From Bioblast
- high-resolution terminology - matching measurements at high-resolution
2-mercaptoacetate
Description
2-mercaptoacetate is an inhibitor of medium-chain acyl-CoA dehydrogenase, MCAD, the rate-limiting enzyme of octanoylcarnitine oxidation. 2-mercaptoacetate has been used as an inhibitor of fatty acid oxidation (F-pathway control state). In permeabilized rat soleus muscle fibers, pre-incubation with 1 mM 2-mercaptoacetate for 45 min resulted in 58% inhibition of MCAD and decreased octanoylcarnitine&malate stimulated respiration by approximately 60% (Osiki 2016 FASEB J).
Reference: Bauché 1981 Biochem J, Osiki 2016 FASEB J
MitoPedia topics:
Inhibitor
Labels:
MitoPedia:FAT4BRAIN
