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Ahluwalia 2017 Sci Rep
Has abstract About two decades ago, West and coworkers
About two decades ago, West and coworkers established a model which predicts that metabolic rate follows a three quarter power relationship with the mass of an organism, based on the premise that tissues are supplied nutrients through a fractal distribution network. Quarter power scaling is widely considered a universal law of biology and it is generally accepted that were in-vitro cultures to obey allometric metabolic scaling, they would have more predictive potential and could, for instance, provide a viable substitute for animals in research. This paper outlines a theoretical and computational framework for establishing quarter power scaling in three-dimensional spherical constructs in-vitro, starting where fractal distribution ends. Allometric scaling in non-vascular spherical tissue constructs was assessed using models of Michaelis Menten oxygen consumption and diffusion. The models demonstrate that physiological scaling is maintained when about 5 to 60% of the construct is exposed to oxygen concentrations less than the Michaelis Menten constant, with a significant concentration gradient in the sphere. The results have important implications for the design of downscaled in-vitro systems with physiological relevance.
itro systems with physiological relevance.  +
Has editor [[Gnaiger E]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/28169362 PMID: 28169362 Open Access]  +
Has title Ahluwalia A (2017) Allometric scaling in-vitro. Sci Rep 7:42113.  +
MiP area Respiration  + , mt-Biogenesis;mt-density  + , Comparative MiP;environmental MiP  +
Preparation Intact organism  + , Intact cells  +
Respiration and regulation Oxygen kinetics  +
Was published in journal Sci Rep +
Was published in year 2017  +
Was written by Ahluwalia A +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
03:49:11, 17 August 2017  +
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