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Souza 2018 Sci Rep
Additional label 2018-12  + , Amplex UltraRed  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Enzyme Complex I  + , Complex II;succinate dehydrogenase  + , Complex III  + , Complex IV;cytochrome c oxidase  + , Complex V;ATP synthase  + , TCA cycle and matrix dehydrogenases  +
Has abstract Given the association between high aerobic
Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. Oxidative post-translational modifications (Ox-PTMs) of proteins can regulate cellular homeostasis in skeletal and cardiac muscles, but the relationship between Ox-PTMs and intrinsic components of oxidative energy metabolism is still unclear. Here, we evaluated the Ox-PTM profile in cardiac and skeletal muscles of rats bred for low (LCR) and high (HCR) intrinsic aerobic capacity. Redox proteomics screening revealed different cysteine (Cys) Ox-PTM profile between HCR and LCR rats. HCR showed a higher number of oxidized Cys residues in skeletal muscle compared to LCR, while the opposite was observed in the heart. Most proteins with differentially oxidized Cys residues in the skeletal muscle are important regulators of oxidative metabolism. The most oxidized protein in the skeletal muscle of HCR rats was malate dehydrogenase (MDH1). HCR showed higher MDH1 activity compared to LCR in skeletal, but not cardiac muscle. These novel findings indicate a clear association between Cys Ox-PTMs and aerobic capacity, leading to novel insights into the role of Ox-PTMs as an essential signal to maintain metabolic homeostasis.
signal to maintain metabolic homeostasis.  +
Has editor [[Plangger M]]  +
Has info [ PMID: 30538258 Open Access]  +
Has title Souza RWA, Alves CRR, Medeiros A, Rolim N,
Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep 8:17772.
and low aerobic capacity. Sci Rep 8:17772.  +
Instrument and method Oxygraph-2k  + , O2k-Fluorometer  +
Mammal and model Rat  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  +
Pathways N  + , S  + , NS  +
Preparation Permeabilized tissue  +
Tissue and cell Heart  + , Skeletal muscle  +
Was published by MiPNetLab NO Trondheim Rognmo O +
Was published in journal Sci Rep +
Was published in year 2018  +
Was written by Souza RWA + , Alves CRR + , Medeiros A + , Rolim N + , Silva GJJ + , Moreira JBN + , Alves MN + , Wohlwend M + , Gebriel M + , Hagen L + , Sharma A + , Koch LG + , Britton SL + , Slupphaug G + , Wisloeff U + , Brum PC +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
10:20:07, 24 May 2019  +
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