From Bioblast
Description
Spermidine is a polycationic bioactive polyamine mainly found in wheat germ, soybean and various vegetables, involved in the regulation of mitophagy, cell growth and cell death. Like other caloric restriction mimetics, spermidine is effective in cardioprotection, neuroprotection and anticancer immunosuppression by preserving mitochondrial function and control of autophagy.
Reference: Madeo 2018 Science
Spermidine and mitObesity
Work in progress by Gnaiger E 2020-02-18 linked to a preprint in preparation on mitObesity drugs.
References: Spermidine
Year | Reference | Organism | Tissue;cell | Pathology | |
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Tyrrell 2019 Circ Res | 2019 | Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298â314. | Mouse | Endothelial;epithelial;mesothelial cell | Aging;senescence |
GabandĂ©-RodrĂguez 2019 Cells | 2019 | GabandĂ©-RodrĂguez E, M GĂłmez de Las Heras M, Mittelbrunn M (2019) Control of inflammation by calorie restriction mimetics: on the crossroad of autophagy and mitochondria. Cells 2019;9:E82. | Aging;senescence | ||
Madeo 2018 Science | 2018 | Madeo F, Eisenberg T, Pietrocola F, Kroemer G (2018) Spermidine in health and disease. Science 359:eaan2788. | Human | Aging;senescence Cancer Cardiovascular Obesity | |
Fan 2017 Oncotarget | 2017 | Fan J, Yang X, Li J, Shu Z, Dai J, Liu X, Li B, Jia S, Kou X, Yang Y, Chen N (2017) Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway. Oncotarget 8:17475â90. | Rat | Skeletal muscle | Aging;senescence |
Eisenberg 2016 Nat Med | 2016 | Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, BĂŒttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, MĂŒhlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med 22:1428-38. | Mouse | Heart | Aging;senescence Cardiovascular |
Bonhoure 2015 Genes Dev | 2015 | Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM1 (2015) Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev 29:934-47. | Mouse | Liver | Obesity Other |
Angiulli 2015 Biochim Biophys Acta | 2015 | Angiulli G, Lantella A, Forte E, Angelucci F, Colotti G, Ilari A, Malatesta F (2015) Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase. Biochim Biophys Acta 1850:1891-7. | |||
Ruiz-Perez 2015 J Biol Chem | 2015 | Ruiz-PĂ©rez MV, Medina MĂ, Urdiales JL, KeinĂ€nen TA, SĂĄnchez-JimĂ©nez F (2015) Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem 290:6106-19. | Human | Nervous system Other cell lines Neuroblastoma | Cancer |
Morselli 2011 J Cell Biol | 2011 | Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, BĂ©nit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, LĂłpez-OtĂn C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G (2011) Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol 192:615â29. | Human Caenorhabditis elegans Saccharomyces cerevisiae | ||
Rustenbeck 1998 Biochem Pharmacol | 1998 | Rustenbeck I, Eggers G, Reiter H, MĂŒnster W, Lenzen S (2020) Polyamine modulation of mitochondrial calcium transport. I. Stimulatory and inhibitory effects of aliphatic polyamines, aminoglucosides and other polyamine analogues on mitochondrial calcium uptake. Biochem Pharmacol 56:977â85. | Rat | Liver |
MitoPedia: mitObesity drugs
Healthy reference population | Body mass excess | BFE | BME cutoffs | BMI | H | M | VO2max | mitObesity drugs |
MitoPedia concepts:
MiP concept
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MitoPedia:mitObesity drug