TissueModels

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TissueModels

TissueModels - Establishing tissue-specific cell models with culture medium additives

FFG


TissueModels: FFG BRIDGE Young Scientists

  • BRIDGE Young Scientists 2. Call - Project No. 878654, Medical University Innsbruck, Institute of Human Genetics
  • Duration: 36 months
  • Start: 2020-04-01


About TissueModels

Led by the Institute of Human Genetics at the Medical University Innsbruck, the TissueModels project aims to establish physiological models for the specific tissue type under investigation by defining medium compositions that preserve or re-establish structural and metabolic characteristics of cells during in vitro culture.


Aims

The specific aims are:
  • To identify medium composition with emphasis on the levels of selected fatty acids and of glucose that support growth and viability of cell lines originally derived from different tissues.
  • To evaluate the metabolic consequences of incubation with selected media with emphasis on mitochondrial energetics.
  • To assess the membrane lipid architecture of cells exposed to selected media to evaluate to which extent the remodeling and/or de novo synthesis of cell lipids were altered and to compare the lipidome with that of the original tissue.


Coordinator


Network

Participants

Institute of Human Genetics, Medical University Innsbruck - http://www.humgen.at/forschung_keller.htm
Oroboros Instruments GmbH - www.oroboros.at



Oroboros project involvement

Oroboros Instruments will provide both infrastructure and the expertise required to conduct the respirometric measurements of the project.


MitoKIN Events

Links

News and articles

Bridge-Projekt „Tissue Models“ erforscht das Potential gewebsspezifischer Zellkultur, www.i-med.ac.at, 2020-06-04


Support

This project has received funding from the Austrian Research Promotion Funding Agency (FFG).

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