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Hanssen 2015 Nat Med
Coupling states LEAK  + , OXPHOS  + , ET  +
Diseases Diabetes  +
Enzyme Complex II;succinate dehydrogenase  + , Complex III  + , Complex IV;cytochrome c oxidase  + , Complex V;ATP synthase  +
Has abstract Cold exposure may be a potential therapy f
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
ly a minor increase in BAT glucose uptake.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/26147760 PMID: 26147760]  +
Has title Hanssen MJ, Hoeks J, Brans B, van der Lans
Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P (2015) Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 21:863-5.
ype 2 diabetes mellitus. Nat Med 21:863-5.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  + , Patients  +
Pathways F  + , N  + , NS  + , Other combinations  +
Preparation Permeabilized tissue  +
Stress Temperature  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab NL Maastricht Schrauwen P +
Was published in journal Nat Med +
Was published in year 2015  +
Was written by Hanssen MJ + , Hoeks J + , Brans B + , Van der Lans AA + , Schaart G + , Van den Driessche JJ + , Joergensen JA + , Boekschoten MV + , Hesselink MK + , Havekes B + , Kersten S + , Mottaghy FM + , Van Marken Lichtenbelt WD + , Schrauwen P +
Categories Publications
Modification date
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12:31:40, 13 November 2017  +
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