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Gnaiger 2015 Scand J Med Sci Sports
Additional label 1OctM;2D;3G;4S;5Rot;6Omy;7U-  + , BMI  + , MitoFitPublication  + , SUIT-016  + , SUIT-016 O2 pfi D044  + , VO2max  +
Coupling states ET  + , LEAK  + , OXPHOS  +
Enzyme Marker enzyme  + , TCA cycle and matrix dehydrogenases  +
Has abstract [[Image:O2k-Publications.jpg|80px|link=O2k
[[Image:O2k-Publications.jpg|80px|link=O2k-Publications: Topics|O2k-Publications: Topics]][ O2k-''in brief''] [[File:1OctM;2D;3G;4S;5Rot;6Omy;7U;7c-8Ama.jpg|right|300px|link=1OctM;2D;3G;4S;5Rot;6Omy;7U-]] During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from ''V''<sub>O2max</sub> and maximum capacities of oxidative phosphorylation.
m capacities of oxidative phosphorylation.  +
Has editor [[Gnaiger E]]  +
Has info [
[ PMID: 26589126] [ Open Access] »[[File:O2k-brief.png|36px|link= |O2k-brief]]
_Med_Sci_Sports_O2k-brief.pdf |O2k-brief]]  +
Has publicationkeywords BMI  + , VO2max  +
Has title Gnaiger E, Boushel R, Søndergaard H, Munch
Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34.
cand J Med Sci Sports 25 (Suppl 4):126–34.  +
Instrument and method O2k-Protocol  + , Oxygraph-2k  +
Mammal and model Human  +
MiP area Comparative MiP;environmental MiP  + , Exercise physiology;nutrition;life style  + , Gender  + , Respiration  + , mt-Biogenesis;mt-density  + , mtDNA;mt-genetics  +
Pathways F  + , N  + , ROX  + , S  +
Preparation Permeabilized tissue  +
Respiration and regulation Coupling efficiency;uncoupling  + , Cyt c  +
Stress Temperature  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab AT Innsbruck Gnaiger E + , AT Innsbruck Oroboros + , CA Vancouver Boushel RC + , NL Maastricht Schrauwen P + , DK Copenhagen Christiansen M + , ES CN Las Palmas Calbet JA +
Was published in journal Scand J Med Sci Sports +
Was published in year 2015  +
Was written by Gnaiger E + , Boushel RC + , Soendergaard NH + , Munch-Andersen T + , Damsgaard R + , Hagen C + , Diez-Sanchez C + , Ara I + , Wright-Paradis C + , Schrauwen P + , Hesselink MK + , Calbet JA + , Christiansen M + , Helge JW + , Saltin B +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
09:55:49, 10 April 2019  +
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