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Amigo 2016 Aging Cell
Additional label 2016-11  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Enzyme Complex I  + , Complex III  + , Complex IV;cytochrome c oxidase  + , Complex V;ATP synthase  +
Has abstract Caloric restriction (CR) protects against
Caloric restriction (CR) protects against many cerebral pathological conditions that are associated with excitotoxic damage and calcium overload, although the mechanisms are still poorly understood. Here we show that CR strongly protects against excitotoxic insults ''in vitro'' and ''in vivo'' in a manner associated with significant changes in mitochondrial function. CR increases electron transport chain activity, enhances antioxidant defenses, and favors mitochondrial calcium retention capacity in the brain. These changes are accompanied by a decrease in cyclophilin D activity and acetylation and an increase in Sirt3 expression. This suggests that Sirt3-mediated deacetylation and inhibition of cyclophilin D in CR promote the inhibition of mitochondrial permeability transition, resulting in enhanced mitochondrial calcium retention. Altogether, our results indicate that enhanced mitochondrial calcium retention capacity underlies the beneficial effects of CR against excitotoxic conditions. This protection may explain the many beneficial effects of CR in the aging brain. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
cal Society and John Wiley & Sons Ltd.  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/27619151 PMID: 27619151 Open Access]  +
Has publicationkeywords Aging  + , Brain  + , Calcium  + , Caloric restriction  + , Mitochondria  +
Has title Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  +
Pathways N  + , S  +
Preparation Isolated mitochondria  +
Respiration and regulation Calcium  +
Tissue and cell Nervous system  +
Was published by MiPNetLab BR Sao Paulo Kowaltowski AJ +
Was published in journal Aging Cell +
Was published in year 2016  +
Was written by Amigo I + , Menezes-Filho SL + , Luevano-Martinez LA + , Chausse B + , Kowaltowski AJ +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
14:43:14, 9 November 2017  +
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