US VA Blacksburg Brown DA

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US VA Blacksburg Brown DA

Oroboros O2k-Network

O2k-Network
O2k-Network Lab Virgina Tech

Human Nutrition, Foods and Exercise (HNFE)

Clinical Physiology and Metabolism

Address 1981 Kraft Drive, 1035 ILSB, 24060
City Blacksburg
State/Prov Virginia (VA)
Country USA
Weblink
Contact Brown David A
Team Perry Justin, Mitchell Allen, Goswami Ishan, Specht Kalyn S, Thomson Alexander H
Team previous Tsang Alvin Ming-Yun
Status 5 Power-O2k 2015-2019 previous: US NC Greenville Brown DA
Oroboros Events MitoFit Science Camp 2016, IOC104, MiPschool 2015 US, IOC99, MiPschool 2015 ZA, MiP2014
Topics


O2k-Publications

 PublishedReference
Le 2020 J Biol Chem2020Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria . J Biol Chem [Epub ahead of print].
Allen 2020 Commun Biol2020Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.
Perry 2019 J Mol Cell Cardiol2019Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.
Goswami 2018 Biophys J2018Goswami I, Perry JB, Allen ME, Brown DA, von Spakovsky MR, Verbridge SS (2018) Influence of pulsed electric fields and mitochondria-cytoskeleton interactions on cell respiration. Biophys J 114:2951-64.
Alleman 2016 Am J Physiol Heart Circ Physiol2016Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA (2016) Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am J Physiol Heart Circ Physiol 310:H1360-70.
Ryan 2016 J Mol Cell Cardiol2016Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM (2016) Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia. J Mol Cell Cardiol 97:191-6.
Brown 2014 J Cardiovasc Pharmacol Ther2014Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA (2014) Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther 19:121-32.

O2k-Abstracts

 PublishedReference
Brown 2015 Abstract MiPschool Cape Town 20152015Protection of post-ischemic mitochondrial bioenergetics by targeting cardiolipin-dependent membrane fluidity.
Shaikh 2014 Circulation2014Shaikh SR, Moukdar F, Alleman RJ, Lark DS, Neufer PD, Brown D (2014) The cardiolipin-targeting peptide Bendavia improves post-ischemic mitochondrial energetics by sustaining native respiratory protein complexes. Am Heart Assoc 130:A17592.
Brown DA 2014 Abstract MiP20142014The cardiolipin-targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes.

East Carolina Heart Institute


K-Regio MitoFit

MitoFit

Strategic partner of the K-Regio MitoFit project.


9th MiPschool Greenville 2015

Location: Greenville, North Carolina, USA
Date: August 10-14, 2015
Local organizers: P Darrell Neufer, David A Brown and Ashley Busada, East Carolina University, NC, US; The MiPsociety.
Venue: East Carolina University, East Carolina Heart Institute, Greenville, North Carolina, USA
» More details: MiPschool Greenville 2015
» Global conference highlights mitochondria expertise at ECU, by Kathryn Kennedy ECU News Services.


O2k-Workshop 2015 Greenville

104th Workshop on High-Resolution Respirometry & O2k-Fluorometry
2015 Aug 9-10
East Carolina Diabetes and Obesity Institute, East Carolina Heart Institute
East Carolina University
115 Heart Drive, 4th floor
» More details: IOC104 Greenville