Uncoupler

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MitoPedia

Uncoupler

Description

An uncoupler is a protonophore (CCCP, FCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the noncoupled state of ET capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed.

Abbreviation: U

Reference: Noncoupled respiration

List of uncouplers

» MitoPedia: Uncouplers


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Specific
» Artefacts by single dose uncoupling
» ATP synthase
» CCCP
» Coupling-control protocol
» DNP
» Dyscoupled respiration
» FCCP
» Is respiration uncoupled - noncoupled - dyscoupled?
» Noncoupled respiration: Discussion
» Uncoupler
» Uncoupled respiration - see » Noncoupled respiration
» Uncoupling proteins
» Uncoupling protein 1
» Uncoupler titrations - Optimum uncoupler concentration
Respiratory states and control ratios
» Biochemical coupling efficiency
» Coupling-control state
» Electron-transfer-pathway state
» Electron-transfer pathway
E.jpg ET capacity
» E-L coupling efficiency
» Flux control efficiency
» Flux control ratio
» LEAK-control ratio
» LEAK respiration
» Noncoupled respiration
» OXPHOS
» OXPHOS capacity; » State 3
» OXPHOS-control ratio, P/E ratio
» Respiratory acceptor control ratio
» ROUTINE-control ratio
» ROUTINE respiration
» ROUTINE state
» State 3u
» State 4
» Uncoupling-control ratio UCR
General (alphabetical order)
» Adenine nucleotide translocase
» Adenylates
» Electron transfer pathway
» Mitochondrial preparations
» mt-membrane potential
» Oxygen flux
» Phosphorylation system
» Proton leak
» Proton slip
» TIP2k
Other keyword lists
» Template:Keywords: Force and membrane potential



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Fundamental relationships
» Force
» Affinity
» Flux
» Advancement
» Advancement per volume
» Stoichiometric number
mt-Membrane potential and protonmotive force
» Protonmotive force
» Mitochondrial membrane potential
» Chemical potential
» Faraday constant
» Format
» Uncoupler
O2k-Potentiometry
» O2k-Catalogue: O2k-TPP+ ISE-Module
» O2k-Manual: MiPNet15.03 O2k-MultiSensor-ISE
» TPP - O2k-Procedures: Tetraphenylphosphonium
» Specifications: MiPNet15.08 TPP electrode
» Poster
» Unspecific binding of TPP+
» TPP+ inhibitory effect
O2k-Fluorometry
» O2k-Catalogue: O2k-FluoRespirometer
» O2k-Manual: MiPNet22.11 O2k-FluoRespirometer manual
» Safranin - O2k-Procedures: MiPNet20.13 Safranin mt-membranepotential / Safranin
» TMRM - O2k-Procedures: TMRM
O2k-Publications
» O2k-Publications: mt-Membrane potential
» O2k-Publications: Coupling efficiency;uncoupling


»O2k-Publications: Coupling efficiency;uncoupling


MitoPedia topics: Uncoupler