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Beaudoin 2013 Am J Physiol Regul Integr Comp Physiol
Coupling states LEAK  + , OXPHOS  + , ET  +
Diseases Diabetes  +
Has abstract Resveratrol (RSV) is a polyphenolic compou
Resveratrol (RSV) is a polyphenolic compound suggested to have anti-diabetic properties. Surprisingly, little is known regarding the effects of RSV supplementation on adipose tissue (AT) metabolism ''in vivo''. The purpose of this study was to assess the effects of RSV on mitochondrial content and respiration, glyceroneogenesis (GNG), and adiponectin secretion in adipose tissue from Zucker diabetic fatty (ZDF) rats. Five-week-old ZDF rats were fed a chow diet with (ZDF RSV) or without (ZDF chow) RSV (200 mg/kg body wt) for 6 wk. Changes in adipose tissue metabolism were assessed in subcutaneous (scAT) and intra-abdominal [retroperitoneal (rpWAT), epididymal (eWAT)] adipose tissue depots. ZDF RSV rats showed lower fasting glucose and higher circulating adiponectin, as well as lower glucose area under the curve during intraperitoneal glucose and insulin tolerance tests than ZDF chow. [¹⁴C]pyruvate incorporation into triglycerides and adiponectin secretion were higher in scAT from ZDF RSV rats, concurrent with increases in adipose tissue triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and the phosphorylation of pyruvate dehydrogenase-E1α (PDH) (Ser293) protein content in this depot. Moreover, uncoupled mitochondrial respiration and complex I and II-supported respiration were increased in both scAT and rpWAT, which correlated with increases in cytochrome c oxidase subunit IV (COX4) protein content. ''In vitro'' treatment of scAT with RSV (50 μmol/l; 24 h) induced pyruvate dehydrogenase kinase 4 (PDK4) and peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α (PGC-1α) mRNA expression. Collectively, these data demonstrate that RSV can induce adipose tissue mitochondrial biogenesis in parallel with increases in GNG and adiponectin secretion.
ncreases in GNG and adiponectin secretion.  +
Has info [ PMID: 23824959 Open Access]  +
Has publicationkeywords Adipose tissue  + , Glucose homeostasis  + , Glyceroneogenesis  + , Mitochondrial biogenesis  + , Rat  +
Has title Beaudoin MS, Snook LA, Arkell AM, Simpson JA, Holloway GP, Wright DC (2013) Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 305:542-51.  +
Instrument and method Oxygraph-2k  +
Mammal and model Rat  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  +
Pathways N  + , NS  +
Preparation Permeabilized cells  +
Tissue and cell Fat  +
Was published by MiPNetLab CA Guelph Holloway GP +
Was published in journal Am J Physiol Regul Integr Comp Physiol +
Was published in year 2013  +
Was written by Beaudoin MS + , Snook LA + , Arkell AM + , Simpson JA + , Holloway GP + , Wright DC +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
14:55:26, 9 November 2017  +
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