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Alves 2017 Free Radic Biol Med
Additional label 2017-09  + , Labels  +
Coupling states LEAK  + , ROUTINE  +
Diseases Cancer  +
Has abstract The present study evaluated the ''in vivo'
The present study evaluated the ''in vivo'' antitumor effects and toxicity of a new Ru(II) compound, cis-(Ru[phen]2[ImH]2)<sup>2+</sup> (also called RuphenImH [RuC]), against Walker-256 carcinosarcoma in rats. After subcutaneous inoculation of Walker-256 cells in the right pelvic limb, male Wistar rats received 5 or 10mgkg<sup>-1</sup> RuC orally or intraperitoneally (i.p.) every 3 days for 13 days. A positive control group (2mgkg<sup>-1</sup> cisplatin) and negative control group (vehicle) were also used. Tumor progression was checked daily. After treatment, tumor weight, plasma biochemistry, hematology, oxidative stress, histology, and tumor cell respiration were evaluated. RuC was effective against tumors when administered i.p. but not orally. The highest i.p. dose of RuC (10mgkg<sup>-1</sup>) significantly reduced tumor volume and weight, induced oxidative stress in tumor tissue, reduced the respiration of tumor cells, and induced necrosis but did not induce apoptosis in the tumor. No clinical signs of toxicity or death were observed in tumor-bearing or healthy rats that were treated with RuC. These results suggest that RuC has antitumor activity through the modulation of oxidative stress and impairment of oxidative phosphorylation, thus promoting Walker-256 cell death without causing systemic toxicity. These effects make RuC a promising anticancer drug for clinical evaluation. Copyright © 2017 Elsevier Inc. All rights reserved.
© 2017 Elsevier Inc. All rights reserved.  +
Has editor [[Kandolf G]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/28629835 PMID: 28629835]  +
Has publicationkeywords Oxidative stress  + , Rats  + , RuphenImH  + , Ruthenium  + , Tumor  + , Walker-256  +
Has title Alves de Souza CE, Alves de Souza HM, Stip
Alves de Souza CE, Alves de Souza HM, Stipp MC, Corso CR, Galindo CM, Cardoso CR, Dittrich RL, de Souza Ramos EA, Klassen G, Carlos RM, Correia Cadena SMS, Acco A (2017) Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats. Free Radic Biol Med 110:228-39.
ring rats. Free Radic Biol Med 110:228-39.  +
Instrument and method Oxygraph-2k  +
Mammal and model Rat  +
MiP area Pharmacology;toxicology  + , Respiration  +
Pathways ROX  +
Was published in journal Free Radic Biol Med +
Was published in year 2017  +
Was written by Alves de Souza CE + , Alves de Souza HM + , Stipp MC + , Corso CR + , Galindo CM + , Cardoso CR + , Dittrich RL + , De Souza Ramos EA + , Klassen G + , Carlos RM + , Correia Cadena SMS + , Acco A +
Has processing error
"Has processing error" is a predefined property provided by Semantic MediaWiki and represents errors that appeared in connection with improper value annotations or input processing.
Alves 2017 Free Radic Biol Med +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
12:12:22, 12 October 2017  +
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