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Amo 2007 Biochem J
Coupling states LEAK  +
Has abstract We introduce a general test of the bioener
We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223-226] that particular mtDNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups.
an mitochondria from tropical haplogroups.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/17355224 PMID: 17355224 Open Access]  +
Has title Amo T, Brand MD (2007) Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines.. Biochem J 404:345-51.  +
Mammal and model Human  +
MiP area Respiration  + , mtDNA;mt-genetics  + , Comparative MiP;environmental MiP  +
Respiration and regulation Coupling efficiency;uncoupling  + , mt-Membrane potential  +
Was published in journal Biochem J +
Was published in year 2007  +
Was written by Amo T + , Brand MD +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
14:02:33, 19 February 2015  +
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