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Difference between revisions of "Additive effect of convergent electron flow"

From Bioblast
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*Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCH-4W04KR1-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6456620daa0d8cca022b5f934f2cf30 Int. J. Biochem. Cell Biol. 41: 1837–1845].
*Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCH-4W04KR1-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6456620daa0d8cca022b5f934f2cf30 Int. J. Biochem. Cell Biol. 41: 1837–1845].


[[Category:MitoPedia]]
{{MitoPedia}}

Revision as of 18:04, 15 August 2010

Electron flow converges at the Q-junction from respiratory Complexes I and II (CI+II e-input), glycerophosphate dehydrogenase and electron-transferring flavoprotein. Convergent electron flow corresponds to the operation of the TCA cycle and mitochondrial substrate supply in vivo.

Additive effect

Convergent electron flow simultaneously through CI+II into the Q-junction supports higher OXPHOS capacity and ETS capacity than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular TCA cycle function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with mt-preparations have underestimated cellular OXPHOS capacities.

References



high-resolution terminology - matching measurements at high-resolution


Additive effect of convergent electron flow

Description