,Year,Reference,Coupling,Pathway,Preparation,Organism,Tissue;cell
"Fisher 2020 Placenta",2020,"Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.","LEAK,OXPHOS,ET","N,NS,ROX","Isolated mitochondria",Human,Genital
"Simard 2020 Metabolites",2020,"Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in ''Drosophila melanogaster''. Metabolites 109:E363.","LEAK,OXPHOS,ET","N,S,Gp,NS,ROX","Permeabilized tissue",Drosophila,
"Dawson 2020 J Exp Biol",2020,"Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.","LEAK,OXPHOS","N,CIV,NS,ROX","Permeabilized tissue",Fishes,Lung;gill
"Vega 2020 Physiol Rep",2020,"Vega RB, Brouwers B, Parsons SA, Stephens NA, Pino MF, Hodges A, Yi F, Yu G, Pratley RE, Smith SR, Sparks LM (2020) An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. Physiol Rep 8:e14416.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Kamarauskaite 2020 Biomed Res Int",2020,"Kamarauskaite J, Baniene R, Trumbeckas D, Strazdauskas A, Trumbeckaite S (2020) Increased succinate accumulation induces ROS generation in ''in vivo'' ischemia/reperfusion-affected rat kidney mitochondria. Biomed Res Int 2020:8855585.","LEAK,OXPHOS","N,S",,Rat,Kidney
"Cornelissen 2020 Hum Mol Genet",2020,"Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells",Human,Fibroblast
"Briones-Herrera 2020 Free Radic Biol Med",2020,"Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.","LEAK,OXPHOS","F,N,S,NS,ROX","Isolated mitochondria",Rat,Kidney
"Courtes 2020 Brain Res Bull",2020,"Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Rat,"Nervous system"
"P-L control efficiency",2020,"Gnaiger E (2020) Cell ergometry: OXPHOS-control and ET-coupling efficiency. Mitochondr Physiol Network (2015-01-18) last update 2020-11-12.","LEAK,OXPHOS",,,,
"MitoEAGLE muscle 1",2020,"Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) '''Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.''' - Updated: 2020-03-08","LEAK,OXPHOS,ET","N,NS,S,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Burtscher 2020 eNeuro",2020,"Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Mouse,"Nervous system"
"Buch 2020 FASEB J",2020,"Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Cipullo 2020 Nucleic Acids Res",2020,"Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res 49:354-70.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,HEK
"Woessner 2020 Thesis",2020,"Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Oellermann 2020 Sci Rep",2020,"Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202.","LEAK,OXPHOS,ET","N,S,NS",Homogenate,Crustaceans,Heart
"Abid 2020 FASEB J",2020,"Abid H, Ryan ZC, Delmotte P, Sieck GC, Lanza IR (2020) Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways. FASEB J 34:14458-72.","LEAK,OXPHOS","N,S,NS","Intact cells",Mouse,"Skeletal muscle"
"Esselun 2020 Neuromolecular Med",2020,"Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Isolated mitochondria",Mouse,"Nervous system"
"Friederich-Persson 2020 Am J Physiol Renal Physiol",2020,"Friederich-Persson M, Persson P (2020) Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats. Am J Physiol Renal Physiol 318:F683-88.","LEAK,OXPHOS","N,Gp","Isolated mitochondria",Rat,Kidney
"Cubizolle 2020 J Cell Mol Med",2020,"Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P (2020) Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. J Cell Mol Med 24:5057-69.","LEAK,OXPHOS,ET","N,S,CIV,NS","Permeabilized cells",Rat,"Endothelial;epithelial;mesothelial cell"
"Kapser-Fischer 2020 Thesis",2020,"Kapser-Fischer IP (2020) Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters. PhD Thesis 120.","LEAK,OXPHOS",,Homogenate,Mouse,Fat
"Chandramouleeswaran 2020 PLoS One",2020,"Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klein-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H (2020) Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. PLoS One 15:e0239625.","ROUTINE,OXPHOS","N,S,CIV,ROX","Permeabilized cells,Intact cells",Mouse,"Endothelial;epithelial;mesothelial cell"
"Ost 2020 EMBO Rep",2020,"Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Li Puma 2020 Am J Physiol Regul Integr Comp Physiol",2020,"Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:972-80.","LEAK,OXPHOS","N,NS","Permeabilized tissue,Homogenate,Isolated mitochondria",Mouse,"Heart,Skeletal muscle"
"Weger 2020 Sci Rep",2020,"Weger M, Alpern D, Cherix A, Ghosal S, Grosse J, Russeil J, Gruetter R, de Kloet ER, Deplancke B, Sandi C (2020) Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Sci Rep 10:18308.","OXPHOS,ET","N,S,NS,ROX",Homogenate,Mouse,"Nervous system"
"Bertero 2020 Circ Res",2020,"Bertero E, O'Rourke B, Maack C (2020) Mitochondria do not survive calcium overload during transplantation. Circ Res 126:784-86.","LEAK,OXPHOS",N,"Isolated mitochondria",Mouse,"Skeletal muscle"
"Mahul-Mellier 2020 Proc Natl Acad Sci U S A",2020,"Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA (2020) The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A 117:4971-82.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Mouse,"Nervous system"
"Sowton 2020 Mol Genet Metab Rep",2020,"Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Mol Genet Metab Rep 23:100580.","LEAK,OXPHOS","N,NS",Homogenate,Mouse,Liver
"Smith 2020 J Biol Chem",2020,"Smith CD, Schmidt CA, Lin CT, Fisher-Wellman KH, Neufer PD (2020) Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure. J Biol Chem 295:16207-16.","LEAK,OXPHOS,ET","F,N","Isolated mitochondria",Mouse,"Skeletal muscle"
"Rodriguez 2020 J Gerontol A Biol Sci Med Sci",2020,"Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.","LEAK,OXPHOS,ET","F,N,S,Gp,CIV,ROX","Isolated mitochondria",Molluscs,
"Schoepf 2020 Nat Commun",2020,"Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5","LEAK,ROUTINE,OXPHOS,ET","N,S,NS","Permeabilized cells,Permeabilized tissue",Human,"Genital,Other cell lines"
"Liu 2020 Cell Death Dis",2020,"Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.","LEAK,OXPHOS","N,S,CIV,ROX","Permeabilized tissue",Mouse,"Endothelial;epithelial;mesothelial cell"
"Keller 2020 Oxid Med Cell Longev",2020,"Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629.","LEAK,OXPHOS,ET","N,NS","Permeabilized cells",Human,"Endothelial;epithelial;mesothelial cell"
"Agil 2020 J Clin Med",2020,"Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916.","LEAK,OXPHOS","N,S","Isolated mitochondria",Rat,Kidney
"Sharma 2020 Integr Cancer Ther",2020,"Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437.","LEAK,OXPHOS","N,S","Permeabilized cells",Human,"Endothelial;epithelial;mesothelial cell"
"Dawid 2020 Biochim Biophys Acta Bioenerg",2020,"Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.","LEAK,ROUTINE,OXPHOS,ET","N,S,Gp,NS,ROX","Permeabilized cells,Isolated mitochondria,Intact cells","Human,Mouse","Nervous system,HEK"
"Hroudova 2020 Mol Neurobiol",2020,"Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z (2020) Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity-''in vitro'' study. Mol Neurobiol 58:1102-13.",OXPHOS,"N,S,ROX","Isolated mitochondria",Pig,"Nervous system"
"Mohsin 2020 Arch Biochem Biophys",2020,"Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299.","LEAK,OXPHOS","N,S","Permeabilized cells",Rat,"Skeletal muscle"
"Feng 2020 Int J Biol Macromol",2020,"Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in ''Musca domestica''. Int J Biol Macromol 155:524-34.","LEAK,OXPHOS","N,S,ROX","Isolated mitochondria",Hexapods,
"Belosludtsev 2020 Biochimie",2020,"Belosludtsev KN, Belosludtseva NV, Kosareva EA, Talanov EY, Gudkov SV, Dubinin MV (2020) Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria. Biochimie 176:150-57.","LEAK,OXPHOS","N,S,CIV","Isolated mitochondria",Rat,Liver
"Contreras Mostazo 2020 Cancers (Basel)",2020,"Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.","LEAK,ROUTINE,OXPHOS,ET","F,N,S,Gp,CIV,ROX","Permeabilized cells,Intact cells",Human,"Blood cells"
"Monaco 2020 Am J Physiol Endocrinol Metab",2020,"Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ (2020) Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab 318:E44-E51.",OXPHOS,"N,S","Permeabilized tissue",Human,"Skeletal muscle"
"Xia 2020 Biomed Res Int",2020,"Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation ''in vivo''. Biomed Res Int 2020:1202189.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,Fibroblast
"BEC 2020.1 doi10.26124bec2020-0001.v1",2020,"Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1","LEAK,OXPHOS,ET","F,N,S,Gp,DQ,CIV,NS,Other combinations,ROX","Permeabilized cells,Permeabilized tissue,Homogenate,Isolated mitochondria",,
"Hoffmann 2020 J Clin Endocrinol Metab",2020,"Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Baggio 2020 Neurotoxicology",2020,"Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Zebrafish,"Nervous system"
"Barsottini 2020 Commun Biol",2020,"Barsottini MRO, Copsey A, Young L, Baroni RM, Cordeiro AT, Pereira GAG, Moore AL (2020) Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen ''Moniliophthora perniciosa''. Commun Biol 3:263.",OXPHOS,"F,N,S,CIV",,Protists,
"Mikulas 2020 Materials",2020,"Mikulás K, Komlódi T, Földes A, Sváb G, Horváth G, Nagy AM, Ambrus A, Gyulai-Gaál Sz, Gera I, Hermann P, Varga G, Tretter L (2020) Bioenergetic Impairment of triethylene glycol dimethacrylate- (TEGDMA-) treated dental pulp stem cells (DPSCs) and isolated brain mitochondria are amended by redox compound methylene blue. Materials (Basel) 13(16):3472.","OXPHOS,ET,ROUTINE","N,S,ROX","Isolated mitochondria,Permeabilized cells,Intact cells","Guinea pig,Human","Stem cells"
"Severo 2020 Life Sci",2020,"Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Mouse,"Nervous system"
"Bose 2020 Aging Cell",2020,"Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261.","LEAK,OXPHOS","F,N,CIV,NS,ROX","Permeabilized tissue",Mouse,Heart
"Doig 2020 Skelet Muscle",2020,"Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Cecatto 2020 Toxicol In Vitro",2020,"Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2020) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665.","LEAK,OXPHOS,ET","N,S","Permeabilized tissue,Isolated mitochondria",Rat,"Skeletal muscle"
"Ulgherait 2020 Nat Commun",2020,"Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Isolated mitochondria",Drosophila,
"Weber 2020 FASEB J",2020,"Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J 34:11816-37.","LEAK,OXPHOS","N,NS","Isolated mitochondria",Mouse,Liver
"Palavicini 2020 JCI Insight",2020,"Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Mouse,"Nervous system"
"Brand 2020 J Clin Med",2020,"Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.","LEAK,OXPHOS,ET","N,CIV,ROX","Permeabilized cells",Human,Lymphocyte
"Lozano 2020 Part Fibre Toxicol",2020,"Lozano O, Silva-Platas C, Chapoy-Villanueva H, Pérez BE, Lees JG, Ramachandra CJA, Contreras-Torres FF, Lázaro-Alfaro A, Luna-Figueroa E, Bernal-Ramírez J, Gordillo-Galeano A, Benitez A, Oropeza-Almazán Y, Castillo EC, Koh PL, Hausenloy DJ, Lim SY, García-Rivas G (2020) Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part Fibre Toxicol 17:15.","LEAK,OXPHOS,ET",S,"Isolated mitochondria",Rat,Heart
"Boardman 2020 Am J Physiol Heart Circ Physiol",2020,"Boardman NT, Pedersen TM, Rossvoll L, Hafstad AD, Aasum E (2020) Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance. Am J Physiol Heart Circ Physiol 319:H682-93.","LEAK,OXPHOS","F,N","Isolated mitochondria",Mouse,Heart
"Gnaiger 2020 BEC MitoPathways",2020,"Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002","LEAK,ROUTINE,OXPHOS,ET","F,N,S,Gp,CIV,NS,ROX","Permeabilized cells,Permeabilized tissue,Homogenate,Isolated mitochondria,Intact cells","Human,Mouse","Heart,Skeletal muscle,Fibroblast"
"Madeo 2020 US Patent",2020,"Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1.","LEAK,OXPHOS,ET","N,ROX","Isolated mitochondria",Mouse,Heart
"Mahalingam 2020 J Physiol",2020,"Mahalingam S, Cheviron ZA, Storz JF, McClelland GB, Scott GR (2020) Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes. J Physiol 598:5411-26. https://doi.org/10.1113/JP280298","LEAK,OXPHOS","F,N,S,CIV,NS","Isolated mitochondria",Mouse,"Skeletal muscle"
"Zavadskis 2020 Pharmaceutics",2020,"Zavadskis S, Weidinger A, Hanetseder D, Banerjee A, Schneider C, Wolbank S, Marolt Presen D, Kozlov AV (2020) Effect of diphenyleneiodonium chloride on intracellular reactive oxygen species metabolism with emphasis on NADPH oxidase and mitochondria in two therapeutically relevant human cell types. Pharmaceutics 13:E10.","LEAK,OXPHOS,ET","N,S","Permeabilized cells",Human,"Other cell lines"
"Gvozdjakova 2020 Diagnostics (Basel)",2020,"Gvozdjáková A, Sumbalová Z, Kucharská J, Komlósi M, Rausová Z, Vančová O, Számošová M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:176.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,Platelet
"Politis-Barber 2020 Am J Physiol Endocrinol Metab",2020,"Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87.","LEAK,OXPHOS","F,N,Gp,NS","Permeabilized cells",Mouse,Fat
"Avila-Rojas 2020 Food Chem Toxicol",2020,"Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Rat,Kidney
"Stankova 2020 Int J Mol Sci",2020,"Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.","LEAK,OXPHOS","F,N,S,Gp,NS,ROX",Homogenate,Mouse,Liver
"Carvalho 2020 BMC Nutr",2020,"Carvalho E, Adams SH, Borsheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.","LEAK,OXPHOS","N,NS,ROX","Permeabilized tissue",Pig,Liver
"Edmunds 2020 Mol Metab",2020,"Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051.","LEAK,OXPHOS,ET","F,N,ROX",Homogenate,Mouse,Liver
"P/E control ratio",2020,"Gnaiger E (2020) ''P/E'' from mouse to man. Mitochondr Physiol Network (2014-05-20) last update 2020-11-12.","OXPHOS,ET",,,,
"Burtscher 2020 Int J Mol Sci",2020,"Burtscher J, Di Pardo A, Maglione V, Schwarzer C, Squitieri F (2020) Mitochondrial respiration changes in R6/2 Huntington's Disease model mice during aging in a brain region specific manner. Int J Mol Sci 21:5412.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX",Homogenate,Mouse,"Nervous system"
"Reutzel 2020 Oxid Med Cell Longev",2020,"Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.","LEAK,ET,OXPHOS","N,S,CIV,ROX","Isolated mitochondria",Mouse,"Nervous system"
"Heinonen 2020 Sci Rep",2020,"Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Pig,Heart
"Wen 2020 Biomedicines",2020,"Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue",Rat,Heart
"Larsen 2020 Acta Physiol (Oxf)",2020,"Larsen FJ, Schiffer TA, Zinner C, Willis SJ, Morales-Alamo D, Calbet J, Boushel R, Holmberg HC (2020) Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake. https://doi.org/10.1111/apha.13463",OXPHOS,"N,NS","Isolated mitochondria",Human,"Skeletal muscle"
"Brunetta 2020 J Physiol",2020,"Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Mouse,Fat
"Al-Azab 2020 FEBS J",2020,"Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.","LEAK,ROUTINE,OXPHOS,ET","N,ROX","Permeabilized cells,Intact cells",Human,"Other cell lines"
"Vaccari 2020 Eur J Appl Physiol",2020,"Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Rodrigues 2020 J Appl Physiol (1985)",2020,"Rodrigues GC, Rocha NN, Maia LA, Melo I, Simões AC, Antunes MA, Bloise FF, Woyames J, da-Silva WS, Capelozzi VL, Abela G, Ball L, Pelosi P, Rocco PRM, Silva PL (2020) Impact of experimental obesity on diaphragm structure, function and bioenergetics. J Appl Physiol (1985) 129:1062-74.","LEAK,OXPHOS,ET","N,CIV,NS","Permeabilized tissue",Rat,"Skeletal muscle"
"No 2020 Pflugers Arch",2020,"No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Rat,Heart
"Venediktova 2020 Mitochondrion",2020,"Venediktova NI, Mashchenko OV, Talanov EY, Belosludtseva NV, Mironova GD (2020) Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion 52:190-96.","LEAK,OXPHOS","N,NS","Isolated mitochondria",Rat,Liver
"Pereira 2020 PLoS One",2020,"Pereira GC, Lee L, Rawlings N, Ouwendijk J, Parker JE, Andrienko TN, Henley JM, Halestrap AP (2020) Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia. PLoS One 15:e0234653.","LEAK,OXPHOS",N,"Isolated mitochondria",Rat,Heart
"McLaughlin 2020b Sci Rep",2020,"McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.","LEAK,OXPHOS,ET","F,N,S,Gp,CIV,ROX","Isolated mitochondria",Mouse,"Heart,Liver,Kidney,Fat"
"Hedges 2020 Biosci Rep",2020,"Hedges CP, Pham T, Shetty B, Masson SWC, Hickey AJR, Shepherd PR, Merry TL (2020) Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function. https://doi.org/10.1042/bsr20201128","LEAK,OXPHOS,ET","N,CIV,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle,Liver"
"Hassan 2020 MitoFit Preprint Arch",2020,"Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells",Human,
"Pelster 2020 PLoS One",2020,"Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (''Arapaima gigas''). PLoS One 15:e0236507.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized tissue",Fishes,"Kidney,Lung;gill"
"Piel 2020 FEBS J",2020,"Piel MS, Masscheleyn S, Bouillaud F, Moncoq K, Miroux B (2020) Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant. FEBS J 288:3024-33.","LEAK,OXPHOS,ET",,"Permeabilized cells","Saccharomyces cerevisiae",
"Hraoui 2020 J Exp Biol",2020,"Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized tissue",Molluscs,Lung;gill
"Xiong 2020 Biomed Pharmacother",2020,"Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized cells","Human,Rat","Endothelial;epithelial;mesothelial cell"
"Chang 2020 J Biol Chem",2020,"Chang L, Liu X, Diggle CP, Boyle JP, Hopkins PM, Shaw MA, Allen PD (2020) Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia. J Biol Chem 295:15226-35.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Bloise 2020 Thyroid",2020,"Bloise FF, Santos AT, Brito JT, Andrade CBV, Oliveira TS, Souza AF, Fontes KN, Silva JD, Blanco NG, Silva PL, Rocco PRM, Fliers E, Boelen A, da-Silva WS, Ortiga-Carvalho TM (2020) Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm. Thyroid 30:1079-90.","LEAK,OXPHOS,ET","N,CIV,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Serna 2020 J Bioenerg Biomembr",2020,"Serna JDC, Caldeira da Silva CC, Kowaltowski AJ (2020) Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria. J Bioenerg Biomembr 52:269-77.","LEAK,OXPHOS",S,"Isolated mitochondria",Rat,"Heart,Skeletal muscle"
"Musi 2020 Aging Cell",2020,"Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Mouse,"Nervous system"
"Eshima 2020 J Appl Physiol (1985)",2020,"Eshima H, Siripoksup P, Mahmassani ZS, Johnson JM, Ferrara PJ, Verkerke ARP, Salcedo A, Drummond MJ, Funai K (2020) Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice. J Appl Physiol (1985) 129:124-32.","LEAK,OXPHOS,ET","N,NS","Isolated mitochondria",Mouse,"Skeletal muscle"
"Cheng 2020 Am J Physiol Heart Circ Physiol",2020,"Cheng TC, Philip JL, Tabima DM, Kumari S, Yakubov B, Frump AL, Hacker TA, Bellofiore A, Li R, Sun X, Goss KN, Lahm T, Chesler N (2020) Estrogen receptor alpha prevents right ventricular diastolic dysfunction and fibrosis in female rats . Am J Physiol Heart Circ Physiol 319:H1459-73.","LEAK,OXPHOS","N,S,CIV,ROX","Permeabilized tissue",Rat,Heart
"Kawamura 2021 Mol Ther Nucleic Acids",2020,"Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y (2021) Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-porter. Mol Ther Nucleic Acids 20:687-98.","LEAK,OXPHOS",,"Permeabilized cells",Human,Fibroblast
"Schneider 2020 PLoS One",2020,"Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.","LEAK,OXPHOS","F,N,S,CIV,NS,ROX","Permeabilized tissue",Rat,Heart
"Matsuo 2020 Am J Physiol Endocrinol Metab",2020,"Matsuo FS, Araújo PHC, Mota RF, Carvalho AJR, Queiroz MS, Almeida BB, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK (2020) RANKL induces beige adipocyte differentiation in preadipocytes. Am J Physiol Endocrinol Metab 318:E866-77.","LEAK,OXPHOS",N,"Permeabilized cells",Mouse,Fat
"Allen 2020 Commun Biol",2020,"Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.","LEAK,OXPHOS,ET","N,S,CIV","Permeabilized tissue",Rat,Heart
"Fisher 2020 J Physiol",2020,"Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ, Perkins AV (2020) Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J Physiol 599:1291-305.","OXPHOS,ET","N,NS,ROX","Isolated mitochondria",Human,Genital
"Skemiene 2020 J Bioenerg Biomembr",2020,"Skemiene K, Pampuscenko K, Rekuviene E, Borutaite V (2020) Protective effects of anthocyanins against brain ischemic damage. J Bioenerg Biomembr 52:71-82.","LEAK,OXPHOS",N,"Isolated mitochondria",Rat,"Nervous system"
"Guo 2020 Hum Gene Ther",2020,"Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther 31:1178-89.","LEAK,OXPHOS,ET","N,NS,ROX","Isolated mitochondria",Mouse,Heart
"Cassereau 2020 Exp Neurol",2020,"Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized cells",Human,Fibroblast
"Fecker 2020 Biomolecules",2020,"Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of ''Oenothera biennis'' L. hydroalcoholic extract. Biomolecules 10:E818.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,"Endothelial;epithelial;mesothelial cell"
"Bhaskaran 2020 Aging Cell",2020,"Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Rebane-Klemm 2020 Cancers (Basel)",2020,"Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Human,"Endothelial;epithelial;mesothelial cell"
"Falcao-Tebas 2020 J Physiol",2020,"Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized tissue",Rat,"Skeletal muscle"
"Nicolaisen 2020 FASEB J",2020,"Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C (2020) Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 34:15480-91.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Silaidos 2020 Mitochondrion",2020,"Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29.","LEAK,ROUTINE,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells,Intact cells",Human,"Blood cells"
"Wefers 2020 Mol Metab",2020,"Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Risiglione 2020 Int J Mol Sci",2020,"Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. https://doi.org/10.3390/ijms21217809","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,Neuroblastoma
"Groennebaek 2020 Cells",2020,"Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.","LEAK,OXPHOS","N,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Aparicio-Trejo 2020 Free Radic Biol Med",2020,"Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.","LEAK,OXPHOS","F,N,S,ROX","Isolated mitochondria",Rat,Kidney
"Larsen 2020 Cardiovasc Drugs Ther",2020,"Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther 35:491-503.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Makrecka-Kuka 2020 Sci Rep",2020,"Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. https://doi.org/10.1038/s41598-020-78620-8.","LEAK,OXPHOS","N,S,NS,ROX","Permeabilized cells",Mouse,"Endothelial;epithelial;mesothelial cell"
"Krajcova 2020 PLOS ONE",2020,"Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142.","LEAK,OXPHOS,ET","N,S,NS,ROX","Homogenate,Isolated mitochondria",Human,Heart
"Khamoui 2020 Physiol Genomics",2020,"Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16.","LEAK,OXPHOS,ET","N,NS","Intact cells",Mouse,Liver
"Rodriguez de Yurre 2020 An Acad Bras Cienc",2020,"Rodriguez de Yurre A, Martins EGL, Lopez-Alarcon M, Cabral B, Vera N, Lopes JA, Galina A, Takiya CM, Lindoso RS, Vieyra A, SÁenz OC, Medei E (2020) Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model. An Acad Bras Cienc 92:e20191340.","LEAK,OXPHOS","N,NS,ROX","Isolated mitochondria",Mouse,Heart
"Tichanek 2020 Sci Rep",2020,"Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX",Homogenate,Mouse,"Nervous system"
"Rondot 2020 Thesis",2020,"Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (''Bombus impatiens''). Master's Thesis 41.","LEAK,OXPHOS","N,S,NS,ROX","Permeabilized tissue",Hexapods,"Skeletal muscle"
"Lensu 2020 Preprints",2020,"Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Linden J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides targeting ''Faecalibacterium prausnitzii'' prevent high fat diet-induced hepatic steatosis in rats. Preprints 2020:2020090241.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Rat,Liver
"Hartmann 2020 Free Radic Res",2020,"Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue",Rat,"Skeletal muscle"
"Song 2020 Life Sci",2020,"Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci 252:117633.","LEAK,OXPHOS,ET","F,N,NS",Homogenate,Mouse,Liver
"Jespersen 2020 Sci Rep",2020,"Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Rat,Heart
"Skemiene 2020 Biomolecules",2020,"Skemiene K, Rekuviene E, Jekabsone A, Cizas P, Morkuniene R, Borutaite V (2020) Comparison of effects of metformin, phenformin, and inhibitors of mitochondrial complex I on mitochondrial permeability transition and ischemic brain injury. Biomolecules 10:E1400.","LEAK,OXPHOS",N,"Isolated mitochondria",Rat,"Nervous system"
"Marrocco 2020 Thesis",2020,"Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108.","LEAK,OXPHOS,ET","S,ROX","Intact cells",Mouse,Macrophage-derived
"Kupats 2020 Oxid Med Cell Longev",2020,"Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598.","LEAK,OXPHOS,ET","N,S,NS","Homogenate,Isolated mitochondria",Mouse,"Nervous system"
"Dirks 2020 J Physiol",2020,"Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Zhang 2020 Chemosphere",2020,"Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in ''Musca domestica'' larvae. Chemosphere 248:126009.","LEAK,OXPHOS","N,S,ROX","Isolated mitochondria",Hexapods,
"Magnesa 2020 Thesis",2020,"Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Baxter 2020 Elife",2020,"Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX",Homogenate,Mouse,Heart
"Cecatto 2020 Mitochondrion",2020,"Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2020) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13.","LEAK,OXPHOS,ET","N,S","Permeabilized cells,Isolated mitochondria",Rat,"Liver,Other cell lines"
"Schleier 2020 J Cardiovasc Transl Res",2020,"Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res 14:271-82.","LEAK,OXPHOS","N,NS,ROX","Isolated mitochondria",Mouse,Heart
"Silva-Rodrigues 2020 Free Radic Biol Med",2020,"Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806.","LEAK,OXPHOS,ET","N,NS","Isolated mitochondria",Rat,"Nervous system"
"Liepinsh 2020 Physiol Rep",2020,"Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489.","LEAK,ROUTINE,OXPHOS","F,N,CIV","Permeabilized cells,Intact cells",Human,"Blood cells"
"Simard 2020b Metabolites",2020,"Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in ''Drosophila melanogaster'' exposed to dietary sucrose. Metabolites 10:E411.","LEAK,OXPHOS,ET","N,Gp,NS,Other combinations,ROX","Permeabilized tissue",Drosophila,
"Pajuelo-Reguera 2020 Cells",2020,"Pajuelo Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443.","OXPHOS,ET","N,S,Gp,NS,Other combinations","Permeabilized cells,Oxidase;biochemical oxidation",Human,HEK
"Remie 2020 Am J Clin Nutr",2020,"Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26.","LEAK,OXPHOS,ET","F,N,S,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Seo 2020 J Clin Med",2020,"Seo DY, Heo JW, No MH, Yoo SZ, Ko JR, Park DH, Kang JH, Kim CJ, Jung SJ, Han J, Kwak HB (2020) Exercise training protects against atorvastatin-induced skeletal muscle dysfunction and mitochondrial dysfunction in the skeletal muscle of rats. J Clin Med 9:E2292.","LEAK,OXPHOS",N,"Permeabilized tissue",Rat,"Skeletal muscle"
"Maddison 2020 PLoS Genet",2020,"Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F (2020) A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics. PLoS Genet 16:e1009129.","OXPHOS,ET","N,S,NS",Homogenate,Drosophila,
"Vulczak 2020 Cells",2020,"Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.","LEAK,OXPHOS,ET","N,ROX","Permeabilized cells",Mouse,"Endothelial;epithelial;mesothelial cell"
"Visavadiya 2020 Mol Cell Biochem",2020,"Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells",Mouse,Liver
"Pham 2020 Eur J Appl Physiol",2020,"Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.","LEAK,OXPHOS,ET","N,CIV,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Bundgaard 2020 J Exp Biol",2020,"Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A (2020) Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. J Exp Biol 222:jeb200410.","LEAK,OXPHOS,ET","N,NS","Permeabilized tissue",Amphibians,Heart
"De-Souza 2020 J Biol Chem",2020,"De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.","LEAK,OXPHOS","N,Gp,NS,ROX","Isolated mitochondria,Intact cells","Caenorhabditis elegans,Saccharomyces cerevisiae",
"Kanellopoulos 2020 Cell",2020,"Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX",Homogenate,Drosophila,"Nervous system,Other cell lines"
"Dulac 2020 J Physiol",2020,"Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710.","LEAK,OXPHOS","N,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Wei 2020 Cell Rep",2020,"Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Isolated mitochondria",Rat,Kidney
"Ramos 2020 PLoS One",2020,"Ramos SV, Hughes MC, Delfinis LJ, Bellissimo CA, Perry CGR (2020) Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle. https://doi.org/10.1371/journal.pone.0237138","LEAK,OXPHOS","N,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Romeiro 2020 bioRxiv",2020,"Romeiro NC, Ferreira CM, Oliveira MF (2020) Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion. bioRxiv doi: https://doi.org/10.1101/2020.02.19.956870.","LEAK,OXPHOS,ET","S,ROX","Permeabilized tissue",Mouse,Fat
"Fuller 2020 J Appl Physiol (1985)",2020,"Fuller KNZ, McCoin CS, Allen J, Bell-Glenn S, Koestler DC, Dorn Ii GW, Thyfault JP (2020) Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice. J Appl Physiol (1985) 128:1251-61.","LEAK,OXPHOS,ET","F,N,NS","Isolated mitochondria",Mouse,Liver
"Macasoi 2020 Oncol Rep",2020,"Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,"Endothelial;epithelial;mesothelial cell"
"Alston 2020 Am J Hum Genet",2020,"Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101.","LEAK,ROUTINE,OXPHOS,ET","N,NS","Permeabilized cells,Intact cells",Human,Fibroblast
"Cruz 2020 Drug Alcohol Depend",2020,"Cruz JV, Maba IK, Correia D, Kaziuk FD, Cadena SMSC, Zampronio AR (2020) Intermittent binge-like ethanol exposure during adolescence attenuates the febrile response by reducing brown adipose tissue thermogenesis in rats. Drug Alcohol Depend 209:107904.","LEAK,OXPHOS",N,"Isolated mitochondria",Rat,Fat
"Roginski 2020 Biochim Biophys Acta Mol Basis Dis",2020,"Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized cells,Isolated mitochondria,Homogenate",Rat,"Heart,Other cell lines"
"Gruenig 2020 Biochem Pharmacol",2020,"Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.","LEAK,OXPHOS,ET","N,S,DQ,CIV,ROX","Isolated mitochondria",Mouse,Liver
"MiPNet18.05 Amplex-Mouse-heart",2019-06-24,"[[Image:O2k-Protocols.jpg|right|80px|link=O2k-Protocols|O2k-Protocols]] O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate.","LEAK,OXPHOS,ET","N,S,NS",Homogenate,Mouse,Heart
"MiPNet20.14 AmplexRed H2O2-production",2019-06-24,"[[Image:O2k-Protocols.jpg|right|80px|link=O2k-Protocols|O2k-Protocols]] O2k-FluoRespirometry: HRR and simultaneous determination of H2O2 production with Amplex UltraRed.","LEAK,OXPHOS,ET",S,"Isolated mitochondria",Mouse,Heart
"Papadimitriou 2019 Sci Rep",2019,"Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A ""human knockout"" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Lau 2019 Comp Biochem Physiol B Biochem Mol Biol",2019,"Lau GY, Milsom WK, Richards JG, Pamenter ME (2019) Heart mitochondria from naked mole-rats (''Heterocephalus glaber'') are more coupled, but similarly susceptible to anoxia-reoxygenation stress than in laboratory mice (''Mus musculus''). Comp Biochem Physiol B Biochem Mol Biol 240:110375.","LEAK,OXPHOS,ET","N,S","Isolated mitochondria","Mouse,Other mammals",Heart
"Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol",2019,"Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.","OXPHOS,ET,LEAK","N,S,Gp,CIV,NS,ROX","Permeabilized tissue","Other invertebrates","Skeletal muscle"
"Yan 2019 Int Immunopharmacol",2019,"Yan M, Yu Y, Mao X, Feng J, Wang Y, Chen H, Xie K, Yu Y (2019) Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. Int Immunopharmacol 71:61-7.","LEAK,OXPHOS",S,"Isolated mitochondria",Mouse,Liver
"Long 2019 Methods Mol Biol",2019,"Long Q, Huang L, Huang K, Yang Q (2019) Assessing mitochondrial bioenergetics in isolated mitochondria from mouse heart tissues using Oroboros Oxygraph-2k. Methods Mol Biol 1966:237-46.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Isolated mitochondria",Mouse,Heart
"Oakey 2019 Wellcome Open Res",2019,"Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion. Wellcome Open Res 3:147.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells",Mouse,"Skeletal muscle"
"Woodman 2019 Cardiovasc Res",2019,"Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2019) Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress. Cardiovasc Res 116:183-92.","LEAK,OXPHOS,ET","N,S,CIV,NS",Homogenate,Rat,Kidney
"Blais-Lecours 2019 Am J Respir Cell Mol Biol",2019,"Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D (2019) Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. Am J Respir Cell Mol Biol 62:35-42.","LEAK,ROUTINE,OXPHOS,ET",ROX,"Intact cells",Human,"Other cell lines"
"Jiang 2019 EMBO Rep",2019,"Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG (2019) TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20:e48101.","LEAK,OXPHOS,ET","N,S","Isolated mitochondria",Mouse,Heart
"Bukowska 2019 Eur J Pharmacol",2019,"Bukowska A, Schild L, Bornfleth P, Peter D, Wiese-Rischke C, Gardemann A, Isermann B, Walles T, Goette A (2019) Activated clotting factor X mediates mitochondrial alterations and inflammatory responses via protease-activated receptor signaling in alveolar epithelial cells. Eur J Pharmacol 869:172875.",OXPHOS,S,"Intact cells",Human,"Lung;gill,Endothelial;epithelial;mesothelial cell"
"Gaglianone 2019 Sci Rep",2019,"Gaglianone RB, Santos AT, Bloise FF, Ortiga-Carvalho TM, Costa ML, Quirico-Santos T, da Silva WS, Mermelstein C (2019) Reduced mitochondrial respiration and increased calcium deposits in the EDL muscle, but not in soleus, from 12-week-old dystrophic mdx mice. Sci Rep 9:1986.","LEAK,OXPHOS,ET","N,CIV,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Anton 2019 Front Physiol",2019,"Anton L, DeVine A, Polyak E, Olarerin-George A, Brown AG, Falk MJ, Elovitz MA (2019) HIF-1α stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol 10:699.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells",Human,Genital
"Mazaki 2019 Biochem Biophys Res Commun",2019,"Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H (2019) Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells. Biochem Biophys Res Commun 513:708-13.",OXPHOS,"N,S","Permeabilized cells",Human,"Blood cells"
"Majiene 2019 Nutrients",2019,"Majiene D, Kuseliauskyte J, Stimbirys A, Jekabsone A (2019) Comparison of the effect of native 1,4-naphthoquinones plumbagin, menadione, and lawsone on viability, redox status, and mitochondrial functions of C6 glioblastoma cells. Nutrients 11:E1294.","LEAK,OXPHOS,ET","N,NS","Permeabilized cells",Rat,"Nervous system"
"Wolf 2019 Cells",2019,"Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289.","LEAK,ROUTINE,ET,OXPHOS","ROX,N,NS","Intact cells,Permeabilized cells",Mouse,Fibroblast
"Hamraz 2019 FASEB J",2019,"Hamraz M, Abolhassani R, Andriamihaja M, Ransy C, Lenoir V, Schwartz L, Bouillaud F (2019) Hypertonic external medium represses cellular respiration and promotes Warburg/Crabtree effect. FASEB J 34:222-36.","LEAK,ET,OXPHOS","ROX,N,CIV","Isolated mitochondria,Intact cells","Other mammals,Human,Rat","Endothelial;epithelial;mesothelial cell,Liver,HEK,Neuroblastoma"
"Lefranc 2019 Hypertension",2019,"Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68.","OXPHOS,LEAK",N,"Isolated mitochondria",Mouse,Fat
"Krylova 2019 Mitochondrion",2019,"Krylova TD, Sheremet NL, Tabakov VY, Lyamzaev KG, Itkis YS, Tsygankova PG, Andreeva NA, Shmelkova MS, Nevinitsyna TA, Kadyshev VV, Zakharova EY (2019) Three rare pathogenic mtDNA substitutions in LHON patients with low heteroplasmy. Mitochondrion 50:139-144.","LEAK,ROUTINE,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells,Intact cells",Human,Fibroblast
"Teh 2019 Mol Cancer Ther",2019,"Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.","LEAK,ROUTINE,OXPHOS,ET","N,S,DQ,ROX","Intact cells,Permeabilized cells,Permeabilized tissue","Human,Mouse","Other cell lines"
"Detaille 2019 PLoS One",2019,"Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.","LEAK,OXPHOS","N,S,NS,ROX","Isolated mitochondria",Rat,Heart
"Inigo 2019 Mol Metab",2019,"Inigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE (2019) Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab 34:1-15.","LEAK,OXPHOS","F,N,S,CIV,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Mousovich-Neto 2019 Exp Physiol",2019,"Mousovich-Neto F, Matos MS, Costa ACR, de Melo Reis RA, Atella GC, Miranda-Alves L, Carvalho DP, Ketzer LA, Corrêa da Costa VM (2019) Brown adipose tissue remodeling induced by corticosterone in Wistar male rats. Exp Physiol 104:514-28.",OXPHOS,NS,"Isolated mitochondria",Rat,Fat
"Oses 2019 Epilepsy Res",2019,"Oses JP, Müller AP, Strogulski NR, Moreira JD, Böhmer AE, Hansel G, Carteri RB, Busnello JV, Kopczynski A, Rodolphi MS, Souza DO, Portela LV (2019) Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production. Epilepsy Res 152:35-41.","LEAK,OXPHOS,ROUTINE","N,CIV,NS",Homogenate,Rat,"Nervous system"
"Halbach 2019 Am J Physiol Regul Integr Comp Physiol",2019,"Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A (2019) Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol 317:R160-R168.","LEAK,OXPHOS","N,NS","Intact cells",Mouse,Liver
"Cooper 2019 Exp Physiol",2019,"Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2019) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.","LEAK,OXPHOS,ET","F,N","Permeabilized tissue",Mouse,"Nervous system"
"Qaed 2019 Oxid Med Cell Longev",2019,"Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway ''in vivo'' and ''in vitro''. Oxid Med Cell Longev 2019:6521218.","LEAK,OXPHOS,ET,ROUTINE","N,S,NS,ROX","Homogenate,Isolated mitochondria,Permeabilized cells,Intact cells",Rat,Heart
"Ramos 2019 Am J Physiol Cell Physiol",2019,"Ramos SV, Hughes MC, Perry CGR (2019) Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies. Am J Physiol Cell Physiol 316:C449-C455.",OXPHOS,N,"Permeabilized tissue",Rat,"Skeletal muscle"
"Lewis 2019 Am J Physiol Regul Integr Comp Physiol",2019,"Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes. Am J Physiol Regul Integr Comp Physiol 317:R356-68.","LEAK,OXPHOS","F,N","Isolated mitochondria",Rat,"Skeletal muscle"
"Chao 2019 J Appl Physiol (1985)",2019,"Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 126:1541-49.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Pig,"Skeletal muscle"
"Powers 2019 Neurourol Urodyn",2019,"Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL (2019) Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourol Urodyn 38:1524-32.","LEAK,OXPHOS","N,S,CIV,NS",Homogenate,Mouse,"Other cell lines"
"Miranda-Silva 2019 Acta Physiologica",2019,"Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Intact organ,Permeabilized tissue,Isolated mitochondria",Rat,Heart
"Havird 2019 Philos Trans R Soc Lond B Biol Sci",2019,"Havird JC, Shah AA, Chicco AJ (2019) Powerhouses in the cold: mitochondrial function during thermal acclimation in montane mayflies. Philos Trans R Soc Lond B Biol Sci 375:20190181.","LEAK,OXPHOS","N,NS","Isolated mitochondria",Hexapods,
"Ahn 2019 J Cachexia Sarcopenia Muscle",2019,"Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28.","OXPHOS,LEAK","N,S,CIV,NS,ROX","Isolated mitochondria",Mouse,"Skeletal muscle"
"Tetsi 2019 Antioxidants (Basel)",2019,"Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B (2019) Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 8:E93.","LEAK,OXPHOS","N,CIV,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Fink 2019 FASEB J",2019,"Fink BD, Yu L, Sivitz WI (2019) Modulation of complex II-energized respiration in muscle, heart, and brown adipose mitochondria by oxaloacetate and complex I electron flow. FASEB J 33:11696-705.",OXPHOS,"N,S","Isolated mitochondria",Mouse,"Heart,Skeletal muscle,Fat"
"Aguilar 2019 Cell Rep",2019,"Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16.","LEAK,OXPHOS",N,Homogenate,Mouse,"Endothelial;epithelial;mesothelial cell"
"Bundgaard 2019 Sci Rep",2019,"Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A (2019) Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury. Sci Rep 9:2850.","LEAK,OXPHOS",S,"Isolated mitochondria","Mouse,Reptiles",Heart
"Hafen 2019 J Appl Physiol (1985)",2019,"Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Grauso 2019 Sci Rep",2019,"Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function ''in vitro''. Sci Rep 9:11360.","LEAK,ROUTINE,OXPHOS,ET","N,NS","Permeabilized cells,Intact cells",Human,"Endothelial;epithelial;mesothelial cell,Other cell lines"
"Chroeis 2019 Basic Clin Pharmacol Toxicol",2019,"Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. https://doi.org/10.1111/bcpt.13304","LEAK,OXPHOS","N,S,ROX","Intact cells",Human,Liver
"Nakajima 2019 Sci Rep",2019,"Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S (2019) Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Sci Rep 9:3535.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized tissue",Human,Fat
"Cikankova 2019 Naunyn Schmiedebergs Arch Pharmacol",2019,"Cikánková T, Fišar Z, Bakhouche Y, Ľupták M, Hroudová J (2019) ''In vitro'' effects of antipsychotics on mitochondrial respiration. Naunyn Schmiedebergs Arch Pharmacol 392:1209-23.",OXPHOS,"N,S,ROX","Isolated mitochondria",Pig,"Nervous system"
"Axton 2019 J Nutr",2019,"Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Zebrafish,"Skeletal muscle"
"Glombik 2019 Neurotox Res",2019,"Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Rat,"Nervous system"
"Petrick 2019 J Physiol",2019,"Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol 597:3985-97.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Liu 2019 J Ethnopharmacol",2019,"Liu M, Yu S, Wang J, Qiao J, Liu Y, Wang S, Zhao Y (2019) Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease. J Ethnopharmacol 247:112213.",OXPHOS,"N,S",Homogenate,Drosophila,
"Gratl 2019 Eur J Vasc Endovasc Surg",2019,"Gratl A, Frese J, Speichinger F, Pesta D, Frech A, Omran S, Greiner A (2019) Regeneration of mitochondrial function in gastrocnemius muscle in peripheral arterial disease after successful revascularisation. Eur J Vasc Endovasc Surg 59:109-15.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Fisar 2019 Clin Biochem",2019,"Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,"Platelet,Blood cells"
"Azevedo 2019 Food Chem Toxicol",2019,"Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694.","LEAK,OXPHOS,ET","N,S,ROX","Permeabilized tissue",Rat,Liver
"Berru 2019 Sci Rep",2019,"Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Zhang 2019 Nephron",2019,"Zhang R, Wang X, Gao Q, Jiang H, Zhang S, Lu M, Liu F, Xue X (2019) Taurine supplementation reverses diabetes-induced podocytes injury via modulation of the CSE/TRPC6 axis and improvement of mitochondrial function. Nephron 144:84-95.","LEAK,ROUTINE,OXPHOS,ET","N,S,CIV,NS,ROX","Intact cells,Permeabilized cells",Mouse,Kidney
"Chiba 2019 J Am Soc Nephrol",2019,"Chiba T, Peasley KD, Cargill KR, Maringer KV, Bharathi SS, Mukherjee E, Zhang Y, Holtz A, Basisty N, Yagobian SD, Schilling B, Goetzman ES, Sims-Lucas S (2019) Sirtuin 5 regulates proximal tubule fatty acid oxidation to protect against AKI. J Am Soc Nephrol 30:2384-98.",OXPHOS,"N,S",Homogenate,Mouse,Kidney
"Douros 2019 JCI Insight",2019,"Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.","LEAK,OXPHOS,ET","N,Gp,NS","Permeabilized tissue",Mouse,"Islet cell;pancreas;thymus"
"Li 2019 Int Urol Nephrol",2019,"Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70.","ROUTINE,OXPHOS,ET,LEAK","N,S,CIV,NS,ROX","Intact cells,Permeabilized cells",Human,"Endothelial;epithelial;mesothelial cell"
"Szibor 2019 Biochim Biophys Acta Bioenerg",2019,"Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Mouse,Heart
"Reda 2019 Sci Rep",2019,"Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.","LEAK,OXPHOS","N,S,CIV,ROX","Permeabilized cells",Human,"Endothelial;epithelial;mesothelial cell"
"Fang 2019 Nat Commun",2019,"Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA (2019) NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun 10:5284.","LEAK,OXPHOS","F,N,S,CIV,ROX",Homogenate,Mouse,"Heart,Nervous system,Liver"
"Kim 2019 Pflugers Arch",2019,"Kim Y, Triolo M, Erlich AT, Hood DA (2019) Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pflugers Arch 471:431-40.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Rat,"Skeletal muscle"
"Larsen 2019 Appl Physiol Nutr Metab",2019,"Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab 44:958-64.","OXPHOS,ET,LEAK","N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Paradis 2019 Antioxidants (Basel)",2019,"Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168.","LEAK,OXPHOS","N,S,CIV","Permeabilized tissue",Mouse,"Skeletal muscle"
"Shirakawa 2019 Sci Rep",2019,"Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T (2019) Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Sci Rep 9:14709.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized cells",Human,"Blood cells"
"Gregg 2019 J Biol Chem",2019,"Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66.","OXPHOS,ET,LEAK","N,S,NS,ROX","Permeabilized tissue",Mouse,"Islet cell;pancreas;thymus"
"Teulier 2019 Comp Biochem Physiol A Mol Integr Physiol",2019,"Teulier L, Thoral E, Queiros Q, McKenzie DJ, Roussel D, Dutto G, Gasset E, Bourjea J, Saraux C (2019) Muscle bioenergetics of two emblematic Mediterranean fish species: ''Sardina pilchardus'' and ''Sparus aurata''. Comp Biochem Physiol A Mol Integr Physiol 235:174-79.","LEAK,OXPHOS,ET","F,N,NS,ROX","Intact cells",Fishes,"Skeletal muscle"
"Lewis 2019 Int J Mol Sci",2019,"Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Quantification of mitochondrial oxidative phosphorylation in metabolic disease: application to Type 2 diabetes. Int J Mol Sci 20:5271. https://doi.org/10.3390/ijms20215271",OXPHOS,,,"Human,Rat","Skeletal muscle"
"Rudler 2019 Sci Adv",2019,"Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5:eaay2118.","LEAK,OXPHOS,ET","N,S","Isolated mitochondria",Mouse,Heart
"Zhao 2019 Basic Res Cardiol",2019,"Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Intact cells,Permeabilized cells",Rat,"Heart,Fibroblast"
"Berg 2019 Front Physiol",2019,"Berg J, Undebakke V, Rasch-Halvorsen Ø, Aakerøy L, Sandbakk Ø, Tjønna AE (2019) Comparison of mitochondrial respiration in ''M. triceps brachii'' and ''M. vastus lateralis'' between elite cross-country skiers and physically active controls. Front Physiol 10:365.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Itkis 2019 Mitochondrion",2019,"Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17.","LEAK,ROUTINE,OXPHOS,ET","N,CIV,NS,ROX","Intact cells,Permeabilized cells",Human,Fibroblast
"Okoye 2019 Aquat Toxicol",2019,"Okoye CN, MacDonald-Jay N, Kamunde C (2019) Effects of bioenergetics, temperature and cadmium on liver mitochondria reactive oxygen species production and consumption. Aquat Toxicol 214:105264.","LEAK,OXPHOS",N,"Isolated mitochondria",Fishes,Liver
"Latham 2019 J Anim Sci",2019,"Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print].","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Horse,"Skeletal muscle"
"Kluckova 2019 FASEB J",2019,"Kluckova K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA (2019) Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function. FASEB J 34:303-315.","LEAK,ROUTINE,OXPHOS,ET","F,N,NS,ROX","Permeabilized cells,Intact cells",Mouse,"Nervous system"
"Stepanova 2019 Antioxid Redox Signal",2019,"Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin Alexander (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22.","LEAK,OXPHOS","N,NS","Isolated mitochondria",Mouse,"Nervous system"
"Datzmann 2019 Pharmacol Res",2019,"Datzmann T, Hoffmann A, McCook O, Merz T, Wachter U, Preuss J, Vettorazzi S, Calzia E, Gröger M, Kohn F, Schmid A, Denoix N, Radermacher P, Wepler M (2019) Effects of sodium thiosulfate (Na2S2O3) during resuscitation from hemorrhagic shock in swine with preexisting atherosclerosis. Pharmacol Res 151:104536.","LEAK,OXPHOS","N,NS",Homogenate,Pig,"Heart,Liver,Kidney"
"Wang H 2019 J Biol Chem",2019,"Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV (2019) Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. J Biol Chem 294:5466-86.","ROUTINE,OXPHOS,ET","F,N,S,NS","Permeabilized cells,Isolated mitochondria,Intact cells",Rat,Fibroblast
"Wang 2019 Free Radic Biol Med",2019,"Wang SQ, Yang XY, Cui SX, Gao ZH, Qu XJ (2019) Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer. Free Radic Biol Med 134:87-98.","OXPHOS,LEAK",,"Isolated mitochondria",Mouse,"Heart,Liver,Endothelial;epithelial;mesothelial cell"
"Fiorenza 2019 FASEB J",2019,"Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J 33:8976-89.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Gancheva 2019 Nat Commun",2019,"Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, Jähnert M, Weiss J, Strassburger K, Schlensak M, Schürmann A, Roden M (2019) Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat Commun 10:4179.","LEAK,OXPHOS,ET",,"Permeabilized tissue",Human,"Skeletal muscle"
"Du 2019 J Virol",2019,"Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol 93:e00653-19.",OXPHOS,,"Intact cells",Horse,"Blood cells,Other cell lines"
"Bajzikova 2019 Cell Metab",2019,"Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416.","OXPHOS,ET","N,S,ROX","Permeabilized cells,Homogenate",Mouse,"Endothelial;epithelial;mesothelial cell,Genital,Other cell lines"
"Doerrier 2019 MitoFit Preprint Arch EA",2019,"Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0009","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Martines 2019 Sci Rep",2019,"Martines AMF, Gerding A, Stolle S, Vieira-Lara MA, Wolters JC, Jurdzinski A, Bongiovanni L, de Bruin A, van der Vlies P, van der Vries G, Bloks VW, Derks TGJ, Reijngoud DJ, Bakker BM (2019) Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Sci Rep 9:14539.","LEAK,OXPHOS","F,N","Isolated mitochondria",Mouse,Liver
"Heden 2019 Sci Adv",2019,"Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019) Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv 5:eaax8352.","LEAK,OXPHOS","F,N,S,DQ,CIV,NS,ROX","Permeabilized tissue,Isolated mitochondria",Mouse,"Skeletal muscle"
"Magga 2019 Mol Ther",2019,"Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R (2019) Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury. Mol Ther 27:600-10.","LEAK,OXPHOS,ET","N,S,NS",Homogenate,Mouse,Heart
"Gaviraghi 2019 Anal Biochem",2019,"Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of ''Aedes aegypti'' mosquitoes. Anal Biochem 576:33-41.","LEAK,OXPHOS,ET","N,Gp,CIV,ROX","Permeabilized tissue",Hexapods,"Skeletal muscle"
"Mazzoli 2019 Nutrients",2019,"Mazzoli A, Crescenzo R, Cigliano L, Spagnuolo MS, Cancelliere R, Gatto C, Iossa S (2019) Early hepatic oxidative stress and mitochondrial changes following western diet in middle aged rats. Nutrients 11:E2670.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Rat,Liver
"Flis 2019 Int J Mol Sci",2019,"Flis DJ, Dzik K, Kaczor JJ, Cieminski K, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2019) Swim training modulates mouse skeletal muscle energy metabolism and ameliorates reduction in grip strength in a mouse model of amyotrophic lateral sclerosis. Int J Mol Sci 20:E233.","LEAK,OXPHOS",N,"Isolated mitochondria",Mouse,"Skeletal muscle"
"Pichaud 2019 Front Genet",2019,"Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.","LEAK,OXPHOS,ET","N,Gp,CIV,ROX","Permeabilized tissue",Drosophila,"Skeletal muscle"
"McCoin 2019 Am J Physiol Endocrinol Metab",2019,"McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab 317:E298-E311.","LEAK,OXPHOS,ET","F,N,NS","Isolated mitochondria",Mouse,Liver
"Dilberger 2019 Nutrients",2019,"Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.","LEAK,OXPHOS,ET","N,S,CIV,NS","Isolated mitochondria","Caenorhabditis elegans",
"Doig 2019 bioRxiv",2019,"Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Gonzalez-Armenta 2019 J Nutr",2019,"Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502.","LEAK,OXPHOS,ET","F,N,S,Gp,NS,ROX","Permeabilized tissue","Other mammals","Skeletal muscle"
"Kumar 2019 Free Radic Biol Med",2019,"Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99.","LEAK,ROUTINE,OXPHOS,ET","F,N,S,DQ,CIV,NS,ROX","Permeabilized cells,Permeabilized tissue,Intact cells",Mouse,"Skeletal muscle"
"Shao 2019 Cardiovasc Diabetol",2019,"Shao Q, Meng L, Lee S, Tse G, Gong M, Zhang Z, Zhao J, Zhao Y, Li G, Liu T (2019) Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induce diabetic rats. Cardiovasc Diabetol 18:165.","LEAK,OXPHOS",N,"Isolated mitochondria",Rat,Heart
"Garrido-Maraver 2019 Cell Death Dis",2019,"Garrido-Maraver J, Celardo I, Costa AC, Lehmann S, Loh SHY, Martins LM (2019) Enhancing folic acid metabolism suppresses defects associated with loss of ''Drosophila'' mitofusin. Cell Death Dis 10:288.","OXPHOS,ET","N,S","Permeabilized tissue",Drosophila,
"Kappler 2019 Am J Physiol Endocrinol Metab",2019,"Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R (2019) Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints. Am J Physiol Endocrinol Metab 317:E374-E387.","LEAK,OXPHOS,ET","F,N,S,NS","Permeabilized tissue,Isolated mitochondria","Human,Mouse","Skeletal muscle,Liver"
"Ederle 2019 J Clin Med",2019,"Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells",Human,"Blood cells"
"Pignanelli 2019 Am J Physiol Regul Integr Comp Physiol",2019,"Pignanelli C, Petrick HL, Keyvani F, Heigenhauser GJF, Quadrilatero J, Holloway GP, Burr JF (2019) Low-load resistance training to task-failure with and without blood flow restriction: muscular functional and structural adaptations. Am J Physiol Regul Integr Comp Physiol 318:R284-95.","OXPHOS,LEAK","N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Maresch 2019 Hepatol Commun",2019,"Maresch LK, Benedikt P, Feiler U, Eder S, Zierler KA, Taschler U, Kolleritsch S, Eichmann TO, Schoiswohl G, Leopold C, Wieser B, Lackner C, Rülicke T, van Klinken J, Kratky D, Moustafa T, Hoefler G, Haemmerle G (2019) Intestine‐specific overexpression of carboxylesterase 2c protects mice from diet‐induced liver steatosis and obesity. Hepatol Commun 3:227-45.","LEAK,OXPHOS",F,Homogenate,Mouse,"Endothelial;epithelial;mesothelial cell"
"Neyroud 2019 J Muscle Res Cell Motil",2019,"Neyroud D, Nosacka RL, Judge AR, Hepple RT (2019) Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content. J Muscle Res Cell Motil 40:59-65.",OXPHOS,"N,NS","Permeabilized cells",Mouse,"Skeletal muscle"
"Sukovas 2019 J Bioenerg Biomembr",2019,"Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr 51:301-10.","LEAK,OXPHOS",N,"Permeabilized cells",Human,Genital
"Cannon 2019 J Appl Physiol (1985)",2019,"Cannon DT, Rodewohl L, Adams V, Breen EC, Bowen TS (2019) Skeletal myofiber VEGF deficiency leads to mitochondrial, structural and contractile alterations in mouse diaphragm. J Appl Physiol (1985) 127:1360-69.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Datzmann 2019 J Neurosurg",2019,"Datzmann T, Kapapa T, Scheuerle A, McCook O, Merz T, Unmuth S, Hoffmann A, Mathieu R, Mayer S, Mauer UM, Roehrer S, Yilmazer-Hanke D, Moeller P, Nussbaum BL, Calzia E, Groeger M, Hartmann C, Radermacher P, Wepler M (2019) In-depth characterization of a long-term, resuscitated model of acute subdural hematoma-induced brain injury. https://doi.org/10.3171/2019.9.jns191789","LEAK,OXPHOS,ET","N,NS",Homogenate,Pig,"Nervous system"
"Moretti-Almeida 2019 Fungal Genet Biol",2019,"Moretti-Almeida G, Thomazella DPT, Pereira GAG, Monteiro G (2019) Heterologous expression of an alternative oxidase from ''Moniliophthora perniciosa'' in ''Saccharomyces cerevisiae'': antioxidant function and ''in vivo'' platform for the study of new drugs against witches' broom disease. Fungal Genet Biol 126:50-55.",OXPHOS,ROX,"Isolated mitochondria","Saccharomyces cerevisiae",
"Harhous 2019 J Mol Cell Cardiol",2019,"Harhous Z, Badawi S, Bona NG, Pillot B, Augeul L, Paillard M, Booz GW, Canet-Soulas E, Ovize M, Kurdi M, Bidaux G (2019) Critical appraisal of STAT3 pattern in adult cardiomyocytes. J Mol Cell Cardiol 131:91-100.","OXPHOS,ET","N,CIV,ROX","Isolated mitochondria",Mouse,Heart
"Pignanelli 2019 Thesis",2019,"Pignanelli CJ (2019) Muscular adaptations to low-load resistance training to repetition failure with and without blood flow restriction. Master's Thesis 80.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Wang 2019 Life Sci",2019,"Wang JW, Xue ZY, Wu AS (2019) Mechanistic insights into δ-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria. Life Sci 247:116942.","LEAK,OXPHOS","N,S","Isolated mitochondria",Mouse,Heart
"Mann 2019 Oncogene",2019,"Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.","LEAK,ROUTINE,OXPHOS,ET","N,S,CIV,NS,ROX,F","Permeabilized cells,Intact cells",Human,"Endothelial;epithelial;mesothelial cell"
"Crescenzo 2019 Mol Neurobiol",2019,"Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Rat,"Nervous system"
"Svab 2019 Neurochem Res",2019,"Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47.","LEAK,OXPHOS,ET","N,S","Isolated mitochondria,Intact cells","Guinea pig","Nervous system"
"Ferreira 2019 EMBO J",2019,"Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O (2019) Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation. EMBO J 38:e102155.","LEAK,OXPHOS,ET","N,S","Isolated mitochondria",Mouse,"Heart,Liver"
"Ruegsegger 2019 FASEB J",2019,"Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.","LEAK,OXPHOS","N,NS,ROX","Isolated mitochondria",Mouse,"Nervous system"
"Driescher 2019 Heliyon",2019,"Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.","LEAK,OXPHOS,ET","F,N,CIV,ROX","Permeabilized tissue",Rat,Heart
"Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis",2019,"Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,Fibroblast
"Hunter 2019 J Appl Physiol (1985)",2019,"Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between VO2max, cycle economy & mitochondrial respiration in untrained/trained. J Appl Physiol (1985) 127:1562-68.","LEAK,OXPHOS","F,N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Desmoulins 2019 Mol Metab",2019,"Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77.","OXPHOS,ET,LEAK","N,NS",Homogenate,Rat,"Nervous system"
"Repp 2019 Thesis",2019,"Repp BM (2019) Identification and verification of novel disease-causing genes and therapy options for patients with mitochondrial disorders – Focus on ACAD9. PhD Thesis 178.","LEAK,OXPHOS","N,S,CIV,ROX","Permeabilized cells",Human,HEK
"Kunz 2019 Am J Physiol Endocrinol Metab",2019,"Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab 317:E460-E472.","LEAK,OXPHOS","F,N,S,NS,ROX","Isolated mitochondria",Mouse,"Skeletal muscle,Liver"
"Kim 2019 Biochim Biophys Acta Mol Basis Dis",2019,"Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I, Minamino T, Cho KI, Park YS, Kim S, Han J (2019) Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis 1865:165524.","LEAK,OXPHOS",N,"Isolated mitochondria,Permeabilized tissue",Mouse,Heart
"Naszai 2019 Sci Rep",2019,"Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca(2+)N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229.","LEAK,OXPHOS","N,S,NS,ROX","Isolated mitochondria",Rat,Liver
"Scheiber 2019 Exp Mol Med",2019,"Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized tissue,Isolated mitochondria",Human,Heart
"Ng 2019 J Biol Chem",2019,"Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells",Human,Neuroblastoma
"Zeng 2019 Toxicol Rep",2019,"Zeng R, Zhou Q, Zhang W, Fu X, Wu Q, Lu Y, Shi J, Zhou S (2019) Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and ''in vitro''. Toxicol Rep 6:637-44.",OXPHOS,S,"Isolated mitochondria,Intact cells",Rat,"Nervous system"
"Tomasic 2019 Biochim Biophys Acta Mol Basis Dis",2019,"Tomašić N, Kotarsky H, de Oliveira Figueiredo R, Hansson E, Mörgelin M, Tomašić I, Kallijärvi J, Elmér E, Jauhiainen M, Eklund EA, Fellman V (2019) Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165573.","LEAK,OXPHOS,ET","N,S,NS","Isolated mitochondria",Mouse,Liver
"Skrivergaard 2019 Viruses",2019,"Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122.","LEAK,ROUTINE,OXPHOS,ET","N,S,ROX","Permeabilized cells,Intact cells",Human,"Other cell lines,HeLa"
"Rajendran 2019 EMBO Mol Med",2019,"Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456.","LEAK,OXPHOS,ET","N,S,CIV,NS","Isolated mitochondria",Mouse,"Liver,Kidney,Heart"
"Vaka 2019 Am J Physiol Regul Integr Comp Physiol",2019,"Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.","LEAK,OXPHOS,ET","N,CIV,ROX","Intact cells,Isolated mitochondria","Human,Rat","Endothelial;epithelial;mesothelial cell,Genital"
"Electron-transfer-pathway state",2019,"Gnaiger E (2019) ET-pathway states. Mitochondr Physiol Network 2019-06-11 (last edit since 2016-11-08).","LEAK,OXPHOS,ET","F,N,S,Gp,CIV,NS,Other combinations","Permeabilized cells,Permeabilized tissue,Homogenate,Isolated mitochondria,SMP",,
"Malyala 2019 PLoS Comput Biol",2019,"Malyala S, Zhang Y, Strubbe JO, Bazil JN (2019) Calcium phosphate precipitation inhibits mitochondrial energy metabolism. PLoS Comput Biol 15:e1006719.","OXPHOS,LEAK","N,S","Isolated mitochondria","Guinea pig",Heart
"Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol",2019,"Rodríguez-Enríquez S, Pacheco-Velázquez SC, Marín-Hernández Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernández-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernández-Esquivel L, Sánchez-Thomas R, Moreno-Sánchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77.","LEAK,OXPHOS","N,S","Isolated mitochondria",Rat,"Heart,Liver"
"Chroeis 2019 Eur J Sport Sci",2019,"Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45.","LEAK,OXPHOS,ET","N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Bahhir 2019 PLoS Genet",2019,"Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA ''in vivo'' reprograms metabolism via novel response mechanisms. PLoS Genet 15:e1008410.","LEAK,OXPHOS","N,Gp,CIV,ROX",Homogenate,Drosophila,
"Altinok 2019 J Cell Physiol",2019,"Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:2569-81.","LEAK,OXPHOS","N,S","Isolated mitochondria",Human,"Other cell lines"
"McManus 2019 Cell Metab",2019,"McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90.","LEAK,OXPHOS","N,ROX","Isolated mitochondria",Mouse,Heart
"Zhang 2019 Redox Biol",2019,"Zhang Y, Bharathi SS, Beck ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol 26:101253.","LEAK,OXPHOS","N,NS,F","Isolated mitochondria",Mouse,Liver
"Trevino 2019 Am J Physiol Endocrinol Metab",2019,"Trevino MB, Zhang X, Standley RA, Wang M, Han X, Reis FCG, Periasamy M1, Yu G, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2019) Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Metab 317:E899-910.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Hsu 2019 J Clin Med",2019,"Hsu CC, Tsai HH, Fu TC, Wang JS (2019) Exercise training enhances platelet mitochondrial bioenergetics in stroke patients: a randomized controlled trial. J Clin Med 8:E2186.","LEAK,OXPHOS,ET","F,N,S,Gp,NS,ROX","Permeabilized cells",Human,"Platelet,Blood cells"
"Kharechkina 2019 Biochim Biophys Acta Gen Subj",2019,"Kharechkina ES, Nikiforova AB, Teplova VV, Odinokova IV, Krestinina OV, Baburina YL, Kruglova SA, Kruglov AG (2019) Regulation of permeability transition pore opening in mitochondria by external NAD(H). Biochim Biophys Acta Gen Subj 1863:771-83.","LEAK,OXPHOS,ET",S,"Isolated mitochondria",Rat,Liver
"Miotto 2019 FASEB J",2019,"Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40.","LEAK,OXPHOS","N,NS,F","Permeabilized tissue",Human,"Skeletal muscle"
"Mueller 2019 Neurochem Int",2019,"Mueller TE, Nunes MEM, Rodrigues NR, Fontana BD, Hartmann DD, Franco JL, Rosemberg DB (2019) Neurochemical mechanisms underlying acute and chronic ethanol-mediated responses in zebrafish: The role of mitochondrial bioenergetics. Neurochem Int 131:104584.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Zebrafish,"Nervous system"
"Haberman 2019 Nat Commun",2019,"Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA (2019) Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun 10:38.","OXPHOS,ET","N,S,NS",Homogenate,Human,"Endothelial;epithelial;mesothelial cell"
"Chatfield 2019 JACC Basic Transl Sci",2019,"Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue",Human,Heart
"Bouitbir 2019 Toxicology",2019,"Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Permeabilized cells,Permeabilized tissue","Rat,Mouse",Heart
"Carteri 2019 Toxicol Lett",2019,"Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.","LEAK,OXPHOS,ET","N,NS,ROX","Isolated mitochondria",Mouse,"Nervous system"
"Robinson 2019 Am J Physiol Cell Physiol",2019,"Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.","LEAK,OXPHOS,ET","F,N,S,Gp,NS,Other combinations,ROX","Permeabilized cells","Mouse,Rat","Skeletal muscle"
"De Moura Escobar 2019 Toxicol In Vitro",2019,"de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640.","LEAK,OXPHOS","N,S,ROX","Permeabilized cells",Human,Neuroblastoma
"Esselun 2019 Oxid Med Cell Longev",2019,"Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP (2019) Differential effects of silibinin A on mitochondrial function in neuronal PC12 and HepG2 liver cells. Oxid Med Cell Longev 2019:1652609.","LEAK,OXPHOS,ET","N,S,CIV,NS","Permeabilized cells","Human,Rat","Nervous system,Liver"
"Poudel 2019 Can J Physiol Pharmacol",2019,"Poudel A, Zhou JY, Mekala N, Welchko R, Rosca MG, Li L (2019) Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol 97:699-707.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells",Mouse,"Skeletal muscle"
"Ma 2019 Biochem Biophys Res Commun",2019,"Ma T, Lin S, Wang B, Wang Q, Xia W, Zhang H, Cui Y, He C, Wu H, Sun F, Zhao Z, Gao P, Zhu Z, Liu D (2019) TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction. Biochem Biophys Res Commun 519:674-81.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells",Mouse,Heart
"Miranda Mendonca 2019 Neurochem Int",2019,"Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17.","LEAK,OXPHOS,ET","N,CIV,ROX","Permeabilized tissue",Mouse,"Nervous system"
"Belosludtsev 2019 Biochim Biophys Acta Biomembr",2019,"Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2019) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr 1861:288-97.","LEAK,OXPHOS","N,S,NS","Isolated mitochondria",Rat,Liver
"Gvozdjakova 2019 Bratisl Lek Listy",2019,"Gvozdjakova A, Sumbalova Z, Kucharska J, Chladekova A, Rausova Z, Vancova O, Komlosi M, Ulicna O, Mojto V (2019) Platelet mitochondrial bioenergetic analysis in patients with nephropathies and non-communicable diseases: a new method. Bratisl Lek Listy 120:630-35.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Human,"Platelet,Blood cells"
"Simon 2019 J Biol Chem",2019,"Simon MC, Reinbeck AL, Wessel C, Heindirk J, Jelenik T, Kaul K, Arreguin-Cano J, Strom A, Blaut M, Bäckhed F, Burkart V, Roden M (2019) Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in non-obese diabetic mice. J Biol Chem 295:969-80.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle,Liver"
"Aubin 2019 Thesis",2019,"Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99.","ROUTINE,OXPHOS,ET","N,S,NS,ROX","Intact cells,Permeabilized cells",Human,Lymphocyte
"Dall 2019 J Biol Chem",2019,"Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem 294:13304-26.","LEAK,OXPHOS,ET","F,N,S","Intact cells",Mouse,Liver
"Mejia 2019 Reprod Biol Endocrinol",2019,"Mejia JF, Hirschi KM, Tsai KYF, Long MG, Tullis BC, Bitter EEK, Bikman BT, Reynolds PR, Arroyo JA (2019) Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reprod Biol Endocrinol 17:81.","LEAK,OXPHOS,ET","N,NS","Permeabilized cells",Human,Genital
"Maekawa 2019 Biochem Biophys Rep",2019,"Maekawa S, Takada S, Furihata T, Fukushima A, Yokota T, Kinugawa S (2019) Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle. Biochem Biophys Rep 21:100717.",OXPHOS,"N,S,NS","Permeabilized tissue,Isolated mitochondria",Mouse,"Skeletal muscle"
"Nold 2019 Psychoneuroendocrinology",2019,"Nold V, Sweatman C, Karabatsiakis A, Böck C, Bretschneider T, Lawless N, Fundel-Clemens K, Kolassa IT, Allers KA (2019) Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress. Psychoneuroendocrinology 107:148-59.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX",Homogenate,Rat,"Nervous system"
"Shuvo 2019 J Bioenerg Biomembr",2019,"Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less ''Neurospora crassa'' mitochondria. J Bioenerg Biomembr 51:341-54.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Fungi,
"Dechandt 2019 Front Neurol",2019,"Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007.","LEAK,OXPHOS,ET","N,ROX","Permeabilized tissue",Rat,"Nervous system"
"Weinstein 2019 bioRxiv",2019,"Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells",Human,"Other cell lines,Lymphocyte"
"Sambeat 2019 Nat Commun",2019,"Sambeat A, Ratajczak J, Joffraud M, Sanchez-Garcia JL, Giner MP, Valsesia A, Giroud-Gerbetant J, Valera-Alberni M, Cercillieux A, Boutant M, Kulkarni SS, Moco S, Canto C (2019) Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage. Nat Commun 10:4291.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue,Homogenate",Mouse,"Skeletal muscle,Liver"
"Penniman 2019 Mol Metab",2019,"Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220.","LEAK,OXPHOS,ET","F,N,S,NS","Permeabilized tissue,Isolated mitochondria",Mouse,"Skeletal muscle"
"Madlala 2019 Integr Food Nutr Metab",2019,"Madlala HP, Maarman GJ, Ojuka E (2019) Fructose impairs mitochondrial respiration and substrate utilization in hepatocytes via the enzyme, glutamate oxaloacetate transaminase. Integr Food Nutr Metab doi: 10.15761/IFNM.1000228.","LEAK,OXPHOS,ET","N,CIV,ROX","Permeabilized cells",Human,Liver
"Richter 2019 Life Sci Alliance",2019,"Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ (2019) Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance 2:e201800219.","OXPHOS,ET","N,CIV,NS","Permeabilized cells",Human,Fibroblast
"Ferey 2019 Am J Physiol Heart Circ Physiol",2019,"Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210.","LEAK,OXPHOS","N,S,NS","Permeabilized tissue",Mouse,Heart
"Cadiz 2019 Comp Biochem Physiol B Biochem Mol Biol",2019,"Cadiz L, Bundgaard A, Malte H, Fago A (2019) Hypoxia enhances blood O2 affinity and depresses skeletal muscle O2 consumption in zebrafish (''Danio rerio''). Comp Biochem Physiol B Biochem Mol Biol 234:18-25.","LEAK,OXPHOS,ET","N,NS","Permeabilized tissue",Zebrafish,"Skeletal muscle"
"Perry 2019 J Mol Cell Cardiol",2019,"Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.","LEAK,OXPHOS","N,S,ROX","Isolated mitochondria,Permeabilized cells",Rat,Heart
"Baekkerud 2019 Cardiovasc Toxicol",2019,"Bækkerud FH, Salerno S, Ceriotti P, Morland C, Storm-Mathisen J, Bergersen LH, Høydal MA, Catalucci D, Stølen TO (2019) High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol 19:422-31.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Permeabilized tissue",Mouse,Heart
"Bianco 2019 PLoS One",2019,"Bianco M, Lopes JA, Beiral HJV, Filho JDD, Frankenfeld SP, Fortunato RS, Gattass CR, Vieyra A, Takiya CM (2019) The contralateral kidney presents with impaired mitochondrial functions and disrupted redox homeostasis after 14 days of unilateral ureteral obstruction in mice. PLoS One 14:e0218986.","LEAK,OXPHOS,ET","N,S","Isolated mitochondria",Mouse,Kidney
"Viana 2019 Sci Rep",2019,"Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529.","LEAK,OXPHOS",N,"Permeabilized tissue",Rat,"Endothelial;epithelial;mesothelial cell"
"Bittel 2019 Diabetologia",2019,"Bittel AJ, Bittel DC, Mittendorfer B, Patterson BW, Okunade AL, Yoshino J, Porter LC, Abumrad NA, Reeds DN, Cade WT (2019) A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes. Diabetologia 63:611-23.","LEAK,OXPHOS,ET","F,N,S,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Devaux 2019 Front Physiol",2019,"Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941.","LEAK,OXPHOS,ET","Other combinations,N,NS","Permeabilized tissue,Isolated mitochondria",Fishes,"Nervous system"
"De-Souza-Ferreira 2019 J Neurochem",2019,"de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40.","LEAK,OXPHOS,ET","N,Gp,CIV,NS","Isolated mitochondria",Rat,"Nervous system"
"Pajak 2019 PLoS Genet",2019,"Pajak A, Laine I, Clemente P, El-Fissi N, Schober FA, Maffezzini C, Calvo-Garrido J, Wibom R, Filograna R, Dhir A, Wedell A, Freyer C, Wredenberg A (2019) Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA ''in vivo''. PLoS Genet 15:e1008240.","LEAK,OXPHOS","N,S,CIV","Permeabilized tissue",Drosophila,
"Kumari 2019 Am J Physiol Heart Circ Physiol",2019,"Kumari S, Braun RK, Tetri L, Barton GP, Hacker TA, Goss KN (2019) Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart. Am J Physiol Heart Circ Physiol 317:H1272-81.","LEAK,OXPHOS,ET","N,S,CIV,ROX","Permeabilized tissue",Rat,Heart
"Johnson 2019 Mol Metab",2019,"Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K (2019) Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Mol Metab 31:55-66.","LEAK,OXPHOS",N,"Isolated mitochondria",Mouse,Fat
"Laouafa 2019 Acta Physiol (Oxf)",2019,"Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.","LEAK,OXPHOS,ET","N,S,NS,ROX,CIV","Permeabilized tissue",Rat,"Nervous system"
"Krischek 2019 Meat Sci",2019,"Krischek C, Popp J, Sharifi AR (2019) Biochemical alterations in the ''Musculus triceps brachii'' and ''Musculus longissimus thoracis'' during early postmortem period in pigs. Meat Sci 152:121-26.",OXPHOS,N,"Permeabilized tissue",Pig,"Skeletal muscle"
"Rawat 2019 J Mol Biol",2019,"Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.","OXPHOS,LEAK","N,S,CIV,ROX","Permeabilized cells",Mouse,"Nervous system,Other cell lines"
"Cormier 2019 Sci Rep",2019,"Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in ''Drosophila melanogaster''. Sci Rep 9:4531.","LEAK,OXPHOS,ET","N,Gp,NS,ROX,CIV","Permeabilized tissue",Drosophila,"Skeletal muscle"
"Braganza 2019 JCI Insight",2019,"Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248.","LEAK,OXPHOS,ET,ROUTINE","N,NS","Permeabilized tissue,Intact cells",Human,"Skeletal muscle,Blood cells,Platelet"
"Chao 2019 Am J Physiol Cell Physiol",2019,"Chao T, Gomez BI, Heard TC, Smith BW, Dubick MA, Burmeister DM (2019) Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine. Am J Physiol Cell Physiol 317:C1229-38.","LEAK,OXPHOS,ET","F,N,S,NS","Permeabilized tissue",Pig,Heart
"Schweitzer 2019 FASEB J",2019,"Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN (2019) Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. FASEB J 33:652-67.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Zhou 2019 Int J Mol Sci",2019,"Zhou X, Luethi D, Sanvee GM, Bouitbir J, Liechti ME, Krähenbühl S (2019) Molecular toxicological mechanisms of synthetic cathinones on C2C12 myoblasts. Int J Mol Sci 20:E1561.",OXPHOS,N,"Permeabilized cells",Mouse,"Skeletal muscle"
"Cardinale 2019 Front Physiol",2019,"Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730.","LEAK,OXPHOS,ET","F,N,CIV,NS,ROX","Permeabilized tissue,Isolated mitochondria",Human,"Skeletal muscle"
"Kolleritsch 2019 Cardiovasc Res",2019,"Kolleritsch S, Kien B, Schoiswohl G, Diwoky C, Schreiber R, Heier C, Maresch LK, Schweiger M, Eichmann TO, Stryeck S, Krenn P, Tomin T, Kolb D, Rülicke T, Hoefler G, Wolinski H, Madl T, Birner-Gruenberger R, Haemmerle G (2019) Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Cardiovasc Res 116:339-52.","LEAK,OXPHOS",N,Homogenate,Mouse,Heart
"Hunter 2019 J Appl Physiol",2019,"Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between V̇o2peak, cycle economy, and mitochondrial respiration in untrained/trained. J Appl Physiol 127:1562-8.","LEAK,OXPHOS","F,N","Permeabilized tissue",Human,"Skeletal muscle"
"Friederich 2019 Mol Genet Metab",2019,"Friederich MW, Perez FA, Knight KM, Van Hove RA, Yang SP, Saneto RP, Van Hove JLK (2019) Pathogenic variants in NUBPL result in failure to assemble the matrix arm of complex I and cause a complex leukoencephalopathy with thalamic involvement. Mol Genet Metab 129:236-42.","OXPHOS,ET","N,S,CIV,NS",,Human,Fibroblast
"Spinazzi 2019 Proc Natl Acad Sci U S A",2019,"Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Intact cells,Permeabilized cells,Isolated mitochondria",Mouse,"Nervous system"
"Koop 2019 Int J Cardiol",2019,"Koop AMC, Hagdorn QAJ, Bossers GPL, van Leusden T, Gerding A, van Weeghel M, Vaz FM, Koonen DPY, Silljé HHW, Berger RMF, Bartelds B (2019) Right ventricular pressure overload alters cardiac lipid composition. Int J Cardiol 287:96-105.",OXPHOS,"F,N","Isolated mitochondria",Rat,Heart
"Diao 2019 Brain Res",2019,"Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res 1727:146514.","LEAK,OXPHOS,ET",N,"Isolated mitochondria",Mouse,"Nervous system"
"Cesnekova 2019 Thesis",2019,"Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133.","OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells",Human,HEK
"Garnham 2019 J Cachexia Sarcopenia Muscle",2019,"Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle 11:79-88.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"McBride 2019 Arch Biochem Biophys",2019,"McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.","LEAK,OXPHOS","F,N,CIV,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Wiberg 2019 Eur Heart J Acute Cardiovasc Care",2019,"Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care 9:S138-44.","OXPHOS,ET,LEAK","N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Lemieux 2019 bioRxiv",2019,"Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .","LEAK,ROUTINE,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells,Intact cells",Mouse,"Blood cells"
"Boardman 2019 Can J Physiol Pharmacol",2019,"Boardman NT, Falck AT, Lund T, Chu X, Martin-Armas M, Norvik JV, Jenssen TG, Ytrehus K (2019) Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Can J Physiol Pharmacol 98:139-46.","LEAK,OXPHOS",N,"Isolated mitochondria",Rat,Heart
"Mitroshina 2019 Oxid Med Cell Longev",2019,"Mitroshina EV, Mishchenko TA, Shirokova OM, Astrakhanova TA, Loginova MM, Epifanova EA, Babaev AA, Tarabykin VS, Vedunova MV (2019) Intracellular neuroprotective mechanisms in neuron-glial networks mediated by glial cell line-derived neurotrophic factor. Oxid Med Cell Longev 2019:1036907.","LEAK,OXPHOS","N,NS","Isolated mitochondria",Mouse,"Nervous system"
"Thome 2019 Am J Physiol Cell Physiol",2019,"Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13.","LEAK,ROUTINE,OXPHOS,ET","N,NS,ROX","Isolated mitochondria,Intact cells",Mouse,"Skeletal muscle"
"Catalao 2019 Brain Res",2019,"Catalão CHR, Souza AO, Santos-Júnior NN, da Silva SC, da Costa LHA, Alberici LC, Rocha MJA, da Silva Lopes L (2019) Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats. Brain Res 1724:146408.","LEAK,OXPHOS,ET","N,ROX",Homogenate,Rat,"Nervous system"
"Tufi 2019 Cell Rep",2019,"Tufi R, Gleeson TP, von Stockum S, Hewitt VL, Lee JJ, Terriente-Felix A, Sanchez-Martinez A, Ziviani E, Whitworth AJ (2019) Comprehensive genetic characterization of mitochondriaasl Ca2+ uniporter components reveals their different physiological requirements ''in vivo''. https://doi.org/10.1016/j.celrep.2019.04.033",OXPHOS,"N,S",Homogenate,Drosophila,
"Chang 2019 Br J Anaesth",2019,"Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX",,Human,"Skeletal muscle"
"Park 2019 Behav Brain Res",2019,"Park SS, Park HS, Kim CJ, Baek SS, Kim TW (2019) Exercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe. Behav Brain Res 372:112049.","LEAK,OXPHOS","N,NS",,Rat,"Nervous system"
"McMurray 2019 FASEB J",2019,"McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26.","LEAK,OXPHOS","F,N,S,CIV,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Langley 2019 Biochim Biophys Acta Mol Basis Dis",2019,"Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA (2019) High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis 1866:165630.","LEAK,OXPHOS,ET","N,NS,ROX","Isolated mitochondria",Mouse,"Nervous system"
"Gonzalez-Mariscal 2019 FASEB J",2019,"González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Monteiro 2019 Thesis",2019,"Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82.","LEAK,OXPHOS,ET",N,"Permeabilized tissue",Rat,"Skeletal muscle"
"Hirschi 2019 Biol Reprod",2019,"Hirschi KM, Tsai KYF, Davis T, Clark JC, Knowlton MN, Bikman BT, Reynolds PR, Arroyo JA (2019) Growth arrest specific protein (Gas)-6/AXL signaling induces preeclampsia (PE) in rats. Biol Reprod 102:199-210.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized cells,Permeabilized tissue",Rat,Genital
"Kirby 2019 Comp Biochem Physiol C Toxicol Pharmacol",2019,"Kirby AR, Cox GK, Nelson D, Heuer RM, Stieglitz JD, Benetti DD, Grosell M, Crossley DA 2nd (2019) Acute crude oil exposure alters mitochondrial function and ADP affinity in cardiac muscle fibers of young adult Mahi-mahi (''Coryphaena hippurus''). Comp Biochem Physiol C Toxicol Pharmacol 218:88-95.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized tissue",Fishes,Heart
"Tiebe 2019 Sci Rep",2019,"Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.","LEAK,OXPHOS,ROUTINE","F,N,Gp,ROX","Permeabilized cells,Intact cells",Mouse,"Skeletal muscle,Liver"
"Manfredini 2019 Clin Sci (Lond)",2019,"Manfredini A, Constantino L, Pinto MC, Michels M, Burger H, Kist LW, Silva MC, Gomes LM, Dominguini D, Steckert A, Simioni C, Bogo M, Streck E, Barichello T, de Quevedo J, Singer M, Ritter C, Dal-Pizzol F (2019) Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model. Clin Sci (Lond) 133:1993-2004.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Rat,"Nervous system"
"Halle 2019 Am J Physiol Regul Integr Comp Physiol",2019,"Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue,Intact cells",Mouse,"Skeletal muscle,Liver,Fat"
"Gururaja Rao 2019 Cells",2019,"Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in ''Drosophila melanogaster''. Cells 8:E945.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Drosophila,
"Pharaoh 2019 Mol Neurobiol",2019,"Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Permeabilized tissue,Isolated mitochondria,Intact cells",Mouse,"Skeletal muscle,Nervous system,Fat"
"Chiurillo 2019 Mol Biol Cell",2019,"Chiurillo MA, Lander N, Bertolini MS, Vercesi AE, Docampo R (2019) Functional analysis and importance for host cell infection of the Ca2+-conducting subunits of the mitochondrial calcium uniporter of ''Trypanosoma cruzi''. Mol Biol Cell 30:1676-90.","LEAK,OXPHOS,ET",S,"Permeabilized cells",Protists,
"Dent 2019 J Appl Physiol (1985)",2019,"Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Greenway 2019 J Evol Biol",2019,"Greenway EVG, Cirino LA, Wilner D, Somjee U, Anagnostou ME, Hepple RT, Miller CW (2019) Extreme variation in testes size in an insect is linked to recent mating activity. J Evol Biol 33:142-50.","LEAK,OXPHOS","N,CIV,NS,ROX","Permeabilized cells",Hexapods,Genital
"Hughes 2019 J Physiol",2019,"Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR (2019) Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol 598:1377-92.","OXPHOS,LEAK","N,NS","Permeabilized tissue",Mouse,Heart
"Fernando 2019 Exp Gerontol",2019,"Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Silva Ramos 2019 PLoS Genet",2019,"Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085.","LEAK,OXPHOS,ET","N,S,Gp","Permeabilized cells,Isolated mitochondria",Mouse,"Heart,Fibroblast"
"Turnbull 2019 Am J Physiol Cell Physiol",2019,"Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88.","LEAK,OXPHOS",N,"Permeabilized cells",Human,"Endothelial;epithelial;mesothelial cell"
"Salin 2019 Proc Biol Sci",2019,"Salin K, Villasevil EM, Anderson GJ, Lamarre SG, Melanson CA, McCarthy I, Selman C, Metcalfe NB (2019) Differences in mitochondrial efficiency explain individual variation in growth performance. Proc Biol Sci 286:20191466.",OXPHOS,"N,CIV,NS",Homogenate,Fishes,"Skeletal muscle,Liver"
"Fisher-Wellman 2019 Cell Rep",2019,"Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.","LEAK,OXPHOS,ET","F,N,S,Gp","Isolated mitochondria",Mouse,"Heart,Skeletal muscle"
"Kwak 2019 Int J Environ Res Public Health",2019,"Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized cells",Human,"Skeletal muscle"
"Kopinski 2019 Proc Natl Acad Sci U S A",2019,"Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells",Human,"Other cell lines"
"Sabogal-Guaqueta 2019 Biomed Pharmacother",2019,"Sabogal-Guáqueta AM, Hobbie F, Keerthi A, Oun A, Kortholt A, Boddeke E, Dolga A (2019) Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomed Pharmacother 118:109295.","LEAK,OXPHOS,ET",N,"Isolated mitochondria",Mouse,"Nervous system"
"Monteiro 2019 J Bioenerg Biomembr",2019,"Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15.","LEAK,OXPHOS","N,S,NS,ROX","Isolated mitochondria",Mouse,"Nervous system"
"Pedrotti 2019 Sci Adv",2019,"Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Intact cells",Mouse,Fat
"Rodinova 2019 Dis Model Mech",2019,"Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.","LEAK,OXPHOS,ET","N,S,CIV,ROX","Isolated mitochondria",Pig,"Skeletal muscle"
"Dollerup 2019 J Physiol",2019,"Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"D'Amico 2019 Mol Cell",2019,"D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J (2019) The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell 73:775-87.",OXPHOS,"S,NS,ROX",Homogenate,Mouse,"Skeletal muscle"
"Thomas 2019 Redox Biol",2019,"Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.","LEAK,OXPHOS,ET","N,S,NS,ROX","Intact cells",Rat,Liver
"Jaiswal 2019 Mol Metab",2019,"Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM (2019) The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Mol Metab 28:1-13.","LEAK,OXPHOS",N,"Isolated mitochondria",Mouse,"Skeletal muscle"
"Deutschman 2019 J Cell Sci",2019,"Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized cells",Human,"Endothelial;epithelial;mesothelial cell"
"Tyrrell 2019 Circ Res",2019,"Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314.","OXPHOS,ET","N,S,NS,ROX",,Mouse,"Endothelial;epithelial;mesothelial cell"
"Paumelle 2019 J Hepatol",2019,"Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.","OXPHOS,LEAK","F,N",Homogenate,Human,Liver
"Garcia-Roche 2019 PLoS One",2019,"García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.","LEAK,OXPHOS,ET","N,S,NS,ROX","Intact cells",Bovines,Liver
"Christian 2019 Respir Physiol Neurobiol",2019,"Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62.","LEAK,OXPHOS",N,"Permeabilized tissue",Mouse,"Nervous system"
"Ruegsegger 2019 JCI Insight",2019,"Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681.","LEAK,OXPHOS,ET",ROX,"Isolated mitochondria",Mouse,"Nervous system"
"Courtes 2019 Biomed Pharmacother",2019,"Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.","OXPHOS,LEAK","N,S,NS,ROX","Isolated mitochondria",Rat,Liver
"Halling 2019 Am J Physiol Endocrinol Metab",2019,"Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Grandoch 2019 Nat Metab",2019,"Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized tissue,Isolated mitochondria",Mouse,Fat
"Bodis 2019 J Clin Endocrinol Metab",2019,"Bodis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Muessig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schuermann A, Roden M, Szendroedi J (2019) Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes. J Clin Endocrinol Metab 105:dgz267.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized cells",Human,Fat
"Huerta 2019 Aquat Toxicol",2019,"Huerta B, Chung-Davidson YW, Bussy U, Zhang Y, Bazil JN, Li W (2019) Sea lamprey cardiac mitochondrial bioenergetics after exposure to TFM and its metabolites. Aquat Toxicol 219:105380.","LEAK,OXPHOS,ET","N,S,ROX","Isolated mitochondria",Fishes,Heart
"Calabria 2019 Front Neurosci",2019,"Calabria Elisa, Scambi Ilaria, Bonafede Roberta, Schiaffino Lorenzo, Peroni Daniele, Potrich Valentina, Capelli Carlo, Schena Federico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an ''in vitro'' model of ALS. Front Neurosci 13:1070.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX","Permeabilized cells,Intact cells",Mouse,"Nervous system"
"Fowler 2019 Int J Mol Sci",2019,"Fowler ED, Hauton D, Boyle J, Egginton S, Steele DS, White E (2019) Energy metabolism in the failing right ventricle: limitations of oxygen delivery and the creatine kinase system . Int J Mol Sci 20:1805.",OXPHOS,,"Permeabilized cells",Rat,Heart
"Scavuzzo 2019 J Neurophysiol",2019,"Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.","LEAK,OXPHOS","N,S,CIV,NS,ROX",Homogenate,Rat,"Nervous system"
"Macedo 2019 Biochim Biophys Acta Mol Cell Biol Lipids",2019,"Macedo F, Martins GL, Luévano-Martínez LA, Viana GM, Riske KA, Inague A, Yoshinaga MY, Aguilaniu H, Miyamoto S, Glezer I, da Cunha FM (2019) Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in ''Caenorhabditis elegans''. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158539.","LEAK,OXPHOS","N,CIV,NS","Isolated mitochondria","Caenorhabditis elegans",
"Petrick 2019 Biochem J",2019,"Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.","OXPHOS,LEAK","F,N,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Cedrone 2019 Thesis",2019,"Cedrone M (2019) Low birth weight and post-natal diet induced alterations in skeletal muscle oxygen consumption and fiber type composition. Master's Thesis 83.","LEAK,OXPHOS","N,S","Permeabilized tissue,Intact cells","Guinea pig,Mouse","Skeletal muscle"
"Jaskiewicz 2019 J Clin Med",2019,"Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.","ROUTINE,OXPHOS,ET,LEAK","N,S,NS,ROX","Permeabilized cells,Intact cells",Mouse,"Skeletal muscle,Other cell lines"
"Ferreira 2019 Nat Commun",2019,"Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun 10:329.","LEAK,OXPHOS,ET",NS,"Isolated mitochondria",Rat,Heart
"Sonjak 2019 J Gerontol A Biol Sci Med Sci",2019,"Sonjak V, Jacob KJ, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT (2019) Reduced mitochondrial content, elevated ROS, and modulation by denervation in skeletal muscle of pre-frail/frail elderly women. J Gerontol A Biol Sci Med Sci 74:1887-95.","LEAK,OXPHOS","N,CIV,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Jansen 2019 Am J Physiol Heart Circ Physiol",2019,"Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Mouse,Heart
"Chabi 2019 MitoFit Preprint Arch EA",2019,"Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Nunes 2019 Oxid Med Cell Longev",2019,"Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS,ROX",Homogenate,Zebrafish,
"Rutai 2019 Shock",2019,"Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95.","LEAK,OXPHOS","N,S,ROX",Homogenate,Rat,Liver
"Seo 2019 Exp Neurol",2019,"Seo JH, Park HS, Park SS, Kim CJ, Kim DH, Kim TW (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043.","LEAK,OXPHOS","N,NS","Isolated mitochondria",Rat,"Nervous system"
"Wessels 2019 Obesity (Silver Spring)",2019,"Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized cells",Human,Fat
"Havird 2019 Mitochondrion",2019,"Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Isolated mitochondria",Plants,
"Brunetta 2019 J Funct Foods",2019,"Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.","LEAK,OXPHOS","N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Shrum 2019 Biomolecules",2019,"Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury ''in vitro''. Biomolecules 9:E825.","LEAK,OXPHOS","N,S,CIV,ROX","Permeabilized cells",Rat,Kidney
"Bettinazzi 2019 Proc Biol Sci",2019,"Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.","LEAK,OXPHOS,ET","N,Gp,CIV,NS,ROX","Permeabilized cells",Molluscs,"Lung;gill,Genital"
"Power 2019 PLoS One",2019,"Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740.","LEAK,OXPHOS","N,NS","Permeabilized tissue",Rat,Heart
"Andreazza 2019 Nat Commun",2019,"Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, Whitworth AJ (2019) Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in ''Drosophila''. https://doi.org/10.1038/s41467-019-10857-y",OXPHOS,"N,S",Homogenate,Drosophila,
"Mayeuf-Louchart 2019 Cell Rep",2019,"Mayeuf-Louchart A, Lancel S, Sebti Y, Pourcet B, Loyens A, Delhaye S, Duhem C, Beauchamp J, Ferri L, Thorel Q, Boulinguiez A, Zecchin M, Dubois-Chevalier J, Eeckhoute J, Vaughn LT, Roach PJ, Dani C, Pederson BA, Vincent SD, Staels B, Duez H (2019) Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation. Cell Rep 29:1410-18.","LEAK,OXPHOS","F,N,S,NS","Permeabilized cells",Mouse,Fat
"Rojas-Morales 2019 Free Radic Biol Med",2019,"Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.","LEAK,OXPHOS",N,"Isolated mitochondria",Rat,Kidney
"Holsgrove 2019 Thesis",2019,"Holsgrove A (2019) The effect of temperature on cardiac energetics in the rainbow trout, ''Onchorhynchus mykiss''. Phd Thesis 166.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX",Homogenate,Fishes,Heart
"Bertolini 2019 MBio",2019,"Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca2+ uptake, growth, and infectivity of the human pathogen ''Trypanosoma cruzi''. MBio 10:e00348-19.","LEAK,OXPHOS,ET",,"Permeabilized cells",Protists,
"Zhang 2019 Biochem Biophys Res Commun",2019,"Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.","LEAK,OXPHOS,ET","N,NS,ROX","Isolated mitochondria",Mouse,Liver
"Nambu 2019 Eur J Pharmacol",2019,"Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S (2019) Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. Eur J Pharmacol 866:172810.","LEAK,OXPHOS","F,N,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Devaux 2019 J Exp Biol",2019,"Devaux JBL, Hickey AJR, Renshaw GMC (2019) Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/reoxygenation. J Exp Biol 222:jeb191353.","LEAK,ROUTINE,OXPHOS,ET","N,S,NS",Homogenate,Fishes,"Nervous system"
"Lerchner 2019 Anal Bioanal Chem",2019,"Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of ''Trypanosoma cruzi'' by chip calorimetry. Anal Bioanal Chem 411:3763-68.","LEAK,OXPHOS,ET",ROX,"Intact cells",Protists,
"Esteves 2019 Oncogene",2019,"Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36.","LEAK,ROUTINE,OXPHOS,ET","N,ROX","Permeabilized cells,Intact cells",Human,"Endothelial;epithelial;mesothelial cell"
"Bettink 2019 Mitochondrion",2019,"Bettink MAW, Harms FA, Dollee N, Specht PAC, Raat NJH, Schoonderwoerd GC, Mik EG (2019) Non-invasive versus ex vivo measurement of mitochondrial function in an endotoxemia model in rat: toward monitoring of mitochondrial therapy. Mitochondrion 50:149-57.","LEAK,OXPHOS,ET","N,S",Homogenate,Rat,"Skeletal muscle"
"Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol",2019,"Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (''Sciaenops ocellatus''). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Fishes,"Heart,Skeletal muscle"
"Pino 2019 Physiol Genomics",2019,"Pino MF, Stephens NA, Eroshkin AM, Yi F, Hodges A, Cornnell HH, Pratley RE, Smith SR, Wang M, Han X, Coen PM, Goodpaster BH, Sparks LM (2019) Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with type 2 diabetes. Physiol Genomics 51:586-95.","LEAK,OXPHOS,ET","N,NS","Permeabilized cells,Permeabilized tissue",Human,"Skeletal muscle"
"Svensson 2019 Am J Physiol Endocrinol Metab",2019,"Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S (2019) Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab 318:E145-51.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Kakimoto 2019 PLoS One",2019,"Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733.","LEAK,OXPHOS","F,NS","Isolated mitochondria",Mouse,Liver
"Rose 2019 Am J Physiol Endocrinol Metab",2019,"Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. https://doi.org/10.1152/ajpendo.00084.2019","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized cells,Permeabilized tissue,Intact cells",Human,"Skeletal muscle,Blood cells,Platelet"
"Karusheva 2019 Am J Clin Nutr",2019,"Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107.","LEAK,OXPHOS,ET","F,N,NS,ROX","Permeabilized tissue,Isolated mitochondria",Human,"Skeletal muscle"
"Munro 2019 Aging Cell",2019,"Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.","LEAK,OXPHOS","N,S,NS","Isolated mitochondria","Mouse,Other mammals","Heart,Skeletal muscle"
"Bettinazzi 2019 Cryobiology",2019,"Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.","LEAK,OXPHOS,ET","N,Gp,CIV,NS,ROX,S,Other combinations","Permeabilized tissue",Molluscs,Lung;gill
"Campos 2019 Thesis",2019,"Campos DF (2019) Os peixes amazônicos vivem perto dos seus limites térmicos? O efeito das mudanças climáticas sobre a ecofisiologia de peixes de Igarapé da Amazônia Central. PhD Thesis 106.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Intact cells",Fishes,Lung;gill
"Ling 2019 Am J Clin Nutr",2019,"Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr 110:605-16.","LEAK,OXPHOS,ET","N,S,NS","Permeabilized tissue",Human,"Skeletal muscle,Fat"
"Maekawa 2019 Cell Commun Signal",2019,"Maekawa S, Takada S, Nambu H, Furihata T, Kakutani N, Setoyama D, Ueyanagi Y, Kang D, Sabe H, Kinugawa S (2019) Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure. Cell Commun Signal 17:128.","LEAK,OXPHOS","N,NS","Isolated mitochondria",Mouse,Heart
"Zhu 2019 Aging Cell",2019,"Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.","LEAK,OXPHOS,ET","N,NS,S,ROX","Isolated mitochondria",Mouse,Liver
"MiPNet21.06 SUIT RP",2018-06-25,"[[Image:O2k-Protocols.jpg|right|80px|link=O2k-Protocols|O2k-Protocols]] SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.","LEAK,OXPHOS,ET","F,N,S,Gp,CIV,NS,Other combinations","Permeabilized cells,Permeabilized tissue,Homogenate,Isolated mitochondria",,
"Pileggi 2018 Free Radic Biol Med",2018,"Pileggi CA, Hedges CP, D'Souza RF, Durainayagam BR, Markworth JF, Hickey AJR, Mitchell CJ, Cameron-Smith D (2018) Exercise recovery increases skeletal muscle H2O2 emission and mitochondrial respiratory capacity following two-weeks of limb immobilization. Free Radic Biol Med 124:241-8.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Isohanni 2018 Neurogenetics",2018,"Isohanni P, Carroll CJ, Jackson CB, Pohjanpelto M, Lönnqvist T, Suomalainen A (2018) Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth. Neurogenetics 19:49-53.","OXPHOS,ET","N,S,CIV,NS","Permeabilized cells",Human,"Skeletal muscle,Blood cells,Fibroblast"
"Cree-Green 2018 Diabetes",2018,"Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, Mcclatchey PM, Bauer TA, Regensteiner JG, Reusch JEB (2018) Supplemental oxygen improves ''in-vivo'' mitochondrial oxidative phosphorylation flux in sedentary obese adults with type 2 diabetes. Diabetes 67:1369-79.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Lu 2018 Cell Rep",2018,"Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Mouse,Heart
"Belosludtsev 2018 Biochemistry (Mosc)",2018,"Belosludtsev KN, Belosludtseva NV, Tenkov KS, Sharapov VA, Kosareva EA, Dubinin MV (2018) Effect of dequalinium on respiration and the inner membrane permeability of rat liver mitochondria. Biochemistry (Mosc) 12:121–27.",OXPHOS,ROX,"Isolated mitochondria",Rat,Liver
"Wang 2018 J Nutr Biochem",2018,"Wang Y, Fouret G, Bonafos B, Blachnio-Zabielska A, Leroy T, Crouzier D, Barea B, Gaillet S, Moro C, Lecomte J, Coudray C, Feillet-Coudray C (2018) Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats. J Nutr Biochem 64:182-97.","OXPHOS,LEAK","N,NS","Isolated mitochondria",Rat,"Skeletal muscle"
"Warnsmann 2018 Mech Ageing Dev",2018,"Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD (2018) A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction. Mech Ageing Dev 170:45-58.","LEAK,OXPHOS,ET",N,"Isolated mitochondria",Fungi,
"Cardinale 2018 Thesis",2018,"Cardinale DA (2018) The significance of mitochondrial respiratory function in regulating oxygen uptake and performance in humans. PhD Thesis 99.","LEAK,OXPHOS","F,N,NS","Permeabilized tissue,Isolated mitochondria",Human,"Skeletal muscle"
"Martinez 2018 Arch Biochem Biophys",2018,"Martínez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A, Coluccio Leskow F, Velazquez F (2018) Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment. Arch Biochem Biophys 651:1-12.","LEAK,OXPHOS,ET","N,S,ROX","Isolated mitochondria",Rat,"Nervous system"
"Trumbeckaite 2018 J Bioenerg Biomembr",2018,"Trumbeckaite S, Cesna V, Jasukaitiene A, Baniene R, Gulbinas A (2018) Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines. J Bioenerg Biomembr 50:329-38.",OXPHOS,"N,S","Permeabilized cells",Human,"Other cell lines"
"Martins 2018 Oxid Med Cell Longev",2018,"Martins IK, de Carvalho NR, Macedo GE, Rodrigues NR, Ziech CC, Vinadé L, Filho VMB, Menezes IA, Franco J, Posser T (2018) ''Anacardium microcarpum'' promotes neuroprotection dependently of AKT and ERK phosphorylation but does not prevent mitochondrial damage by 6-OHDA. Oxid Med Cell Longev 2018:2131895.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Chicken,"Nervous system"
"Tetri 2018 Front Physiol",2018,"Tetri LH, Diffee GM, Barton GP, Braun RK, Yoder HE, Haraldsdottir K, Eldridge MW, Goss KN (2018) Sex-specific skeletal muscle fatigability and decreased mitochondrial oxidative capacity in adult rats exposed to postnatal hyperoxia. Front Physiol 9:326.","LEAK,OXPHOS,ET","N,S,CIV,ROX","Permeabilized tissue",Rat,"Skeletal muscle"
"Kauppila 2018 Nucleic Acids Res",2018,"Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.","LEAK,OXPHOS,ET","N,S,NS","Isolated mitochondria",Mouse,
"Monaco 2018 Am J Physiol Regul Integr Comp Physiol",2018,"Monaco CMF, Miotto PM, Huber JS, van Loon LJC, Simpson JA, Holloway GP (2018) Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats. Am J Physiol Regul Integr Comp Physiol 315:R191-R204.","LEAK,OXPHOS","N,NS","Permeabilized tissue,Isolated mitochondria",Rat,Heart
"De Moura Alvorcem 2018 Mitochondrion",2018,"De Moura Alvorcem L, Britto R, Parmeggiani B, Glanzel NM, Da Rosa-Junior NT, Cecatto C, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2018) Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum. Mitochondrion 47:141-50.","LEAK,OXPHOS,ET","N,S,NS","Isolated mitochondria,Intact cells",Rat,"Nervous system"
"Christen 2018 Free Radic Biol Med",2018,"Christen F, Desrosiers V, Dupont-Cyr BA, Vandenberg GW, Le François NR, Tardif JC, Dufresne F, Lamarre SG, Blier PU (2018) Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production. Free Radic Biol Med 116:11-8.","LEAK,OXPHOS,ET","N,S,CIV,NS,ROX","Isolated mitochondria",Fishes,Heart
"Aparicio-Trejo 2018 Free Radic Biol Med",2018,"Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96.","LEAK,OXPHOS","N,S,NS,ROX","Intact cells,Isolated mitochondria",Rat,Kidney
"Allard 2018 J Clin Endocrinol Metab",2018,"Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84.",OXPHOS,"F,N,S,Gp,CIV,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Ahn 2018 Redox Biol",2018,"Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47-58.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Paech 2018a Toxicology",2018,"Paech F, Mingard C, Grünig D, Abegg VF, Bouitbir J, Krähenbühl S (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology 395:34-44.","LEAK,OXPHOS,ET","N,S,DQ,CIV,ROX","Permeabilized cells,Isolated mitochondria","Human,Mouse","Liver,Other cell lines"
"Real-Hohn 2018 bioRxiv",2018,"Real-Hohn A, Navegantes C, Ramos K, Ramos-Filho D, Cahuê F, Galina A, Salerno V (2018) Hexokinase: a central player in the synergism of high-intensity intermittent exercise and every-other-day intermittent fasting regimen on energy metabolism adaptations. bioRxiv doi: https://doi.org/10.1101/389668.","LEAK,OXPHOS,ET","N,NS","Permeabilized tissue",Rat,"Skeletal muscle"
"Gonzalez-Freire 2018 Aging Cell",2018,"Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L (2018) Skeletal muscle ''ex vivo'' mitochondrial respiration parallels decline ''in vivo'' oxidative capacity, cardiorespiratory fitness, and muscle strength: the Baltimore longitudinal study of aging. Aging Cell 17.","LEAK,OXPHOS",NS,"Permeabilized tissue",Human,"Skeletal muscle"
"Bhaskaran 2018 EMBO Rep",2018,"Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep 19. pii: e45009.","LEAK,OXPHOS","N,S,NS",,Mouse,Fat
"Kappler 2018 Thesis",2018,"Kappler L (2018) Method development for valid high‐resolution profiling of mitochondria and Omics investigation of mitochondrial adaptions to excess energy intake and physical exercise. Dissertation p181.","LEAK,OXPHOS,ET","F,N,S,CIV,NS,ROX","Permeabilized cells,Homogenate,Isolated mitochondria","Human,Mouse","Skeletal muscle,Liver,Other cell lines"
"Belosludtsev 2018 Biochim Biophys Acta",2018,"Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2018) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta 1861:288-97.",OXPHOS,"N,S,NS","Isolated mitochondria",Rat,Liver
"Civiletto 2018 EMBO Mol Med",2018,"Civiletto G, Dogan SA, Cerutti R, Fagiolari G, Moggio M, Lamperti C, Benincá C, Viscomi C, Zeviani M (2018) Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis. EMBO Mol Med 10:e8799.",OXPHOS,"S,CIV","Isolated mitochondria",Mouse,"Skeletal muscle"
"Hancock 2018 Elife",2018,"Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M (2018) Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. Elife 7:e41044.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Isolated mitochondria",Mouse,Heart
"Fuhrmann 2018 Cell Mol Life Sci",2018,"Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci 75:3051-67.","LEAK,ROUTINE,OXPHOS,ET","N,S,ROX","Isolated mitochondria,Intact cells",Human,
"Marini 2018 Proc Natl Acad Sci U S A",2018,"Marini A, Rotblat B, Sbarrato T, Niklison-Chirou MV, Knight JRP, Dudek K, Jones C, Bushell M, Knight RA, Amelio I, Willis AE, Melino G (2018) TAp73 contributes to the oxidative stress response by regulating protein synthesis. Proc Natl Acad Sci U S A 115:6219-24.",OXPHOS,N,Homogenate,Human,"Kidney,Lung;gill,HEK"
"Burtscher 2018 Front Mol Neurosci",2018,"Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C (2018) Proenkephalin derived peptides are involved in the modulation of mitochondrial respiratory control during epileptogenesis. Front Mol Neurosci doi:10.3389/fnmol.2018.00351.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Mouse,"Nervous system"
"Ko 2018 Pflugers Arch",2018,"Ko TH, Marquez JC, Kim HK, Jeong SH, Lee S, Youm JB, Song IS, Seo DY, Kim HJ, Won DN, Cho KI, Choi MG, Rhee BD, Ko KS, Kim N, Won JC, Han J (2018) Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts. Pflugers Arch 470:263-75.","LEAK,OXPHOS","N,ROX","Isolated mitochondria",Rat,Heart
"Weisz 2018 Hum Mol Genet",2018,"Weisz ED, Towheed A, Monyak RE, Toth MS, Wallace DC, Jongens TA (2018) Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function. Hum Mol Genet 27:95-106.","OXPHOS,ET,LEAK","N,S,NS,ROX","Isolated mitochondria",Drosophila,"Skeletal muscle"
"MacMillan-Crow 2018 Intern Med Rev (Wash D C)",2018,"MacMillan-Crow LA, Mayeux PR (2018) Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis. Intern Med Rev (Wash D C) 4.","OXPHOS,LEAK","N,S,ROX","Permeabilized tissue",Mouse,Kidney
"Chen 2018 Hum Mol Genet",2018,"Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein ''MRPS22'' lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.","OXPHOS,ET","F,N,S,DQ,CIV,NS","Isolated mitochondria",Human,"Endothelial;epithelial;mesothelial cell,Fibroblast"
"Kriel 2018 Sci Rep",2018,"Kriel J, Mueller-Nedebock K, Maarman G, Mbizana S, Ojuka E, Klumperman B, Loos B (2018) Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Sci Rep 8:10348.","LEAK,OXPHOS,ET,ROUTINE","N,ROX","Permeabilized cells",Human,"Nervous system,Other cell lines"
"Lund 2018 Acta Physiol (Oxf)",2018,"Lund MT, Larsen S, Hansen M, Courraud J, Floyd AK, Støckel M, Helge JW, Dela F (2018) Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery. Acta Physiol (Oxf) 223:e13032.","LEAK,OXPHOS,ET","F,N,NS","Permeabilized tissue",Human,"Skeletal muscle"
"Barca 2018 Hum Mol Genet",2018,"Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12.","LEAK,ROUTINE,OXPHOS,ET","F,N,S,DQ,NS,ROX","Permeabilized cells,Intact cells",Human,Fibroblast
"Maurya 2018 Cell Rep",2018,"Maurya SK, Herrera JL, Sahoo SK, Reis FCG, Vega RB, Kelly DP, Periasamy M (2018) Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle. Cell Rep 24:2919-31.",OXPHOS,"N,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Wilmanns 2018 Mol Metab",2018,"Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14.","LEAK,OXPHOS,ET","F,N,NS,ROX","Permeabilized tissue",Mouse,Heart
"Gratl 2018 Thesis",2018,"Gratl A (2018) High-resolution respirometry for measurement of mitochondrial function in PAD patients before and after revascularisation. PhD Thesis 69.","LEAK,OXPHOS,ET","F,N,S,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Song 2018 Proc Natl Acad Sci U S A",2018,"Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, Sweeney G (2018) Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes. Proc Natl Acad Sci U S A 115:1576-81.","LEAK,OXPHOS,ET","N,S,NS","Intact cells",Rat,Heart
"Manoharan 2018 Thesis",2018,"Manoharan N (2018) Characterization of mitochondrial respiration in atlantic salmon (''Salmo salar'') fed with glutamate and succinate enhanced diet. Master's Thesis 52.","LEAK,OXPHOS,ET","N,S,NS,ROX",Homogenate,Fishes,"Heart,Liver"
"Monaco 2018b Diabetologia",2018,"Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ, Perry CGR (2018) Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia 61:1411-23.",OXPHOS,"N,S,Gp,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Khamoui 2018 J Dev Orig Health Dis",2018,"Khamoui AV, Desai M, Ross MG, Rossiter HB (2018) Sex-specific effects of maternal and postweaning high-fat diet on skeletal muscle mitochondrial respiration. J Dev Orig Health Dis 16:1-8.","LEAK,OXPHOS,ET","N,NS,ROX","Permeabilized tissue",Mouse,"Skeletal muscle"
"Pardo 2018 FASEB J",2018,"Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58.","LEAK,OXPHOS,ET","N,S,NS,ROX","Permeabilized tissue",Mouse,Fat
"Niu 2018 Cancer Metab",2018,"Niu X, Chen YJ, Crawford PA, Patti GJ (2018) Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells. Cancer Metab 6:19.","LEAK,OXPHOS,ET","N,S,NS,ROX","Isolated mitochondria",Human,HeLa
"Thrush 2018 Int J Obes (Lond)",2018,"Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack R, Al-Dirbashi OY, Dent R, McPherson R, Harper ME (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond) 42:353-62.","LEAK,OXPHOS,ET","F,N,CIV,NS,ROX","Permeabilized tissue",Human,"Skeletal muscle"
"Astrakhanova 2018 Sovrem Tekhnologii Med",2018,"Astrakhanova ТА, Urazov МD, Usenko АV, Mitroshina ЕV, Mishchenko ТА, Schelchkova NА, Vedunova МV (2018) BDNF-mediated regulation of the brain mitochondria functional state in hypoxia. Sovrem Tekhnologii Med 10:88-94.","OXPHOS,LEAK","N,S","Isolated mitochondria",Mouse,"Nervous system"
"Ravasz 2018 Biochim Biophys Acta",2018,"Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2018) Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD+ supports substrate-level phosphorylation during respiratory inhibition. Biochim Biophys Acta 1859:909-24.","LEAK,OXPHOS","F,N,DQ","Isolated mitochondria",Mouse,Liver
"Audia 2018 Basic Res Cardiol",2018,"Audia JP, Yang XM, Crockett ES, Housley N, Haq EU, O'Donnell K, Cohen MV, Downey JM, Alvarez DF (2018) Caspase‑1 inhibition by VX‑765 administered at reperfusion in P2Y12 receptor antagonist‑treated rats provides long‑term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol 113:32.","OXPHOS,ET","N,S,CIV,NS,ROX","Permeabilized tissue",Rat,Heart
"Lo 2018 Am J Physiol Renal Physiol",2018,"Lo S, MacMillan-Crow LA, Parajuli N (2018) Renal cold storage followed by transplantation impairs proteasome function and subsequently mitochondrial protein homeostasis. Am J Physiol Renal Physiol 316:F42-F53.","OXPHOS,LEAK","N,S,ROX","Permeabilized cells",Rat,"Kidney,Other cell lines"
"Singh 2018 Arch Toxicol",2018,"Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, Krähenbühl S, Bouitbir J (2018) PGC-1β modulates statin-associated myotoxicity in mice. Arch Toxicol 93:487-504.","OXPHOS,LEAK","N,S,NS","Permeabilized tissue",Mouse,"Skeletal muscle"
"Zhuang 2018 Thesis",2018,"Zhuang Y (2018) Potential application of alternative oxidase (AOX) in neurodegenerative diseases. Master's Thesis p71.",OXPHOS,"N,S,CIV,ROX","Isolated mitochondria",Mouse,"Nervous system"
"Briones-Herrera 2018 Food Chem Toxicol",2018,"Briones-Herrera A, Avila-Rojas SH, Aparicio-Trejo OE, Cristóbal M, León-Contreras JC, Hernández-Pando R, Pinzón E, Pedraza-Chaverri J, Sánchez-Lozada LG, Tapia E (2018) Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Food Chem Toxicol 115:185-97.","LEAK,OXPHOS","N,NS,S","Isolated mitochondria",Rat,Kidney
"Sirsat 2018 Comp Biochem Physiol A Mol Integr Physiol",2018,"Sirsat SKG, Dzialowski EM (2018) Ontogeny of skeletal and cardiac muscle mitochondria oxygen fluxes in two breeds of chicken. Comp Biochem Physiol A Mol Integr Physiol 215:20-7.","LEAK,OXPHOS","N,S,CIV,NS,ROX","Permeabilized tissue",Birds,"Heart,Skeletal muscle"
"Vinel 2018 Nat Med",2018,"Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradere JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C (2018) The exerkine apelin reverses age-associated sarcopenia. Nat Med 24:1360-71.",OXPHOS,"N,S","Permeabilized tissue",Mouse,"Skeletal muscle"