Affiliation

3rd Department of Internal Medicine, Gerontology and Metabolism, University hospital and Faculty of Medicine in Hradec Kralove, Charles University, CZ - pustik@lfhk.cuni.cz

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