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Abou-Hamdan 2015 Methods Enzymol
Additional label Sulfide  +
Coupling states OXPHOS  +
Has abstract Hydrogen sulfide (H2S) is the third gasotr
Hydrogen sulfide (H2S) is the third gasotransmitter described in mammals. These gasotransmitters (H2S, CO, and NO) are small molecules able to diffuse freely across membranes and thus susceptible to reach easily intracellular targets, one of which is the respiratory enzyme cytochrome oxidase subject to complete inhibition by low micromolar concentrations of these gases. However in contrast to NO or CO, H2S can be metabolized by a sulfide quinone reductase feeding the mitochondrial respiratory chain with the hydrogen atoms of sulfide. Sulfide is thus a two-sided molecule: substrate or poison according to the concentration. The aim of this chapter is to present a mean to monitor sulfide oxidation by isolated mitochondria or cells and to summarize how the properties of this amazing couple (mitochondria and sulfide) translate into practical and conceptual consequences.
nto practical and conceptual consequences.  +
Has info [ PMID:25725524]  +
Has title Abou-Hamdan A, Guedouari-Bounihi H, Lenoir V, Andriamihaja M, Blachier F, Bouillaud F (2015) Oxidation of H2S in mammalian cells and mitochondria. Methods Enzymol 554:201-28.  +
Instrument and method Oxygraph-2k  + , TIP2k  +
Mammal and model Human  + , Pig  + , Mouse  + , Rat  +
MiP area Respiration  + , Instruments;methods  +
Pathways N  + , S  + , CIV  +
Preparation Intact cells  + , Homogenate  + , Isolated mitochondria  +
Respiration and regulation Coupling efficiency;uncoupling  +
Tissue and cell Heart  + , Nervous system  + , Liver  + , Kidney  + , Genital  + , CHO  + , Neuroblastoma  + , Fibroblast  +
Was published by MiPNetLab FR Paris Bouillaud F +
Was published in journal Methods Enzymol +
Was published in year 2015  +
Was written by Abou-Hamdan A + , Guedouari-Bounihi H + , Lenoir V + , Andriamihaja M + , Blachier F + , Bouillaud F +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
08:26:08, 9 November 2016  +
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