Vevera 2016 Physiol Res

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Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.

» https://www.ncbi.nlm.nih.gov/pubmed/27429121 PMID: 27429121 Open Access]

Vevera J, Fisar Z, Nekovarova T, Vrablik M, Zlatohlavek L, Hroudova J, Singh N*, Raboch J, Vales K (2016) Physiol Res

Abstract: 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used drugs for lowering blood lipid levels and preventing cardiovascular diseases. However, statins can have serious adverse effects, which may be related to development of mitochondrial dysfunctions. The aim of study was to demonstrate the in vivo effect of high and therapeutic doses of statins on mitochondrial respiration in blood platelets. Model approach was used model in the study. Simvastatin was administered to rats at a high dose for 4 weeks. Humans were treated with therapeutic doses of rosuvastatin or atorvastatin for 6 weeks. Platelet mitochondrial respiration was measured using high-resolution respirometry. In rats, a significantly lower physiological respiratory rate was found in intact platelets of simvastatin-treated rats compared to controls. In humans, no significant changes in mitochondrial respiration were detected in intact platelets; however, decreased complex I-linked respiration was observed after statin treatment in permeabilized platelets. We propose that the small in vivo effect of statins on platelet energy metabolism can be attributed to drug effects on complex I of the electron transport system. Both intact and permeabilized platelets can be used as a readily available biological model to study changes in cellular energy metabolism in patients treated with statins.

Keywords: Statin, Mitochondria, Platelet

O2k-Network Lab: CZ Prague Fisar Z


Labels: MiParea: Respiration, Comparative MiP;environmental MiP, mt-Medicine, Pharmacology;toxicology 


Organism: Human, Rat  Tissue;cell: Blood cells, Platelet  Preparation: Intact cells, Permeabilized cells 


Coupling state: LEAK, ROUTINE, OXPHOS, ET  Pathway: N, S, NS, Other combinations, ROX  HRR: Oxygraph-2k 

2016-09 

Remark

  • Sing N refers to Namrata Singh of the Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague rather than Singh Nitesh of the Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University