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Allard 2018 J Clin Endocrinol Metab
Additional label BMI  + , VO2max  +
Coupling states OXPHOS  +
Diseases Myopathy  +
Enzyme Complex I  + , Complex II;succinate dehydrogenase  + , Complex III  + , Complex IV;cytochrome c oxidase  + , Complex V;ATP synthase  +
Has abstract Statin myopathy is linked to disturbances
Statin myopathy is linked to disturbances in mitochondrial function and exercise intolerance. To determine whether differences exist in exercise performance, muscle function, and muscle mitochondrial oxidative capacity and content between symptomatic and asymptomatic statin users, and control subjects. Cross-sectional study. Department of Physiology, Radboud University Medical Center. Long-term symptomatic and asymptomatic statin users, and control subjects (n = 10 per group). Maximal incremental cycling tests, involuntary electrically stimulated isometric quadriceps-muscle contractions, and biopsy of vastus lateralis muscle. Maximal exercise capacity, substrate use during exercise, muscle function, and mitochondrial energy metabolism. Peak oxygen uptake, maximal work load, and ventilatory efficiency were comparable between groups, but both statin groups had a depressed anaerobic threshold compared with the control group (P = 0.01). Muscle relaxation time was prolonged in both statin groups compared with the control group and rate of maximal force rise was decreased (P<sub>time×group</sub> < 0.001 for both measures). Mitochondrial activity of complexes II and IV was lower in symptomatic statin users than control subjects and tended to be lower for complex (C) III (CII: P = 0.03; CIII: P = 0.05; CIV: P = 0.04). Mitochondrial content tended to be lower in both statin groups than in control subjects. Statin use attenuated substrate use during maximal exercise performance, induced muscle fatigue during repeated muscle contractions, and decreased muscle mitochondrial oxidative capacity. This suggests disturbances in mitochondrial oxidative capacity occur with statin use even in patients without statin-induced muscle complaints.
without statin-induced muscle complaints.  +
Has editor [[Kandolf G]]  +
Has info [ PMID: 29040646]  +
Has title Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  + , Pharmacology;toxicology  +
Pathways F  + , N  + , S  + , Gp  + , CIV  + , NS  +
Preparation Permeabilized tissue  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab NL Nijmegen Rodenburg R + , NL Maastricht Schrauwen P +
Was published in journal J Clin Endocrinol Metab +
Was published in year 2018  +
Was written by Allard NAE + , Schirris TJJ + , Verheggen RJ + , Russel FGM + , Rodenburg RJ + , Smeitink JAM + , Thompson PD + , Hopman MTE + , Timmers S +
Categories Publications
Modification date
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11:13:52, 16 August 2018  +
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