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Oemer 2018 Proc Nat Acad Sci U S A
Coupling states LEAK  + , ROUTINE  + , OXPHOS  + , ET  +
Diseases Cardiovascular  +
Has abstract Current strategies used to quantitatively
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipids, hampering their accurate identification. This is especially true for cardiolipins, a mitochondria-specific class of phospholipids, which are functionally involved in many cellular functions, including energy metabolism, cristae structure, and apoptosis. Substituted with four fatty acyl side chains, cardiolipins offer a particularly high potential to achieve complex mixtures of molecular species. Here we demonstrate, how systematically generated high performance liquid chromatography - tandem mass spectral data can be utilized in a mathematical structural modeling approach, in order to comprehensively analyze and characterize the molecular diversity of mitochondrial cardiolipin compositions in a broad set of biological samples.
ions in a broad set of biological samples.  +
Has editor Krumschnabel G  +
Has info [ PMID: 29618609 Open Access]»[[File:O2k-brief.png|36px|link=|O2k-brief]]  +
Has title Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  + , mt-Membrane  +
Pathways F  + , N  + , S  + , Gp  + , CIV  + , NS  + , ROX  +
Preparation Intact cells  + , Permeabilized cells  +
Tissue and cell HeLa  +
Was published by MiPNetLab AT Innsbruck Oroboros + , AT Innsbruck Gnaiger E +
Was published in journal Proc Natl Acad Sci U S A +
Was published in year 2018  +
Was written by Oemer G + , Lackner L + , Muigg K + , Krumschnabel G + , Watschinger K + , Sailer S + , Lindner H + , Wortmann SB + , Werner ER + , Zschocke J + , Keller MA + , Gnaiger E +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
09:57:21, 10 April 2019  +
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