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Menezes-Filho 2017 Free Radic Biol Med
Additional label Labels  + , 2017-09  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Has abstract Caloric restriction (CR) promotes lifespan
Caloric restriction (CR) promotes lifespan extension and protects against many pathological conditions, including ischemia/reperfusion injury to the brain, heart and kidney. In the liver, ischemia/reperfusion damage is related to excessive mitochondrial Ca<sup>2+</sup> accumulation, leading to the mitochondrial permeability transition. Indeed, liver mitochondria isolated from animals maintained on CR for 4 months were protected against permeability transition and capable of taking up Ca<sup>2+</sup> at faster rates and in larger quantities. These changes were not related to modifications in mitochondrial respiratory activity, but rather to a higher proportion of ATP relative to ADP in CR liver mitochondria. Accordingly, both depletion of mitochondrial adenine nucleotides and loading mitochondria with exogenous ATP abolished the differences between CR and ad libitum (AL) fed groups. The prevention against permeability transition promoted by CR strongly protected against ''in vivo'' liver damage induced by ischemia/reperfusion. Overall, our results show that CR strongly protects the liver against ischemia/reperfusion and uncover a mechanism for this protection, through a yet undescribed diet-induced change in liver mitochondrial Ca<sup>2+</sup> handling related to elevated intramitochondrial ATP. Copyright © 2017 Elsevier Inc. All rights reserved.
© 2017 Elsevier Inc. All rights reserved.  +
Has editor [[Kandolf G]]  +
Has info [ PMID: 28642067]  +
Has publicationkeywords ATP  + , Ca(2+)  + , Calorie restriction  + , Ischemic protection  + , Liver  + , Mitochondria  +
Has title Menezes-Filho SL, Amigo I, Prado FM, Ferre
Menezes-Filho SL, Amigo I, Prado FM, Ferreira NC, Koike MK, Pinto IFD, Miyamoto S, Montero EFS, Medeiros MHG, Kowaltowski AJ (2017) Caloric restriction protects livers from ischemia/reperfusion damage by preventing Ca<sup>2+</sup>-induced mitochondrial permeability transition. Free Radic Biol Med 110:219-27.
ransition. Free Radic Biol Med 110:219-27.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  +
Preparation Isolated mitochondria  +
Stress Ischemia-reperfusion  + , Permeability transition  +
Tissue and cell Liver  +
Was published by MiPNetLab BR Sao Paulo Kowaltowski AJ +
Was published in journal Free Radic Biol Med +
Was published in year 2017  +
Was written by Menezes-Filho SL + , Amigo I + , Prado FM + , Ferreira NC + , Koike MK + , Pinto IFD + , Miyamoto S + , Montero EFS + , Medeiros MHG + , Kowaltowski AJ +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
13:18:04, 13 November 2017  +
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