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Asping 2017 Eur J Clin Pharmacol
Additional label Labels  + , 2017-11  + , BMI  + , VO2max  +
Coupling states LEAK  + , ET  +
Has abstract Statins are used to lower cholesterol in p
Statins are used to lower cholesterol in plasma and are one of the most used drugs in the world. Many statin users experience muscle pain, but the mechanisms are unknown at the moment. Many studies have hypothesized that mitochondrial function could be involved in these side effects. The aim of the study was to investigate mitochondrial function after 2 weeks of treatment with simvastatin (S; n = 10) or pravastatin (P; n = 10) in healthy middle-aged participants. Mitochondrial respiratory capacity and substrate sensitivity were measured in permeabilized muscle fibers by high-resolution respirometry. Mitochondrial content (citrate synthase (CS) activity), antioxidant content, as well as coenzyme Q<sub>10</sub> concentration (Q<sub>10</sub>) were determined. Fasting plasma glucose and insulin concentrations were measured, and whole body maximal oxygen uptake (''V''<sub>O2max</sub>) was determined. No differences were seen in mitochondrial respiratory capacity although a tendency was observed for a reduction when complex IV respiration was analyzed in both S (229 (169; 289 (95% confidence interval)) vs. 179 (146; 211) pmol/s/mg, respectively; P = 0.062) and P (214 (143; 285) vs. 162 (104; 220) pmol/s/mg, respectively; P = 0.053) after treatment. A tendency (1.64 (1.28; 2.00) vs. 1.28 (0.99; 1.58) mM, respectively; P = 0.092) for an increased mitochondrial substrate sensitivity (complex I-linked substrate; glutamate) was seen only in S after treatment. No differences were seen in Q<sub>10</sub>, CS activity, or antioxidant content after treatment. Fasting glucose and insulin as well as ''V''<sub>O2max</sub> were not changed after treatment. Two weeks of statin (S or P) treatment have no major effect on mitochondrial function. The tendency for an increased mitochondrial substrate sensitivity after simvastatin treatment could be an early indication of the negative effects linked to statin treatment.
gative effects linked to statin treatment.  +
Has editor [[Kandolf G]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/28246888 PMID: 28246888]  +
Has publicationkeywords Human  + , Mitochondrial function  + , Side effects  + , Skeletal muscle  + , Statins  +
Has title Asping M, Stride N, Søgaard D, Dohlmann TL, Helge JW, Dela F, Larsen S (2017) The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study. Eur J Clin Pharmacol 73:679-87.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  + , mt-Medicine  + , Pharmacology;toxicology  +
Pathways F  + , N  + , S  + , CIV  + , NS  + , ROX  +
Preparation Permeabilized tissue  +
Was published by MiPNetLab DK Copenhagen Dela F + , DK Copenhagen Larsen S +
Was published in journal Eur J Clin Pharmacol +
Was published in year 2017  +
Was written by Asping M + , Stride N + , Soegaard D + , Dohlmann T + , Helge JW + , Dela F + , Larsen S +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
13:48:04, 5 March 2019  +
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