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Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum
Additional label Palmitoylcarnitine  +
Coupling states OXPHOS  + , ET  +
Has abstract I am sending you a graph with some mitocho
I am sending you a graph with some mitochondrial respiration measurements obtained from the left ventricular human tissue of patients undergoing CABG surgery. As can be seen from the graph, we used FFA substrate to evoke the State 2 and State 3 respiration, and then followed with other substrates and an uncoupler. FFA substrate was palmitoyl-carnitine (40 µM concentration). We performed quite a few of experiments using palmitoyl-carnitine, also in the range of concentrations from 1 – 40 µM. We usually see a gradual increase in State 3 respiration with concentration increments (1, 2.5, 5, 10, 15, 40 µM). However, the respiration is always lower then when pyruvate is used (although in much higher concentration, from 2 mM up). All of the observations come from the human left ventricular tissue, that we almost exclusively use in past couple of years for our experiments on mitochondria (we also measured activity of some enzymes and protein expression).
y of some enzymes and protein expression).  +
Has title Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum  +
Mammal and model Human  +
MiP area Patients  +
Pathways F  + , N  + , NS  +
Preparation Permeabilized tissue  +
Tissue and cell Heart  +
Was published by MiPNetLab HR Split Ljubkovic M +
Was submitted in year 2015  +
Was submitted to event Talk:Fatty acid oxidation +
Was written by Ljubkovic M +
Categories Abstracts
Modification date
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12:21:00, 26 March 2018  +
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