User talk:Beno Marija/FAT4BRAIN

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User talk:Beno Marija/FAT4BRAIN

FAT4BRAIN - Networking for excellence in functional pharmacology to study the role of fatty acid metabolism in neurological disorders


FAT4BRAIN: H2020-WIDESPREAD-2018-2020

Web

Contents

The Latvian Institute of Organic Synthesis (LIOS) is in great need to enhance its scientific performance and this could be accomplished through stronger international collaboration within the defined National RIS3 specialization in biomedicine. Latvia is performing well below the EU-average in terms of research excellence and innovation scoreboard. The FAT4BRAIN project builds cooperation between LIOS from the Widening region and world-leading partners in translational neuropharmacology (Uppsala University), metabolism and neuropsychiatric imaging research (Eberhard Karls University Tuebingen) as well as innovative mitochondria research company (Oroboros Instruments). The aim of FAT4BRAIN is to establish a network of excellence focused on the pivotal and common role of fatty acid metabolism in the development of neurological disorders, an issue of utmost biomedical and societal interest. FAT4BRAIN will use a multidisciplinary, functional pharmacology approach to promote cutting-edge research in this field. A comprehensive set of activities including workshops, expert meetings and dedicated training for early-stage researchers will enhance knowledge-bridging and networking. FAT4BRAIN activities will specifically focus on strengthening capacities in areas that need improvement at LIOS, using the internationally-leading partners’ excellence and experience. Dissemination of results to the research community, industry partners and public through presentations at conferences, media outputs as well as high impact publications will be facilitated by the partners’ extraordinary reputation and high-impact profile. Importantly, the research excellence of the partnering institutions together with the targeted activities of FAT4BRAIN will help LIOS to improve their own research profile by increasing methodological capacities in preclinical and translational research and scientific output in terms of publications of highest quality and impact.


Objectives

WP1 Brain energy metabolism in health & disease
  • to increase competence and expertise in scientific background and in various cutting edge methods
  • to promote the exchange of experience and scientific know-how; to build the capacity of LIOS researchers by obtaining the necessary knowledge and skills
» scientific skills on metabolism and cognition
» methodological skills on state-of-the-art techniques (e.g. genetic and molecular methods)
» procedural skills on translational medicine and clinical trial organisation
  • to strengthen the networking with partner organisations and to ensure long lasting further cooperation
WP2 Mitochondrial fitness & neuronal functions
  • to get training in the use of High-Resolution FluoRespirometry (HRFR) for the assessment of mitochondrial energetics in preclinical and clinical samples and to learn how to apply fluorometry in HRFR for the detection of hydrogen peroxide, calcium, and the assessment of mitochondrial membrane the potential in preclinical and clinical samples
  • review the potential for measurements of mitochondrial energetics, hydrogen peroxide production, calcium, and mitochondrial membrane potential in samples from CNS-related disorder models and patients
  • develop a platform for evaluation of mitochondria-related effects of drugs applied for interventions against CNS-related disorders
WP3 Novel targets & method development
  • to increase research competence in neuroscience
  • to guarantee compliance to international experimental research standards and ethical guidelines in LIOS
  • to promote visibility of the research of LIOS by conference attendance and publications
WP4 Career development of early-stage researchers (ESR)
  • to organise dedicated trainings and seminars for ESR and promote ESR participation in FAT4BRAINorganised activities
  • to establish a mentoring platform for ESR
  • to establish a networking platform of ESR from partner institutions for future collaborations
WP5 Outreach & promotion
  • to disseminate and exploit research results fostered by FAT4BRAIN within the scientific community of Europe
  • to provide information about FAT4BRAIN project activities and results to the general public
  • to enhance the attractiveness and networking of LIOS in order to compete for national and international research funding
WP6 Management & coordination
  • the overall goal of WP6 is to coordinate the consortium and manage the project activities to reach the planned results and impact within the proposed budget and time at the highest quality.
This includes:
  • to set-up the operational bodies of FAT4BRAIN
  • to coordinate and oversee the project activities to be carried out
  • to perform overall administrative and financial management of the project
  • to take care of legal and contractual management (compliance of the project activities with Grant Agreement and the Consortium Agreement)
  • to establish effective internal communication procedures and channels inside the consortium and to maintain the communication with the EC



Working Group Leader

WP1: Prof. Helgi Schiöth
WP2: Prof. Erich Gnaiger
WP3: Dr. Liga Zvejniece
WP4: Dr. Laura Clemensson (UU), Dr. Edijs Vavers (LIOS)
WP5: Dr. Marina Makrecka-Kuka
WP6: Dr. Edgars Liepinsh


Oroboros project involvement

Oroboros Instruments is a beneficiary at the FAT4BRAIN project and will contribute by training participants in the Oroboros MitoFit Laboratory and also send people from Oroboros to other institutes.



Secondments

Project Duration

Start: November 2019
End: December 2022


Social media

Events




Contribution of Oroboros in the activities planned

Oroboros provides the worldwide leading concept and technology of high-resolution respirometry (HRR) applied for the functional diagnosis of mitochondrial defects, namely the MitoFit Lab with fourteen O2k (28 O2k-Chambers) for mitochondria metabolism screen. Oroboros will (1) train visiting researchers for the assessment of mitochondrial energetics in preclinical and clinical samples and to learn how to apply fluorometry in HRFR for the detection of hydrogen peroxide, calcium, and the assessment of mitochondrial membrane potential in preclinical and clinical samples; (2) review the potential for measurements of mitochondrial energetics, hydrogen peroxide production, calcium, and mitochondrial membrane potential in samples from CNS-related disorder models and patients and (3) develop a platform for evaluation of mitochondria-related effects of drugs applied for interventions against CNS-related disorders.

Coordinator

Participants/Beneficiaries

Selected publications

Research innovation products: Oroboros Oroboros O2k (O2k) for high-resolution respirometry, O2kFluorometer
1) Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ. Metabolic basis to Sherpa altitude adaptation. Proc Natl Acad Sci U S A2017;114:6382–7.
2) Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25:104-12.
3) Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E.Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol2015; 1264:245-61.
4) Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B. Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports2015; 25 (Suppl 4):126–34.
5) Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80pp.


Official announcement of the WIDESPREAD Action [link FAT4BRAIN] ##