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Acuña-Castroviejo 2014 Cell Mol Life Sci
Additional label Review  +
Diseases Cancer  +
Has abstract Endogenous melatonin is synthesized from t
Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is considered an indoleamine from a biochemical point of view because the melatonin molecule contains a substituted indolic ring with an amino group. The circadian production of melatonin by the pineal gland explains its chronobiotic influence on organismal activity, including the endocrine and non-endocrine rhythms. Other functions of melatonin, including its antioxidant and anti-inflammatory properties, its genomic effects, and its capacity to modulate mitochondrial homeostasis, are linked to the redox status of cells and tissues. With the aid of specific melatonin antibodies, the presence of melatonin has been detected in multiple extrapineal tissues including the brain, retina, lens, cochlea, Harderian gland, airway epithelium, skin, gastrointestinal tract, liver, kidney, thyroid, pancreas, thymus, spleen, immune system cells, carotid body, reproductive tract, and endothelial cells. In most of these tissues, the melatonin-synthesizing enzymes have been identified. Melatonin is present in essentially all biological fluids including cerebrospinal fluid, saliva, bile, synovial fluid, amniotic fluid, and breast milk. In several of these fluids, melatonin concentrations exceed those in the blood. The importance of the continual availability of melatonin at the cellular level is important for its physiological regulation of cell homeostasis, and may be relevant to its therapeutic applications. Because of this, it is essential to compile information related to its peripheral production and regulation of this ubiquitously acting indoleamine. Thus, this review emphasizes the presence of melatonin in extrapineal organs, tissues, and fluids of mammals including humans.
s, and fluids of mammals including humans.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/24554058 PMID: 24554058]  +
Has publicationkeywords Melatonin receptors  + , Oxidative stress  + , Free radicals  + , Mitochondria  + , Cytoprotection  + , Homeostasis  +
Has title Acuña-Castroviejo D, Escames G, Venegas C, Díaz-Casado ME, Lima-Cabello E, López LC, Rosales-Corral S, Tan DX, Reiter RJ (2014) Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci 71:2997-25.  +
MiP area mt-Medicine  + , Pharmacology;toxicology  +
Stress Cell death  + , Oxidative stress;RONS  +
Was published by MiPNetLab ES Granada Acuna-Castroviejo D +
Was published in journal Cell Mol Life Sci +
Was published in year 2014  +
Was written by Acuna-Castroviejo D + , Escames G + , Venegas C + , Diaz-Casado ME + , Lima-Cabello E + , Lopez Garcia LC + , Rosales-Corral S + , Tan DX + , Reiter RJ +
Categories Publications
Modification date
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14:04:07, 27 March 2018  +
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