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Albertini 2012 Abstract Bioblast
Coupling states LEAK  + , ROUTINE  + , ET  +
Diseases Aging;senescence  +
Has abstract [[File:Eva albertini.jpg|right|150px|Eva A
[[File:Eva albertini.jpg|right|150px|Eva Albertini]] Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood. In eukaryotic cells, methionine can be converted to cysteine through the reverse transsulfuration pathway thereby modulating intracellular methionine availability. Whereas previous results obtained in yeast and fruit flies suggest that alterations in the reverse transsulfuration pathway modulate the rate of aging, it is not known whether this function is conserved in evolution. Here we show that depletion of cystathionine beta synthase (CBS), a rate limiting enzyme in the reverse transsulfuration pathway, induces premature senescence in human endothelial cells. We found that CBS depletion induces mild mitochondrial dysfunction and increases the sensitivity of endothelial cells to homocysteine, a known inducer of endothelial cell senescence and an established risk factor for vascular disease. Our finding that CBS deficiency induces endothelial cell senescence in vitro, involving both mitochondrial dysfunction and increased susceptibility of the cells to homocysteine, suggests a new mechanism linking CBS deficiency to vascular aging and disease. # [[Albertini 2012 Aging (Albany NY)|Albertini E, Kozieł R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Aging (Albany NY) 4:664-73.]]
elial cells. Aging (Albany NY) 4:664-73.]]  +
Has publicationkeywords Methionine  + , Cysteine  + , Cystathionine beta synthase  +
Has title Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.  +
Instrument and method Oxygraph-2k  +
MiP area Respiration  + , Genetic knockout;overexpression  +
Preparation Intact cells  +
Respiration and regulation mt-Membrane potential  +
Tissue and cell Endothelial;epithelial;mesothelial cell  + , HUVEC  +
Was published by MiPNetLab AT Innsbruck Jansen-Duerr P +
Was submitted in year 2012  +
Was submitted to event Bioblast 2012 +
Was written by Albertini E + , Koziel R + , Duerr A + , Neuhaus M + , Jansen-Duerr P +
Categories Abstracts
Modification date
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12:14:17, 26 March 2018  +
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